BRPI0814310A2 - Enzima lecitina-colesterol acetiltransferase modificada - Google Patents

Enzima lecitina-colesterol acetiltransferase modificada

Info

Publication number
BRPI0814310A2
BRPI0814310A2 BRPI0814310A BRPI0814310A2 BR PI0814310 A2 BRPI0814310 A2 BR PI0814310A2 BR PI0814310 A BRPI0814310 A BR PI0814310A BR PI0814310 A2 BRPI0814310 A2 BR PI0814310A2
Authority
BR
Brazil
Prior art keywords
acetiltransferase
cholesterol
enzyme
modified lecithin
lecithin
Prior art date
Application number
Other languages
English (en)
Inventor
Mingyue Zhou
Thomas Boone
David Park Meininger
Margrit Schwartz
Bei Shan
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of BRPI0814310A2 publication Critical patent/BRPI0814310A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y203/00—Acyltransferases (2.3)
    • C12Y203/01—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C12Y203/01043—Phosphatidylcholine-sterol O-acyltransferase (2.3.1.43), i.e. lecithin-cholesterol acyltransferase or LCAT

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Obesity (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
BRPI0814310 2007-07-26 2008-07-25 Enzima lecitina-colesterol acetiltransferase modificada BRPI0814310A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US95200707P 2007-07-26 2007-07-26
PCT/US2008/071119 WO2009015314A2 (en) 2007-07-26 2008-07-25 Modified lecithin-cholesterol acyltransferase enzymes

Publications (1)

Publication Number Publication Date
BRPI0814310A2 true BRPI0814310A2 (pt) 2015-01-06

Family

ID=39864722

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0814310 BRPI0814310A2 (pt) 2007-07-26 2008-07-25 Enzima lecitina-colesterol acetiltransferase modificada

Country Status (25)

Country Link
US (3) US8168416B2 (pt)
EP (4) EP2489731B1 (pt)
JP (5) JP5643643B2 (pt)
KR (1) KR20100040937A (pt)
CN (1) CN101855344B (pt)
AU (1) AU2008279065B2 (pt)
BR (1) BRPI0814310A2 (pt)
CA (1) CA2694590A1 (pt)
CR (1) CR11272A (pt)
CY (2) CY1114857T1 (pt)
DK (2) DK2489731T3 (pt)
EA (1) EA201070187A1 (pt)
ES (3) ES2449483T3 (pt)
HR (1) HRP20140315T1 (pt)
IL (1) IL203399A0 (pt)
MX (1) MX348799B (pt)
MY (1) MY159075A (pt)
NZ (2) NZ582794A (pt)
PL (2) PL2181190T3 (pt)
PT (2) PT2181190E (pt)
RS (1) RS53237B (pt)
SG (1) SG186016A1 (pt)
SI (2) SI2489731T1 (pt)
UA (1) UA103304C2 (pt)
WO (1) WO2009015314A2 (pt)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI2489731T1 (sl) * 2007-07-26 2014-12-31 Amgen Inc. Patent Operations, M/S 28-2-C Modificirani encimi lecitin-holesterol aciltransferaze
CN102802659B (zh) * 2009-06-12 2015-11-25 阿尔法科制药有限责任公司 Lcat治疗贫血和红细胞功能障碍的用途
BR112012028462A2 (pt) * 2010-05-06 2016-07-19 Alphacore Pharma Llc liberação de éster de colesterol para tecidos esteroidogênicos
EP2701732B1 (en) * 2011-02-25 2017-08-30 University Of Patras Lecithin:cholesterol acyltransferase (lcat) and its role in nonalcoholic fatty liver disease (nafld)
SG194780A1 (en) * 2011-05-05 2013-12-30 Wellstat Immunotherapeutics Llc Complement factor b analogs and their uses
WO2013086443A1 (en) 2011-12-08 2013-06-13 Amgen Inc. Agonistic human lcat antigen binding proteins and their use in therapy
US10583104B2 (en) * 2014-08-06 2020-03-10 Indiana University Research And Technology Corporation Tuneable delivery of nanoparticle bound active plasmin for the treatment of thrombosis
US20180265885A1 (en) * 2015-01-29 2018-09-20 Plantvax, Inc. Highly expressed protective plant-derived broadly neutralizing hiv monoclonal antibodies for use in passive immunotherapy
WO2018022511A1 (en) 2016-07-25 2018-02-01 The Trustees Of The University Of Pennsylvania Compositions comprising a lecithin cholesterol acyltransferase variant and uses thereof
US20200261549A1 (en) * 2017-11-07 2020-08-20 Alphacore Pharma Llc Methods of treating and protecting against cardiac disease, cardiovascular disease and related conditions and symptoms
EA202092799A1 (ru) 2018-05-22 2021-03-01 ДСМ АйПи АССЕТС Б.В. Модифицированные стерол-ацилтрансферазы
US11612619B2 (en) 2018-11-01 2023-03-28 National Institute Of Health (Nih), U.S. Dept. Of Health And Human Services (Dhhs), U.S. Government Compostions and methods for enabling cholesterol catabolism in human cells
US12544402B2 (en) 2020-02-28 2026-02-10 Repair Biotechnologies, Inc. Targeted expression of microbial cholesterol catalysis genes reduces excess lipid

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Also Published As

Publication number Publication date
NZ597885A (en) 2013-08-30
US8168416B2 (en) 2012-05-01
CY1115573T1 (el) 2017-01-04
EP2522721B1 (en) 2016-05-04
WO2009015314A2 (en) 2009-01-29
HRP20140315T1 (hr) 2014-05-09
EP2489730A1 (en) 2012-08-22
US9006408B2 (en) 2015-04-14
PT2489731E (pt) 2014-09-15
MX348799B (es) 2017-06-29
HK1138039A1 (en) 2010-08-13
UA103304C2 (ru) 2013-10-10
CN101855344B (zh) 2015-12-09
EP2489731A1 (en) 2012-08-22
EP2489730B1 (en) 2015-12-30
CN101855344A (zh) 2010-10-06
DK2181190T3 (da) 2014-03-31
CA2694590A1 (en) 2009-01-29
DK2489731T3 (en) 2014-11-17
PL2489731T3 (pl) 2015-01-30
JP2016182136A (ja) 2016-10-20
PT2181190E (pt) 2014-02-24
JP6033258B2 (ja) 2016-11-30
CR11272A (es) 2010-05-26
SI2181190T1 (sl) 2014-04-30
CY1114857T1 (el) 2016-12-14
KR20100040937A (ko) 2010-04-21
JP2018161134A (ja) 2018-10-18
EA201070187A1 (ru) 2010-08-30
JP5643643B2 (ja) 2014-12-17
IL203399A0 (en) 2011-07-31
SI2489731T1 (sl) 2014-12-31
US8703926B1 (en) 2014-04-22
AU2008279065A1 (en) 2009-01-29
WO2009015314A3 (en) 2009-03-12
EP2489731B1 (en) 2014-08-27
AU2008279065B2 (en) 2013-12-12
EP2522721A2 (en) 2012-11-14
JP2014198047A (ja) 2014-10-23
ES2513716T3 (es) 2014-10-27
MY159075A (en) 2016-12-15
JP2010534479A (ja) 2010-11-11
EP2181190A2 (en) 2010-05-05
RS53237B (sr) 2014-08-29
US20090081182A1 (en) 2009-03-26
EP2181190B1 (en) 2014-01-08
ES2559353T3 (es) 2016-02-11
NZ582794A (en) 2012-09-28
EP2522721A3 (en) 2013-01-23
US20140287479A1 (en) 2014-09-25
PL2181190T3 (pl) 2014-06-30
ES2449483T3 (es) 2014-03-19
SG186016A1 (en) 2012-12-28
JP2020058366A (ja) 2020-04-16

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Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements