BRPI0813709A2 - Derivados de nucleosídeo substituído com propriedades antiviral e antimicrobiana - Google Patents
Derivados de nucleosídeo substituído com propriedades antiviral e antimicrobianaInfo
- Publication number
- BRPI0813709A2 BRPI0813709A2 BRPI0813709-9A2A BRPI0813709A BRPI0813709A2 BR PI0813709 A2 BRPI0813709 A2 BR PI0813709A2 BR PI0813709 A BRPI0813709 A BR PI0813709A BR PI0813709 A2 BRPI0813709 A2 BR PI0813709A2
- Authority
- BR
- Brazil
- Prior art keywords
- antimicrobian
- antiviral
- properties
- nucleoside derivatives
- derivatives replaced
- Prior art date
Links
- 230000003515 anti-microbian Effects 0.000 title 1
- 230000000840 anti-viral effect Effects 0.000 title 1
- 150000003833 nucleoside derivatives Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D411/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms
- C07D411/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D411/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Tropical Medicine & Parasitology (AREA)
- Gynecology & Obstetrics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- AIDS & HIV (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US92968307P | 2007-07-09 | 2007-07-09 | |
| PCT/US2008/069571 WO2009009625A2 (en) | 2007-07-09 | 2008-07-09 | Substituted nucleoside derivatives with antiviral and antimicrobial properties |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0813709A2 true BRPI0813709A2 (pt) | 2015-01-06 |
Family
ID=40229471
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0813709-9A2A BRPI0813709A2 (pt) | 2007-07-09 | 2008-07-09 | Derivados de nucleosídeo substituído com propriedades antiviral e antimicrobiana |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US9296776B2 (pt) |
| EP (1) | EP2175863B1 (pt) |
| CN (1) | CN101835374B (pt) |
| BR (1) | BRPI0813709A2 (pt) |
| CA (1) | CA2717788A1 (pt) |
| MX (1) | MX2010000424A (pt) |
| WO (1) | WO2009009625A2 (pt) |
| ZA (1) | ZA201000158B (pt) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI433674B (zh) | 2006-12-28 | 2014-04-11 | Infinity Discovery Inc | 環杷明（ｃｙｃｌｏｐａｍｉｎｅ）類似物類 |
| EP2244782A4 (en) * | 2008-01-25 | 2011-09-14 | Univ Utah Res Found | POLYMER WITH LINEAR ORDER RELEASE |
| AU2009280253A1 (en) * | 2008-08-04 | 2010-02-11 | Sammy Opiyo | Conjugated suramin amino compounds for medical conditions |
| EP2579871B1 (en) * | 2010-06-11 | 2015-08-26 | Gilead Sciences, Inc. | Topical antiviral formulations for prevention of transmission of hsv-2 |
| US8877744B2 (en) * | 2011-04-04 | 2014-11-04 | Hoffmann-La Roche Inc. | 1,4-Oxazepines as BACE1 and/or BACE2 inhibitors |
| US11311545B2 (en) * | 2014-10-09 | 2022-04-26 | Board Of Regents Of The University Of Nebraska | Compositions and methods for the delivery of therapeutics |
| US11219623B2 (en) * | 2015-02-26 | 2022-01-11 | University Of Kentucky Research Foundation | Inflammasome inhibition for the treatment of Parkinson's disease, Alzheimer's disease and multiple sclerosis |
| HRP20251395T1 (hr) | 2015-06-04 | 2026-02-13 | Sol-Gel Technologies Ltd. | Topikalne formulacije za isporuku spojeva inhibitora hedgehog signalnog puta i njihova uporaba |
| MX391226B (es) * | 2015-09-23 | 2025-03-21 | Merck Sharp & Dohme Llc | Inhibidores de transcriptasa inversa de nucleosido 4'-substituido y preparaciones de los mismos. |
| US10010627B2 (en) | 2016-06-03 | 2018-07-03 | International Business Machines Corporation | Modified polycationic polymers |
| GB201610327D0 (en) * | 2016-06-14 | 2016-07-27 | Univ Nelson Mandela Metropolitan | Process for producing Lamivudine and Entricitabine |
| WO2018230479A1 (ja) * | 2017-06-13 | 2018-12-20 | 大原薬品工業株式会社 | ヌクレオシド系抗がん剤又は抗ウィルス剤の５'位シリルエーテル誘導体 |
| AU2018350825B2 (en) * | 2017-10-16 | 2024-09-26 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Macromolecular platform for targeting scavenger receptor A1 |
