BRPI0816372A2 - Ácidos 6-fenilnicotínicos substituídos e seu uso - Google Patents

Ácidos 6-fenilnicotínicos substituídos e seu uso

Info

Publication number: BRPI0816372A2
Authority: BR; Brazil
Prior art keywords: phenylnicotinic; acids; replaced; phenylnicotinic acids
Prior art date: 2007-09-07

Application number

BRPI0816372-3A2A

Other languages

English (en)

Inventor

Lars Baerfacker

Jens Schamberger

Klemens Lustig

Barbara Albrecht-Kuepper

Peter Kolkhof

Yolanda Cancho Grande

Adam Nitsche

Heinrich Meier

Carsten Schmeck

Original Assignee

Bayer Animal Health Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-09-07

Filing date

2008-08-26

Publication date

2015-02-24

2008-08-26 Application filed by Bayer Animal Health Gmbh filed Critical Bayer Animal Health Gmbh

2015-02-24 Publication of BRPI0816372A2 publication Critical patent/BRPI0816372A2/pt

Links

239000002253 acid Substances 0.000 title 1
150000007513 acids Chemical class 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/80—Acids; Esters in position 3
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
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- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
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- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
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- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Cardiology (AREA)
Dermatology (AREA)
Physical Education & Sports Medicine (AREA)
Rheumatology (AREA)
Hematology (AREA)
Diabetes (AREA)
Pain & Pain Management (AREA)
Heart & Thoracic Surgery (AREA)
Orthopedic Medicine & Surgery (AREA)
Urology & Nephrology (AREA)
Pulmonology (AREA)
Oncology (AREA)
Vascular Medicine (AREA)
Communicable Diseases (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Obesity (AREA)
Gastroenterology & Hepatology (AREA)
Endocrinology (AREA)
Psychology (AREA)
Virology (AREA)
Immunology (AREA)

BRPI0816372-3A2A 2007-09-07 2008-08-26 Ácidos 6-fenilnicotínicos substituídos e seu uso BRPI0816372A2 (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE102007042754A DE102007042754A1 (de)	2007-09-07	2007-09-07	Substituierte 6-Phenylnikotinsäuren und ihre Verwendung
PCT/EP2008/006969 WO2009033561A1 (de)	2007-09-07	2008-08-26	Substituierte 6-phenylnikotinsäuren und ihre verwendung

Publications (1)

Publication Number	Publication Date
BRPI0816372A2 true BRPI0816372A2 (pt)	2015-02-24

Family

ID=40032794

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI0816372-3A2A BRPI0816372A2 (pt)	2007-09-07	2008-08-26	Ácidos 6-fenilnicotínicos substituídos e seu uso

Country Status (16)

Country	Link
US (1)	US8143411B2 (pt)
EP (1)	EP2197846A1 (pt)
JP (1)	JP2010538025A (pt)
KR (1)	KR20100066545A (pt)
AU (1)	AU2008298021A1 (pt)
BR (1)	BRPI0816372A2 (pt)
CA (1)	CA2698471A1 (pt)
CL (1)	CL2008002537A1 (pt)
DE (1)	DE102007042754A1 (pt)
MX (1)	MX2010002565A (pt)
NZ (1)	NZ583697A (pt)
PA (1)	PA8794401A1 (pt)
PE (1)	PE20090954A1 (pt)
TW (1)	TW200914002A (pt)
UY (1)	UY31310A1 (pt)
WO (1)	WO2009033561A1 (pt)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PT2404919E (pt)	2005-11-08	2013-10-22	Vertex Pharma	Composto heterocíclico útil como um modulador de transportadores de cassete de ligação a atp
EP2164840A2 (en)	2007-05-09	2010-03-24	Vertex Pharmaceuticals Incorporated	Modulators of cftr
CA2989620C (en) *	2007-12-07	2022-05-03	Vertex Pharmaceuticals Incorporated	Processes for producing cycloalkylcarboxamido-pyridine benzoic acids
HUE049642T2 (hu)	2007-12-07	2020-09-28	Vertex Pharma	3-(6-(1-(2,2-Difluorbenzo[d][1,3]dioxol-5-il)-ciklopropánkarboxamido)-3-metilpiridin-2-il)-benzoesav szilárd formái
CA2716109C (en)	2008-02-28	2016-07-19	Vertex Pharmaceuticals Incorporated	Heteroaryl derivatives as cftr modulators
WO2011107494A1 (de)	2010-03-03	2011-09-09	Sanofi	Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
ES2900353T3 (es)	2010-04-07	2022-03-16	Vertex Pharma	Composiciones farmacéuticas de ácido 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-il)ciclopropanocarboxamido)-3-metilpiriidin-2-il)benzoico y administración de las mismas
US8530413B2 (en)	2010-06-21	2013-09-10	Sanofi	Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TW201215388A (en)	2010-07-05	2012-04-16	Sanofi Sa	(2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
TW201215387A (en)	2010-07-05	2012-04-16	Sanofi Aventis	Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
TW201221505A (en)	2010-07-05	2012-06-01	Sanofi Sa	Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
WO2013037390A1 (en)	2011-09-12	2013-03-21	Sanofi	6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
EP2760862B1 (en)	2011-09-27	2015-10-21	Sanofi	6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
NZ727015A (en)	2012-01-25	2017-12-22	Vertex Pharma	Formulations of 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid
US9113629B2 (en) *	2013-03-15	2015-08-25	Dow Agrosciences Llc	4-amino-6-(4-substituted-phenyl)-picolinates and 6-amino-2-(4-substituted-phenyl)-pyrimidine-4-carboxylates and their use as herbicides
CA2930199C (en)	2013-11-12	2022-10-25	Vertex Pharmaceuticals Incorporated	Process of preparing pharmaceutical compositions for the treatment of cftr mediated diseases
HUE055423T2 (hu)	2014-11-18	2021-11-29	Vertex Pharma	Eljárás nagy áteresztõképességû tesztelõ nagy teljesítményû folyadék-kromatográfia elvégzésére
US12569481B2 (en)	2020-06-12	2026-03-10	Vanderbilt University	Methods of treatment for gastrointestinal motility disorders

