BRPI0813718A2 - Método e aparelho que utilizam um campo elétrico para ensaios biológicos aperfeiçoados - Google Patents

Método e aparelho que utilizam um campo elétrico para ensaios biológicos aperfeiçoados

Info

Publication number
BRPI0813718A2
BRPI0813718A2 BRPI0813718-8A2A BRPI0813718A BRPI0813718A2 BR PI0813718 A2 BRPI0813718 A2 BR PI0813718A2 BR PI0813718 A BRPI0813718 A BR PI0813718A BR PI0813718 A2 BRPI0813718 A2 BR PI0813718A2
Authority
BR
Brazil
Prior art keywords
electric field
biological tests
improved biological
tests
improved
Prior art date
Application number
BRPI0813718-8A2A
Other languages
English (en)
Inventor
Mostafa Ronaghi
Tarun Khurana
Juan G Santiago
Original Assignee
Univ Leland Stanford Junior
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Leland Stanford Junior filed Critical Univ Leland Stanford Junior
Publication of BRPI0813718A2 publication Critical patent/BRPI0813718A2/pt

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads or physically stretching molecules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00306—Reactor vessels in a multiple arrangement
    • B01J2219/00313—Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
    • B01J2219/00315—Microtiter plates
    • B01J2219/00317—Microwell devices, i.e. having large numbers of wells
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00457—Dispensing or evacuation of the solid phase support
    • B01J2219/00459—Beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00457—Dispensing or evacuation of the solid phase support
    • B01J2219/00459—Beads
    • B01J2219/00466—Beads in a slurry
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00596—Solid-phase processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00646—Making arrays on substantially continuous surfaces the compounds being bound to beads immobilised on the solid supports
    • B01J2219/00648—Making arrays on substantially continuous surfaces the compounds being bound to beads immobilised on the solid supports by the use of solid beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00653—Making arrays on substantially continuous surfaces the compounds being bound to electrodes embedded in or on the solid supports
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00702—Processes involving means for analysing and characterising the products
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0668—Trapping microscopic beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0819—Microarrays; Biochips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Fluid Mechanics (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Optical Measuring Cells (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
BRPI0813718-8A2A 2007-07-13 2008-07-10 Método e aparelho que utilizam um campo elétrico para ensaios biológicos aperfeiçoados BRPI0813718A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US95939807P 2007-07-13 2007-07-13
PCT/US2008/069638 WO2009012112A1 (en) 2007-07-13 2008-07-10 Method and apparatus using electric field for improved biological assays

Publications (1)

Publication Number Publication Date
BRPI0813718A2 true BRPI0813718A2 (pt) 2014-12-30

Family

ID=40260000

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0813718-8A2A BRPI0813718A2 (pt) 2007-07-13 2008-07-10 Método e aparelho que utilizam um campo elétrico para ensaios biológicos aperfeiçoados

Country Status (8)

Country Link
US (2) US8277628B2 (pt)
EP (1) EP2173467B1 (pt)
JP (1) JP2010533840A (pt)
CN (1) CN101848757B (pt)
AU (1) AU2008276308A1 (pt)
BR (1) BRPI0813718A2 (pt)
CA (1) CA2693059A1 (pt)
WO (1) WO2009012112A1 (pt)

Families Citing this family (154)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8562804B2 (en) 2006-07-20 2013-10-22 The Board Of Trustees Of The Leland Stanford Junior University Fluorescent finger prints for indirect detection in isotachophoresis
US11339430B2 (en) 2007-07-10 2022-05-24 Life Technologies Corporation Methods and apparatus for measuring analytes using large scale FET arrays
US8262900B2 (en) 2006-12-14 2012-09-11 Life Technologies Corporation Methods and apparatus for measuring analytes using large scale FET arrays
US8349167B2 (en) 2006-12-14 2013-01-08 Life Technologies Corporation Methods and apparatus for detecting molecular interactions using FET arrays
US7948015B2 (en) 2006-12-14 2011-05-24 Life Technologies Corporation Methods and apparatus for measuring analytes using large scale FET arrays
CA2700397A1 (en) * 2007-09-26 2009-04-02 Massachusetts Institute Of Technology Electrokinetic concentration device and methods of use thereof
US8865401B2 (en) * 2007-12-14 2014-10-21 The Johns Hopkins University Purification and concentration of proteins and DNA from a complex sample using isotachophoresis and a device to perform the purification
WO2009079028A1 (en) * 2007-12-14 2009-06-25 Johns Hopkins University Purification and concentration of proteins and dna from a complex sample using isotachophoresis and a device to perform the purification
US8039817B2 (en) 2008-05-05 2011-10-18 Illumina, Inc. Compensator for multiple surface imaging
GB0809237D0 (en) * 2008-05-21 2008-06-25 Vivacta Ltd A sensor
US8470164B2 (en) 2008-06-25 2013-06-25 Life Technologies Corporation Methods and apparatus for measuring analytes using large scale FET arrays
US8383345B2 (en) 2008-09-12 2013-02-26 University Of Washington Sequence tag directed subassembly of short sequencing reads into long sequencing reads
US20100137143A1 (en) 2008-10-22 2010-06-03 Ion Torrent Systems Incorporated Methods and apparatus for measuring analytes
US20100301398A1 (en) 2009-05-29 2010-12-02 Ion Torrent Systems Incorporated Methods and apparatus for measuring analytes
US8846314B2 (en) * 2009-03-03 2014-09-30 The Board Of Trustees Of The Leland Stanford Junior University Isotachophoretic focusing of nucleic acids
US8776573B2 (en) 2009-05-29 2014-07-15 Life Technologies Corporation Methods and apparatus for measuring analytes
US8673627B2 (en) 2009-05-29 2014-03-18 Life Technologies Corporation Apparatus and methods for performing electrochemical reactions
US20120261274A1 (en) 2009-05-29 2012-10-18 Life Technologies Corporation Methods and apparatus for measuring analytes
US8721858B2 (en) * 2010-03-12 2014-05-13 The Board Of Trustees Of The Leland Stanford Junior University Non-focusing tracers for indirect detection in electrophoretic displacement techniques
EP2588850B1 (en) 2010-06-30 2016-12-28 Life Technologies Corporation Method for dry testing isfet arrays
US8487790B2 (en) 2010-06-30 2013-07-16 Life Technologies Corporation Chemical detection circuit including a serializer circuit
JP5720129B2 (ja) * 2010-06-30 2015-05-20 東ソー株式会社 粒子固定用構造体、粒子解析装置、及び解析方法
JP2012013551A (ja) * 2010-06-30 2012-01-19 Tosoh Corp 粒子固定用構造体、粒子解析装置、及び解析方法
JP2012013550A (ja) * 2010-06-30 2012-01-19 Tosoh Corp 粒子固定用構造体、粒子解析装置、及び解析方法
AU2011226767B1 (en) 2010-06-30 2011-11-10 Life Technologies Corporation Ion-sensing charge-accumulation circuits and methods
US20130099143A1 (en) * 2010-06-30 2013-04-25 Tosoh Corporation Structure for particle immobilization and apparatus for particle analysis
US11307166B2 (en) 2010-07-01 2022-04-19 Life Technologies Corporation Column ADC
CN103168341B (zh) 2010-07-03 2016-10-05 生命科技公司 具有轻度掺杂的排出装置的化学敏感的传感器
JP2012029676A (ja) * 2010-07-07 2012-02-16 Sony Corp 核酸濃縮回収用カートリッジ、核酸濃縮回収方法、及び該カートリッジの製造方法
US8986529B2 (en) 2010-09-13 2015-03-24 The Board Of Trustees Of The Leland Stanford Junior University Isotachophoresis having interacting anionic and cationic shock waves
EP2617061B1 (en) 2010-09-15 2021-06-30 Life Technologies Corporation Methods and apparatus for measuring analytes
JP5913323B2 (ja) 2010-09-24 2016-04-27 ライフ テクノロジーズ コーポレーション マッチドペアトランジスタ回路
JP5839790B2 (ja) * 2010-09-28 2016-01-06 国立大学法人 東京大学 Ｄｎａマイクロアレイの製造方法、ｄｎａマイクロアレイ、タンパク質アレイの製造方法、タンパク質アレイ、及び機能性タンパク質の同定方法
US9399217B2 (en) 2010-10-04 2016-07-26 Genapsys, Inc. Chamber free nanoreactor system
US9184099B2 (en) 2010-10-04 2015-11-10 The Board Of Trustees Of The Leland Stanford Junior University Biosensor devices, systems and methods therefor
NZ610129A (en) 2010-10-04 2014-08-29 Genapsys Inc Systems and methods for automated reusable parallel biological reactions
US9074251B2 (en) 2011-02-10 2015-07-07 Illumina, Inc. Linking sequence reads using paired code tags
US8524061B2 (en) 2010-11-29 2013-09-03 The Board Of Trustees Of The Leland Stanford Junior University On-chip hybridization coupled with ITP based purification for fast sequence specific identification
US9097661B2 (en) * 2011-01-27 2015-08-04 Caterpillar, Inc. Electrochemical sulfur sensor and the method of making the same
US10457936B2 (en) 2011-02-02 2019-10-29 University Of Washington Through Its Center For Commercialization Massively parallel contiguity mapping
JP5958066B2 (ja) * 2011-05-13 2016-07-27 株式会社Ｊｖｃケンウッド 試料分析用ディスク
US8585973B2 (en) 2011-05-27 2013-11-19 The Board Of Trustees Of The Leland Stanford Junior University Nano-sensor array
US9926596B2 (en) 2011-05-27 2018-03-27 Genapsys, Inc. Systems and methods for genetic and biological analysis
KR101945566B1 (ko) * 2011-07-29 2019-02-07 도쿄엘렉트론가부시키가이샤 처리액 공급 장치, 처리액 공급 방법 및 컴퓨터 기억 매체
US8691067B2 (en) * 2011-09-16 2014-04-08 International Business Machines Corporation Charged entities as locomotive to control motion of polymers through a nanochannel
US12595500B2 (en) 2011-09-26 2026-04-07 Life Technologies Corporation High efficiency, small volume nucleic acid synthesis
WO2014153188A2 (en) 2013-03-14 2014-09-25 Life Technologies Corporation High efficiency, small volume nucleic acid synthesis
CN103945931B (zh) * 2011-09-26 2017-03-22 基因技术股份公司 高效的小体积核酸合成
WO2013055553A1 (en) * 2011-10-03 2013-04-18 Life Technologies Corporation Electric field directed loading of microwell array
US9970984B2 (en) 2011-12-01 2018-05-15 Life Technologies Corporation Method and apparatus for identifying defects in a chemical sensor array
US10093975B2 (en) * 2011-12-01 2018-10-09 Genapsys, Inc. Systems and methods for high efficiency electronic sequencing and detection
US8821798B2 (en) 2012-01-19 2014-09-02 Life Technologies Corporation Titanium nitride as sensing layer for microwell structure
US8747748B2 (en) 2012-01-19 2014-06-10 Life Technologies Corporation Chemical sensor with conductive cup-shaped sensor surface
EP3540077B1 (en) * 2012-02-16 2021-01-27 Genia Technologies, Inc. Methods for creating bilayers for use with nanopore sensors
EP2645091B1 (en) 2012-03-30 2018-10-17 ams international AG Integrated circuit comprising a gas sensor
US10029915B2 (en) 2012-04-04 2018-07-24 International Business Machines Corporation Functionally switchable self-assembled coating compound for controlling translocation of molecule through nanopores
WO2013176767A1 (en) * 2012-05-25 2013-11-28 The University Of North Carolina At Chapel Hill Microfluidic devices, solid supports for reagents and related methods
US8786331B2 (en) 2012-05-29 2014-07-22 Life Technologies Corporation System for reducing noise in a chemical sensor array
US9012022B2 (en) 2012-06-08 2015-04-21 Illumina, Inc. Polymer coatings
US8895249B2 (en) 2012-06-15 2014-11-25 Illumina, Inc. Kinetic exclusion amplification of nucleic acid libraries
JP6128764B2 (ja) * 2012-06-27 2017-05-17 京セラ株式会社 バイオセンサ、検出方法、検出システム及び検出装置
US20140216935A1 (en) * 2012-08-08 2014-08-07 Lehigh University Dielectrophoretic Tweezers as a Platform for Molecular Force Spectroscopy in a Highly Parallel Format
US9034261B2 (en) * 2012-09-12 2015-05-19 Sony Corporation System and method for depositing particles on a disc
US9593371B2 (en) 2013-12-27 2017-03-14 Intel Corporation Integrated photonic electronic sensor arrays for nucleic acid sequencing
CN103055977A (zh) * 2012-12-31 2013-04-24 苏州汶颢芯片科技有限公司 一种电响应的微流体自驱动微流控芯片及其制备方法
CN103055968A (zh) * 2012-12-31 2013-04-24 苏州汶颢芯片科技有限公司 一种油水分离的微流控芯片及其制备方法
CN103055976A (zh) * 2012-12-31 2013-04-24 苏州汶颢芯片科技有限公司 一种电场/界面协同作用下油水破乳分离的微流控芯片及其制备方法
US9080968B2 (en) 2013-01-04 2015-07-14 Life Technologies Corporation Methods and systems for point of use removal of sacrificial material
US9841398B2 (en) 2013-01-08 2017-12-12 Life Technologies Corporation Methods for manufacturing well structures for low-noise chemical sensors
US9683230B2 (en) 2013-01-09 2017-06-20 Illumina Cambridge Limited Sample preparation on a solid support
US8962366B2 (en) 2013-01-28 2015-02-24 Life Technologies Corporation Self-aligned well structures for low-noise chemical sensors
US9512422B2 (en) 2013-02-26 2016-12-06 Illumina, Inc. Gel patterned surfaces
WO2014142850A1 (en) 2013-03-13 2014-09-18 Illumina, Inc. Methods and compositions for nucleic acid sequencing
US8841217B1 (en) 2013-03-13 2014-09-23 Life Technologies Corporation Chemical sensor with protruded sensor surface
US8963216B2 (en) 2013-03-13 2015-02-24 Life Technologies Corporation Chemical sensor with sidewall spacer sensor surface
US9322820B2 (en) * 2013-03-14 2016-04-26 Wisconsin Alumni Research Foundation System and apparatus for nanopore sequencing
EP2971141B1 (en) 2013-03-15 2018-11-28 Genapsys, Inc. Systems for biological analysis
US9193998B2 (en) * 2013-03-15 2015-11-24 Illumina, Inc. Super resolution imaging
US20140274747A1 (en) 2013-03-15 2014-09-18 Illumina, Inc. Super resolution imaging
CN105264366B (zh) 2013-03-15 2019-04-16 生命科技公司 具有一致传感器表面区域的化学传感器
CN105283758B (zh) 2013-03-15 2018-06-05 生命科技公司 具有一致传感器表面区域的化学传感器
US9835585B2 (en) 2013-03-15 2017-12-05 Life Technologies Corporation Chemical sensor with protruded sensor surface
US20140264471A1 (en) 2013-03-15 2014-09-18 Life Technologies Corporation Chemical device with thin conductive element
US9116117B2 (en) 2013-03-15 2015-08-25 Life Technologies Corporation Chemical sensor with sidewall sensor surface
US20140336063A1 (en) 2013-05-09 2014-11-13 Life Technologies Corporation Windowed Sequencing
US10458942B2 (en) 2013-06-10 2019-10-29 Life Technologies Corporation Chemical sensor array having multiple sensors per well
US9188578B2 (en) 2013-06-19 2015-11-17 Globalfoundries Inc. Nanogap device with capped nanowire structures
GB201312035D0 (en) * 2013-07-04 2013-08-21 Cytomos Ltd Biological sensing apparatus
US9352315B2 (en) 2013-09-27 2016-05-31 Taiwan Semiconductor Manufacturing Company, Ltd. Method to produce chemical pattern in micro-fluidic structure
WO2015089238A1 (en) 2013-12-11 2015-06-18 Genapsys, Inc. Systems and methods for biological analysis and computation
US9354195B2 (en) * 2013-12-12 2016-05-31 Intel Corporation Highly selective coated-electrode nanogap transducers for the detection of redox molecules
CN106414765A (zh) 2013-12-20 2017-02-15 Illumina公司 在片段化的基因组dna样品中保留基因组连接信息
CN106459869B (zh) * 2014-03-11 2020-01-21 伊鲁米那股份有限公司 一次性的集成微流体盒及其制备和使用的方法
US9822401B2 (en) 2014-04-18 2017-11-21 Genapsys, Inc. Methods and systems for nucleic acid amplification
JP6700246B2 (ja) 2014-07-09 2020-05-27 シーメンス・ヘルスケア・ダイアグノスティックス・インコーポレーテッドＳｉｅｍｅｎｓ Ｈｅａｌｔｈｃａｒｅ Ｄｉａｇｎｏｓｔｉｃｓ Ｉｎｃ． 少量試料検知装置
EP3460075B1 (en) 2014-07-15 2020-11-04 Illumina, Inc. Biochemically activated electronic device
US10519499B2 (en) 2014-07-31 2019-12-31 Illumina, Inc. Hybrid nanopore sensors
US11873480B2 (en) 2014-10-17 2024-01-16 Illumina Cambridge Limited Contiguity preserving transposition
JP6594975B2 (ja) * 2014-11-19 2019-10-23 アイメック・ヴェーゼットウェー マイクロバブル発生装置、システム、および製造方法
US10407676B2 (en) 2014-12-09 2019-09-10 Life Technologies Corporation High efficiency, small volume nucleic acid synthesis
CN111505087A (zh) 2014-12-18 2020-08-07 生命科技公司 使用大规模 fet 阵列测量分析物的方法和装置
EP3234576B1 (en) 2014-12-18 2023-11-22 Life Technologies Corporation High data rate integrated circuit with transmitter configuration
US10077472B2 (en) 2014-12-18 2018-09-18 Life Technologies Corporation High data rate integrated circuit with power management
AU2016200047A1 (en) * 2015-01-07 2016-07-21 Personal Genomics, Inc. Oriented Loading Systems And Method For Orienting A Particle Loaded In A Well
WO2016168490A1 (en) 2015-04-15 2016-10-20 University Of Washington Isotachophoresis enhanced isothermal nucleic acid amplification
KR20180019500A (ko) 2015-04-22 2018-02-26 선전 제노리비전 테크놀로지 컴퍼니, 리미티드 생물감지기
EP3315461B1 (en) * 2015-06-23 2021-07-07 BGI Shenzhen Micro-porous electrode and method for analysis of chemical substances
CN114272966B (zh) 2015-07-22 2023-11-07 北卡罗来纳-查佩尔山大学 含有具有空间分离的珠保留和信号检测段的珠孔几何结构的流体装置和相关方法
US10920312B2 (en) * 2015-08-31 2021-02-16 Roche Sequencing Solutions, Inc. Electrochemical cell with increased current density
CN108449970A (zh) * 2015-09-14 2018-08-24 深圳源光科技有限公司 生物感测器
US10170289B2 (en) 2015-09-14 2019-01-01 Shenzhen Genorivision Technology Co., Ltd. Phototube and method of making it
ES2618892B1 (es) * 2015-12-22 2018-04-10 Universidad De Burgos Dispositivo para la realización de medidas espectroelectroquímicas de absorción UV/VIS y de dispersión Raman simultáneamente.
JP7277050B2 (ja) 2016-01-29 2023-05-18 ピューリジェン バイオシステムズ， インコーポレイテッド 核酸の精製のための等速電気泳動
WO2018017884A1 (en) 2016-07-20 2018-01-25 Genapsys, Inc. Systems and methods for nucleic acid sequencing
US10711300B2 (en) * 2016-07-22 2020-07-14 Pacific Biosciences Of California, Inc. Methods and compositions for delivery of molecules and complexes to reaction sites
GB201704754D0 (en) 2017-01-05 2017-05-10 Illumina Inc Kinetic exclusion amplification of nucleic acid libraries
US11927560B2 (en) * 2017-02-08 2024-03-12 Essenlix Corporation Bio/chemical material extraction and assay
WO2018168819A1 (ja) * 2017-03-14 2018-09-20 凸版印刷株式会社 解析デバイス、解析キット、及び解析システム
KR101852719B1 (ko) * 2017-04-06 2018-04-27 인제대학교 산학협력단 박막을 이용하여 분리 가능한 구조를 갖는 미세 유체 유속 측정장치
NL2019043B1 (en) * 2017-04-25 2018-11-05 Illumina Inc Sensors having integrated protection circuitry
US10710079B2 (en) 2017-06-29 2020-07-14 International Business Machines Corporation Electro-kinectic device for species exchange
WO2019028123A1 (en) 2017-08-01 2019-02-07 Essenlix Corporation COLLECTION, MAINTENANCE AND DETERMINATION OF SAMPLES
SG11202000871WA (en) 2017-08-02 2020-02-27 Purigen Biosystems Inc Systems, devices, and methods for isotachophoresis
US20190056384A1 (en) * 2017-08-17 2019-02-21 Abbott Point Of Care Inc. Single-use test device for imaging assay beads
US11067526B2 (en) 2017-08-17 2021-07-20 Abbott Point Of Care Inc. Devices, systems, and methods for performing optical and electrochemical assays
EP3669178B1 (en) 2017-08-17 2023-07-19 Abbott Point Of Care Inc Systems for performing optical and electrochemical assays
WO2019060628A1 (en) 2017-09-21 2019-03-28 Genapsys, Inc. SYSTEMS AND METHODS FOR NUCLEIC ACID SEQUENCING
US11072827B2 (en) * 2018-01-08 2021-07-27 Quantum-Si Incorporated System and methods for electrokinetic loading of sub-micron-scale reaction chambers
WO2019147722A1 (en) 2018-01-24 2019-08-01 Perkinelmer Health Sciences, Inc. Purification of nucleic acids in a microfluidic chip by separation
US12228535B2 (en) 2018-04-25 2025-02-18 Spectrohm, Inc. Methods for determining regional impedance characteristics of inhomogenous specimens using guided electromagnetic fields
US10542906B2 (en) * 2018-04-25 2020-01-28 Spectrohm, Inc. Tomographic systems and methods for determining characteristics of inhomogenous specimens using guided electromagnetic fields
EP3794080B1 (en) 2018-05-18 2024-04-10 The University of North Carolina at Chapel Hill Compositions, devices, and methods for improving a surface property of a substrate
NL2021377B1 (en) 2018-07-03 2020-01-08 Illumina Inc Interposer with first and second adhesive layers
US11143585B2 (en) * 2018-12-28 2021-10-12 National Applied Research Laboratories Photoelectrical device for concentration detection, method for concentration detection thereof and method for testing an antibiotic susceptibility on bacteria
US20220057315A1 (en) * 2019-01-23 2022-02-24 Hewlett-Packard Development Company, L.P. Particle monitoring
US11815430B2 (en) 2019-02-22 2023-11-14 Hewlett-Packard Development Company, L.P. Nucleic acid detection
CN110066723A (zh) * 2019-05-05 2019-07-30 京东方科技集团股份有限公司 基因测序芯片、设备、制造方法
AU2020276115A1 (en) 2019-05-16 2021-01-07 Illumina, Inc. Systems and devices for characterization and performance analysis of pixel-based sequencing
US11593649B2 (en) 2019-05-16 2023-02-28 Illumina, Inc. Base calling using convolutions
US11423306B2 (en) 2019-05-16 2022-08-23 Illumina, Inc. Systems and devices for characterization and performance analysis of pixel-based sequencing
EP3976827A4 (en) * 2019-05-31 2023-10-18 Illumina, Inc. Obtaining information from a biological sample in a flow cell
US11712177B2 (en) 2019-08-12 2023-08-01 Essenlix Corporation Assay with textured surface
CN110591903A (zh) * 2019-09-19 2019-12-20 京东方科技集团股份有限公司 基因测序基板及其制作方法和基因测序芯片
EP4065886A4 (en) * 2019-11-26 2023-03-29 Regents of the University of Minnesota LOW VOLTAGE MICROFLUIDIC DEVICES
KR102776052B1 (ko) 2020-01-03 2025-03-05 삼성디스플레이 주식회사 유리 제품 및 이의 제조 방법
CN111321066A (zh) * 2020-03-18 2020-06-23 重庆信络威科技有限公司 一种集成了病毒预处理结构的核酸图像荧光检测装置
CN111440854B (zh) * 2020-03-18 2023-12-12 贝塔智能科技(北京)有限公司 一种基于荧光图像测序的核酸智能检测方法
CN114517145A (zh) * 2020-11-20 2022-05-20 京东方科技集团股份有限公司 生物分子捕获机构和微流控芯片
WO2022142763A1 (en) * 2020-12-29 2022-07-07 International Business Machines Corporation Nanoparticle trapping and transport techniques
TWI796673B (zh) * 2021-04-23 2023-03-21 國立中正大學 微流體裝置
WO2023220958A1 (en) * 2022-05-18 2023-11-23 Singleron (Nanjing) Biotechnologies, Ltd. Microfluidic device, system, kit, method of analyzing nucleic acids, method of manipulating nucleic acids, method of detecting biomolecule, and method of analyzing biomolecule
CN115420725B (zh) * 2022-09-22 2025-10-10 生益电子股份有限公司 一种电路板孔壁的导电层上胶渣的探测方法及系统
WO2024108390A1 (zh) * 2022-11-22 2024-05-30 深圳华大智造科技股份有限公司 基因测序芯片、封装结构、系统及清洗、制作、测序方法
CN119549208B (zh) * 2024-12-02 2026-04-24 石河子大学 一种双极电化学发光微流控芯片及其应用

Family Cites Families (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5824477A (en) 1990-09-12 1998-10-20 Scientific Generics Limited Electrochemical denaturation of double-stranded nucleic acid
US5527670A (en) 1990-09-12 1996-06-18 Scientific Generics Limited Electrochemical denaturation of double-stranded nucleic acid
US6051380A (en) 1993-11-01 2000-04-18 Nanogen, Inc. Methods and procedures for molecular biological analysis and diagnostics
US6017696A (en) 1993-11-01 2000-01-25 Nanogen, Inc. Methods for electronic stringency control for molecular biological analysis and diagnostics
IL103674A0 (en) * 1991-11-19 1993-04-04 Houston Advanced Res Center Method and apparatus for molecule detection
US5846708A (en) 1991-11-19 1998-12-08 Massachusetts Institiute Of Technology Optical and electrical methods and apparatus for molecule detection
US5965452A (en) 1996-07-09 1999-10-12 Nanogen, Inc. Multiplexed active biologic array
US6225059B1 (en) 1993-11-01 2001-05-01 Nanogen, Inc. Advanced active electronic devices including collection electrodes for molecular biological analysis and diagnostics
US7172864B1 (en) 1993-11-01 2007-02-06 Nanogen Methods for electronically-controlled enzymatic reactions
DE69507289T2 (de) 1994-03-15 1999-07-08 Scientific Generics Ltd., Cambridge Elektrochemische denatusierung von doppelsträngiger nukleinsäure
US6071394A (en) 1996-09-06 2000-06-06 Nanogen, Inc. Channel-less separation of bioparticles on a bioelectronic chip by dielectrophoresis
US6001229A (en) 1994-08-01 1999-12-14 Lockheed Martin Energy Systems, Inc. Apparatus and method for performing microfluidic manipulations for chemical analysis
US6207369B1 (en) * 1995-03-10 2001-03-27 Meso Scale Technologies, Llc Multi-array, multi-specific electrochemiluminescence testing
EP0821726B1 (en) * 1995-03-10 2014-05-07 Meso Scale Technologies, LLC. Multi-array, multi-specific electrochemiluminescence testing
US5968745A (en) 1995-06-27 1999-10-19 The University Of North Carolina At Chapel Hill Polymer-electrodes for detecting nucleic acid hybridization and method of use thereof
US5661028A (en) * 1995-09-29 1997-08-26 Lockheed Martin Energy Systems, Inc. Large scale DNA microsequencing device
NZ331865A (en) 1996-03-18 1999-04-29 Univ Wales Bangor Change Of Na Apparatus with electrode arrays for carrying out chemical, physical or physico-chemical reactions
US5728532A (en) 1996-05-31 1998-03-17 Ackley; Donald E. Electrode configuration for matrix addressing of a molecular detection device
US7381525B1 (en) * 1997-03-07 2008-06-03 Clinical Micro Sensors, Inc. AC/DC voltage apparatus for detection of nucleic acids
US7014992B1 (en) 1996-11-05 2006-03-21 Clinical Micro Sensors, Inc. Conductive oligomers attached to electrodes and nucleoside analogs
EP0864860A1 (en) 1997-03-10 1998-09-16 Japan Science and Technology Corporation Sample plate and multicapillary electrophoresis apparatus
JP3171827B2 (ja) * 1997-08-04 2001-06-04 株式会社先端生命科学研究所 ウイルスの検出又は測定方法
EP1801591B1 (en) * 1997-08-04 2016-12-28 Advanced Life Science Institute, Inc. Methods for detection or measurement of viruses
JP3176570B2 (ja) * 1997-08-04 2001-06-18 株式会社先端生命科学研究所 Ｈｃｖの検出又は測定方法
US20050244954A1 (en) * 1998-06-23 2005-11-03 Blackburn Gary F Binding acceleration techniques for the detection of analytes
US6136171A (en) 1998-09-18 2000-10-24 The University Of Utah Research Foundation Micromachined electrical field-flow fractionation system
US6482306B1 (en) * 1998-09-22 2002-11-19 University Of Washington Meso- and microfluidic continuous flow and stopped flow electroösmotic mixer
US6913679B1 (en) * 1999-02-11 2005-07-05 The Regents Of The University Of California Apparatus and methods for high resolution separation of sample components on microfabricated channel devices
US6942771B1 (en) * 1999-04-21 2005-09-13 Clinical Micro Sensors, Inc. Microfluidic systems in the electrochemical detection of target analytes
US6238909B1 (en) 1999-05-04 2001-05-29 Motorola, Inc. Method and apparatus for obtaining electric field-enhanced bioconjugation
US6287774B1 (en) 1999-05-21 2001-09-11 Caliper Technologies Corp. Assay methods and system
