BRPI0820113A2 - Derivados de isoxazolo-piridazina - Google Patents

Derivados de isoxazolo-piridazina

Info

Publication number
BRPI0820113A2
BRPI0820113A2 BRPI0820113A BRPI0820113A2 BR PI0820113 A2 BRPI0820113 A2 BR PI0820113A2 BR PI0820113 A BRPI0820113 A BR PI0820113A BR PI0820113 A2 BRPI0820113 A2 BR PI0820113A2
Authority
BR
Brazil
Prior art keywords
isoxazole
pyridazine derivatives
pyridazine
derivatives
Prior art date
Application number
Other languages
English (en)
Inventor
Bernd Buettelmann
Roland Jakob-Roetne
Henner Knust
Andrew Thomas
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BRPI0820113A2 publication Critical patent/BRPI0820113A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
BRPI0820113 2007-12-04 2008-11-26 Derivados de isoxazolo-piridazina BRPI0820113A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07122293 2007-12-04
PCT/EP2008/066226 WO2009071477A1 (en) 2007-12-04 2008-11-26 Isoxazolo-pyridazine derivatives

Publications (1)

Publication Number Publication Date
BRPI0820113A2 true BRPI0820113A2 (pt) 2015-05-05

Family

ID=40328910

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0820113 BRPI0820113A2 (pt) 2007-12-04 2008-11-26 Derivados de isoxazolo-piridazina

Country Status (15)

Country Link
US (1) US7943619B2 (pt)
EP (1) EP2231651B1 (pt)
JP (1) JP5301558B2 (pt)
KR (1) KR101175855B1 (pt)
CN (1) CN101868458B (pt)
AR (1) AR069525A1 (pt)
AU (1) AU2008333327B2 (pt)
BR (1) BRPI0820113A2 (pt)
CA (1) CA2707821C (pt)
CL (1) CL2008003593A1 (pt)
IL (1) IL205753A0 (pt)
MX (1) MX2010006182A (pt)
PE (1) PE20091446A1 (pt)
TW (1) TW200924775A (pt)
WO (1) WO2009071477A1 (pt)

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BRPI1013762A2 (pt) * 2009-05-05 2015-08-25 Hoffmann La Roche "derivados isoxazol-piridazina"
ES2601181T3 (es) * 2009-05-05 2017-02-14 F. Hoffmann-La Roche Ag Derivados de isoxazol-tiazol como agonistas inversos del receptor GABA A para su uso en el tratamiento de trastornos cognitivos
US8415379B2 (en) * 2009-05-05 2013-04-09 Hoffmann-La Roche Inc. Pyridines
EP2560488B1 (en) 2010-04-23 2015-10-28 Cytokinetics, Inc. Certain amino-pyridines and amino-triazines, compositions thereof, and methods for their use
AR081626A1 (es) * 2010-04-23 2012-10-10 Cytokinetics Inc Compuestos amino-piridazinicos, composiciones farmaceuticas que los contienen y uso de los mismos para tratar trastornos musculares cardiacos y esqueleticos
AR081331A1 (es) 2010-04-23 2012-08-08 Cytokinetics Inc Amino- pirimidinas composiciones de las mismas y metodos para el uso de los mismos
RU2582337C2 (ru) * 2010-11-09 2016-04-27 Ф.Хоффманн-Ля Рош Аг Производные триазола в качестве лигандов рецепторов гамк
AU2011328993B2 (en) * 2010-11-15 2017-03-02 Agenebio, Inc. Pyridazine derivatives, compositions and methods for treating cognitive impairment
EP2760866B1 (en) 2011-09-27 2017-12-13 Genfit Derivatives of 6-substituted triazolopyridazines as rev-erb agonists
US8604062B2 (en) 2011-10-20 2013-12-10 Hoffman-La Roche Inc. Process for the preparation of isoxazolyl-methoxy nicotinic acids
EP3243815B1 (en) * 2011-10-28 2019-07-10 Inhibitaxin Limited Pyridazine derivatives useful in therapy
US20150374705A1 (en) 2012-02-14 2015-12-31 Shanghai Institues for Biological Sciences Substances for treatment or relief of pain
WO2014001278A1 (en) 2012-06-26 2014-01-03 Aniona Aps A phenyl triazole derivative and its use for modulating the gabaa receptor complex
WO2014001280A1 (en) 2012-06-26 2014-01-03 Aniona Aps A phenyl triazole derivative and its use for modulating the gabaa receptor complex
WO2014001279A1 (en) 2012-06-26 2014-01-03 Aniona Aps A phenyl triazole derivative and its use for modulating the gabaa receptor complex
EP2885290B1 (en) 2012-06-26 2017-10-18 Saniona A/S A phenyl triazole derivative and its use for modulating the gabaa receptor complex
MX357504B (es) 2012-06-26 2018-07-12 Saniona Aps Derivado de feniltriazol y su uso para modular complejo del receptor gabaa.
EP4032889B1 (en) 2013-12-20 2026-05-06 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
EP3310785B1 (en) 2015-06-19 2024-11-20 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
CN107344939A (zh) * 2016-05-06 2017-11-14 如东赛默罗生物科技有限公司 咪唑[2,1-a]酞嗪类衍生物、其制备方法、药物组合物和用途
MA48594B1 (fr) * 2016-12-08 2022-05-31 Hoffmann La Roche Nouveaux dérivés d'éther d'isoxazolyle en tant que pam alpha5 gaba a
US20180170941A1 (en) 2016-12-19 2018-06-21 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
AU2019286312B2 (en) * 2018-06-13 2023-08-17 F. Hoffmann-La Roche Ag New isoxazolyl ether derivatives as GABA A alpha5 PAM
AU2019288382B2 (en) 2018-06-19 2024-07-25 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
BR102019014802A2 (pt) * 2018-07-20 2020-02-04 Boehringer Ingelheim Int difluorometil-fenil triazóis
HU231223B1 (hu) 2018-09-28 2022-01-28 Richter Gedeon Nyrt. GABAA A5 receptor modulátor hatású biciklusos vegyületek
US12391667B2 (en) 2019-07-22 2025-08-19 Boehringer Ingelheim International Gmbh N-methyl, n-(6-(methoxy)pyridazin-3-yl) amine derivatives as Autotaxin (ATX) modulators for the treatment of inflammatory airway or fibrotic diseases
CN112979655A (zh) * 2019-12-16 2021-06-18 上海赛默罗生物科技有限公司 三唑并哒嗪类衍生物、其制备方法、药物组合物和用途
TWI901650B (zh) 2020-03-26 2025-10-21 匈牙利商羅特格登公司 啶及吡啶并〔３，４－ｃ〕嗒衍生物
US12649738B2 (en) 2020-03-26 2026-06-09 Richter Gedeon Nyrt. 1,3-dihydro-2H-pyrrolo[3,4-c]pyridine derivatives as GABAA α5 receptor modulators
US20240425491A1 (en) 2021-05-05 2024-12-26 University College Cardiff Consultants Limited Heteroaryl compounds useful in the treatment of cognitive disorders
HU231691B1 (hu) 2021-09-29 2025-10-28 Richter Gedeon Nyrt GABAA ALFA5 receptor modulátor hatású biciklusos aminszármazékok
CN116854685A (zh) * 2022-03-28 2023-10-10 上海赛默罗生物科技有限公司 异噁唑-稠环类衍生物、药物组合物和用途
CN116854680A (zh) * 2022-03-28 2023-10-10 上海赛默罗生物科技有限公司 异噁唑-杂环类衍生物、药物组合物和用途
KR20250092192A (ko) * 2022-10-25 2025-06-23 에프. 호프만-라 로슈 아게 알로가바트 제조 방법
WO2024251133A1 (zh) * 2023-06-05 2024-12-12 武汉人福创新药物研发中心有限公司 作为α5-GABAA受体调节剂的杂环化合物及其用途
CN117486792A (zh) * 2023-09-26 2024-02-02 北京四环科宝制药股份有限公司 尼可地尔中间体及其制备方法

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Also Published As

Publication number Publication date
US20090143385A1 (en) 2009-06-04
US7943619B2 (en) 2011-05-17
CA2707821A1 (en) 2009-06-11
CA2707821C (en) 2016-06-07
EP2231651A1 (en) 2010-09-29
AR069525A1 (es) 2010-01-27
KR101175855B1 (ko) 2012-08-24
AU2008333327A1 (en) 2009-06-11
KR20100074320A (ko) 2010-07-01
MX2010006182A (es) 2010-07-01
AU2008333327B2 (en) 2012-12-06
JP2011505402A (ja) 2011-02-24
TW200924775A (en) 2009-06-16
JP5301558B2 (ja) 2013-09-25
CN101868458A (zh) 2010-10-20
PE20091446A1 (es) 2009-09-24
CL2008003593A1 (es) 2010-01-04
EP2231651B1 (en) 2018-11-21
WO2009071477A1 (en) 2009-06-11
CN101868458B (zh) 2012-11-28
IL205753A0 (en) 2010-11-30

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Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements