BRPI0815754A2 - métodos para preparar compostos à base de 4-fenil-6-(2,2,2-trifluoro-1-feniletóxi)pirimidina - Google Patents

métodos para preparar compostos à base de 4-fenil-6-(2,2,2-trifluoro-1-feniletóxi)pirimidina

Info

Publication number
BRPI0815754A2
BRPI0815754A2 BRPI0815754A BRPI0815754A BRPI0815754A2 BR PI0815754 A2 BRPI0815754 A2 BR PI0815754A2 BR PI0815754 A BRPI0815754 A BR PI0815754A BR PI0815754 A BRPI0815754 A BR PI0815754A BR PI0815754 A2 BRPI0815754 A2 BR PI0815754A2
Authority
BR
Brazil
Prior art keywords
phenylethyloxy
trifluoro
phenyl
preparing
methods
Prior art date
Application number
BRPI0815754A
Other languages
English (en)
Inventor
Zhang Haiming
Alfred Burgoon Hugh Jr
Yan Jie
Stephen Bednarz Mark
Song Qiuling
C Kanamarlapudi Ramanaiah
Iimura Shinya
Wu Wenxue
Original Assignee
Lexicon Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lexicon Pharmaceuticals Inc filed Critical Lexicon Pharmaceuticals Inc
Publication of BRPI0815754A2 publication Critical patent/BRPI0815754A2/pt
Publication of BRPI0815754B1 publication Critical patent/BRPI0815754B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
BRPI0815754-5A 2007-08-24 2008-08-22 Métodos para preparar compostos à base de 4-fenil-6-(2,2,2-trifluoro-1-feniletóxi) pirimidina e composto intermediário BRPI0815754B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US95774407P 2007-08-24 2007-08-24
US60/957,744 2007-08-24
PCT/US2008/073950 WO2009029499A1 (en) 2007-08-24 2008-08-22 Methods of preparing 4-phenyl-6-(2,2,2-trifluoro-1-phenylethoxy)pyrimidine-based compounds

Publications (2)

Publication Number Publication Date
BRPI0815754A2 true BRPI0815754A2 (pt) 2017-05-30
BRPI0815754B1 BRPI0815754B1 (pt) 2022-03-22

Family

ID=40040082

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0815754-5A BRPI0815754B1 (pt) 2007-08-24 2008-08-22 Métodos para preparar compostos à base de 4-fenil-6-(2,2,2-trifluoro-1-feniletóxi) pirimidina e composto intermediário

Country Status (15)

Country Link
US (3) US20090062540A1 (pt)
EP (3) EP2529740A1 (pt)
JP (1) JP5553752B2 (pt)
KR (1) KR101582697B1 (pt)
CN (1) CN101801384B (pt)
AU (1) AU2008293679B2 (pt)
BR (1) BRPI0815754B1 (pt)
CA (1) CA2697368C (pt)
ES (2) ES2848152T3 (pt)
IL (2) IL203669A (pt)
MX (1) MX2010001938A (pt)
NZ (1) NZ583017A (pt)
RU (1) RU2493156C2 (pt)
WO (1) WO2009029499A1 (pt)
ZA (1) ZA201000785B (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA99270C2 (en) * 2006-12-12 2012-08-10 Лексикон Фармасьютикалз, Инк. 4-phenyl-6-(2,2,2-trifluoro-1-phenylethoxy)pyrimidine-based compounds and methods of their use
TWI439457B (zh) * 2007-09-28 2014-06-01 Lexicon Pharmaceuticals Inc （ｓ）－２－胺基－３－（４－（２－胺基－６－（（ｒ）－１－（４－氯－２－（３－甲基－１ｈ－吡唑－１－基）苯基）－２，２，２－三氟乙氧）－嘧啶－４－基）苯基）丙酸乙酯之固體形式與其使用方法
US8759364B2 (en) * 2008-03-31 2014-06-24 The Trustees Of Columbia University In The City Of New York Methods of treating bone mass diseases
WO2011053977A1 (en) 2009-11-02 2011-05-05 The Trustees Of Columbia University In The City Of New York Compounds and methods for inhibiting serotonin synthesis
TW201245183A (en) 2010-11-05 2012-11-16 Lexicon Pharmaceuticals Inc Solid forms of (S)-2-amino-3-(4-(2-amino-6-((R)-1-(4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethoxy)pyrimidin-4-yl)phenyl)propanoic acid
US9029592B2 (en) * 2012-02-09 2015-05-12 Boehringer Ingelheim International Gmbh Process for preparing carboxamidine compounds
TW201818964A (zh) 2016-09-30 2018-06-01 瑞士商諾伊曼特醫療公司 使用色胺酸羥化酶抑制劑之方法
CN116496496B (zh) * 2023-04-27 2024-11-05 中国石油大学(华东) 一种基于三嗪共价框架材料（CTFs）制备单位点催化剂的制备方法
IT202300021255A1 (it) * 2023-10-12 2025-04-12 Univ Degli Studi Di Perugia Composto telotristat etile per l’uso nel trattamento della malaria, combinazione e kit

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4866181A (en) * 1986-08-29 1989-09-12 Aldrich-Boranes, Inc. Process for producing optically active alcohols
US4916074A (en) * 1986-10-30 1990-04-10 Chisso Corporation Process for producing optically active compounds
DE69129843T2 (de) * 1991-03-21 1999-03-11 Solutia Europe N.V./S.A., Bruessel/Bruxelles Verbessertes katalytisches Verfahren zur selektiven Alkylierung von aromatischen Kohlenwasserstoffen
DE4131924A1 (de) * 1991-09-25 1993-07-08 Hoechst Ag Substituierte 4-alkoxypyrimidine, verfahren zu ihrer herstellung und ihre verwendung als schaedlingsbekaempfungsmittel
WO1998014436A1 (en) * 1996-10-02 1998-04-09 Dupont Pharmaceuticals Company 4,4-disubstituted-1,4-dihydro-2h-3,1-benzoxazin-2-ones useful as hiv reverse transcriptase inhibitors and intermediates and processes for making the same
US6388084B1 (en) * 1999-12-06 2002-05-14 Hoffmann-La Roche Inc. 4-pyridinyl-n-acyl-l-phenylalanines
FR2804427B1 (fr) * 2000-01-27 2002-09-06 Rhodia Chimie Sa Procede de preparation de cetones alpha-halogenees
MY129000A (en) * 2000-08-31 2007-03-30 Tanabe Seiyaku Co INHIBITORS OF a4 MEDIATED CELL ADHESION
TW200407310A (en) 2002-06-07 2004-05-16 Glaxo Group Ltd Compounds
GB0213122D0 (en) 2002-06-07 2002-07-17 Glaxo Group Ltd Compounds
JP2006517918A (ja) * 2003-04-21 2006-08-03 ウスタブ オルガニケ ケミエ ア ビオケミエ ア カデミエ ベド チェスケ レプブリキ （プリン−６−イル）アミノ酸およびその製造方法
JP4638423B2 (ja) * 2003-06-20 2011-02-23 ガルデルマ・リサーチ・アンド・デヴェロップメント ＰＰＡＲγタイプ受容体を調節する新規化合物および化粧品組成物または医薬品組成物へのその使用
RU2367659C2 (ru) * 2003-11-05 2009-09-20 Ф.Хоффманн-Ля Рош Аг Гетероарильные производные в качестве активаторов рецепторов, активируемых пролифераторами пероксисом (ppar)
US7855291B2 (en) * 2005-12-29 2010-12-21 Lexicon Pharmaceuticals, Inc. Process for the preparation of substituted phenylalanines
EA019879B1 (ru) * 2005-12-29 2014-07-30 Лексикон Фармасьютикалз, Инк. Полициклические производные аминокислот, содержащая их фармацевтическая композиция и способ лечения, использующий эти производные
UA99270C2 (en) * 2006-12-12 2012-08-10 Лексикон Фармасьютикалз, Инк. 4-phenyl-6-(2,2,2-trifluoro-1-phenylethoxy)pyrimidine-based compounds and methods of their use
WO2009014972A1 (en) * 2007-07-26 2009-01-29 Lexicon Pharmaceuticals, Inc. Methods of affecting gastrointestinal transit and gastric emptying, and compounds useful therein
TWI439457B (zh) * 2007-09-28 2014-06-01 Lexicon Pharmaceuticals Inc （ｓ）－２－胺基－３－（４－（２－胺基－６－（（ｒ）－１－（４－氯－２－（３－甲基－１ｈ－吡唑－１－基）苯基）－２，２，２－三氟乙氧）－嘧啶－４－基）苯基）丙酸乙酯之固體形式與其使用方法

Also Published As

Publication number Publication date
US20110301349A1 (en) 2011-12-08
WO2009029499A1 (en) 2009-03-05
CN101801384A (zh) 2010-08-11
IL203669A (en) 2015-07-30
BRPI0815754B1 (pt) 2022-03-22
EP2187887A1 (en) 2010-05-26
AU2008293679B2 (en) 2013-09-12
EP2187887B1 (en) 2017-11-15
ES2656798T3 (es) 2018-02-28
CN101801384B (zh) 2012-03-21
NZ583017A (en) 2012-02-24
US7968729B2 (en) 2011-06-28
IL226441A (en) 2014-06-30
HK1143749A1 (en) 2011-01-14
IL226441A0 (en) 2013-06-27
EP2529740A1 (en) 2012-12-05
JP5553752B2 (ja) 2014-07-16
CA2697368A1 (en) 2009-03-05
JP2010536879A (ja) 2010-12-02
RU2010111125A (ru) 2011-09-27
US8575362B2 (en) 2013-11-05
KR20100046026A (ko) 2010-05-04
RU2493156C2 (ru) 2013-09-20
MX2010001938A (es) 2010-03-11
US20090062540A1 (en) 2009-03-05
EP3318260A1 (en) 2018-05-09
ZA201000785B (en) 2011-04-28
AU2008293679A1 (en) 2009-03-05
ES2848152T3 (es) 2021-08-05
KR101582697B1 (ko) 2016-01-05
US20100240906A1 (en) 2010-09-23
CA2697368C (en) 2016-06-21
EP3318260B1 (en) 2020-09-23

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Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B25A Requested transfer of rights approved

Owner name: TERSERA THERAPEUTICS LLC (US)

B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 22/08/2008, OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF, QUE DETERMINA A ALTERACAO DO PRAZO DE CONCESSAO.