UA99626C2 - Соединения хинолина, пригодные для лечения нарушений, реагирующих на модуляцию рецептора 5-нт6 серотонина - Google Patents

Соединения хинолина, пригодные для лечения нарушений, реагирующих на модуляцию рецептора 5-нт6 серотонина

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Publication number
UA99626C2
UA99626C2 UAA201002519A UAA201002519A UA99626C2 UA 99626 C2 UA99626 C2 UA 99626C2 UA A201002519 A UAA201002519 A UA A201002519A UA A201002519 A UAA201002519 A UA A201002519A UA 99626 C2 UA99626 C2 UA 99626C2
Authority
UA
Ukraine
Prior art keywords
serotonin
respond
modulation
receptor
quinoline compounds
Prior art date
Application number
UAA201002519A
Other languages
English (en)
Ukrainian (uk)
Inventor
Шон Кольм ТЕРНЕР
Вильфрид БРАЙЕ
Андреас ХАУПТ
Удо ЛАНГЕ
Карла ДРЕШЕР
Карстен ВИККЕ
Лилиане УНГЕР
Марио МЕЦЛЕР
Вольфганг ВЕРНЕТ
Маттиас МАЙРЕР
Original Assignee
Эбботт Гмбх Унд Ко. Кг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Эбботт Гмбх Унд Ко. Кг filed Critical Эбботт Гмбх Унд Ко. Кг
Publication of UA99626C2 publication Critical patent/UA99626C2/ru

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    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • General Health & Medical Sciences (AREA)
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  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Anesthesiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Child & Adolescent Psychology (AREA)
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  • Endocrinology (AREA)
  • Psychology (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Данное изобретение касается соединений хинолина формулы (I) и их солей. Эти соединения имеют полезные терапевтические свойства и являются особенно пригодными для лечения заболеваний, отвечаюших на модуляцию рецептора серотонина 5-НТ. В формуле (I) R означает группу формулы (R), в которой * указывает сайт связывания с хинолинильным радикалом и в которой А, В, X’, Y, Q, R, R, R, R, R, m, n, p, q, Ra, Rb, X и Ar имеют значения, определенные в п. 1 формулы изобретения.
UAA201002519A 2007-08-07 2008-08-06 Соединения хинолина, пригодные для лечения нарушений, реагирующих на модуляцию рецептора 5-нт6 серотонина UA99626C2 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP07113962 2007-08-07

Publications (1)

Publication Number Publication Date
UA99626C2 true UA99626C2 (ru) 2012-09-10

Family

ID=39809897

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA201002519A UA99626C2 (ru) 2007-08-07 2008-08-06 Соединения хинолина, пригодные для лечения нарушений, реагирующих на модуляцию рецептора 5-нт6 серотонина

Country Status (22)

Country Link
US (2) US8293913B2 (ru)
EP (1) EP2185555B1 (ru)
JP (1) JP5501230B2 (ru)
KR (1) KR20100039300A (ru)
CN (1) CN101687866B (ru)
AU (1) AU2008285652B2 (ru)
BR (1) BRPI0812853A2 (ru)
CA (1) CA2691529C (ru)
CO (1) CO6251268A2 (ru)
CR (1) CR11187A (ru)
DO (1) DOP2009000291A (ru)
EC (1) ECSP099831A (ru)
ES (1) ES2574154T3 (ru)
GT (1) GT200900333A (ru)
IL (1) IL202706A (ru)
MX (1) MX2009013956A (ru)
NZ (1) NZ581986A (ru)
RU (1) RU2483068C2 (ru)
TW (1) TWI478919B (ru)
UA (1) UA99626C2 (ru)
WO (1) WO2009019286A1 (ru)
ZA (1) ZA200909075B (ru)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR095079A1 (es) 2013-03-12 2015-09-16 Hoffmann La Roche Derivados de octahidro-pirrolo[3,4-c]-pirrol y piridina-fenilo
NO3074400T3 (ru) 2013-11-26 2018-04-14
MA39792B1 (fr) 2014-03-26 2019-12-31 Hoffmann La Roche Composés bicycliques en tant qu'inhibiteurs de production d'autotaxine (atx) et d'acide lysophosphatidique (lpa)
KR102390045B1 (ko) * 2014-04-30 2022-04-22 카티바, 인크. 가스 쿠션 장비 및 기판 코팅 기술
MX387736B (es) 2015-09-04 2025-03-18 Hoffmann La Roche Derivados de fenoximetilo.
CN107635995B (zh) 2015-09-24 2022-08-19 豪夫迈·罗氏有限公司 作为atx抑制剂的二环化合物
MX2017015034A (es) * 2015-09-24 2018-04-13 Hoffmann La Roche Nuevos compuestos biciclicos como inhibidores duales de autotaxina (atx)/anhidrasa carbonica (ca).
PE20180451A1 (es) 2015-09-24 2018-03-05 Hoffmann La Roche Nuevos compuestos biciclicos como inhibidores de atx
KR20180054634A (ko) 2015-09-24 2018-05-24 에프. 호프만-라 로슈 아게 이중 오토탁신(atx)/탄산 무수화효소(ca) 억제제로서 신규한 이환형 화합물
AR106515A1 (es) 2015-10-29 2018-01-24 Bayer Cropscience Ag Sililfenoxiheterociclos trisustituidos y análogos
WO2017157929A1 (en) * 2016-03-14 2017-09-21 AbbVie Deutschland GmbH & Co. KG Quinoline compounds suitable for treating disorders that respond to the modulation of the serotonin 5-ht6 receptor
MA49879A (fr) 2017-03-16 2020-06-24 Hoffmann La Roche Composés hétérocycliques utiles en tant qu'inhibiteurs doubles d'atx/ca
CN110382484B (zh) 2017-03-16 2022-12-06 豪夫迈·罗氏有限公司 新的作为atx抑制剂的二环化合物
WO2020239073A1 (zh) * 2019-05-30 2020-12-03 中国科学院上海药物研究所 一种并环化合物、其制备方法和用途
CA3225439A1 (en) * 2021-06-26 2022-12-29 Cedilla Therapeutics, Inc. Cdk2 inhibitors and methods of using the same
EP4644396A1 (en) * 2022-12-28 2025-11-05 Visionpharma (Nantong) Co., Ltd Toll-like receptor inhibitor, and preparation therefor and application thereof
JP2026508826A (ja) * 2023-01-18 2026-03-13 蘇州旺山旺水生物医薬股▲ふん▼有限公司 抗うつ化合物の塩、その製造方法、それを含む医薬組成物およびその用途

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PT861236E (pt) * 1995-11-13 2002-07-31 Hoechst Ag Acidos alfa-iminohidoxamicos e carboxilicos n-substituidos ciclicos e heterociclicos
GB9803411D0 (en) * 1998-02-18 1998-04-15 Smithkline Beecham Plc Novel compounds
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SI1497266T1 (sl) * 2002-03-27 2008-10-31 Glaxo Group Ltd Derivati kinolina in njihova uporaba kot ligandi 5-ht6
GB0321473D0 (en) 2003-09-12 2003-10-15 Glaxo Group Ltd Novel compounds
GB0322510D0 (en) * 2003-09-25 2003-10-29 Glaxo Group Ltd Novel compounds
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Also Published As

Publication number Publication date
ECSP099831A (es) 2010-01-29
JP2010535739A (ja) 2010-11-25
EP2185555B1 (en) 2016-03-16
IL202706A0 (en) 2010-06-30
MX2009013956A (es) 2010-04-30
US20100292271A1 (en) 2010-11-18
ZA200909075B (en) 2013-03-27
EP2185555A1 (en) 2010-05-19
DOP2009000291A (es) 2010-01-31
IL202706A (en) 2014-08-31
TW200914453A (en) 2009-04-01
HK1143588A1 (zh) 2011-01-07
RU2483068C2 (ru) 2013-05-27
CA2691529C (en) 2016-01-05
CN101687866A (zh) 2010-03-31
AU2008285652A1 (en) 2009-02-12
US20130005703A1 (en) 2013-01-03
CO6251268A2 (es) 2011-02-21
CN101687866B (zh) 2014-06-04
NZ581986A (en) 2012-02-24
AU2008285652B2 (en) 2013-09-05
BRPI0812853A2 (pt) 2014-12-23
GT200900333A (es) 2015-10-14
KR20100039300A (ko) 2010-04-15
JP5501230B2 (ja) 2014-05-21
US8440694B2 (en) 2013-05-14
US8293913B2 (en) 2012-10-23
ES2574154T3 (es) 2016-06-15
CA2691529A1 (en) 2009-02-12
WO2009019286A1 (en) 2009-02-12
TWI478919B (zh) 2015-04-01
RU2010108282A (ru) 2011-09-20
CR11187A (es) 2010-05-27

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