BRPI0923786A2 - compostos 5,6-dihidro-6-fenilbenzo(f) isoquinolina-2- amina substituidos - Google Patents
compostos 5,6-dihidro-6-fenilbenzo(f) isoquinolina-2- amina substituidosInfo
- Publication number
- BRPI0923786A2 BRPI0923786A2 BRPI0923786A BRPI0923786A BRPI0923786A2 BR PI0923786 A2 BRPI0923786 A2 BR PI0923786A2 BR PI0923786 A BRPI0923786 A BR PI0923786A BR PI0923786 A BRPI0923786 A BR PI0923786A BR PI0923786 A2 BRPI0923786 A2 BR PI0923786A2
- Authority
- BR
- Brazil
- Prior art keywords
- phenylbenzo
- isoquinoline
- dihydro
- substituted
- amine compounds
- Prior art date
Links
- IKLWZGVCUZDMEL-UHFFFAOYSA-N 6-phenyl-5,6-dihydrobenzo[f]isoquinolin-2-amine Chemical class C1=NC(N)=CC(C2=CC=CC=C22)=C1CC2C1=CC=CC=C1 IKLWZGVCUZDMEL-UHFFFAOYSA-N 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
- A01N43/54—1,3-Diazines; Hydrogenated 1,3-diazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/06—Ring systems of three rings
- C07D221/10—Aza-phenanthrenes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14143908P | 2008-12-30 | 2008-12-30 | |
| US61/141.439 | 2008-12-30 | ||
| US26050509P | 2009-11-12 | 2009-11-12 | |
| US61/260.505 | 2009-11-12 | ||
| PCT/US2009/069813 WO2010078421A1 (en) | 2008-12-30 | 2009-12-30 | Substituted 5,6-dihydro-6-phenylbenzo[f] isoquinolin-2-amine compounds |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| BRPI0923786A2 true BRPI0923786A2 (pt) | 2016-07-26 |
| BRPI0923786B1 BRPI0923786B1 (pt) | 2020-11-24 |
| BRPI0923786C1 BRPI0923786C1 (pt) | 2021-05-11 |
| BRPI0923786C8 BRPI0923786C8 (pt) | 2021-05-25 |
Family
ID=41682678
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0923786A BRPI0923786C8 (pt) | 2008-12-30 | 2009-12-30 | compostos 5,6-dihidro-6-fenilbenzo(f) isoquinolina-2- amina substituidos e composições farmacêuticas compreendendo ditos compostos |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US8357694B2 (pt) |
| EP (1) | EP2379506B1 (pt) |
| JP (1) | JP5739820B2 (pt) |
| KR (1) | KR101714799B1 (pt) |
| CN (1) | CN102325755B (pt) |
| BR (1) | BRPI0923786C8 (pt) |
| CA (1) | CA2748491C (pt) |
| DK (1) | DK2379506T3 (pt) |
| ES (1) | ES2554623T3 (pt) |
| IL (1) | IL213787A (pt) |
| MX (1) | MX2011006959A (pt) |
| TW (1) | TWI461410B (pt) |
| WO (1) | WO2010078421A1 (pt) |
| ZA (1) | ZA201104706B (pt) |
Families Citing this family (41)
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| US8754114B2 (en) | 2010-12-22 | 2014-06-17 | Incyte Corporation | Substituted imidazopyridazines and benzimidazoles as inhibitors of FGFR3 |
| WO2013012681A1 (en) * | 2011-07-15 | 2013-01-24 | Abbott Laboratories | Tricyclic inhibitors of kinases useful for the treatment of proliferative diseases |
| GB2499666A (en) * | 2012-02-27 | 2013-08-28 | Nanyang Polytechnic | Mcl-1 inhibitors for the treatment of conditions associated with proliferative disorders |
| RS58514B1 (sr) | 2012-06-13 | 2019-04-30 | Incyte Holdings Corp | Supstituisana triciklična jedinjenja kao inhibitori fgfr |
| US9388185B2 (en) | 2012-08-10 | 2016-07-12 | Incyte Holdings Corporation | Substituted pyrrolo[2,3-b]pyrazines as FGFR inhibitors |
| US9266892B2 (en) | 2012-12-19 | 2016-02-23 | Incyte Holdings Corporation | Fused pyrazoles as FGFR inhibitors |
| AR094812A1 (es) | 2013-02-20 | 2015-08-26 | Eisai R&D Man Co Ltd | Derivado de piridina monocíclico como inhibidor del fgfr |
| PH12015502383B1 (en) | 2013-04-19 | 2023-02-03 | Incyte Holdings Corp | Bicyclic heterocycles as fgfr inhibitors |
| KR102344105B1 (ko) | 2014-08-18 | 2021-12-29 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 모노시클릭 피리딘 유도체의 염 및 이의 결정 |
| SG11201701704XA (en) * | 2014-09-05 | 2017-04-27 | Arqule Inc | Compositions and methods for treating proliferation disorders |
| US10851105B2 (en) | 2014-10-22 | 2020-12-01 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
| MA41551A (fr) | 2015-02-20 | 2017-12-26 | Incyte Corp | Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4 |
| TWI712601B (zh) | 2015-02-20 | 2020-12-11 | 美商英塞特公司 | 作為fgfr抑制劑之雙環雜環 |
| US9580423B2 (en) | 2015-02-20 | 2017-02-28 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
| EP3275442B1 (en) | 2015-03-25 | 2021-07-28 | National Cancer Center | Therapeutic agent for bile duct cancer |
| CA3006077A1 (en) * | 2015-12-17 | 2017-06-22 | Arqule, Inc. | Methods for preparing polymorphs of substituted 5,6-dihydrobenzo[h]quinazolin-2-amine |
| IL259556B2 (en) * | 2015-12-17 | 2023-09-01 | Arqule Inc | Solid forms of substituted 6,5-dihydro-6-phenyl-benzo[f]isoquinoline-2-amine compounds |
| CN108367000A (zh) | 2015-12-17 | 2018-08-03 | 卫材R&D管理有限公司 | 用于乳腺癌的治疗剂 |
| AR111960A1 (es) | 2017-05-26 | 2019-09-04 | Incyte Corp | Formas cristalinas de un inhibidor de fgfr y procesos para su preparación |
| US11219619B2 (en) | 2018-03-28 | 2022-01-11 | Eisai R&D Management Co., Ltd. | Therapeutic agent for hepatocellular carcinoma |
| HRP20241288T1 (hr) | 2018-05-04 | 2024-12-06 | Incyte Corporation | Čvrsti oblici fgfr inhibitora i postupci za njihovu proizvodnju |
| AU2019262579B2 (en) | 2018-05-04 | 2024-09-12 | Incyte Corporation | Salts of an FGFR inhibitor |
| CN110669015A (zh) * | 2018-07-03 | 2020-01-10 | 上海喀露蓝科技有限公司 | 一种fgfr抑制剂的制备方法 |
| KR20210066839A (ko) * | 2018-09-27 | 2021-06-07 | 베타 파머수티컬 컴퍼니 리미티드 | Fgfr4 저해제 및 그것의 용도 |
| US11628162B2 (en) | 2019-03-08 | 2023-04-18 | Incyte Corporation | Methods of treating cancer with an FGFR inhibitor |
| US11591329B2 (en) | 2019-07-09 | 2023-02-28 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
| WO2021067374A1 (en) | 2019-10-01 | 2021-04-08 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
| CA3157361A1 (en) | 2019-10-14 | 2021-04-22 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
| WO2021076728A1 (en) | 2019-10-16 | 2021-04-22 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
| JP7832891B2 (ja) | 2019-12-04 | 2026-03-18 | インサイト・コーポレイション | Ｆｇｆｒ阻害剤の誘導体 |
| CA3163875A1 (en) | 2019-12-04 | 2021-06-10 | Incyte Corporation | Tricyclic heterocycles as fgfr inhibitors |
| US12012409B2 (en) | 2020-01-15 | 2024-06-18 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
| CN116547280A (zh) * | 2020-10-08 | 2023-08-04 | 雷多纳治疗公司 | 用于治疗癌症的苯并[h]喹唑啉-4-胺和噻吩并[3,2-h]喹唑啉-4-胺衍生物 |
| AU2021356130A1 (en) | 2020-10-08 | 2023-05-18 | Redona Therapeutics, Inc. | Benzo[h]quinazolin-4-amine and thieno[3,2-h]quinazolin-4-amine derivatives for the treatment of cancer |
| US20230416271A1 (en) * | 2020-11-26 | 2023-12-28 | Chengdu Cynogen Bio-Pharmaceutical Technology Co., Ltd. | Heteroarylquinazoline compounds as protein kinase inhibitors |
| WO2022221170A1 (en) | 2021-04-12 | 2022-10-20 | Incyte Corporation | Combination therapy comprising an fgfr inhibitor and a nectin-4 targeting agent |
| US11939331B2 (en) | 2021-06-09 | 2024-03-26 | Incyte Corporation | Tricyclic heterocycles as FGFR inhibitors |
| CA3220155A1 (en) | 2021-06-09 | 2022-12-15 | Incyte Corporation | Tricyclic heterocycles as fgfr inhibitors |
| CN113354630B (zh) * | 2021-06-30 | 2022-11-01 | 江南大学 | 一种5,6-二氢苯并[h]喹唑啉类化合物及其应用 |
| WO2023072913A1 (en) * | 2021-10-25 | 2023-05-04 | Twentyeight-Seven, Inc. | Benzo[h]quinazoline-4-amine derivatives for the treatment of cancer |
| WO2023196629A1 (en) * | 2022-04-07 | 2023-10-12 | Redona Therapeutics, Inc. | Benzo[h]quinazoline-4-amine derivatives for the treatment of cancer |
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| DE2623846A1 (de) | 1976-05-28 | 1977-12-15 | Hoechst Ag | 4-chinazolinyl-guanidine und verfahren zu ihrer herstellung |
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| DD280109A1 (de) | 1989-02-22 | 1990-06-27 | Univ Berlin Humboldt | Verfahren zur herstellung substituierter 1.2.4-triazolo/1.5-a/-pyridine |
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2009
- 2009-12-30 TW TW098145881A patent/TWI461410B/zh active
- 2009-12-30 WO PCT/US2009/069813 patent/WO2010078421A1/en not_active Ceased
- 2009-12-30 DK DK09793690.0T patent/DK2379506T3/en active
- 2009-12-30 CA CA2748491A patent/CA2748491C/en active Active
- 2009-12-30 KR KR1020117017777A patent/KR101714799B1/ko active Active
- 2009-12-30 JP JP2011544603A patent/JP5739820B2/ja active Active
- 2009-12-30 BR BRPI0923786A patent/BRPI0923786C8/pt active IP Right Grant
- 2009-12-30 EP EP09793690.0A patent/EP2379506B1/en active Active
- 2009-12-30 CN CN200980156889.XA patent/CN102325755B/zh active Active
- 2009-12-30 US US12/649,573 patent/US8357694B2/en active Active
- 2009-12-30 MX MX2011006959A patent/MX2011006959A/es active IP Right Grant
- 2009-12-30 ES ES09793690.0T patent/ES2554623T3/es active Active
-
2011
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Also Published As
| Publication number | Publication date |
|---|---|
| CA2748491A1 (en) | 2010-07-08 |
| TWI461410B (zh) | 2014-11-21 |
| WO2010078421A1 (en) | 2010-07-08 |
| US8357694B2 (en) | 2013-01-22 |
| CN102325755A (zh) | 2012-01-18 |
| ES2554623T3 (es) | 2015-12-22 |
| MX2011006959A (es) | 2011-12-06 |
| DK2379506T3 (en) | 2015-12-14 |
| AU2009335010A8 (en) | 2011-08-11 |
| BRPI0923786C8 (pt) | 2021-05-25 |
| CN102325755B (zh) | 2015-07-01 |
| ZA201104706B (en) | 2012-08-29 |
| BRPI0923786C1 (pt) | 2021-05-11 |
| IL213787A0 (en) | 2011-07-31 |
| KR101714799B1 (ko) | 2017-03-09 |
| EP2379506A1 (en) | 2011-10-26 |
| EP2379506B1 (en) | 2015-09-02 |
| AU2009335010A1 (en) | 2011-07-21 |
| WO2010078421A8 (en) | 2011-10-27 |
| IL213787A (en) | 2014-08-31 |
| JP2012514045A (ja) | 2012-06-21 |
| TW201035055A (en) | 2010-10-01 |
| JP5739820B2 (ja) | 2015-06-24 |
| US20100239525A1 (en) | 2010-09-23 |
| KR20110099790A (ko) | 2011-09-08 |
| CA2748491C (en) | 2019-08-06 |
| BRPI0923786B1 (pt) | 2020-11-24 |
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