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3655679A (en) *	1969-06-25	1972-04-11	Merck & Co Inc	Certain aryl pyridine carboxylic acid derivatives
US5217982A (en)	1990-09-25	1993-06-08	Rhone-Poulenc Rorer Pharmaceuticals Inc.	Compounds having antihypertensive properties
US6225310B1 (en)	1996-01-17	2001-05-01	Novo Nordisk A/S	Fused 1,2,4-thiadiazine derivatives, their preparation and use
CZ220498A3 (cs)	1996-01-17	1998-11-11	Novo Nordisk A/S	Deriváty 1,2,4-thiadiazinu a 1,4-thiazinu, příprava a použití
CA2285548C (en)	1997-04-04	2006-07-11	Pfizer Products Inc.	Nicotinamide derivatives
AU757693B2 (en)	1997-07-16	2003-03-06	Novo Nordisk A/S	Fused 1,2,4-thiadiazine derivatives, their preparation and use
DE19834044A1 (de)	1998-07-29	2000-02-03	Bayer Ag	Neue substituierte Pyrazolderivate
DE19834047A1 (de)	1998-07-29	2000-02-03	Bayer Ag	Substituierte Pyrazolderivate
DE19943635A1 (de)	1999-09-13	2001-03-15	Bayer Ag	Neuartige Aminodicarbonsäurederivate mit pharmazeutischen Eigenschaften
DE19943639A1 (de)	1999-09-13	2001-03-15	Bayer Ag	Dicarbonsäurederivate mit neuartigen pharmazeutischen Eigenschaften
DE19943634A1 (de)	1999-09-13	2001-04-12	Bayer Ag	Neuartige Dicarbonsäurederivate mit pharmazeutischen Eigenschaften
DE19943636A1 (de)	1999-09-13	2001-03-15	Bayer Ag	Neuartige Dicarbonsäurederivate mit pharmazeutischen Eigenschaften
AR031176A1 (es)	2000-11-22	2003-09-10	Bayer Ag	Nuevos derivados de pirazolpiridina sustituidos con piridina
DE10110749A1 (de)	2001-03-07	2002-09-12	Bayer Ag	Substituierte Aminodicarbonsäurederivate
DE10110750A1 (de)	2001-03-07	2002-09-12	Bayer Ag	Neuartige Aminodicarbonsäurederivate mit pharmazeutischen Eigenschaften
EP1492784A4 (en) *	2002-03-28	2006-03-29	Merck & Co Inc	SUBSTITUTED 2,3-DIPHENYLPYRIDINES
DE10220570A1 (de)	2002-05-08	2003-11-20	Bayer Ag	Carbamat-substituierte Pyrazolopyridine
AU2003291403A1 (en)	2002-11-08	2004-06-03	Neurogen Corporation	3-substituted-6-aryl pyridined as ligands of c5a receptors
US20050065144A1 (en)	2003-09-08	2005-03-24	Syrrx, Inc.	Dipeptidyl peptidase inhibitors
RU2374230C2 (ru)	2003-11-05	2009-11-27	Ф.Хоффманн-Ля Рош Аг	Фенильные производные в качестве ppar агонистов
AU2004291259A1 (en) *	2003-11-05	2005-06-02	F. Hoffmann-La Roche Ag	Heteroaryl derivatives as PPAR activators
WO2006028958A2 (en)	2004-09-02	2006-03-16	Genentech, Inc.	Pyridyl inhibitors of hedgehog signalling
DE102005027150A1 (de)	2005-03-12	2006-09-28	Bayer Healthcare Ag	Pyrimidincarbonsäure-Derivate und ihre Verwendung
WO2006103120A2 (en)	2005-04-01	2006-10-05	Insa Rouen	New heterocyclic compounds, their preparation and their use as medicaments, in particular as anti-alzheimer agents
WO2006124874A2 (en)	2005-05-12	2006-11-23	Kalypsys, Inc.	Inhibitors of b-raf kinase
US7932270B2 (en)	2006-08-01	2011-04-26	Cytokinetics, Inc.	Certain chemical entities, compositions, and methods
DE102006043519A1 (de)	2006-09-12	2008-03-27	Bayer Healthcare Ag	4-Phenoxynikotinsäure-Derivate und ihre Verwendung
DE102006043520A1 (de)	2006-09-12	2008-03-27	Bayer Healthcare Ag	2-Phenoxynikotinsäure-Derivate und ihre Verwendung
EP2114940A1 (en) *	2007-02-09	2009-11-11	AstraZeneca AB	Aza-isoindolones and their use as metabotropic glutamate receptor potentiators - 613

2007
- 2007-09-07 DE DE102007042754A patent/DE102007042754A1/de not_active Withdrawn
2008
- 2008-08-26 BR BRPI0816372-3A2A patent/BRPI0816372A2/pt not_active IP Right Cessation
- 2008-08-26 MX MX2010002565A patent/MX2010002565A/es active IP Right Grant
- 2008-08-26 CA CA2698471A patent/CA2698471A1/en not_active Abandoned
- 2008-08-26 AU AU2008298021A patent/AU2008298021A1/en not_active Abandoned
- 2008-08-26 JP JP2010523302A patent/JP2010538025A/ja not_active Withdrawn
- 2008-08-26 KR KR1020107007500A patent/KR20100066545A/ko not_active Withdrawn
- 2008-08-26 US US12/676,568 patent/US8143411B2/en active Active
- 2008-08-26 NZ NZ583697A patent/NZ583697A/en not_active IP Right Cessation
- 2008-08-26 EP EP08801700A patent/EP2197846A1/de not_active Withdrawn
- 2008-08-26 WO PCT/EP2008/006969 patent/WO2009033561A1/de not_active Ceased
- 2008-08-27 UY UY31310A patent/UY31310A1/es not_active Application Discontinuation
- 2008-08-28 PA PA20088794401A patent/PA8794401A1/es unknown
- 2008-08-28 CL CL2008002537A patent/CL2008002537A1/es unknown
- 2008-08-28 PE PE2008001459A patent/PE20090954A1/es not_active Application Discontinuation
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Publication number	Publication date
NZ583697A (en)	2012-04-27
JP2010538025A (ja)	2010-12-09
AU2008298021A1 (en)	2009-03-19
UY31310A1 (es)	2009-04-30
US8143411B2 (en)	2012-03-27
PE20090954A1 (es)	2009-07-24
WO2009033561A1 (de)	2009-03-19
KR20100066545A (ko)	2010-06-17
EP2197846A1 (de)	2010-06-23
CA2698471A1 (en)	2009-03-19
TW200914002A (en)	2009-04-01
MX2010002565A (es)	2010-04-30
DE102007042754A1 (de)	2009-03-12
WO2009033561A8 (de)	2010-06-10
PA8794401A1 (es)	2009-07-23
US20100234432A1 (en)	2010-09-16
CL2008002537A1 (es)	2009-03-20

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2015-12-01	B08F	Application fees: application dismissed [chapter 8.6 patent gazette]	Free format text: REFERENTE AS 6A E 7A ANUIDADES.
2016-03-29	B08K	Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]	Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2343 DE 01-12-2015 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.

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