BRPI0812005A2 - anticorpos humanizados para o globulômeros de ab(20-42) e seus usos. - Google Patents
anticorpos humanizados para o globulômeros de ab(20-42) e seus usos.Info
- Publication number
- BRPI0812005A2 BRPI0812005A2 BRPI0812005A BRPI0812005A BRPI0812005A2 BR PI0812005 A2 BRPI0812005 A2 BR PI0812005A2 BR PI0812005 A BRPI0812005 A BR PI0812005A BR PI0812005 A BRPI0812005 A BR PI0812005A BR PI0812005 A2 BRPI0812005 A2 BR PI0812005A2
- Authority
- BR
- Brazil
- Prior art keywords
- globulomers
- humanized antibodies
- humanized
- antibodies
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- General Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Physics & Mathematics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Plant Pathology (AREA)
- Veterinary Medicine (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US94093207P | 2007-05-30 | 2007-05-30 | |
| US99035907P | 2007-11-27 | 2007-11-27 | |
| PCT/US2008/065205 WO2008150949A1 (en) | 2007-05-30 | 2008-05-30 | HUMANIZED ANTIBODIES TO Aß(20-42) GLOBULOMER AND USES THEREOF |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0812005A2 true BRPI0812005A2 (pt) | 2019-09-24 |
Family
ID=39791050
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0812005A BRPI0812005A2 (pt) | 2007-05-30 | 2008-05-30 | anticorpos humanizados para o globulômeros de ab(20-42) e seus usos. |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US20090175847A1 (pt) |
| EP (1) | EP2150563A1 (pt) |
| JP (1) | JP2010530740A (pt) |
| KR (1) | KR20100032398A (pt) |
| CN (1) | CN101827862A (pt) |
| AR (1) | AR066794A1 (pt) |
| AU (1) | AU2008260062A1 (pt) |
| BR (1) | BRPI0812005A2 (pt) |
| CA (1) | CA2687414A1 (pt) |
| CL (1) | CL2008001580A1 (pt) |
| CO (1) | CO6251291A2 (pt) |
| CR (1) | CR11179A (pt) |
| DO (1) | DOP2009000269A (pt) |
| EC (1) | ECSP099833A (pt) |
| IL (1) | IL202243A0 (pt) |
| MX (1) | MX2009012950A (pt) |
| PA (1) | PA8782201A1 (pt) |
| PE (1) | PE20090329A1 (pt) |
| RU (1) | RU2009149370A (pt) |
| TW (1) | TW200914465A (pt) |
| UY (1) | UY31114A1 (pt) |
| WO (1) | WO2008150949A1 (pt) |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10022078B2 (en) | 2004-07-13 | 2018-07-17 | Dexcom, Inc. | Analyte sensor |
| DE10303974A1 (de) | 2003-01-31 | 2004-08-05 | Abbott Gmbh & Co. Kg | Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung |
| US7920906B2 (en) | 2005-03-10 | 2011-04-05 | Dexcom, Inc. | System and methods for processing analyte sensor data for sensor calibration |
| US9247900B2 (en) | 2004-07-13 | 2016-02-02 | Dexcom, Inc. | Analyte sensor |
| BRPI0506629A (pt) * | 2004-02-10 | 2007-05-02 | Univ Colorado | inibição do fator b, a via alternativa do sistema complemento e métodos relacionados |
| US7946984B2 (en) | 2004-07-13 | 2011-05-24 | Dexcom, Inc. | Transcutaneous analyte sensor |
| PL2343380T3 (pl) | 2004-11-16 | 2020-03-31 | Humanigen, Inc. | Wymiana kasety dla regionu zmiennego immunoglobuliny |
| CN103505728A (zh) * | 2005-05-26 | 2014-01-15 | 科罗拉多大学评议会法人机构 | 用于治疗外伤性脑损伤、脊髓损伤及相关病症的补体旁路抑制 |
| PL1976877T5 (pl) | 2005-11-30 | 2017-09-29 | Abbvie Inc | Przeciwciała monoklonalne przeciwko białku amyloidu beta oraz ich zastosowania |
| RU2442793C2 (ru) | 2005-11-30 | 2012-02-20 | Эбботт Лэборетриз | АНТИТЕЛА ПРОТИВ ГЛОБУЛОМЕРА Аβ, ИХ АНТИГЕНСВЯЗЫВАЮЩИЕ ЧАСТИ, СООТВЕТСТВУЮЩИЕ ГИБРИДОМЫ, НУКЛЕИНОВЫЕ КИСЛОТЫ, ВЕКТОРЫ, КЛЕТКИ-ХОЗЯЕВА, СПОСОБЫ ПОЛУЧЕНИЯ УКАЗАННЫХ АНТИТЕЛ, КОМПОЗИЦИИ, СОДЕРЖАЩИЕ УКАЗАННЫЕ АНТИТЕЛА, ПРИМЕНЕНИЯ УКАЗАННЫХ АНТИТЕЛ И СПОСОБЫ ИСПОЛЬЗОВАНИЯ УКАЗАННЫХ АНТИТЕЛ |
