BRPI0816922A2 - Moduladores tieno e furo-pirimidina do receptor de histamina h4 - Google Patents

Moduladores tieno e furo-pirimidina do receptor de histamina h4

Info

Publication number: BRPI0816922A2
Authority: BR; Brazil
Prior art keywords: tieno; histamine; receptor; hole; modulators
Prior art date: 2007-09-14

Application number

Other languages

English (en)

Inventor

James P Edwards

Danielle K Wiener

Deborah M Smith

Jennifer D Venable

Original Assignee

Janssen Pharmaceutica Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-09-14

Filing date

2008-09-12

Publication date

2015-03-17

2008-09-12 Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv

2015-03-17 Publication of BRPI0816922A2 publication Critical patent/BRPI0816922A2/pt

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/04—Artificial tears; Irrigation solutions
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P27/16—Otologicals
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
- A61P5/16—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4 for decreasing, blocking or antagonising the activity of the thyroid hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Immunology (AREA)
Diabetes (AREA)
Pulmonology (AREA)
Endocrinology (AREA)
Biomedical Technology (AREA)
Hematology (AREA)
Physical Education & Sports Medicine (AREA)
Dermatology (AREA)
Reproductive Health (AREA)
Neurology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Orthopedic Medicine & Surgery (AREA)
Rheumatology (AREA)
Neurosurgery (AREA)
Ophthalmology & Optometry (AREA)
Pain & Pain Management (AREA)
Emergency Medicine (AREA)
Gastroenterology & Hepatology (AREA)
Otolaryngology (AREA)
Gynecology & Obstetrics (AREA)
Pregnancy & Childbirth (AREA)
Obesity (AREA)
Transplantation (AREA)
Vascular Medicine (AREA)

BRPI0816922 2007-09-14 2008-09-12 Moduladores tieno e furo-pirimidina do receptor de histamina h4 BRPI0816922A2 (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US97258907P	2007-09-14	2007-09-14
PCT/US2008/010691 WO2009038673A2 (en)	2007-09-14	2008-09-12	Thieno-and furo-pyrimidine modulators of the histamine h4 receptor

Publications (1)

Publication Number	Publication Date
BRPI0816922A2 true BRPI0816922A2 (pt)	2015-03-17

Family

ID=40455164

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI0816922 BRPI0816922A2 (pt)	2007-09-14	2008-09-12	Moduladores tieno e furo-pirimidina do receptor de histamina h4

Country Status (17)

Country	Link
US (5)	US8193178B2 (pt)
EP (1)	EP2200595B1 (pt)
JP (1)	JP5439377B2 (pt)
KR (1)	KR101470933B1 (pt)
CN (1)	CN101998958B (pt)
AR (1)	AR068513A1 (pt)
AU (1)	AU2008301897B2 (pt)
BR (1)	BRPI0816922A2 (pt)
CA (1)	CA2705719C (pt)
CL (1)	CL2008002747A1 (pt)
MX (1)	MX2010002926A (pt)
NZ (1)	NZ583509A (pt)
PA (1)	PA8796001A1 (pt)
PE (1)	PE20091083A1 (pt)
TW (1)	TW200924781A (pt)
UY (1)	UY31340A1 (pt)
WO (1)	WO2009038673A2 (pt)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TW200924781A (en)	2007-09-14	2009-06-16	Janssen Pharmaceutica Nv	Thieno- and furo-pyrimidine modulators of the histamine H4 receptor
EP2379523A1 (en)	2008-12-22	2011-10-26	Incyte Corporation	4, 6-disubstituted 2-amino-pyrimidines as histamine h4 receptor modulators
EP2201982A1 (en)	2008-12-24	2010-06-30	INSERM (Institut National de la Santé et de la Recherche Médicale)	Histamine H4 receptor antagonists for the treatment of vestibular disorders
US8481732B2 (en)	2009-03-20	2013-07-09	Incyte Corporation	Substituted heterocyclic compounds
BR112013007566A2 (pt)	2010-09-28	2016-08-02	Panacea Biotec Ltd	novos compostos bicíclicos
BR112013011737A2 (pt)	2010-11-15	2016-08-09	Univ Leuven Kath	composto, uso de um composto composição farmacêutica, e, método de tratamento ou prevenção de uma infecção por hiv
AR090037A1 (es) *	2011-11-15	2014-10-15	Xention Ltd	Derivados de tieno y/o furo-pirimidinas y piridinas inhibidores de los canales de potasio
PL2858647T3 (pl)	2012-06-08	2018-10-31	Sensorion	Inhibitory receptora h4 do leczenia szumów usznych
CN104981247A (zh) *	2012-09-06	2015-10-14	普莱希科公司	用于激酶调节的化合物和方法及其适应症
WO2014079545A1 (en)	2012-11-20	2014-05-30	Ktb Tumorforschungsgesellschaft Mbh	Thioether derivatives as protein kinase inhibitors
GB201410816D0 (en) *	2014-06-17	2014-07-30	Ucb Biopharma Sprl And Katholieke Universiteit Leuven	Therapeutic agents
EP4599894A3 (en)	2019-05-23	2025-11-12	Novartis AG	Methods of treating chronic spontaneous urticaria using a bruton s tyrosine kinase inhibitor

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE1470356A1 (de) *	1964-01-15	1970-04-30	Thomae Gmbh Dr K	Neue Thieno[3,2-d]pyrimidine und Verfahren zu ihrer Herstellung
BE759371A (fr) *	1969-11-24	1971-05-24	Bristol Myers Co	Azaspirodecanediones heterocycliques et procedes pour leur preparation
AU3162695A (en) *	1994-08-03	1996-03-04	Asta Medica Aktiengesellschaft	Indol, indazol, pyridopyrrol and pyridopyrazol derivatives with anti-asthmatic, anti-allergic, anti-inflammatory and immunomodulating effects
EP1437348A1 (fr)	2003-01-13	2004-07-14	L'oreal	Dérivés de de la 6-méthyl-pyrimidine-2,4-diamine, procédé de synthèse, compositions les comprenant et utilisations comme agents neutralisants basiques
EP1505064A1 (en)	2003-08-05	2005-02-09	Bayer HealthCare AG	2-Aminopyrimidine derivatives
WO2005054239A1 (en)	2003-12-05	2005-06-16	Bayer Healthcare Ag	2-aminopyrimidine derivatives
US20050187389A1 (en) *	2004-01-13	2005-08-25	Ambit Biosciences Corporation	Pyrrolopyrimidine derivatives and analogs and their use in the treatment and prevention of diseases
JP4559749B2 (ja) *	2004-02-16	2010-10-13	あすか製薬株式会社	ピペラジニルピリジン誘導体
JP4596792B2 (ja) *	2004-02-24	2010-12-15	あすか製薬株式会社	５−ｈｔ１ａ作動作用と５−ｈｔ３拮抗作用を併有する薬剤
MXPA06011021A (es) *	2004-03-25	2007-04-13	Johnson & Johnson	Compuestos de imidazol.
EP1776982A1 (en) *	2005-10-18	2007-04-25	Argenta Discovery Limited	Pyrimidine compounds as histamine modulators
JP2008519794A (ja) *	2004-11-11	2008-06-12	アージェンタ・ディスカバリー・リミテッド	ピリミジン化合物
US20060281769A1 (en) *	2005-06-10	2006-12-14	Baumann Christian A	Synergistic modulation of flt3 kinase using thienopyrimidine and thienopyridine kinase modulators
US20060281768A1 (en) *	2005-06-10	2006-12-14	Gaul Michael D	Thienopyrimidine and thienopyridine kinase modulators
EP1767537A1 (en) *	2005-09-21	2007-03-28	Cellzome (UK) Ltd.	Pyrimidine compounds for the treatment of inflammatory disorders
WO2007090853A1 (en)	2006-02-10	2007-08-16	Cellzome (Uk) Ltd.	Enantiomers of amino pyrimidine compounds for the treatment of inflammatory disorders
EP1829879A1 (en) *	2006-02-10	2007-09-05	Cellzome (UK) Ltd.	Amino pyrimidine compounds for the treatment of inflammatory disorders
TW200924781A (en)	2007-09-14	2009-06-16	Janssen Pharmaceutica Nv	Thieno- and furo-pyrimidine modulators of the histamine H4 receptor
PE20091035A1 (es)	2007-11-30	2009-07-16	Palau Pharma Sa	Derivados de 2-aminopirimidina

2008
- 2008-09-12 TW TW097135159A patent/TW200924781A/zh unknown
- 2008-09-12 AU AU2008301897A patent/AU2008301897B2/en not_active Ceased
- 2008-09-12 BR BRPI0816922 patent/BRPI0816922A2/pt not_active Application Discontinuation
- 2008-09-12 US US12/283,700 patent/US8193178B2/en not_active Expired - Fee Related
- 2008-09-12 CA CA2705719A patent/CA2705719C/en active Active
- 2008-09-12 JP JP2010524876A patent/JP5439377B2/ja not_active Expired - Fee Related
- 2008-09-12 WO PCT/US2008/010691 patent/WO2009038673A2/en not_active Ceased
- 2008-09-12 CN CN200880106875.2A patent/CN101998958B/zh not_active Expired - Fee Related
- 2008-09-12 EP EP08831409.1A patent/EP2200595B1/en active Active
- 2008-09-12 KR KR1020107008023A patent/KR101470933B1/ko not_active Expired - Fee Related
- 2008-09-12 NZ NZ583509A patent/NZ583509A/en not_active IP Right Cessation
- 2008-09-12 MX MX2010002926A patent/MX2010002926A/es active IP Right Grant
- 2008-09-15 AR ARP080104005A patent/AR068513A1/es unknown
- 2008-09-15 UY UY31340A patent/UY31340A1/es unknown
- 2008-09-15 CL CL2008002747A patent/CL2008002747A1/es unknown
- 2008-09-15 PA PA20088796001A patent/PA8796001A1/es unknown
- 2008-09-15 PE PE2008001613A patent/PE20091083A1/es not_active Application Discontinuation
2012
- 2012-04-25 US US13/456,148 patent/US8440654B2/en not_active Expired - Fee Related
- 2012-04-25 US US13/456,165 patent/US8937075B2/en active Active
- 2012-04-25 US US13/456,174 patent/US8445482B2/en not_active Expired - Fee Related
- 2012-04-25 US US13/456,180 patent/US8927555B2/en active Active

Also Published As

Publication number	Publication date
US8440654B2 (en)	2013-05-14
KR101470933B1 (ko)	2014-12-09
US8445482B2 (en)	2013-05-21
PA8796001A1 (es)	2009-04-23
CA2705719A1 (en)	2009-03-26
NZ583509A (en)	2012-01-12
US20090075970A1 (en)	2009-03-19
AU2008301897B2 (en)	2013-08-01
TW200924781A (en)	2009-06-16
CA2705719C (en)	2016-10-11
CN101998958A (zh)	2011-03-30
US20120208793A1 (en)	2012-08-16
AU2008301897A1 (en)	2009-03-26
US8193178B2 (en)	2012-06-05
PE20091083A1 (es)	2009-07-23
WO2009038673A2 (en)	2009-03-26
UY31340A1 (es)	2009-03-31
MX2010002926A (es)	2010-03-31
US20120238544A1 (en)	2012-09-20
JP5439377B2 (ja)	2014-03-12
EP2200595A4 (en)	2011-06-01
HK1143325A1 (en)	2010-12-31
EP2200595B1 (en)	2013-11-20
WO2009038673A3 (en)	2009-08-20
US20120214792A1 (en)	2012-08-23
EP2200595A2 (en)	2010-06-30
US8937075B2 (en)	2015-01-20
US8927555B2 (en)	2015-01-06
CN101998958B (zh)	2014-03-12
JP2010539169A (ja)	2010-12-16
KR20100085913A (ko)	2010-07-29
CL2008002747A1 (es)	2009-01-16
US20120270855A1 (en)	2012-10-25
AR068513A1 (es)	2009-11-18

Publication	Publication Date	Title
IL196448A0 (en)	2009-11-18	Benzofuro-and benzothienopyryimidine modulators of the histamine h4 receptor
BRPI0817601A2 (pt)	2016-10-04	dispositivos de segurança
DK2297100T3 (da)	2012-12-17	Tetrahydrocyclopenta[b]indol-androgenreceptor-modulatorer
BRPI0909375A2 (pt)	2015-08-04	Moduladores de receptores de quimiocinas
BRPI0809978A2 (pt)	2014-10-07	Dispositivos e métodos de dispensação de gotículas
BRPI0812547A2 (pt)	2015-02-10	Método e dispositivo de segurança de documentos
FI20075978A0 (fi)	2007-12-31	Järjestely ja menetelmä
BRPI0923305A2 (pt)	2016-12-13	moduladores de receptores toll-like
PL2124831T3 (pl)	2017-03-31	Urządzenia protetyczne
BRPI0813546A2 (pt)	2017-05-23	interface ortopédica
BRPI0810906A2 (pt)	2014-10-29	Dispositivo baseado em personalidade
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BRPI0918949A2 (pt)	2019-09-24	moduladores de receptores de 5-ht2a e piperazina d3
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Legal Events

Date	Code	Title	Description
2017-10-24	B07D	Technical examination (opinion) related to article 229 of industrial property law
2018-04-17	B06F	Objections, documents and/or translations needed after an examination request according art. 34 industrial property law
2019-05-28	B07E	Notice of approval relating to section 229 industrial property law	Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI
2019-08-13	B06U	Preliminary requirement: requests with searches performed by other patent offices: suspension of the patent application procedure
2019-11-26	B11B	Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements