BRPI0815754A2 - métodos para preparar compostos à base de 4-fenil-6-(2,2,2-trifluoro-1-feniletóxi)pirimidina - Google Patents

métodos para preparar compostos à base de 4-fenil-6-(2,2,2-trifluoro-1-feniletóxi)pirimidina

Info

Publication number
BRPI0815754A2
BRPI0815754A2 BRPI0815754A BRPI0815754A BRPI0815754A2 BR PI0815754 A2 BRPI0815754 A2 BR PI0815754A2 BR PI0815754 A BRPI0815754 A BR PI0815754A BR PI0815754 A BRPI0815754 A BR PI0815754A BR PI0815754 A2 BRPI0815754 A2 BR PI0815754A2
Authority
BR
Brazil
Prior art keywords
phenylethyloxy
trifluoro
phenyl
preparing
methods
Prior art date
Application number
BRPI0815754A
Other languages
English (en)
Inventor
Zhang Haiming
Alfred Burgoon Hugh Jr
Yan Jie
Stephen Bednarz Mark
Song Qiuling
C Kanamarlapudi Ramanaiah
Iimura Shinya
Wu Wenxue
Original Assignee
Lexicon Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lexicon Pharmaceuticals Inc filed Critical Lexicon Pharmaceuticals Inc
Publication of BRPI0815754A2 publication Critical patent/BRPI0815754A2/pt
Publication of BRPI0815754B1 publication Critical patent/BRPI0815754B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
BRPI0815754-5A 2007-08-24 2008-08-22 Métodos para preparar compostos à base de 4-fenil-6-(2,2,2-trifluoro-1-feniletóxi) pirimidina e composto intermediário BRPI0815754B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US95774407P 2007-08-24 2007-08-24
US60/957,744 2007-08-24
PCT/US2008/073950 WO2009029499A1 (en) 2007-08-24 2008-08-22 Methods of preparing 4-phenyl-6-(2,2,2-trifluoro-1-phenylethoxy)pyrimidine-based compounds

Publications (2)

Publication Number Publication Date
BRPI0815754A2 true BRPI0815754A2 (pt) 2017-05-30
BRPI0815754B1 BRPI0815754B1 (pt) 2022-03-22

Family

ID=40040082

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0815754-5A BRPI0815754B1 (pt) 2007-08-24 2008-08-22 Métodos para preparar compostos à base de 4-fenil-6-(2,2,2-trifluoro-1-feniletóxi) pirimidina e composto intermediário

Country Status (15)

Country Link
US (3) US20090062540A1 (pt)
EP (3) EP3318260B1 (pt)
JP (1) JP5553752B2 (pt)
KR (1) KR101582697B1 (pt)
CN (1) CN101801384B (pt)
AU (1) AU2008293679B2 (pt)
BR (1) BRPI0815754B1 (pt)
CA (1) CA2697368C (pt)
ES (2) ES2848152T3 (pt)
IL (2) IL203669A (pt)
MX (1) MX2010001938A (pt)
NZ (1) NZ583017A (pt)
RU (1) RU2493156C2 (pt)
WO (1) WO2009029499A1 (pt)
ZA (1) ZA201000785B (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA99270C2 (en) * 2006-12-12 2012-08-10 Лексикон Фармасьютикалз, Инк. 4-phenyl-6-(2,2,2-trifluoro-1-phenylethoxy)pyrimidine-based compounds and methods of their use
TWI439457B (zh) * 2007-09-28 2014-06-01 Lexicon Pharmaceuticals Inc （ｓ）－２－胺基－３－（４－（２－胺基－６－（（ｒ）－１－（４－氯－２－（３－甲基－１ｈ－吡唑－１－基）苯基）－２，２，２－三氟乙氧）－嘧啶－４－基）苯基）丙酸乙酯之固體形式與其使用方法
AU2009231892A1 (en) * 2008-03-31 2009-10-08 The Trustees Of Columbia University In The City Of New York Methods of diagnosing, preventing and treating bone mass diseases
WO2011053977A1 (en) 2009-11-02 2011-05-05 The Trustees Of Columbia University In The City Of New York Compounds and methods for inhibiting serotonin synthesis
TW201245183A (en) 2010-11-05 2012-11-16 Lexicon Pharmaceuticals Inc Solid forms of (S)-2-amino-3-(4-(2-amino-6-((R)-1-(4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethoxy)pyrimidin-4-yl)phenyl)propanoic acid
WO2013119751A1 (en) * 2012-02-09 2013-08-15 Boehringer Ingelheim International Gmbh Process for preparing carboxamidine compounds
TW201818964A (zh) 2016-09-30 2018-06-01 瑞士商諾伊曼特醫療公司 使用色胺酸羥化酶抑制劑之方法
CN116496496B (zh) * 2023-04-27 2024-11-05 中国石油大学(华东) 一种基于三嗪共价框架材料（CTFs）制备单位点催化剂的制备方法
IT202300021255A1 (it) * 2023-10-12 2025-04-12 Univ Degli Studi Di Perugia Composto telotristat etile per l’uso nel trattamento della malaria, combinazione e kit

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4866181A (en) * 1986-08-29 1989-09-12 Aldrich-Boranes, Inc. Process for producing optically active alcohols
US4916074A (en) * 1986-10-30 1990-04-10 Chisso Corporation Process for producing optically active compounds
EP0504541B1 (en) * 1991-03-21 1998-07-22 Solutia Europe N.V./S.A. Improved catalytic process for selective alkylation of aromatic hydrocarbons
DE4131924A1 (de) * 1991-09-25 1993-07-08 Hoechst Ag Substituierte 4-alkoxypyrimidine, verfahren zu ihrer herstellung und ihre verwendung als schaedlingsbekaempfungsmittel
ES2203790T3 (es) * 1996-10-02 2004-04-16 Bristol-Myers Squibb Pharma Company 1,4-dihidro-2h-3,1-benzoxacin-2-onas 4,4-disustituidas utiles como inhibidores de la transcriptasa reversa del hiv e intermedios y procedimientos para su preparacion.
US6388084B1 (en) * 1999-12-06 2002-05-14 Hoffmann-La Roche Inc. 4-pyridinyl-n-acyl-l-phenylalanines
FR2804427B1 (fr) * 2000-01-27 2002-09-06 Rhodia Chimie Sa Procede de preparation de cetones alpha-halogenees
MY129000A (en) * 2000-08-31 2007-03-30 Tanabe Seiyaku Co INHIBITORS OF a4 MEDIATED CELL ADHESION
GB0213122D0 (en) 2002-06-07 2002-07-17 Glaxo Group Ltd Compounds
WO2003104200A1 (en) 2002-06-07 2003-12-18 Glaxo Group Limited N-mercaptoacyl phenyalanine derivatives, process for their preparation, and pharmaceutical compositions containing them
US20060128956A1 (en) * 2003-04-21 2006-06-15 Ustav Organicke Chemie A Biochemie Akademie Ved Ceske Republiky (Purin-6-yl) amino acid and production method thereof
JP4638423B2 (ja) * 2003-06-20 2011-02-23 ガルデルマ・リサーチ・アンド・デヴェロップメント ＰＰＡＲγタイプ受容体を調節する新規化合物および化粧品組成物または医薬品組成物へのその使用
AU2004291259A1 (en) * 2003-11-05 2005-06-02 F. Hoffmann-La Roche Ag Heteroaryl derivatives as PPAR activators
US7855291B2 (en) * 2005-12-29 2010-12-21 Lexicon Pharmaceuticals, Inc. Process for the preparation of substituted phenylalanines
CA2635531C (en) * 2005-12-29 2014-06-17 Lexicon Pharmaceutical Inc. Multicyclic amino acid derivatives and methods of their use
UA99270C2 (en) * 2006-12-12 2012-08-10 Лексикон Фармасьютикалз, Инк. 4-phenyl-6-(2,2,2-trifluoro-1-phenylethoxy)pyrimidine-based compounds and methods of their use
CN101801385A (zh) * 2007-07-26 2010-08-11 莱西肯医药有限公司 影响胃肠传输和胃排空的方法和可用于该方法的化合物
TWI439457B (zh) * 2007-09-28 2014-06-01 Lexicon Pharmaceuticals Inc （ｓ）－２－胺基－３－（４－（２－胺基－６－（（ｒ）－１－（４－氯－２－（３－甲基－１ｈ－吡唑－１－基）苯基）－２，２，２－三氟乙氧）－嘧啶－４－基）苯基）丙酸乙酯之固體形式與其使用方法

Also Published As

Publication number Publication date
RU2493156C2 (ru) 2013-09-20
MX2010001938A (es) 2010-03-11
US8575362B2 (en) 2013-11-05
EP2529740A1 (en) 2012-12-05
CN101801384A (zh) 2010-08-11
ES2848152T3 (es) 2021-08-05
JP5553752B2 (ja) 2014-07-16
EP3318260B1 (en) 2020-09-23
AU2008293679B2 (en) 2013-09-12
ES2656798T3 (es) 2018-02-28
CA2697368C (en) 2016-06-21
US7968729B2 (en) 2011-06-28
IL226441A0 (en) 2013-06-27
RU2010111125A (ru) 2011-09-27
HK1143749A1 (en) 2011-01-14
CA2697368A1 (en) 2009-03-05
AU2008293679A1 (en) 2009-03-05
JP2010536879A (ja) 2010-12-02
KR101582697B1 (ko) 2016-01-05
EP2187887A1 (en) 2010-05-26
KR20100046026A (ko) 2010-05-04
NZ583017A (en) 2012-02-24
US20110301349A1 (en) 2011-12-08
WO2009029499A1 (en) 2009-03-05
BRPI0815754B1 (pt) 2022-03-22
US20100240906A1 (en) 2010-09-23
US20090062540A1 (en) 2009-03-05
IL203669A (en) 2015-07-30
EP2187887B1 (en) 2017-11-15
ZA201000785B (en) 2011-04-28
IL226441A (en) 2014-06-30
EP3318260A1 (en) 2018-05-09
CN101801384B (zh) 2012-03-21

Similar Documents

Publication Publication Date Title
BRPI0815754A2 (pt) métodos para preparar compostos à base de 4-fenil-6-(2,2,2-trifluoro-1-feniletóxi)pirimidina
DK2380887T3 (da) Fremgangsmåder til fremstilling af 4-amino-2-(2,6-dioxopiperidin-3-yl)isoindolin-1,3-dion-forbindelser
BRPI0923786A2 (pt) compostos 5,6-dihidro-6-fenilbenzo(f) isoquinolina-2- amina substituidos
BRPI0918472A2 (pt) composto 2,4-diaminopirimidina
BRPI0816970A2 (pt) 1,3-dissubstituídas-4-fenil-1h-piridin-2-onas
BRPI0917459A2 (pt) compostos de pirrol(2,3-d)pirimidina
DK1973559T3 (da) Activin-ActRIIa antagonister samt anvendelser til fremme af knoglevækst
BRPI0814809A2 (pt) Compostos di(arilamino)arílicos
EP1890703A4 (en) pyrimidine
DK2205562T3 (da) 1,1,1-trifluor-2-hydroxy-3-phenylpropanderivater
DK1852430T3 (da) Fremgangsmåde til fremstilling af proanthocyanidinoligomer
BRPI0817117A2 (pt) Revestimentos duros à base de eritritol.
DK1926582T3 (da) Fremgangsmåder til beredning af læder
DK2201020T3 (da) Fremgangsmåde til fremstilling af 2' -deoxy-5-azacytidin (decitabin)
DK2144912T3 (da) 18 f-mærkede folater
CU20090141A7 (es) Compuestos 2-amino pirimidina
BRPI0811597A2 (pt) compostos de arilamida pirimidona
DK1856024T3 (da) Fremgangsmåde til fremstilling af substituerede biphenyler
DK2203457T3 (da) Dispiro-1,2,4-trioxolaner som antimalariamidler
BRPI0810993A2 (pt) métodos para preparar compostos à base de imidazol
FR2916669B1 (fr) Outil.
BRPI0817048A2 (pt) Utensílio para prática de teclado.
AP2008004687A0 (en) Insecticidal methods using 4-amino-5-chloro-thieno(2,3-d)-pyrimidine compounds
BRPI0809002A2 (pt) Macrolídeos à base de eritromicina
ITMI20050718A1 (it) Apparecchiatura per la stiratura di pellame

Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B25A Requested transfer of rights approved

Owner name: TERSERA THERAPEUTICS LLC (US)

B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 22/08/2008, OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF, QUE DETERMINA A ALTERACAO DO PRAZO DE CONCESSAO.