BRPI0813140A2 - Composição, método e preparação de ácido biliar sintético - Google Patents

Composição, método e preparação de ácido biliar sintético

Info

Publication number
BRPI0813140A2
BRPI0813140A2 BRPI0813140-6A2A BRPI0813140A BRPI0813140A2 BR PI0813140 A2 BRPI0813140 A2 BR PI0813140A2 BR PI0813140 A BRPI0813140 A BR PI0813140A BR PI0813140 A2 BRPI0813140 A2 BR PI0813140A2
Authority
BR
Brazil
Prior art keywords
synthetic
preparation
composition
biliary acid
biliary
Prior art date
Application number
BRPI0813140-6A2A
Other languages
English (en)
Inventor
Robert M Moriarty
Nathaniel E David
Nadir Ahmeduddin Mahmood
Achampeta Rathan Prasad
Roy A Swaringen Jr
John Gregory Reid
Akhila Kumar Sahoo
Original Assignee
Kythera Biopharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41226994&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0813140(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US12/035,339 external-priority patent/US20080318870A1/en
Priority claimed from GB0807615A external-priority patent/GB2452358C/en
Application filed by Kythera Biopharmaceuticals Inc filed Critical Kythera Biopharmaceuticals Inc
Publication of BRPI0813140A2 publication Critical patent/BRPI0813140A2/pt
Publication of BRPI0813140B1 publication Critical patent/BRPI0813140B1/pt
Publication of BRPI0813140C1 publication Critical patent/BRPI0813140C1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/63—Steroids; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/06—Preparations for care of the skin for countering cellulitis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0011—Androstane derivatives substituted in position 17 by a keto group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0018—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa
    • C07J1/0022—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
    • C07J13/007—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 17 (20)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Birds (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Child & Adolescent Psychology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Peptides Or Proteins (AREA)
BRPI0813140A 2007-06-19 2008-06-18 método para a preparação de ácido desoxicólico (dca) ou um éster desse ou um sal farmaceuticamente aceitável desse e composto intermediário BRPI0813140C1 (pt)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US94503507P 2007-06-19 2007-06-19
US95687507P 2007-08-20 2007-08-20
US12/035,339 US20080318870A1 (en) 2007-06-19 2008-02-21 Synthetic bile acid compositions and methods
GB0807615A GB2452358C (en) 2008-04-25 2008-04-25 Preparation of bile acids.
US12/153,446 US7902387B2 (en) 2008-04-25 2008-05-16 Preparation of bile acids and intermediates thereof
PCT/US2008/067391 WO2008157635A2 (en) 2007-06-19 2008-06-18 Synthetic bile acid composition, method, and preparation

Publications (3)

Publication Number Publication Date
BRPI0813140A2 true BRPI0813140A2 (pt) 2014-12-23
BRPI0813140B1 BRPI0813140B1 (pt) 2019-02-05
BRPI0813140C1 BRPI0813140C1 (pt) 2021-05-25

Family

ID=41226994

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0813140A BRPI0813140C1 (pt) 2007-06-19 2008-06-18 método para a preparação de ácido desoxicólico (dca) ou um éster desse ou um sal farmaceuticamente aceitável desse e composto intermediário

Country Status (28)

Country Link
EP (3) EP2407475B1 (pt)
JP (2) JP2010530876A (pt)
KR (7) KR20160025044A (pt)
CN (4) CN101711254A (pt)
AR (1) AR067440A1 (pt)
AU (1) AU2008265721B2 (pt)
BR (1) BRPI0813140C1 (pt)
CA (2) CA2690841C (pt)
CR (2) CR20170070A (pt)
CY (1) CY1116700T1 (pt)
DK (1) DK2407475T3 (pt)
EA (1) EA020806B1 (pt)
ES (2) ES2826429T3 (pt)
HR (1) HRP20150879T1 (pt)
HU (1) HUE025909T2 (pt)
IL (1) IL202203B (pt)
JO (1) JO3172B1 (pt)
MX (2) MX360094B (pt)
MY (1) MY160040A (pt)
NZ (1) NZ581081A (pt)
PH (1) PH12013500364A1 (pt)
PL (1) PL2407475T3 (pt)
PT (1) PT2407475E (pt)
SI (1) SI2407475T1 (pt)
SM (1) SMP201000003B (pt)
TW (2) TWI503327B (pt)
WO (1) WO2008157635A2 (pt)
ZA (1) ZA200907928B (pt)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080318870A1 (en) 2007-06-19 2008-12-25 Kythera Biopharmaceuticals, Inc. Synthetic bile acid compositions and methods
JOP20180077A1 (ar) 2007-06-19 2019-01-30 Kythera Biopharmaceuticals Inc تركيبات وطرق لحمض صفراوي تخليقي
US8242294B2 (en) 2007-06-19 2012-08-14 Kythera Biopharmaceuticals, Inc. Synthetic bile acid compositions and methods
KR20160025044A (ko) * 2007-06-19 2016-03-07 키쎄라 바이오파마슈티컬즈 인코포레이티드 합성 담즙산 조성물, 방법 및 제조물
GB2480632A (en) * 2010-05-25 2011-11-30 Kythera Biopharmaceuticals Inc Preparation of 12-keto and 12-alpha-hydroxy steroids
US9127036B2 (en) 2010-08-12 2015-09-08 Kythera Biopharmaceuticals, Inc. Synthetic bile acid compositions and methods
ES2746311T3 (es) * 2011-06-16 2020-03-05 Allergan Sales Llc Composiciones que contienen ácido desoxicólico y agua desionizada al 10 % en etanol, dirigidas a la purificación del ácido desoxicólico
US20130102580A1 (en) * 2011-09-22 2013-04-25 Kythera Biopharmaceuticals, Inc. Compositions and methods related to deoxycholic acid and its polymorphs
US10081592B2 (en) 2012-03-23 2018-09-25 The Board Of Trustees Of The University Of Illinois Complex and structurally diverse compounds
CN103059087B (zh) * 2012-12-30 2015-10-14 中山百灵生物技术有限公司 一种脱氧胆酸的合成方法
KR101447901B1 (ko) * 2013-04-16 2014-10-16 한양대학교 산학협력단 지방세포 표적 비바이러스성 유전자 전달체
US12616651B2 (en) 2014-11-21 2026-05-05 Lipodissolve Therapeutics Inc. Topical lipolysis composition and methods
WO2017019524A1 (en) 2015-07-30 2017-02-02 Intercept Pharmaceuticals, Inc. Methods for preparation of bile acids and derivatives thereof
WO2017079700A1 (en) * 2015-11-04 2017-05-11 Kythera Biopharmaceuticals, Inc. Treatments of accumulated fat with deoxycholic acid and salts thereof
KR102527103B1 (ko) 2016-06-06 2023-04-28 크리스탈 파마 에스.에이.유. 디옥시콜린산 제조방법 및 디옥시콜린산의 제조에 유용한 중간물
KR20200026273A (ko) * 2017-08-03 2020-03-10 (주)메디톡스 담즙산류를 제조하기 위한 방법
EP3700916B1 (en) * 2017-10-24 2026-03-18 Curia Spain S.A.U. Preparation of deoxycholic acid
RU2705314C1 (ru) * 2019-03-18 2019-11-06 Федеральное бюджетное учреждение науки "Государственный научный центр прикладной микробиологии и биотехнологии" Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человека (ФБУН ГНЦ ПМБ) Способ производства сухих очищенных солей желчных кислот для бактериологии
KR102456989B1 (ko) * 2020-06-12 2022-10-21 (주)케어젠 항비만 활성을 가지는 디옥시콜산-펩타이드 결합체 및 이의 용도
WO2022059948A1 (ko) * 2020-09-18 2022-03-24 서울대학교 산학협력단 소디움 타우로디옥시콜레이트의 대량 생산 방법
CN114428171A (zh) * 2020-10-29 2022-05-03 深圳迈瑞生物医疗电子股份有限公司 检测甘胆酸的试剂盒、方法及用途
US20240325433A1 (en) 2021-07-16 2024-10-03 Scai Therapeutics Co., Ltd. Molecular association of bile acid or bile salt and pharmaceutical composition comprising same for locally reducing fat
KR20230013003A (ko) 2021-07-16 2023-01-26 주식회사 스카이테라퓨틱스 담즙산 또는 담즙산 염의 분자 회합체 및 이를 포함하는 국소지방제거용 의약 조성물
CN114478676B (zh) * 2022-02-18 2024-05-10 国药集团化学试剂有限公司 一种脱氧胆酸钠的制备方法
CN115974949B (zh) * 2022-10-26 2023-12-22 湖南科瑞生物制药股份有限公司 一种植物源脱氧胆酸中间体的制备方法
CN118344420A (zh) * 2023-01-16 2024-07-16 北京诺博特生物科技有限公司 一种脱氧胆酸的制备方法
TW202602458A (zh) 2024-02-16 2026-01-16 美商賽諾菲巴斯德公司 用於製備去氧膽酸之方法

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US2321598A (en) * 1940-10-07 1943-06-15 George A Breon & Company Inc Preparation of desoxycholic acid
US2615902A (en) * 1950-10-24 1952-10-28 Merck & Co Inc Chemical compounds and processes for preparing the same
US4113882A (en) * 1974-10-21 1978-09-12 Yamanouchi Pharmaceutical Co., Ltd. Stabilized oral prostaglandin formulation and the process for the preparation thereof
US4866044A (en) * 1985-07-09 1989-09-12 Takeda Chemical Industries, Ltd. Solubilized composition of poorly-soluble pharmaceutical product
AU618350B2 (en) * 1988-04-08 1991-12-19 Aventis Pharma S.A. 9-alpha-hydroxy-17-methylene steroids, process for their preparation and their use in the preparation of corticosteroids
FR2754709B1 (fr) * 1996-10-23 1999-03-05 Sanofi Sa Composition cosmetique contenant un antagoniste des recepteurs du neuropeptide gamma et alpha 2 antagonistes susceptibles d'etre incorpores dans une telle composition
GB9910934D0 (en) * 1999-05-11 1999-07-14 Res Inst Medicine Chem Chemical compounds
ES2372499T3 (es) 2004-05-19 2012-01-20 Los Angeles Biomedical Research Institute At Harbor-Ucla Medical Center Uso de un detergente para la eliminación no quirúrgica de grasa.
US7754230B2 (en) 2004-05-19 2010-07-13 The Regents Of The University Of California Methods and related compositions for reduction of fat
US20060127468A1 (en) 2004-05-19 2006-06-15 Kolodney Michael S Methods and related compositions for reduction of fat and skin tightening
EP1888101B1 (en) * 2005-06-06 2012-03-21 Georgetown University Compositions and methods for lipo modeling
KR20160025044A (ko) * 2007-06-19 2016-03-07 키쎄라 바이오파마슈티컬즈 인코포레이티드 합성 담즙산 조성물, 방법 및 제조물

Also Published As

Publication number Publication date
AU2008265721A1 (en) 2008-12-24
EP3002290A2 (en) 2016-04-06
CA2690841C (en) 2012-11-27
CY1116700T1 (el) 2017-03-15
PH12013500364A1 (en) 2014-04-28
CR11174A (es) 2010-03-23
KR101598402B1 (ko) 2016-03-03
HUE025909T2 (en) 2016-04-28
KR20130133881A (ko) 2013-12-09
EA201000032A1 (ru) 2010-04-30
JP2013075918A (ja) 2013-04-25
SMP201000003B (it) 2010-11-12
EP2407475B1 (en) 2015-08-12
EP3002290B1 (en) 2020-09-09
PL2407475T3 (pl) 2015-12-31
EP2407475A2 (en) 2012-01-18
KR20180122483A (ko) 2018-11-12
SI2407475T1 (sl) 2016-03-31
HK1223372A1 (en) 2017-07-28
MY160040A (en) 2017-02-15
CA2789109A1 (en) 2008-12-24
IL202203A0 (en) 2010-06-16
TW201534684A (zh) 2015-09-16
IL202203B (en) 2018-04-30
KR20160025044A (ko) 2016-03-07
CA2690841A1 (en) 2008-12-24
KR101863131B1 (ko) 2018-06-01
DK2407475T3 (en) 2015-10-26
JP5589102B2 (ja) 2014-09-10
ES2550504T3 (es) 2015-11-10
AR067440A1 (es) 2009-10-14
HRP20150879T1 (hr) 2015-09-25
HK1165807A1 (en) 2012-10-12
KR20100031512A (ko) 2010-03-22
TWI503396B (zh) 2015-10-11
ZA200907928B (en) 2011-05-28
SMAP201000003A (it) 2010-03-01
MX360094B (es) 2018-10-19
CA2789109C (en) 2015-10-06
KR20150013305A (ko) 2015-02-04
TW200918550A (en) 2009-05-01
BRPI0813140C1 (pt) 2021-05-25
EP3002290A3 (en) 2016-06-29
EP2069383A2 (en) 2009-06-17
PT2407475E (pt) 2015-11-20
AU2008265721B2 (en) 2014-03-20
CN106146594A (zh) 2016-11-23
MX2009013664A (es) 2010-04-07
JP2010530876A (ja) 2010-09-16
ES2826429T3 (es) 2021-05-18
TWI503327B (zh) 2015-10-11
NZ581081A (en) 2012-12-21
CN101711254A (zh) 2010-05-19
CN108191940B (zh) 2021-02-09
EA020806B1 (ru) 2015-01-30
CN106083969B (zh) 2018-02-27
KR101916024B1 (ko) 2018-11-08
KR20160150646A (ko) 2016-12-30
KR102061001B1 (ko) 2020-01-03
WO2008157635A2 (en) 2008-12-24
KR20180061401A (ko) 2018-06-07
EP2407475A3 (en) 2012-06-13
CR20170070A (es) 2017-04-27
CN108191940A (zh) 2018-06-22
WO2008157635A3 (en) 2009-06-04
CN106083969A (zh) 2016-11-09
BRPI0813140B1 (pt) 2019-02-05
JO3172B1 (ar) 2018-03-08

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B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
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