BRPI0812360A2 - Compostos moduladores de quinase heterocíclica e método de modulação da atividade de uma proteína tirosina quinase - Google Patents

Compostos moduladores de quinase heterocíclica e método de modulação da atividade de uma proteína tirosina quinase

Info

Publication number
BRPI0812360A2
BRPI0812360A2 BRPI0812360-8A2A BRPI0812360A BRPI0812360A2 BR PI0812360 A2 BRPI0812360 A2 BR PI0812360A2 BR PI0812360 A BRPI0812360 A BR PI0812360A BR PI0812360 A2 BRPI0812360 A2 BR PI0812360A2
Authority
BR
Brazil
Prior art keywords
modulating
hyperocyclic
activity
kinase
tyrosine kinase
Prior art date
Application number
BRPI0812360-8A2A
Other languages
English (en)
Inventor
Pierre-Yves Bounaud
Christopher Ronald Smith
Elizabeth Anne Jefferson
Jorg Hendle
Patrick S Lee
Gavin Hirst
Angelina Marie Thayer
Original Assignee
Sgx Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sgx Pharmaceuticals Inc filed Critical Sgx Pharmaceuticals Inc
Publication of BRPI0812360A2 publication Critical patent/BRPI0812360A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
BRPI0812360-8A2A 2007-05-21 2008-05-21 Compostos moduladores de quinase heterocíclica e método de modulação da atividade de uma proteína tirosina quinase BRPI0812360A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US93931307P 2007-05-21 2007-05-21
PCT/US2008/064437 WO2008144767A1 (en) 2007-05-21 2008-05-21 Heterocyclic kinase modulators

Publications (1)

Publication Number Publication Date
BRPI0812360A2 true BRPI0812360A2 (pt) 2015-01-27

Family

ID=40122219

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0812360-8A2A BRPI0812360A2 (pt) 2007-05-21 2008-05-21 Compostos moduladores de quinase heterocíclica e método de modulação da atividade de uma proteína tirosina quinase

Country Status (11)

Country Link
US (1) US20090156594A1 (pt)
EP (1) EP2162132A4 (pt)
JP (1) JP2010528991A (pt)
KR (1) KR101156845B1 (pt)
CN (1) CN101678014B (pt)
AU (1) AU2008254588B2 (pt)
BR (1) BRPI0812360A2 (pt)
CA (1) CA2688823A1 (pt)
EA (1) EA200971077A1 (pt)
MX (1) MX2009012623A (pt)
WO (1) WO2008144767A1 (pt)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7683060B2 (en) 2006-08-07 2010-03-23 Incyte Corporation Triazolotriazines as kinase inhibitors
GEP20125658B (en) 2006-11-22 2012-10-10 Incyte Corp Imidazotriazines and imidazo pyrimidines as kinase inhibitors
DK2193133T3 (en) 2007-09-27 2015-10-05 Fundacion Ct Nac Investigaciones Oncologicas Carlos Iii IMIDAZOLOTHIADIAZOLES USED AS PROTEINKINASE INHIBITORS
SI2300455T1 (sl) 2008-05-21 2017-12-29 Incyte Holdings Corporation Soli 2-fluoro-n-metil-4-(7-(kinolin-6-il-metil)-imidazo(1,2-b)1,2,4) triazin-2-il)benzamid in postopki v zvezi z njihovo pripravo
MX2011005250A (es) * 2008-11-19 2011-07-29 Vertex Pharma Inhibidores de triazolotiadiazol de cinasa de proteina c-met.
AU2010231162B2 (en) * 2009-04-02 2014-12-11 Fundacion Centro Nacional De Investigaciones Oncologicas Carlos Iii Imidazo [2, 1-b] [ 1, 3, 4 ] thiadiazole derivatives
US8269013B2 (en) * 2009-05-28 2012-09-18 Vertex Pharmaceuticals Incorporated Substituted pyrazole inhibitors of c-Met protein kinase
WO2010138673A1 (en) * 2009-05-28 2010-12-02 Vertex Pharmaceuticals Incorporated Inhibitors of c-met protein kinase
UA106082C2 (uk) * 2009-05-28 2014-07-25 Вертекс Фармасьютікалз Інкорпорейтед АМІНОПІРАЗОЛ ТРИАЗОЛОТІАДІАЗОЛЬНІ ІНГІБІТОРИ ПРОТЕЇНКІНАЗИ c-МЕТ
BR112012003262A8 (pt) 2009-08-12 2016-05-17 Novartis Ag compostos de hidrazona heterocíclica e seus usos para tratar câncer e inflamação
IN2012DN01453A (pt) 2009-08-20 2015-06-05 Novartis Ag
US8343977B2 (en) 2009-12-30 2013-01-01 Arqule, Inc. Substituted triazolo-pyrimidine compounds
MX2012008898A (es) 2010-02-03 2012-11-06 Incyte Corp Imidazo - [1, 2 - b] [1, 2, 4] triazinas como inhibidores de c - met.
JP2013527195A (ja) * 2010-05-27 2013-06-27 バーテックス ファーマシューティカルズ インコーポレイテッド ｃ−Ｍｅｔプロテインキナーゼのアミノピラゾールトリアゾロチアジアゾールインヒビター
EP2588107A1 (en) 2010-07-01 2013-05-08 Takeda Pharmaceutical Company Limited COMBINATION OF A cMET INHIBITOR AND AN ANTIBODY TO HGF AND/OR cMET
CN103204862B (zh) * 2012-01-12 2014-12-17 清华大学深圳研究生院 6-苯基咪唑并[2，1-b]噻唑-3-酰胺类衍生物及其制备方法与应用
CN103204825B (zh) * 2012-01-17 2015-03-04 上海科州药物研发有限公司 作为蛋白激酶抑制剂的苯并噻唑化合物及其制备方法和用途
WO2013178572A1 (en) * 2012-05-30 2013-12-05 F. Hoffmann-La Roche Ag Triazolo compounds as pde10 inhibitors
EP2682395A1 (en) 2012-07-04 2014-01-08 Laboratorios Del. Dr. Esteve, S.A. Imidazo[2,1-b]thiazole derivatives, their preparation and use as medicaments
MY189505A (en) 2012-10-16 2022-02-16 Janssen Pharmaceutica Nv Methylene linked quinolinyl modulators of roryt
WO2014062655A1 (en) 2012-10-16 2014-04-24 Janssen Pharmaceutica Nv HETEROARYL LINKED QUINOLINYL MODULATORS OF RORyt
HK1213887A1 (zh) 2012-10-16 2016-07-15 Janssen Pharmaceutica N.V. RORγt的苯基连接的喹啉基调节剂
US20150284380A1 (en) 2012-10-31 2015-10-08 Bayer Cropscience Ag Novel heterocyclic compounds as pest control agents
CN103833771A (zh) * 2012-11-22 2014-06-04 天津滨江药物研发有限公司 作为蛋白激酶Mek抑制剂的苯并五元杂环化合物及其制备方法和用途
CN103073491A (zh) * 2013-01-25 2013-05-01 桑迪亚医药技术（上海）有限责任公司 一种2-（5,7-二氟-6-喹啉基）乙酸/丙酸（酯）的合成方法
US9221804B2 (en) 2013-10-15 2015-12-29 Janssen Pharmaceutica Nv Secondary alcohol quinolinyl modulators of RORγt
CA2926339A1 (en) 2013-10-15 2015-04-23 Janssen Pharmaceutica Nv Alkyl linked quinolinyl modulators of roryt
US9403816B2 (en) 2013-10-15 2016-08-02 Janssen Pharmaceutica Nv Phenyl linked quinolinyl modulators of RORγt
US9284308B2 (en) 2013-10-15 2016-03-15 Janssen Pharmaceutica Nv Methylene linked quinolinyl modulators of RORγt
US9328095B2 (en) 2013-10-15 2016-05-03 Janssen Pharmaceutica Nv Heteroaryl linked quinolinyl modulators of RORgammat
US10555941B2 (en) 2013-10-15 2020-02-11 Janssen Pharmaceutica Nv Alkyl linked quinolinyl modulators of RORγt
CA2927182A1 (en) 2013-10-15 2015-04-23 Janssen Pharmaceutica Nv Quinolinyl modulators of ror.gamma.t
EP3229836B1 (en) 2014-12-09 2019-11-13 Institut National de la Sante et de la Recherche Medicale (INSERM) Human monoclonal antibodies against axl
WO2016135041A1 (en) 2015-02-26 2016-09-01 INSERM (Institut National de la Santé et de la Recherche Médicale) Fusion proteins and antibodies comprising thereof for promoting apoptosis
GR1009565B (el) * 2016-07-14 2019-08-06 Galenica Α.Ε. Νεα παραγωγα 1,2,4-τριαζολο-[3,4-b]-1,3,4-θειαδιαζολιων
RU2020104753A (ru) * 2017-07-10 2021-08-10 Юсб Байофарма Срл Производные 2-оксо-1, 3-оксазолидинилимидазотиазола
CN109897054B (zh) * 2017-12-08 2021-12-10 中国药科大学 三唑并噻二唑类c-Met激酶抑制剂的制备方法及其用途
JP7349450B2 (ja) 2018-04-25 2023-09-22 バイエル・アクチエンゲゼルシヤフト 殺有害生物剤としての新規ヘテロアリール－トリアゾール化合物及びヘテロアリール－テトラゾール化合物
JP7274767B2 (ja) * 2018-05-24 2023-05-17 ▲広▼州市恒▲諾▼康医▲薬▼科技有限公司 芳香族複素環式化合物及びその医薬組成物
CA3148216A1 (en) 2019-07-23 2021-01-28 Bayer Aktiengesellschaft Novel heteroaryl-triazole compounds as pesticides
JP7691973B2 (ja) 2019-07-23 2025-06-12 バイエル・アクチエンゲゼルシヤフト 殺有害生物剤としての新規なヘテロアリール－トリアゾール化合物
PL248221B1 (pl) * 2024-02-09 2025-11-12 Univ Slaski Rozpuszczalny w wodzie kwas 2,9-dimetylo-1,10-fenantrolino-4-ditiokarboksylowy oraz sposób jego otrzymywania

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3050583A (en) * 1958-10-07 1962-08-21 Stephens Trusonic Inc Controllable stereophonic electroacoustic network
GB9416162D0 (en) * 1994-08-10 1994-09-28 Merck Sharp & Dohme Therapeutic agents
GB9918035D0 (en) * 1999-07-30 1999-09-29 Novartis Ag Organic compounds
TW200301251A (en) * 2001-12-20 2003-07-01 Wyeth Corp Azaindolylalkylamine derivatives as 5-hydroxytryptamine-6 ligands
UA78999C2 (en) * 2002-06-04 2007-05-10 Wyeth Corp 1-(aminoalkyl)-3-sulfonylazaindoles as ligands of 5-hydroxytryptamine-6
TW200403243A (en) * 2002-07-18 2004-03-01 Wyeth Corp 1-Heterocyclylalkyl-3-sulfonylazaindole or-azaindazole derivatives as 5-hydroxytryptamine-6 ligands
AU2003256297A1 (en) * 2002-08-09 2004-02-25 Eli Lilly And Company Benzimidazoles and benzothiazoles as inhibitors of map kinase
AU2003298942A1 (en) * 2002-12-11 2004-06-30 Merck And Co., Inc. Tyrosine kinase inhibitors
PA8595001A1 (es) * 2003-03-04 2004-09-28 Pfizer Prod Inc Nuevos compuestos heteroaromaticos condensados que son inhibidores del factor de crecimiento transforante (tgf)
GB0405055D0 (en) * 2004-03-05 2004-04-07 Eisai London Res Lab Ltd JNK inhibitors
ES2364340T3 (es) * 2004-03-30 2011-08-31 Vertex Pharmaceuticals Incorporated Azaindoles útiles como inhibidores de jak y otras proteína quinasas.
US7432373B2 (en) * 2004-06-28 2008-10-07 Bristol-Meyers Squibb Company Processes and intermediates useful for preparing fused heterocyclic kinase inhibitors
US7439246B2 (en) * 2004-06-28 2008-10-21 Bristol-Myers Squibb Company Fused heterocyclic kinase inhibitors
NZ553267A (en) * 2004-07-27 2010-09-30 Sgx Pharmaceuticals Inc Pyrrolo-pyridine kinase modulators
US7452993B2 (en) * 2004-07-27 2008-11-18 Sgx Pharmaceuticals, Inc. Fused ring heterocycle kinase modulators
US7361764B2 (en) * 2004-07-27 2008-04-22 Sgx Pharmaceuticals, Inc. Pyrrolo-pyridine kinase modulators
CA2584368A1 (en) * 2004-10-19 2006-04-27 Arqule, Inc. Synthesis of imidazooxazole and imidazothiazole inhibitors of p38 map kinase
FR2890072A1 (fr) * 2005-09-01 2007-03-02 Fournier S A Sa Lab Nouveaux composesde pyrrolopyridine
US8629147B2 (en) * 2005-11-03 2014-01-14 Chembridge Corporation Heterocyclic compounds useful in the treatment of neoplastic diseases, inflammatory disorders and immunomodulatory disorders
US7728017B2 (en) * 2005-11-30 2010-06-01 Vertex Pharmaceuticals Incorporated Inhibitors of c-Met and uses thereof

Also Published As

Publication number Publication date
AU2008254588A1 (en) 2008-11-27
CA2688823A1 (en) 2008-11-27
EP2162132A1 (en) 2010-03-17
MX2009012623A (es) 2009-12-11
JP2010528991A (ja) 2010-08-26
WO2008144767A1 (en) 2008-11-27
CN101678014B (zh) 2012-12-12
KR101156845B1 (ko) 2012-06-18
EA200971077A1 (ru) 2010-04-30
KR20090130212A (ko) 2009-12-18
EP2162132A4 (en) 2013-01-16
AU2008254588B2 (en) 2013-01-17
US20090156594A1 (en) 2009-06-18
CN101678014A (zh) 2010-03-24

Similar Documents

Publication Publication Date Title
BRPI0816064A2 (pt) Inibidores da atividade de proteína tirosina cinase.
BRPI0717317A2 (pt) Modularoes da proteína cinase triazalopiridazina
CY2019009I2 (el) Αναστολεις πρωτεϊνικων κινασων
BRPI0719195A8 (pt) inibidores de quinase, método de modular uma atividade quinase e composição farmacêutica
BRPI0813311A2 (pt) Composto, métodos para modulara a atividade de uma proteína quinase e para tratar câncer em um indivíduo, e, composição farmacêutica.
ATE522624T1 (de) Identifizierung von krankheitserregern
BRPI0911491A2 (pt) métodos de monitoramento da modulação de atividade de quinase de receptor de fator de crescimento de fibroblasto e usos dos ditos métodos.
EP2306836A4 (en) MODULATORS OF BMI-1 PROTEIN EXPRESSION
DK3136030T3 (da) Fremgangsmåde til lyofilisering
IL189975A0 (en) Methods of modulating neurotrophin-mediated activity
DE602005020209D1 (de) System zur Evaluierung von Herzstörungen
BRPI0910668A2 (pt) inibidores de proteína quinases
SI2303891T1 (sl) Pirazolo kinazolini kot modulatorji aktivnosti protein kinaze
DE602008006293D1 (de) System zur Verschleißminderung von Gelenkoberflächenimplantaten
ZA200908811B (en) N-(2-(hetaryl)aryl) arylsulfonamides and n-(2-(hetaryl)hetaryl)arylsufonamides
PL2358756T3 (pl) Ludzkie przeciwciała o wysokim powinowactwie wobec pcsk9
EP2061765A4 (en) SERIN THREONINE PROTEIN KINASE AND PARP MODULATORS
DE502006004368D1 (de) Wirbelsäulenimplantat
EP1948087A4 (en) HEART VALVE IMPLANT
EP2259678A4 (en) PROTEIN KINASE MODULATORS
PL2999314T3 (pl) Układ sterujący lampą i sposób wysterowania lampy
DE502007001122D1 (de) Humeruskomponente
IL209336B (en) Compositions for treating hyperproliferative diseases and uses thereof
FI20085657L (fi) Valaisin ja ohjausmenetelmä
ATE455102T1 (de) Inhibitoren von akt (proteinkinase b)

Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 7A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2343 DE 01-12-2015 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.