BRPI0813900A2 - Derivados de n5-(2-etoxietil)-n3-(2-piridinil)-3,5-piperidinodicarboxa mida para uso como inibidores de renina - Google Patents

Derivados de n5-(2-etoxietil)-n3-(2-piridinil)-3,5-piperidinodicarboxa mida para uso como inibidores de renina

Info

Publication number
BRPI0813900A2
BRPI0813900A2 BRPI0813900-8A2A BRPI0813900A BRPI0813900A2 BR PI0813900 A2 BRPI0813900 A2 BR PI0813900A2 BR PI0813900 A BRPI0813900 A BR PI0813900A BR PI0813900 A2 BRPI0813900 A2 BR PI0813900A2
Authority
BR
Brazil
Prior art keywords
pyridylin
piperidinodycarbox
etoxyethyl
mida
derivatives
Prior art date
Application number
BRPI0813900-8A2A
Other languages
English (en)
Inventor
Fumiaki Yokokawa
Atsushi Toyao
Takeru Ehara
Shimpei Kawakami
Osamu Irie
Masaki Suzuki
Yuko Hitomi
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39926743&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0813900(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of BRPI0813900A2 publication Critical patent/BRPI0813900A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurosurgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Psychiatry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
BRPI0813900-8A2A 2007-06-25 2008-06-23 Derivados de n5-(2-etoxietil)-n3-(2-piridinil)-3,5-piperidinodicarboxa mida para uso como inibidores de renina BRPI0813900A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP07012412 2007-06-25
EP07111290 2007-06-28
PCT/EP2008/057964 WO2009000811A1 (en) 2007-06-25 2008-06-23 N5-(2-ethoxyethyl)-n3-(2-pyridinyl)-3,5-piperidinedicarboxamide derivatives for use as renin inhibitors

Publications (1)

Publication Number Publication Date
BRPI0813900A2 true BRPI0813900A2 (pt) 2014-12-30

Family

ID=39926743

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0813900-8A2A BRPI0813900A2 (pt) 2007-06-25 2008-06-23 Derivados de n5-(2-etoxietil)-n3-(2-piridinil)-3,5-piperidinodicarboxa mida para uso como inibidores de renina

Country Status (26)

Country Link
US (2) US8383650B2 (pt)
EP (2) EP2181105B1 (pt)
JP (1) JP5086433B2 (pt)
KR (1) KR101238479B1 (pt)
CN (1) CN101687847B (pt)
AR (1) AR067132A1 (pt)
AU (1) AU2008267287B2 (pt)
BR (1) BRPI0813900A2 (pt)
CA (1) CA2689109A1 (pt)
CL (1) CL2008001872A1 (pt)
CO (1) CO6251267A2 (pt)
CR (1) CR11153A (pt)
CU (1) CU23842B1 (pt)
EA (1) EA016446B1 (pt)
EC (1) ECSP099825A (pt)
ES (2) ES2543641T3 (pt)
GT (1) GT200900324A (pt)
HN (1) HN2009003463A (pt)
IL (1) IL202494A0 (pt)
MA (1) MA31538B1 (pt)
NZ (1) NZ582098A (pt)
PE (1) PE20090425A1 (pt)
SG (1) SG182223A1 (pt)
TN (1) TN2009000530A1 (pt)
TW (1) TWI404714B (pt)
WO (1) WO2009000811A1 (pt)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009000811A1 (en) 2007-06-25 2008-12-31 Novartis Ag N5-(2-ethoxyethyl)-n3-(2-pyridinyl)-3,5-piperidinedicarboxamide derivatives for use as renin inhibitors
US20180048921A1 (en) * 2016-08-12 2018-02-15 Microsoft Technology Licensing, Llc Real-time playback diagnostics

Family Cites Families (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ246441A (en) 1991-12-18 1996-02-27 Schering Corp Imidazol or imidazolalkyl substituted with a 4 or 5 membered nitrogen containing heterocycle, preparation and pharmaceutical compositions thereof
IL111176A0 (en) 1993-10-07 1994-12-29 Du Pont Merck Pharma Dipeptide boronic acid inhibitors of trypsin-like enzymes and pharmaceutical compositions containing them
PL193686B1 (pl) 1995-09-07 2007-03-30 Hoffmann La Roche Pochodne piperydyny, środki lecznicze zawierającepochodne piperydyny, sposoby wytwarzania tych pochodnych oraz zastosowanie pochodnych
JP2000500502A (ja) 1995-11-22 2000-01-18 メルク エンド カンパニー インコーポレーテッド ファルネシル―タンパク質トランスフェラーゼ阻害剤
CA2298813A1 (en) 1997-08-28 1999-03-04 Merck & Co., Inc. Pyrrolidine and piperidine modulators of chemokine receptor activity
WO1999065867A1 (en) 1998-06-17 1999-12-23 Du Pont Pharmaceuticals Company Cyclic hydroxamic acids as metalloproteinase inhibitors
US6274735B1 (en) 1998-08-10 2001-08-14 Hoffmann-La Roche Inc. Process and intermediates for preparation of substituted piperidines
JP2002528543A (ja) 1998-10-30 2002-09-03 メルク エンド カムパニー インコーポレーテッド トロンビン阻害剤
AU3386500A (en) 1999-03-02 2000-09-21 Merck & Co., Inc. 3-cyclopropyl and 3-cyclobutyl pyrrolidine modulators of chemokine receptor activity
US6303593B1 (en) 1999-03-02 2001-10-16 Merck & Co., Inc. 3-thienyl and 3-furanyl pyrrolidine modulators of chemokine receptor activity
AU3389300A (en) 1999-03-02 2000-09-21 Merck & Co., Inc. Pyrrolidine modulators of chemokine receptor activity
AU3818900A (en) 1999-04-14 2000-11-02 F. Hoffmann-La Roche Ag Process for the preparation of substituted piperidines
US6376672B1 (en) 1999-04-27 2002-04-23 Hoffmann-La Roche Inc. Naphthalenylmethoxypiperidines as renin inhibitors
US6197959B1 (en) 1999-04-27 2001-03-06 Hoffmann-La Roche Inc. Piperidine derivatives
CN1481377A (zh) 2000-03-17 2004-03-10 ����˹�ж�-����˹˹����ҩƷ��˾ 作为基质金属蛋白酶和TNF-α的抑制剂的环β-氨基酸衍生物
FR2811673B1 (fr) 2000-07-17 2002-09-13 Rhodia Chimie Sa Utilisation de composes insatures comprenant un heterocycle comme stabilisants de polymeres halogenes
EP1326619A2 (en) 2000-10-11 2003-07-16 Merck & Co., Inc. Pyrrolidine modulators of ccr5 chemokine receptor activity
US20060079533A1 (en) 2001-03-23 2006-04-13 Nieman James A Methods of treating alzheimer's disease
AU2002256418A1 (en) 2001-04-27 2002-11-11 Vertex Pharmaceuticals Incorporated Inhibitors of bace
EP1427408A4 (en) 2001-09-17 2005-10-26 Bristol Myers Squibb Co CYCLIC HYDROXAMINE ACIDS AS INHIBITORS OF MATRIX METALLOPROTEINASES AND / OR TNF-a-CONVERTASE (TACE TNF-a-CONVERTING ENZYM)
WO2003031443A1 (en) 2001-10-04 2003-04-17 Morphochem Aktiengesellschaft für kombinatorische Chemie Dual actions antibiotics comprising a oxazoldinone and a quinolone or naphthyridinone moiety
CA2483241C (en) 2002-04-29 2011-05-31 Actelion Pharmaceuticals Ltd Novel diazabicyclononene derivatives
US6878722B2 (en) 2002-05-20 2005-04-12 Bristol-Myers Squibb Company Substituted cycloalkyl P1′ hepatitis C virus inhibitors
AU2003259131A1 (en) 2002-07-09 2004-01-23 Bristol-Myers Squibb Company Substituted heterocyclic derivatives useful as antidiabetic and antiobesity agents and method
US20040204455A1 (en) 2003-04-10 2004-10-14 Cody Wayne Livingston Piperidine derivative rennin inhibitors
US20040214832A1 (en) 2003-04-10 2004-10-28 Cuiman Cai Piperazine derivative renin inhibitors
US20060217371A1 (en) 2003-04-28 2006-09-28 Olivier Bezencon Diazabicyclononene and tetrahydropyriddine derivatives as renin inhibitors
CN1972912A (zh) 2003-04-29 2007-05-30 埃科特莱茵药品有限公司 新型3,4－二取代的1,2,3,6－四氢吡啶衍生物
CN1780663A (zh) 2003-04-30 2006-05-31 埃科特莱茵药品有限公司 作为肾素抑制剂的新型3－位具有杂原子的9－氮杂双环壬烯衍生物
BRPI0409818A (pt) 2003-04-30 2006-05-09 Actelion Pharmaceuticals Ltd compostos, composições farmacêuticas, método para o tratamento ou profilaxia de doenças, e, usos de compostos e de um ou mais compostos em combinação com outros compostos farmacologicamente ativos
US20060205768A1 (en) 2003-04-30 2006-09-14 Olivier Bezencon Tropane derivatives and their use as ace inhibitors
MXPA05011711A (es) 2003-05-02 2006-01-23 Actelion Pharmaceuticals Ltd Derivados de diazabiciclononeno.
US7144907B2 (en) 2003-09-03 2006-12-05 Array Biopharma Inc. Heterocyclic inhibitors of MEK and methods of use thereof
TW200513461A (en) 2003-10-01 2005-04-16 Speedel Experimenta Ag Organische verbindungen
CN1863773A (zh) 2003-10-09 2006-11-15 埃科特莱茵药品有限公司 四氢吡啶衍生物
EP1689702B1 (en) 2003-11-26 2013-01-30 Novartis AG Organic compounds
BRPI0416976A (pt) 2003-11-26 2007-02-21 Novartis Ag derivados de 4-fenilpiperidina como inibidores de renina
CA2553836A1 (en) 2004-01-23 2005-08-04 Speedel Experimenta Ag Amino alcohol derivatives and their use as renin inhibitors
BRPI0506491A (pt) 2004-01-23 2007-02-13 Speedel Experimenta Ag compostos orgánicos
ATE472524T1 (de) 2004-01-23 2010-07-15 Novartis Ag Diaminoalkohole und deren verwendung als renininhibitoren
CA2560195A1 (en) 2004-03-19 2005-09-29 Speedel Experimenta Ag Organic compounds
CN1934083A (zh) 2004-03-19 2007-03-21 斯皮德尔实验股份公司 作为肾素抑制剂用于治疗高血压的5－氨基－4－羟基－7－(1h－吲哚基甲基)－8－甲基壬酰胺衍生物
AR053406A1 (es) 2004-07-09 2007-05-09 Speedel Experimenta Ag Derivados de piperidina como inhibidores de renina. composiciones farmaceuticas
TW200631929A (en) 2004-12-10 2006-09-16 Speedel Experimenta Ag ω -phenyloctanamides
GB0428250D0 (en) 2004-12-23 2005-01-26 Novartis Ag Organic compounds
GB0428526D0 (en) 2004-12-30 2005-02-09 Novartis Ag Organic compounds
GB0500784D0 (en) 2005-01-14 2005-02-23 Novartis Ag Organic compounds
GB0504850D0 (en) 2005-03-09 2005-04-13 Novartis Ag Organic compounds
AR053826A1 (es) 2005-03-11 2007-05-23 Speedel Experimenta Ag Compuestos organicos
GB0505969D0 (en) 2005-03-23 2005-04-27 Novartis Ag Organic compounds
JP2008535825A (ja) 2005-03-31 2008-09-04 シュペーデル・エクスペリメンタ・アーゲー レニン阻害剤としての３，４，５−置換ピペリジン
TW200722424A (en) 2005-03-31 2007-06-16 Speedel Experimenta Ag Substituted piperidines
GB0508992D0 (en) * 2005-05-03 2005-06-08 Novartis Ag Organic compounds
GB0510810D0 (en) 2005-05-26 2005-06-29 Novartis Ag Organic compounds
GB0511063D0 (en) 2005-05-31 2005-07-06 Novartis Ag Organic compounds
GB0514203D0 (en) * 2005-07-11 2005-08-17 Novartis Ag Organic compounds
BRPI0617166A2 (pt) 2005-09-17 2011-07-12 Speedel Experimenta Ag derivados de 5-amino-4-hidróxi-7-(imidazo[1,2-a]piridin-6-ilmetil)-8-me til-nonamidia e compostos relacionados como inibidores de renina para o tratamento de hipertensão
AR057816A1 (es) 2005-09-17 2007-12-19 Speedel Experimenta Ag Compuestos organicos
PE20071079A1 (es) * 2005-11-15 2007-12-16 Cytokinetics Inc Compuestos de piperidina como inhibidores de la proliferacion celular
NZ569135A (en) * 2005-12-30 2011-08-26 Novartis Ag 3,5-Substituted piperidine compounds as renin inhibitors
EP1816122A3 (en) * 2006-01-19 2007-09-19 Speedel Experimenta AG 3,4,5-substituted piperidines as therapeutic compounds
BRPI0706778A2 (pt) 2006-01-30 2011-04-05 Speedel Experimenta Ag processos para a preparação estéreo-seletiva de álcoois a partir de compostos alfa, beta-insaturados
AR061265A1 (es) 2006-06-08 2008-08-13 Speedel Experimenta Ag Piperidinas 2,5- disustituidas
GB0611697D0 (en) 2006-06-13 2006-07-26 Novartis Ag Organic compounds
GB0611696D0 (en) 2006-06-13 2006-07-26 Novartis Ag Organic compounds
TW200831463A (en) 2006-09-12 2008-08-01 Speedel Experimenta Ag Nitrate esters of aminoalcohols
EP1908471A1 (en) 2006-10-04 2008-04-09 Speedel Experimenta AG Tetrahydropyridines as renin inhibitors
EP1921069A1 (de) 2006-11-08 2008-05-14 Speedel Experimenta AG Verfahren zur Herstellung von 2-Alkyl-3-heterocyclyl-prop-2-en-1-olen
AR065792A1 (es) 2007-03-21 2009-07-01 Speedel Experimenta Ag Proceso para preparar (r o s) -5- (1 -azido-3-(6-metoxi-5-(3-metoxi-propoxi) -piridin-3-ilmetil) -4-metil- pentil) -3-alquil-dihidro-furan-2-ona
WO2009000811A1 (en) 2007-06-25 2008-12-31 Novartis Ag N5-(2-ethoxyethyl)-n3-(2-pyridinyl)-3,5-piperidinedicarboxamide derivatives for use as renin inhibitors

Also Published As

Publication number Publication date
CU20090226A7 (es) 2012-02-15
US8383650B2 (en) 2013-02-26
IL202494A0 (en) 2010-06-30
EA201000037A1 (ru) 2010-06-30
EP2181105B1 (en) 2015-04-29
TN2009000530A1 (en) 2011-03-31
TWI404714B (zh) 2013-08-11
AU2008267287A1 (en) 2008-12-31
EA016446B1 (ru) 2012-05-30
PE20090425A1 (es) 2009-05-12
GT200900324A (es) 2011-11-03
CN101687847A (zh) 2010-03-31
US8497286B2 (en) 2013-07-30
SG182223A1 (en) 2012-07-30
CN101687847B (zh) 2013-11-06
ES2543641T3 (es) 2015-08-20
JP2010531328A (ja) 2010-09-24
US20130005770A1 (en) 2013-01-03
KR20100023003A (ko) 2010-03-03
CR11153A (es) 2010-01-21
US20080319018A1 (en) 2008-12-25
HN2009003463A (es) 2012-12-10
CL2008001872A1 (es) 2009-02-20
CA2689109A1 (en) 2008-12-31
EP2527338A1 (en) 2012-11-28
AU2008267287B2 (en) 2012-02-16
AR067132A1 (es) 2009-09-30
EP2527338B1 (en) 2015-05-06
JP5086433B2 (ja) 2012-11-28
CU23842B1 (es) 2012-10-15
EP2181105A1 (en) 2010-05-05
WO2009000811A1 (en) 2008-12-31
CO6251267A2 (es) 2011-02-21
MA31538B1 (fr) 2010-07-01
TW200911782A (en) 2009-03-16
ES2541107T3 (es) 2015-07-16
NZ582098A (en) 2012-03-30
KR101238479B1 (ko) 2013-03-04
ECSP099825A (es) 2010-01-29

Similar Documents

Publication Publication Date Title
BRPI0810984A2 (pt) Micro-descanso extendido para comunicação
BRPI1014572A2 (pt) imidazoprazinas para uso como inibidores de cinase
BRPI0717502A2 (pt) Compostos heterocíclicos contendo nitrogênio bacíclico para uso como inibidores de estearoil-coa desaturase.
DK2078010T3 (da) Polycyklisk heteroaryl-substituerede triazoler, der er anvendelige som axl-hæmmere
BRPI0821668A2 (pt) Uso
BRPI0907563A2 (pt) Derivados de 4,5-di-hidro-xazol-2-il amina
BRPI0813762A2 (pt) Dosador de produtos químicos para uso diário
BRPI0817219A2 (pt) Correção de poço adaptáveis responsáveis pela excentricidade para configuração de laterologs
BRPI0813600A2 (pt) formatação de pulso para egprs-2
BRPI0823082A2 (pt) Uso derivados de sesquiterpeno
BRPI0921950A2 (pt) suporte para ferramentas
BRPI0818459A2 (pt) Composição farmacêutica adequada para uso oftálmico.
BRPI0810580A2 (pt) Conjunto de antenas para utilização em um ambiente explosivo
ATE545417T1 (de) Pyrazoloä3,4-büpyridin-derivate als phosphodiesterasehemmer
DK1846394T3 (da) Pyrazolylaminopyridinderivater, der er egnede som kinaseinhibitorer
BRPI1015367A2 (pt) imidazotiodiazois para uso como inibidores de cinase
BRPI0910987A2 (pt) derivados de triazolopiridinona para uso como inibidores de estearoil-coa dessaturase
BRPI0808813A2 (pt) método para a preparação de compostos de borracha, e, uso de compostos
EP2168952A4 (en) morpholine
BRPI1012047A2 (pt) compostos dímeros contendo oxazolidinona, composições e métodos para fazer e uso
BRPI0816679A2 (pt) Derivados de ftalazinona.
BRPI0814011A2 (pt) método para preparação de biobutanol
FI20070540A0 (fi) Teräsovitelma
BR112013016824A2 (pt) dispositivo de usinagem portátil, particularmente para perfuração
BR112012000561A2 (pt) cartucho de múltiplos componentes para uso único.

Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 7A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2343 DE 01-12-2015 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.