BRPI0816182A2 - Agente para promoção de adesão celular endotelial corneana - Google Patents

Agente para promoção de adesão celular endotelial corneana

Info

Publication number: BRPI0816182A2
Authority: BR; Brazil
Prior art keywords: cell adhesion; endothelial cell; corneal endothelial; adhesion promotion; promotion agent
Prior art date: 2007-08-29

Application number

Other languages

English (en)

Inventor

Noriko Koizumi

Shigeru Kinoshita

Morio Ueno

Original Assignee

Senju Pharma Co

Shigeru Kinoshita

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-08-29

Filing date

2008-08-28

Publication date

2015-04-14

2008-08-28 Application filed by Senju Pharma Co, Shigeru Kinoshita filed Critical Senju Pharma Co

2015-04-14 Publication of BRPI0816182A2 publication Critical patent/BRPI0816182A2/pt

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4409—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 4, e.g. isoniazid, iproniazid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
- C12N5/0621—Eye cells, e.g. cornea, iris pigmented cells
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/70—Enzymes

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Epidemiology (AREA)
Biomedical Technology (AREA)
Ophthalmology & Optometry (AREA)
Bioinformatics & Cheminformatics (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Cell Biology (AREA)
Microbiology (AREA)
Biochemistry (AREA)
General Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Dermatology (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Materials For Medical Uses (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Apparatus Associated With Microorganisms And Enzymes (AREA)

BRPI0816182 2007-08-29 2008-08-28 Agente para promoção de adesão celular endotelial corneana BRPI0816182A2 (pt)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
JP2007223141		2007-08-29
JP2008016088		2008-01-28
PCT/JP2008/065459 WO2009028631A1 (ja)	2007-08-29	2008-08-28	角膜内皮細胞接着促進剤

Publications (1)

Publication Number	Publication Date
BRPI0816182A2 true BRPI0816182A2 (pt)	2015-04-14

Family

ID=40387345

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI0816182 BRPI0816182A2 (pt)	2007-08-29	2008-08-28	Agente para promoção de adesão celular endotelial corneana

Country Status (11)

Country	Link
US (4)	US9248125B2 (pt)
EP (1)	EP2193806B1 (pt)
JP (10)	JP5657252B2 (pt)
KR (8)	KR20240045364A (pt)
CN (3)	CN103937738B (pt)
BR (1)	BRPI0816182A2 (pt)
CA (1)	CA2697895C (pt)
ES (1)	ES2659980T3 (pt)
MX (1)	MX2010002426A (pt)
RU (1)	RU2474434C2 (pt)
WO (1)	WO2009028631A1 (pt)

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WO2011080984A1 (en)	2009-12-29	2011-07-07	Senju Pharmaceutical Co., Ltd.	Therapeutic agent (y - 39983 ) for corneal endothelial dysfunction
TR201903889T4 (tr)	2011-12-06	2019-04-22	Astellas Inst For Regenerative Medicine	Korneal endotelyal hücreler üreten yönlendirilmiş diferansiyasyona yönelik yöntem.
US20150044178A1 (en) *	2011-12-28	2015-02-12	Kyoto Prefectural Public University Corporation	Normalization of culture of corneal endothelial cells
JP6519851B2 (ja) *	2012-07-06	2019-05-29	京都府公立大学法人	眼細胞の分化マーカーおよび分化制御
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CN103053511A (zh) *	2012-12-10	2013-04-24	山东省眼科研究所	一种角膜中期保存液及其制备和使用方法
US10813920B2 (en) *	2013-11-14	2020-10-27	The Doshisha	Drug for treating corneal endothelium by promoting cell proliferation or inhibiting cell damage
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US10959997B2 (en) *	2013-12-27	2021-03-30	Kyoto Prefectural Public University Corporation	Combined agent for cell therapy of corneal endothelial cell
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EP4234682A4 (en)	2020-10-22	2024-11-27	Kyoto Prefectural Public University Corporation	METHOD FOR PRESERVING HUMAN CORNEAL ENDOTHELIAL CELLS AND/OR HUMAN CORNEAL ENDOTHELIAL PROGENITOR CELLS
WO2022159533A1 (en)	2021-01-21	2022-07-28	Kowa Company, Ltd.	Methods of treating fuchs endothelial corneal dystrophy after descemetorhexis
AU2022270611A1 (en)	2021-05-03	2023-10-12	Astellas Institute For Regenerative Medicine	Methods of generating mature corneal endothelial cells
CN115006593B (zh) *	2022-06-26	2023-07-25	中国海洋大学	机械增强型组织工程角膜内皮的体外构建方法
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2008
- 2008-08-28 KR KR1020247009980A patent/KR20240045364A/ko not_active Ceased
- 2008-08-28 CN CN201410200362.5A patent/CN103937738B/zh active Active
- 2008-08-28 WO PCT/JP2008/065459 patent/WO2009028631A1/ja not_active Ceased
- 2008-08-28 CA CA2697895A patent/CA2697895C/en active Active
- 2008-08-28 KR KR1020107006685A patent/KR20100080514A/ko not_active Ceased
- 2008-08-28 EP EP08828145.6A patent/EP2193806B1/en active Active
- 2008-08-28 BR BRPI0816182 patent/BRPI0816182A2/pt not_active Application Discontinuation
- 2008-08-28 RU RU2010111744/15A patent/RU2474434C2/ru active
- 2008-08-28 CN CN201410200380.3A patent/CN103931608B/zh active Active
- 2008-08-28 KR KR1020227037529A patent/KR20220151013A/ko not_active Ceased
- 2008-08-28 KR KR1020147033392A patent/KR20150004899A/ko not_active Ceased
- 2008-08-28 KR KR1020197022179A patent/KR20190091567A/ko not_active Ceased
- 2008-08-28 JP JP2009530186A patent/JP5657252B2/ja active Active
- 2008-08-28 MX MX2010002426A patent/MX2010002426A/es active IP Right Grant
- 2008-08-28 KR KR1020157018932A patent/KR20150088907A/ko not_active Ceased
- 2008-08-28 US US12/675,475 patent/US9248125B2/en active Active
- 2008-08-28 CN CN200880112897.XA patent/CN101835491B/zh active Active
- 2008-08-28 ES ES08828145.6T patent/ES2659980T3/es active Active
- 2008-08-28 KR KR1020187007476A patent/KR20180031066A/ko not_active Ceased
- 2008-08-28 KR KR1020217017484A patent/KR20210070407A/ko not_active Ceased
2013
- 2013-05-17 JP JP2013105593A patent/JP2013151576A/ja not_active Withdrawn
2014
- 2014-10-23 JP JP2014216143A patent/JP5843373B2/ja active Active
2015
- 2015-10-09 US US14/879,857 patent/US11839618B2/en active Active
- 2015-10-09 US US14/879,658 patent/US11633404B2/en active Active
- 2015-10-20 JP JP2015206152A patent/JP5969679B2/ja active Active
2016
- 2016-07-07 JP JP2016135014A patent/JP2016193933A/ja active Pending
2018
- 2018-03-28 JP JP2018062765A patent/JP2018131445A/ja not_active Withdrawn
2019
- 2019-09-10 JP JP2019164741A patent/JP2020050652A/ja not_active Withdrawn
2021
- 2021-02-19 JP JP2021025578A patent/JP2021073322A/ja not_active Withdrawn
2022
- 2022-09-16 JP JP2022148111A patent/JP7631270B2/ja active Active
2023
- 2023-03-13 US US18/182,873 patent/US12702672B2/en active Active
2025
- 2025-02-05 JP JP2025017220A patent/JP2025062082A/ja active Pending

Also Published As

Publication number	Publication date
EP2193806B1 (en)	2017-12-06
JP2021073322A (ja)	2021-05-13
CN101835491A (zh)	2010-09-15
JP2016026199A (ja)	2016-02-12
JP2020050652A (ja)	2020-04-02
US12702672B2 (en)	2026-08-11
JP2025062082A (ja)	2025-04-11
KR20240045364A (ko)	2024-04-05
CN103931608B (zh)	2016-02-03
JP2013151576A (ja)	2013-08-08
JP5969679B2 (ja)	2016-08-17
JP5843373B2 (ja)	2016-01-13
JPWO2009028631A1 (ja)	2010-12-02
EP2193806A1 (en)	2010-06-09
KR20100080514A (ko)	2010-07-08
CN103931608A (zh)	2014-07-23
KR20220151013A (ko)	2022-11-11
JP2016193933A (ja)	2016-11-17
JP2018131445A (ja)	2018-08-23
KR20190091567A (ko)	2019-08-06
US11633404B2 (en)	2023-04-25
MX2010002426A (es)	2010-04-27
US11839618B2 (en)	2023-12-12
US20160030410A1 (en)	2016-02-04
ES2659980T3 (es)	2018-03-20
WO2009028631A1 (ja)	2009-03-05
RU2474434C2 (ru)	2013-02-10
KR20150004899A (ko)	2015-01-13
JP2022171847A (ja)	2022-11-11
US20230210864A1 (en)	2023-07-06
CN103937738A (zh)	2014-07-23
CN101835491B (zh)	2014-11-26
RU2010111744A (ru)	2011-10-10
JP2015013905A (ja)	2015-01-22
KR20210070407A (ko)	2021-06-14
JP5657252B2 (ja)	2015-01-21
KR20180031066A (ko)	2018-03-27
CA2697895C (en)	2017-10-31
KR20150088907A (ko)	2015-08-03
US20160101113A1 (en)	2016-04-14
CN103937738B (zh)	2017-04-12
JP7631270B2 (ja)	2025-02-18
US20100209402A1 (en)	2010-08-19
CA2697895A1 (en)	2009-03-05
US9248125B2 (en)	2016-02-02
EP2193806A4 (en)	2011-03-23

Publication	Publication Date	Title
EP2165609A4 (en)	2011-03-16	MEANS FOR IMPROVED PANSEN FERMENTATION
BRPI1011346A2 (pt)	2016-10-18	partícula de polímero, composição tensoativa, processos de formação de partículas de polímero, e, uso das mesmas
EP2005504A4 (en)	2012-04-04	ELECTROLYTE
BRPI0818572A2 (pt)	2015-04-22	Depósito de material, e, dispositivo elétrico
BRPI0918122A2 (pt)	2015-11-24	molécula de diaboy, diaboy, e mólecula dart
EP2193806A4 (en)	2011-03-23	MEDIUM FOR PROMOTING ENDOTHELIAL CELL ADHESION OF THE HORN SKIN
PL2206494T3 (pl)	2016-06-30	Spienialny żel zawiesinowy
BRPI0716762A2 (pt)	2013-09-24	melhorias da cultura celular
BRPI1008178A2 (pt)	2016-03-01	"descarga de baterias"
DE602008000685D1 (de)	2010-04-08	Wässrige Copolymerlösung und Beschichtungszusammensetzung
BRPI0921822A2 (pt)	2016-09-27	composição compreendendo polímero e enzima
DE112008001799B8 (de)	2013-04-04	Beweglicher Körper
BRPI0809573A8 (pt)	2016-10-11	composição, e, método
BRPI0812920A2 (pt)	2014-10-14	Sistema de expressão de celulase heteróloga e homóloga
BRPI0807911A2 (pt)	2014-06-17	Agonistas de alfa2c adrenorreceptor
EP2135606A4 (en)	2014-06-18	MEDIUM AGAINST TIREDNESS
BRPI0814167A2 (pt)	2015-01-20	Composição, e, método
BRPI0815203A2 (pt)	2017-03-28	gel contendo pirfenidona
EP2050612A4 (en)	2014-10-08	ACCUMULATOR
BRPI0814438A2 (pt)	2015-01-06	Agente de gelificação para baterias
EP2039533A4 (en)	2010-02-17	TIRE
BRPI0911573A2 (pt)	2016-01-05	preservativo com agente ativo localizado.
BRPI0923835A2 (pt)	2015-07-21	Agente de formação de espuma
EP2204178A4 (en)	2010-11-24	LAXATIVE
EP1980237A4 (en)	2012-01-18	GELLING

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2017-10-10	B07D	Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
2018-04-17	B06F	Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
2018-05-08	B07E	Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
2018-07-17	B07A	Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
2019-02-26	B25G	Requested change of headquarter approved	Owner name: SENJU PHARMACEUTICAL CO., LTD (JP) ; SHIGERU KINOS
2019-04-02	B09B	Patent application refused [chapter 9.2 patent gazette]
2019-07-02	B12B	Appeal against refusal [chapter 12.2 patent gazette]