WO2000074850A2 (en) * 1999-06-03 2000-12-14 University Of Washington Microfluidic devices for transverse electrophoresis and isoelectric focusing
US6524456B1 (en) 1999-08-12 2003-02-25 Ut-Battelle, Llc Microfluidic devices for the controlled manipulation of small volumes
US6451191B1 (en) 1999-11-18 2002-09-17 3M Innovative Properties Company Film based addressable programmable electronic matrix articles and methods of manufacturing and using the same
US6303082B1 (en) 1999-12-15 2001-10-16 Nanogen, Inc. Permeation layer attachment chemistry and method
US6551838B2 (en) * 2000-03-02 2003-04-22 Microchips, Inc. Microfabricated devices for the storage and selective exposure of chemicals and devices
US6537433B1 (en) * 2000-03-10 2003-03-25 Applera Corporation Methods and apparatus for the location and concentration of polar analytes using an alternating electric field
WO2002023163A1 (en) * 2000-09-15 2002-03-21 California Institute Of Technology Microfabricated crossflow devices and methods
WO2002045835A2 (en) * 2000-12-08 2002-06-13 The Regents Of The University Of California Microelectronic arrays for cell-based functional genomics / high throughput phenotyping by electrokinetic assembly
US6733244B1 (en) 2000-12-20 2004-05-11 University Of Arkansas, N.A. Microfluidics and small volume mixing based on redox magnetohydrodynamics methods
US7070681B2 (en) 2001-01-24 2006-07-04 The Board Of Trustees Of The Leland Stanford Junior University Electrokinetic instability micromixer
ATE345497T1 (de) * 2001-02-07 2006-12-15 Massachusetts Inst Technology Optoelektronisches nachweissystem
WO2003001889A2 (en) 2001-06-29 2003-01-09 Meso Scale Technologies, Llc. Assay plates reader systems and methods for luminescence test measurements
US6734436B2 (en) * 2001-08-07 2004-05-11 Sri International Optical microfluidic devices and methods
US6942018B2 (en) 2001-09-28 2005-09-13 The Board Of Trustees Of The Leland Stanford Junior University Electroosmotic microchannel cooling system
US6960298B2 (en) 2001-12-10 2005-11-01 Nanogen, Inc. Mesoporous permeation layers for use on active electronic matrix devices
US6887362B2 (en) * 2002-02-06 2005-05-03 Nanogen, Inc. Dielectrophoretic separation and immunoassay methods on active electronic matrix devices
TW200307563A (en) 2002-02-14 2003-12-16 Sixty Inc C Use of BUCKYSOME or carbon nanotube for drug delivery
WO2003091458A1 (en) * 2002-04-26 2003-11-06 The Penn State Research Foundation Integrated nanomechanical sensor array chips
US7217542B2 (en) 2002-10-31 2007-05-15 Hewlett-Packard Development Company, L.P. Microfluidic system for analyzing nucleic acids
JP4328168B2 (ja) * 2003-10-02 2009-09-09 ソニー株式会社 毛細管現象を利用する物質間の相互作用検出部と該検出部を用いる方法及びバイオアッセイ用基板
US7390622B2 (en) 2003-10-16 2008-06-24 Hai Kang Life Corporation Limited Apparatus and methods for detecting nucleic acid in biological samples
JP4461920B2 (ja) * 2004-06-23 2010-05-12 株式会社デンソー 駐車支援装置
JP4630015B2 (ja) * 2004-08-03 2011-02-09 一般社団法人オンチップ・セロミクス・コンソーシアム 細胞分離回収方法および細胞分離チップおよび細胞分離装置
JP4099540B2 (ja) * 2004-08-03 2008-06-11 有限責任中間法人 オンチップ・セロミクス・コンソーシアム 生体試料解析チップおよび解析法
EP1626278A3 (en) * 2004-08-03 2006-06-21 OnChip Cellomics Consortium Cellomics system
US7785785B2 (en) 2004-11-12 2010-08-31 The Board Of Trustees Of The Leland Stanford Junior University Charge perturbation detection system for DNA and other molecules
US8512559B2 (en) * 2005-11-18 2013-08-20 Intel Corporation Device, method, and system for separation and detection of biomolecules and cells
US7782237B2 (en) * 2008-06-13 2010-08-24 The Board Of Trustees Of The Leland Stanford Junior University Semiconductor sensor circuit arrangement

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