| NZ568012A (en) * | 2005-12-12 | 2012-07-27 | Ac Immune Sa | A beta 1-42 specific monoclonal antibodies with therapeutic properties |
| RU2498999C2 (ru) | 2006-07-14 | 2013-11-20 | Ац Иммуне Са | Гуманизированное антитело к амилоиду бета |
| US8455626B2 (en) | 2006-11-30 | 2013-06-04 | Abbott Laboratories | Aβ conformer selective anti-aβ globulomer monoclonal antibodies |
| US8895004B2 (en) | 2007-02-27 | 2014-11-25 | AbbVie Deutschland GmbH & Co. KG | Method for the treatment of amyloidoses |
| WO2008140653A2 (en) * | 2007-03-14 | 2008-11-20 | Taligen Therapeutics, Inc. | Humaneered anti-factor b antibody |
| US8048420B2 (en) * | 2007-06-12 | 2011-11-01 | Ac Immune S.A. | Monoclonal antibody |
| US8613923B2 (en) | 2007-06-12 | 2013-12-24 | Ac Immune S.A. | Monoclonal antibody |
| PL2238166T3 (pl) | 2007-10-05 | 2014-07-31 | Genentech Inc | Zastosowanie przeciwciała anty-Beta amyloidowego w chorobach oczu |
| AU2008311366B2 (en) * | 2007-10-05 | 2015-03-12 | Ac Immune S.A. | Use of anti-amyloid beta antibody in ocular diseases |
| CN102089430B (zh) | 2008-05-09 | 2015-02-04 | Abbvie公司 | 针对渐进性糖化终极产物受体(rage)的抗体及其用途 |
| JP5871798B2 (ja) | 2009-07-02 | 2016-03-01 | エムユーエスシー ファウンデーション フォー リサーチ ディベロップメント | 肝再生を刺激する方法 |
| US9345661B2 (en) * | 2009-07-31 | 2016-05-24 | Genentech, Inc. | Subcutaneous anti-HER2 antibody formulations and uses thereof |
| AU2013202020B2 (en) * | 2009-07-31 | 2014-11-27 | F. Hoffmann-La Roche Ag | Subcutaneous anti-HER2 antibody formulation |
| AR078161A1 (es) | 2009-09-11 | 2011-10-19 | Hoffmann La Roche | Formulaciones farmaceuticas muy concentradas de un anticuerpo anti cd20. uso de la formulacion. metodo de tratamiento. |
| US8420083B2 (en) | 2009-10-31 | 2013-04-16 | Abbvie Inc. | Antibodies to receptor for advanced glycation end products (RAGE) and uses thereof |
| PH12012501744A1 (en) | 2010-03-03 | 2021-08-09 | Boehringer Ingelheim Int | Biparatopic abeta binding polypeptides |
| MX2012011629A (es) * | 2010-04-07 | 2013-03-05 | Abbvie Inc | Proteinas de union a tnf-alfa. |
| WO2011130377A2 (en) * | 2010-04-15 | 2011-10-20 | Abbott Laboratories | Amyloid-beta binding proteins |
| US9320793B2 (en) * | 2010-07-14 | 2016-04-26 | Acumen Pharmaceuticals, Inc. | Method for treating a disease associated with soluble, oligomeric species of amyloid beta 1-42 |
| US9221900B2 (en) | 2010-07-30 | 2015-12-29 | Ac Immune S.A. | Methods for identifying safe and functional humanized antibodies |
| US9062101B2 (en) | 2010-08-14 | 2015-06-23 | AbbVie Deutschland GmbH & Co. KG | Amyloid-beta binding proteins |
| US9067988B2 (en) | 2010-12-01 | 2015-06-30 | Alderbio Holdings Llc | Methods of preventing or treating pain using anti-NGF antibodies |
| US9539324B2 (en) | 2010-12-01 | 2017-01-10 | Alderbio Holdings, Llc | Methods of preventing inflammation and treating pain using anti-NGF compositions |
| US11214610B2 (en) | 2010-12-01 | 2022-01-04 | H. Lundbeck A/S | High-purity production of multi-subunit proteins such as antibodies in transformed microbes such as Pichia pastoris |
| US9884909B2 (en) | 2010-12-01 | 2018-02-06 | Alderbio Holdings Llc | Anti-NGF compositions and use thereof |
| US9783601B2 (en) | 2010-12-01 | 2017-10-10 | Alderbio Holdings Llc | Methods of preventing inflammation and treating pain using anti-NGF compositions |
| US9078878B2 (en) | 2010-12-01 | 2015-07-14 | Alderbio Holdings Llc | Anti-NGF antibodies that selectively inhibit the association of NGF with TrkA, without affecting the association of NGF with p75 |
| CN102516360B (zh) * | 2011-12-08 | 2013-11-06 | 清华大学 | 一种抑制β分泌酶酶切作用的多肽及其应用 |
| US9803005B2 (en) | 2012-05-24 | 2017-10-31 | Alexion Pharmaceuticals, Inc. | Humaneered anti-factor B antibody |
| EP2885010B1 (en) | 2012-08-16 | 2020-01-01 | Ipierian, Inc. | Methods of treating a tauopathy |
| KR102308915B1 (ko) * | 2012-10-15 | 2021-10-06 | 메디뮨 리미티드 | 아밀로이드 베타에 대한 항체 |
| CN105939722A (zh) | 2014-02-14 | 2016-09-14 | 伊皮埃里安股份有限公司 | Tau肽,抗Tau抗体,及其使用方法 |
| TWI806150B (zh) | 2014-11-07 | 2023-06-21 | 瑞士商諾華公司 | 穩定的含有高濃度抗vegf抗體之蛋白質溶液調配物 |
| JP7027321B2 (ja) | 2015-11-03 | 2022-03-01 | ヤンセン バイオテツク,インコーポレーテツド | 抗cd38抗体の皮下製剤及びその使用 |
| CA3313684A1 (en) | 2019-07-16 | 2026-06-21 | Sanofi | Neutralizing anti-amyloid beta antibodies for the treatment of alzheimer's disease |
| CN117589996A (zh) * | 2022-08-09 | 2024-02-23 | 深圳智源生物医药有限公司 | 强毒性淀粉样蛋白寡聚体的诊断用途 |
| CN117491650B (zh) * | 2023-11-01 | 2024-09-20 | 首都医科大学宣武医院 | 一种外周血Hb-Aβ复合物定量检测试剂盒、检测方法及应用 |
| WO2025228315A1 (en) * | 2024-04-28 | 2025-11-06 | Jacobio Pharmaceuticals Co., Ltd. | Anti-n3pglu amyloid beta antibodies and uses thereof |
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-
2008
- 2008-05-29 PE PE2008000921A patent/PE20090329A1/es not_active Application Discontinuation
- 2008-05-29 US US12/129,469 patent/US20090175847A1/en not_active Abandoned
- 2008-05-30 TW TW097120376A patent/TW200914465A/zh unknown
- 2008-05-30 RU RU2009149370/10A patent/RU2009149370A/ru unknown
- 2008-05-30 CN CN200880101484A patent/CN101827862A/zh active Pending
- 2008-05-30 BR BRPI0812005A patent/BRPI0812005A2/pt not_active IP Right Cessation
- 2008-05-30 CL CL2008001580A patent/CL2008001580A1/es unknown
- 2008-05-30 AR ARP080102298A patent/AR066794A1/es unknown
- 2008-05-30 KR KR1020097027470A patent/KR20100032398A/ko not_active Withdrawn
- 2008-05-30 MX MX2009012950A patent/MX2009012950A/es not_active Application Discontinuation
- 2008-05-30 UY UY31114A patent/UY31114A1/es not_active Application Discontinuation
- 2008-05-30 CA CA002687414A patent/CA2687414A1/en not_active Abandoned
- 2008-05-30 PA PA20088782201A patent/PA8782201A1/es unknown
- 2008-05-30 EP EP08769847A patent/EP2150563A1/en not_active Withdrawn
- 2008-05-30 AU AU2008260062A patent/AU2008260062A1/en not_active Abandoned
- 2008-05-30 WO PCT/US2008/065205 patent/WO2008150949A1/en not_active Ceased
- 2008-05-30 JP JP2010510504A patent/JP2010530740A/ja not_active Withdrawn
-
2009
- 2009-11-19 IL IL202243A patent/IL202243A0/en unknown
- 2009-11-27 DO DO2009000269A patent/DOP2009000269A/es unknown
- 2009-12-18 CR CR11179A patent/CR11179A/es not_active Application Discontinuation
- 2009-12-21 CO CO09145798A patent/CO6251291A2/es not_active Application Discontinuation
- 2009-12-29 EC EC2009009833A patent/ECSP099833A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| RU2009149370A (ru) | 2011-07-10 |
| CN101827862A (zh) | 2010-09-08 |
| IL202243A0 (en) | 2010-06-16 |
| DOP2009000269A (es) | 2009-12-15 |
| KR20100032398A (ko) | 2010-03-25 |
| UY31114A1 (es) | 2009-01-05 |
| AR066794A1 (es) | 2009-09-09 |
| JP2010530740A (ja) | 2010-09-16 |
| PE20090329A1 (es) | 2009-03-27 |
| CL2008001580A1 (es) | 2008-12-05 |
| US20090175847A1 (en) | 2009-07-09 |
| TW200914465A (en) | 2009-04-01 |
| AU2008260062A1 (en) | 2008-12-11 |
| PA8782201A1 (es) | 2009-02-09 |
| CR11179A (es) | 2010-05-27 |
| CA2687414A1 (en) | 2008-12-11 |
| ECSP099833A (es) | 2010-01-29 |
| WO2008150949A1 (en) | 2008-12-11 |
| MX2009012950A (es) | 2010-03-26 |
| CO6251291A2 (es) | 2011-02-21 |
| EP2150563A1 (en) | 2010-02-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] | ||
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2543 DE 01-10-2019 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |