BRPI0812853A2 - Compostos de quinolina adequados para tratar distúrbios que respondem à modulação do receptor 5-ht6 de serotonina. - Google Patents

Compostos de quinolina adequados para tratar distúrbios que respondem à modulação do receptor 5-ht6 de serotonina.

Info

Publication number: BRPI0812853A2
Authority: BR; Brazil
Prior art keywords: serotonin; receptor; respond; modulation; compounds suitable
Prior art date: 2007-08-07

Application number

BRPI0812853-7A2A

Other languages

English (en)

Inventor

Sean Colm Turner

Wilfried Braje

Andreas Haupt

Udo Lange

Karla Drescher

Karsten Wicke

Liliane Unger

Mario Mezler

Wolfgang Wernet

Matthias Mayrer

Original Assignee

Abbott Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-08-07

Filing date

2008-08-06

Publication date

2014-12-23

2008-08-06 Application filed by Abbott Gmbh filed Critical Abbott Gmbh

2014-12-23 Publication of BRPI0812853A2 publication Critical patent/BRPI0812853A2/pt

Links

QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 title 2
108091005435 5-HT6 receptors Proteins 0.000 title 1
SMWDFEZZVXVKRB-UHFFFAOYSA-N Quinoline Chemical class N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 title 1
229940076279 serotonin Drugs 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Psychiatry (AREA)
Addiction (AREA)
Diabetes (AREA)
Pain & Pain Management (AREA)
Obesity (AREA)
Hematology (AREA)
Child & Adolescent Psychology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Psychology (AREA)
Hospice & Palliative Care (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
Anesthesiology (AREA)
Pulmonology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Plural Heterocyclic Compounds (AREA)

BRPI0812853-7A2A 2007-08-07 2008-08-06 Compostos de quinolina adequados para tratar distúrbios que respondem à modulação do receptor 5-ht6 de serotonina. BRPI0812853A2 (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP07113962		2007-08-07
PCT/EP2008/060335 WO2009019286A1 (en)	2007-08-07	2008-08-06	Quinoline compounds suitable for treating disorders that respond to modulation of the serotonin 5-ht6 receptor

Publications (1)

Publication Number	Publication Date
BRPI0812853A2 true BRPI0812853A2 (pt)	2014-12-23

Family

ID=39809897

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI0812853-7A2A BRPI0812853A2 (pt)	2007-08-07	2008-08-06	Compostos de quinolina adequados para tratar distúrbios que respondem à modulação do receptor 5-ht6 de serotonina.

Country Status (22)

Country	Link
US (2)	US8293913B2 (pt)
EP (1)	EP2185555B1 (pt)
JP (1)	JP5501230B2 (pt)
KR (1)	KR20100039300A (pt)
CN (1)	CN101687866B (pt)
AU (1)	AU2008285652B2 (pt)
BR (1)	BRPI0812853A2 (pt)
CA (1)	CA2691529C (pt)
CO (1)	CO6251268A2 (pt)
CR (1)	CR11187A (pt)
DO (1)	DOP2009000291A (pt)
EC (1)	ECSP099831A (pt)
ES (1)	ES2574154T3 (pt)
GT (1)	GT200900333A (pt)
IL (1)	IL202706A (pt)
MX (1)	MX2009013956A (pt)
NZ (1)	NZ581986A (pt)
RU (1)	RU2483068C2 (pt)
TW (1)	TWI478919B (pt)
UA (1)	UA99626C2 (pt)
WO (1)	WO2009019286A1 (pt)
ZA (1)	ZA200909075B (pt)

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AR095079A1 (es)	2013-03-12	2015-09-16	Hoffmann La Roche	Derivados de octahidro-pirrolo[3,4-c]-pirrol y piridina-fenilo
DK3074400T3 (en)	2013-11-26	2018-01-15	Hoffmann La Roche	Octahydro-cyclobuta [1,2-c; 3,4-c '] dipyrrole derivatives as autotaxin inhibitors
CA2937616A1 (en)	2014-03-26	2015-10-01	F. Hoffmann-La Roche Ag	Bicyclic compounds as autotaxin (atx) and lysophosphatidic acid (lpa) production inhibitors
KR102850075B1 (ko) *	2014-04-30	2025-08-25	카티바, 인크.	가스 쿠션 장비 및 기판 코팅 기술
CA2992889A1 (en)	2015-09-04	2017-03-09	F. Hoffmann-La Roche Ag	Phenoxymethyl derivatives
JP6876685B2 (ja)	2015-09-24	2021-05-26	エフ．ホフマン−ラロシュアーゲーＦ．Ｈｏｆｆｍａｎｎ−ＬａＲｏｃｈｅＡｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ	Ａｔｘ阻害剤としての二環式化合物
BR112017026682A2 (pt) *	2015-09-24	2018-08-14	Hoffmann La Roche	novos compostos bicíclicos como inibidores de dupla ação de atx/ca
WO2017050732A1 (en)	2015-09-24	2017-03-30	F. Hoffmann-La Roche Ag	Bicyclic compounds as atx inhibitors
AU2016328436B2 (en) *	2015-09-24	2020-05-14	F. Hoffmann-La Roche Ag	New bicyclic compounds as dual ATX/CA inhibitors
AR106515A1 (es) *	2015-10-29	2018-01-24	Bayer Cropscience Ag	Sililfenoxiheterociclos trisustituidos y análogos
WO2017157929A1 (en) *	2016-03-14	2017-09-21	AbbVie Deutschland GmbH & Co. KG	Quinoline compounds suitable for treating disorders that respond to the modulation of the serotonin 5-ht6 receptor
RU2019132254A (ru)	2017-03-16	2021-04-16	Ф. Хоффманн-Ля Рош Аг	Гетероциклические соединения, пригодные в качестве дуальных ингибиторов atx/ca
JP7090099B2 (ja)	2017-03-16	2022-06-23	エフ．ホフマン－ラロシュアーゲー	Ａｔｘインヒビターとしての新規二環式化合物
CN112010859B (zh) *	2019-05-30	2022-07-19	中国科学院上海药物研究所	一种并环化合物、其制备方法和用途
CA3225439A1 (en) *	2021-06-26	2022-12-29	Cedilla Therapeutics, Inc.	Cdk2 inhibitors and methods of using the same
WO2024140851A1 (zh) *	2022-12-28	2024-07-04	上海维申医药有限公司	一类Toll样受体抑制剂及其制备和应用
CN118359619A (zh) *	2023-01-18	2024-07-19	苏州旺山旺水生物医药股份有限公司	一种抗抑郁化合物的盐、其制备方法、包含其的药物组合物及其用途

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US6207672B1 (en)	1995-11-13	2001-03-27	Aventis Pharma Deutschland Gmbh	Cyclic and heterocyclic N-substituted α-iminohydroxamic and carboxyclic acids
GB9803411D0 (en) *	1998-02-18	1998-04-15	Smithkline Beecham Plc	Novel compounds
DE10000739A1 (de)	2000-01-11	2001-07-12	Merck Patent Gmbh	Piperidin- und Piperazinderivate
RU2309154C9 (ru) *	2002-03-27	2016-09-27	Глэксо Груп Лимитед	3-фенилсульфонил-8-пиперазин-1-ил-хинолины, обладающие аффинностью к 5-нт6 рецептору, способы их получения (варианты)
GB0321473D0 (en) *	2003-09-12	2003-10-15	Glaxo Group Ltd	Novel compounds
GB0322510D0 (en) *	2003-09-25	2003-10-29	Glaxo Group Ltd	Novel compounds
JP2007510642A (ja) *	2003-11-03	2007-04-26	ワーナー−ランバートカンパニーリミテッドライアビリティーカンパニー	中枢神経系障害の治療のための新規ノルエピネフリン再取込み阻害薬
GB0411421D0 (en) *	2004-05-21	2004-06-23	Glaxo Group Ltd	Novel compounds
DE102004038268A1 (de) *	2004-08-06	2006-03-16	Sanofi-Aventis Deutschland Gmbh	Substituierte, bizyklische 8-Pyrrolidino-xanthine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
GB0425548D0 (en)	2004-11-19	2004-12-22	Glaxo Group Ltd	Radiolabelled ligands
TW200716594A (en) *	2005-04-18	2007-05-01	Neurogen Corp	Substituted heteroaryl CB1 antagonists
AU2006286654A1 (en)	2005-07-27	2007-03-08	F. Hoffmann-La Roche Ag	4-aryloxy quinoline derivatives as 5-HT6 modulators
GB0519765D0 (en)	2005-09-28	2005-11-09	Glaxo Group Ltd	Novel compounds

2008
- 2008-08-06 RU RU2010108282/04A patent/RU2483068C2/ru not_active IP Right Cessation
- 2008-08-06 ES ES08786942.6T patent/ES2574154T3/es active Active
- 2008-08-06 CN CN200880023108.5A patent/CN101687866B/zh not_active Expired - Fee Related
- 2008-08-06 KR KR1020097027612A patent/KR20100039300A/ko not_active Abandoned
- 2008-08-06 EP EP08786942.6A patent/EP2185555B1/en active Active
- 2008-08-06 AU AU2008285652A patent/AU2008285652B2/en not_active Ceased
- 2008-08-06 CA CA2691529A patent/CA2691529C/en not_active Expired - Fee Related
- 2008-08-06 WO PCT/EP2008/060335 patent/WO2009019286A1/en not_active Ceased
- 2008-08-06 NZ NZ581986A patent/NZ581986A/en not_active IP Right Cessation
- 2008-08-06 JP JP2010519460A patent/JP5501230B2/ja not_active Expired - Fee Related
- 2008-08-06 US US12/664,394 patent/US8293913B2/en not_active Expired - Fee Related
- 2008-08-06 UA UAA201002519A patent/UA99626C2/ru unknown
- 2008-08-06 MX MX2009013956A patent/MX2009013956A/es active IP Right Grant
- 2008-08-06 BR BRPI0812853-7A2A patent/BRPI0812853A2/pt not_active IP Right Cessation
- 2008-08-07 TW TW097130141A patent/TWI478919B/zh active
2009
- 2009-12-13 IL IL202706A patent/IL202706A/en not_active IP Right Cessation
- 2009-12-18 ZA ZA2009/09075A patent/ZA200909075B/en unknown
- 2009-12-28 DO DO2009000291A patent/DOP2009000291A/es unknown
- 2009-12-29 GT GT200900333A patent/GT200900333A/es unknown
- 2009-12-29 EC EC2009009831A patent/ECSP099831A/es unknown
- 2009-12-29 CO CO09148549A patent/CO6251268A2/es active IP Right Grant
2010
- 2010-01-04 CR CR11187A patent/CR11187A/es unknown
2012
- 2012-09-13 US US13/613,344 patent/US8440694B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
CN101687866A (zh)	2010-03-31
CN101687866B (zh)	2014-06-04
NZ581986A (en)	2012-02-24
EP2185555B1 (en)	2016-03-16
HK1143588A1 (zh)	2011-01-07
DOP2009000291A (es)	2010-01-31
CA2691529C (en)	2016-01-05
UA99626C2 (ru)	2012-09-10
GT200900333A (es)	2015-10-14
ZA200909075B (en)	2013-03-27
US20100292271A1 (en)	2010-11-18
JP5501230B2 (ja)	2014-05-21
US8440694B2 (en)	2013-05-14
TWI478919B (zh)	2015-04-01
IL202706A0 (en)	2010-06-30
RU2010108282A (ru)	2011-09-20
IL202706A (en)	2014-08-31
ECSP099831A (es)	2010-01-29
AU2008285652A1 (en)	2009-02-12
MX2009013956A (es)	2010-04-30
RU2483068C2 (ru)	2013-05-27
CR11187A (es)	2010-05-27
CA2691529A1 (en)	2009-02-12
KR20100039300A (ko)	2010-04-15
US20130005703A1 (en)	2013-01-03
ES2574154T3 (es)	2016-06-15
WO2009019286A1 (en)	2009-02-12
EP2185555A1 (en)	2010-05-19
US8293913B2 (en)	2012-10-23
AU2008285652B2 (en)	2013-09-05
JP2010535739A (ja)	2010-11-25
CO6251268A2 (es)	2011-02-21
TW200914453A (en)	2009-04-01

Legal Events

Date	Code	Title	Description
2017-10-10	B07D	Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
2018-04-17	B06F	Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
2018-05-29	B08F	Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]	Free format text: REFERENTE A 10A ANUIDADE.
2018-10-23	B08K	Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]	Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2473 DE 29-05-2018 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.

Publication	Publication Date	Title
BRPI0812853A2 (pt)	2014-12-23	Compostos de quinolina adequados para tratar distúrbios que respondem à modulação do receptor 5-ht6 de serotonina.
BRPI0807987A2 (pt)	2014-06-24	Terapia de combinação para tratamento de distúrbios imunes.
PL2504005T3 (pl)	2014-03-31	Zastosowanie pochodnych 1,3-difenyloprop-2-en-1-onu do leczenia zaburzeń wątroby
BRPI0918527A2 (pt)	2015-12-01	compostos para o tratamento de disturbios do cns
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