| US11839623B2 (en) | 2018-01-12 | 2023-12-12 | Board Of Regents Of The University Of Nebraska | Antiviral prodrugs and formulations thereof |
| US11458136B2 (en) | 2018-04-09 | 2022-10-04 | Board Of Regents Of The University Of Nebraska | Antiviral prodrugs and formulations thereof |
| CN110308145A (zh) * | 2019-07-10 | 2019-10-08 | 迪瑞医疗科技股份有限公司 | 一种沙眼衣原体糖原检测试剂、沙眼衣原体糖原检测试纸条及其制备方法 |
| CN117016549B (zh) * | 2023-03-13 | 2024-02-27 | 山东蓬勃生物科技有限公司 | 核苷类化合物及其组合物在促进植物生长中的应用 |
Family Cites Families (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3100478A1 (de) | 1981-01-09 | 1982-08-12 | Dr. Thilo & Co GmbH, 8021 Sauerlach | 5'ester von pyrimidinnucleosiden mit antiviraler wirksamkeit, verfahren zur herstellung und daraus hergestellte arzneimittel |
| US5223263A (en) | 1988-07-07 | 1993-06-29 | Vical, Inc. | Liponucleotide-containing liposomes |
| US5026688A (en) * | 1988-10-31 | 1991-06-25 | Administrators Of The Tulane Educational Fund | Novel AZT analogs |
| IE980216A1 (en) | 1989-04-17 | 2000-02-23 | Scotia Holdings Plc | Anti-virals |
| US5204466A (en) | 1990-02-01 | 1993-04-20 | Emory University | Method and compositions for the synthesis of bch-189 and related compounds |
| GB9007569D0 (en) * | 1990-04-04 | 1990-05-30 | Nycomed As | Carbo-nucleoside derivatives |
| GB9116054D0 (en) | 1991-07-24 | 1991-09-11 | Efamol Holdings | Preparation of fatty acid medicaments |
| GB2260319B (en) | 1991-10-07 | 1995-12-06 | Norsk Hydro As | Acyl derivatives of nucleosides and nucleoside analogues having anti-viral activity |
| US5512671A (en) * | 1993-02-16 | 1996-04-30 | Wake Forest University | Ether lipid-nucleoside covalent conjugates |
| WO1995000177A1 (en) | 1993-06-17 | 1995-01-05 | Dextran Products Limited | Pharmaceutical preparation and a method for inhibiting the replication of various viruses |
| DE4324450A1 (de) * | 1993-07-21 | 1995-01-26 | Boehringer Mannheim Gmbh | Arzneimittelpräparate enthaltend Phospholipid-Nukleosid-Konjugate zur Kombinationstherapie bei viralen Infektionen |
| WO1995005199A1 (en) * | 1993-08-19 | 1995-02-23 | Dextran Products Limited | Pharmaceutical preparation and a process for making same |
| DE4418690A1 (de) * | 1994-05-28 | 1996-01-11 | Boehringer Mannheim Gmbh | Neue Lipidester von Nucleosid-Monophosphaten und deren Verwendung als immunsuppressive Arzneimittel |
| US5869493A (en) | 1996-02-16 | 1999-02-09 | Medivir Ab | Acyclic nucleoside derivatives |
| US6113920A (en) * | 1996-10-31 | 2000-09-05 | Glaxo Wellcome Inc. | Pharmaceutical compositions |
| IT1290447B1 (it) | 1997-03-28 | 1998-12-03 | Zambon Spa | Derivati 1,3-ossatiolanici ad attivita' antivirale |
| US6407077B1 (en) * | 1998-11-05 | 2002-06-18 | Emory University | β-L nucleosides for the treatment of HIV infection |
| US7635690B2 (en) * | 1999-01-22 | 2009-12-22 | Emory University | HIV-1 mutations selected for by β-2′,3′-didehydro-2′,3′-dideoxy-5-fluorocytidine |
| FR2794753B1 (fr) * | 1999-06-11 | 2001-09-14 | Laphal Sa Lab | Nouveaux composes derives de carraghenane, leurs procedes de preparation et les compositions pharmaceutiques en contenant |
| US7122526B2 (en) | 2000-10-31 | 2006-10-17 | Nanosphere, Inc. | Indolocarbazole anticancer agents and methods of using same |
| CA2428753C (en) * | 2000-11-17 | 2013-05-21 | Universita Degli Studi Di Cagliari | Methods for inhibiting the transmission of hiv using topically applied substituted 6-benzyl-4-oxopyrimidines |
| IL158006A0 (en) | 2001-04-30 | 2004-03-28 | Trommsdorff Arzneimittel | Pharmaceutically active uridine esters |
| US6949522B2 (en) * | 2001-06-22 | 2005-09-27 | Pharmasset, Inc. | β-2′- or 3′-halonucleosides |
| DE10131709B4 (de) | 2001-06-29 | 2006-10-26 | Infineon Technologies Ag | Verfahren zur Herstellung einseitiger Buried-Straps |
| US20050227933A1 (en) | 2001-11-29 | 2005-10-13 | Benkovic Stephen J | Treatment of bacterial induced diseases using DNA methyl transferase inhibitors |
| US7094768B2 (en) | 2002-09-30 | 2006-08-22 | Genelabs Technologies, Inc. | Nucleoside derivatives for treating hepatitis C virus infection |
| WO2005049633A1 (en) | 2003-11-03 | 2005-06-02 | Cognis Ip Management Gmbh | Acyl ribonucleosides and acyl deoxyribonucleosides |
| US20050267051A1 (en) * | 2003-12-19 | 2005-12-01 | Lee Henry J | Antineoplastic and anti-HIV conjugates of steroid acid and nucleosides |
| PL201571B1 (pl) | 2004-05-19 | 2009-04-30 | Fundacja Rozwoju Diagnostyki I | Nowe estry nukleozydów adenozynowych i kwasu karboksylowego, sposób ich otrzymywania oraz zawierająca je kompozycja farmaceutyczna |
| WO2006030217A2 (en) | 2004-09-15 | 2006-03-23 | Drug Discovery Laboratory As | Drug conjugates of long chain fatty acid or ester moieties as protein binding prodrugs |
| GB0500785D0 (en) | 2005-01-14 | 2005-02-23 | Novartis Ag | Organic compounds |
| ES2326041T3 (es) * | 2005-02-10 | 2009-09-29 | Medivir Ab | Inhibidores de proteasas de vih. |
| CN100519536C (zh) | 2006-03-21 | 2009-07-29 | 中国医学科学院医药生物技术研究所 | 一组连有核苷碱基的格尔德霉素衍生物 |
| CN101016322A (zh) * | 2006-04-01 | 2007-08-15 | 沈阳药科大学 | 齐多夫定碳酸胆固醇酯的制备方法及其制剂和分析方法 |
| CN1827632B (zh) * | 2006-04-05 | 2011-07-20 | 沈阳药科大学 | 齐多夫定棕榈酸酯原料精制方法及制剂 |
| GB0607948D0 (en) | 2006-04-21 | 2006-05-31 | Novartis Ag | Organic compounds |
| ATE549337T1 (de) | 2006-04-21 | 2012-03-15 | Novartis Ag | Purinderivate zur verwendung als adenosin-a2a- rezeptoragonisten |
| GB0607951D0 (en) | 2006-04-21 | 2006-05-31 | Novartis Ag | Organic compounds |
-
2008
- 2008-07-09 MX MX2010000424A patent/MX2010000424A/es active IP Right Grant
- 2008-07-09 WO PCT/US2008/069571 patent/WO2009009625A2/en not_active Ceased
- 2008-07-09 CA CA2717788A patent/CA2717788A1/en not_active Abandoned
- 2008-07-09 BR BRPI0813709-9A2A patent/BRPI0813709A2/pt not_active IP Right Cessation
- 2008-07-09 CN CN200880101864.5A patent/CN101835374B/zh not_active Expired - Fee Related
- 2008-07-09 US US12/668,262 patent/US9296776B2/en active Active
- 2008-07-09 EP EP08796131.4A patent/EP2175863B1/en active Active
-
2010
- 2010-01-08 ZA ZA201000158A patent/ZA201000158B/xx unknown
-
2016
- 2016-03-24 US US15/079,918 patent/US9738678B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| ZA201000158B (en) | 2010-09-29 |
| EP2175863A4 (en) | 2012-09-19 |
| WO2009009625A3 (en) | 2009-03-05 |
| EP2175863B1 (en) | 2018-03-21 |
| US20160311843A1 (en) | 2016-10-27 |
| US9296776B2 (en) | 2016-03-29 |
| US20110039798A1 (en) | 2011-02-17 |
| US9738678B2 (en) | 2017-08-22 |
| CN101835374A (zh) | 2010-09-15 |
| CN101835374B (zh) | 2014-08-27 |
| MX2010000424A (es) | 2010-08-10 |
| EP2175863A2 (en) | 2010-04-21 |
| WO2009009625A2 (en) | 2009-01-15 |
| CA2717788A1 (en) | 2009-01-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B25A | Requested transfer of rights approved |
Owner name: EASTERN VIRGINIA MEDICAL SCHOOL (US) , BOARD OF GO |
|
| B25G | Requested change of headquarter approved |
Owner name: EASTERN VIRGINIA MEDICAL SCHOOL (US) , BOARD OF GO |
|
| B06F | Objections, documents and/or translations needed after an examination request according art. 34 industrial property law | ||
| B07D | Technical examination (opinion) related to article 229 of industrial property law |
Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS. |
|
| B08F | Application fees: dismissal - article 86 of industrial property law |
Free format text: REFERENTE A 12A ANUIDADE. |
|
| B07E | Notice of approval relating to section 229 industrial property law | ||
| B08K | Lapse as no evidence of payment of the annual fee has been furnished to inpi (acc. art. 87) |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2598 DE 20-10-2020 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |