PE20091083A1 - Moduladores tieno- y furo- pirimidina del receptor de histamina h4 - Google Patents
Moduladores tieno- y furo- pirimidina del receptor de histamina h4Info
- Publication number
- PE20091083A1 PE20091083A1 PE2008001613A PE2008001613A PE20091083A1 PE 20091083 A1 PE20091083 A1 PE 20091083A1 PE 2008001613 A PE2008001613 A PE 2008001613A PE 2008001613 A PE2008001613 A PE 2008001613A PE 20091083 A1 PE20091083 A1 PE 20091083A1
- Authority
- PE
- Peru
- Prior art keywords
- histamine
- receptor
- furo
- modulators
- ilamine
- Prior art date
Links
- 102000004187 Histamine H4 receptors Human genes 0.000 title abstract 2
- 108090000796 Histamine H4 receptors Proteins 0.000 title abstract 2
- JUQAECQBUNODQP-UHFFFAOYSA-N furo[3,2-d]pyrimidine Chemical compound C1=NC=C2OC=CC2=N1 JUQAECQBUNODQP-UHFFFAOYSA-N 0.000 title 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical compound BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- ICSNLGPSRYBMBD-UHFFFAOYSA-N 2-aminopyridine Chemical compound NC1=CC=CC=N1 ICSNLGPSRYBMBD-UHFFFAOYSA-N 0.000 abstract 1
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical class C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical class [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
- A61P5/16—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4 for decreasing, blocking or antagonising the activity of the thyroid hormones
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Pulmonology (AREA)
- Endocrinology (AREA)
- Neurology (AREA)
- Reproductive Health (AREA)
- Hematology (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Biomedical Technology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Ophthalmology & Optometry (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Neurosurgery (AREA)
- Urology & Nephrology (AREA)
- Otolaryngology (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Transplantation (AREA)
- Vascular Medicine (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Gastroenterology & Hepatology (AREA)
Abstract
REFERIDA A UN DERIVADO DE PIRIMIDINA DE FORMULA (I), DONDE X ES O O S; R1 ES H, METILO O BROMO; R2 ES H O ALQUILO C1-C4; R3 Y R4 SON (a), (b), (c), ENTRE OTROS; q ES 0 O 1; Rb Y Rc SON H O ALQUILO C1-C3; R5 ES H O NH2. SON COMPUESTOS PREFERIDOS: 4-(4-METIL-PIPERAZIN-1-IL)-TIENO[3,2-d]PIRIMIDIN-2-ILAMINA, 4-PIPERAZIN-1-IL-6,7,8,9-TETRAHIDRO-BENZO[4,5]TIENO[3,2-d]PIRIMIDIN-2-ILAMINA, 4-[(3aR,6aR)-HEXAHIDROPIRROLO[3,4-b]PIRROL-5-(1H)-IL]-6,7,8,9-TETRAHIDRO[1]BENZOTIENO[3,2-d]PIRIDIN-2-AMINA, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON MODULADORES DEL RECEPTOR DE HISTAMINA H4 Y SON UTILES EN EL TRATAMIENTO DE TRANSTORNOS INFLAMATORIOS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US97258907P | 2007-09-14 | 2007-09-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20091083A1 true PE20091083A1 (es) | 2009-07-23 |
Family
ID=40455164
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2008001613A PE20091083A1 (es) | 2007-09-14 | 2008-09-15 | Moduladores tieno- y furo- pirimidina del receptor de histamina h4 |
Country Status (17)
| Country | Link |
|---|---|
| US (5) | US8193178B2 (es) |
| EP (1) | EP2200595B1 (es) |
| JP (1) | JP5439377B2 (es) |
| KR (1) | KR101470933B1 (es) |
| CN (1) | CN101998958B (es) |
| AR (1) | AR068513A1 (es) |
| AU (1) | AU2008301897B2 (es) |
| BR (1) | BRPI0816922A2 (es) |
| CA (1) | CA2705719C (es) |
| CL (1) | CL2008002747A1 (es) |
| MX (1) | MX2010002926A (es) |
| NZ (1) | NZ583509A (es) |
| PA (1) | PA8796001A1 (es) |
| PE (1) | PE20091083A1 (es) |
| TW (1) | TW200924781A (es) |
| UY (1) | UY31340A1 (es) |
| WO (1) | WO2009038673A2 (es) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2705719C (en) | 2007-09-14 | 2016-10-11 | Janssen Pharmaceutica N.V. | Thieno-and furo-pyrimidine modulators of the histamine h4 receptor |
| WO2010075270A1 (en) | 2008-12-22 | 2010-07-01 | Incyte Corporation | 4, 6-disubstituted 2-amino-pyrimidines as histamine h4 receptor modulators |
| EP2201982A1 (en) | 2008-12-24 | 2010-06-30 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Histamine H4 receptor antagonists for the treatment of vestibular disorders |
| TW201035078A (en) | 2009-03-20 | 2010-10-01 | Incyte Corp | Substituted heterocyclic compounds |
| BR112013007566A2 (pt) | 2010-09-28 | 2016-08-02 | Panacea Biotec Ltd | novos compostos bicíclicos |
| KR20140003438A (ko) | 2010-11-15 | 2014-01-09 | 카톨리에케 유니버시테이트 루벤 | 항바이러스성 축합 헤테로사이클릭 화합물 |
| AR090037A1 (es) * | 2011-11-15 | 2014-10-15 | Xention Ltd | Derivados de tieno y/o furo-pirimidinas y piridinas inhibidores de los canales de potasio |
| HUE039713T2 (hu) | 2012-06-08 | 2019-02-28 | Sensorion | H4 receptor inhibitorok tinnitus kezelésére |
| EP2892534B8 (en) * | 2012-09-06 | 2021-09-15 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
| JP6218848B2 (ja) | 2012-11-20 | 2017-10-25 | プロキナーゼ ゲゼルシャフト ミット ベシュレンクテル ハフツング | プロテインキナーゼ阻害剤としてのチオエーテル誘導体 |
| GB201410816D0 (en) * | 2014-06-17 | 2014-07-30 | Ucb Biopharma Sprl And Katholieke Universiteit Leuven | Therapeutic agents |
| RS67141B1 (sr) | 2019-05-23 | 2025-09-30 | Novartis Ag | Inhibitor brutonove tirozin kinaze za upotrebu u lečenju hronične spontane urtikarije |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1470356A1 (de) * | 1964-01-15 | 1970-04-30 | Thomae Gmbh Dr K | Neue Thieno[3,2-d]pyrimidine und Verfahren zu ihrer Herstellung |
| BE759371A (fr) | 1969-11-24 | 1971-05-24 | Bristol Myers Co | Azaspirodecanediones heterocycliques et procedes pour leur preparation |
| JPH10503501A (ja) | 1994-08-03 | 1998-03-31 | アスタ メディカ アクチエンゲゼルシャフト | 抗喘息、抗アレルギー、抗炎症及び免疫修飾作用を有するインドール、インダゾール、ピリドピロール及びピリドピラゾール誘導体 |
| EP1437348A1 (fr) | 2003-01-13 | 2004-07-14 | L'oreal | Dérivés de de la 6-méthyl-pyrimidine-2,4-diamine, procédé de synthèse, compositions les comprenant et utilisations comme agents neutralisants basiques |
| EP1505064A1 (en) | 2003-08-05 | 2005-02-09 | Bayer HealthCare AG | 2-Aminopyrimidine derivatives |
| WO2005054239A1 (en) | 2003-12-05 | 2005-06-16 | Bayer Healthcare Ag | 2-aminopyrimidine derivatives |
| US20050239806A1 (en) | 2004-01-13 | 2005-10-27 | Ambit Biosciences Corporation | Pyrrolopyrimidine derivatives and analogs and their use in the treatment and prevention of diseases |
| JP4559749B2 (ja) * | 2004-02-16 | 2010-10-13 | あすか製薬株式会社 | ピペラジニルピリジン誘導体 |
| JP4596792B2 (ja) * | 2004-02-24 | 2010-12-15 | あすか製薬株式会社 | ５−ｈｔ１ａ作動作用と５−ｈｔ３拮抗作用を併有する薬剤 |
| AU2005226729B2 (en) | 2004-03-25 | 2010-01-28 | Janssen Pharmaceutica N.V. | Imidazole compounds |
| EP1812113A1 (en) * | 2004-11-11 | 2007-08-01 | Argenta Discovery Limited | Pyrimidine compounds as histamine modulators |
| EP1776982A1 (en) * | 2005-10-18 | 2007-04-25 | Argenta Discovery Limited | Pyrimidine compounds as histamine modulators |
| US20060281768A1 (en) | 2005-06-10 | 2006-12-14 | Gaul Michael D | Thienopyrimidine and thienopyridine kinase modulators |
| US20060281769A1 (en) * | 2005-06-10 | 2006-12-14 | Baumann Christian A | Synergistic modulation of flt3 kinase using thienopyrimidine and thienopyridine kinase modulators |
| EP1767537A1 (en) * | 2005-09-21 | 2007-03-28 | Cellzome (UK) Ltd. | Pyrimidine compounds for the treatment of inflammatory disorders |
| EP1829879A1 (en) | 2006-02-10 | 2007-09-05 | Cellzome (UK) Ltd. | Amino pyrimidine compounds for the treatment of inflammatory disorders |
| WO2007090853A1 (en) | 2006-02-10 | 2007-08-16 | Cellzome (Uk) Ltd. | Enantiomers of amino pyrimidine compounds for the treatment of inflammatory disorders |
| CA2705719C (en) | 2007-09-14 | 2016-10-11 | Janssen Pharmaceutica N.V. | Thieno-and furo-pyrimidine modulators of the histamine h4 receptor |
| WO2009068512A1 (en) | 2007-11-30 | 2009-06-04 | Palau Pharma, S. A. | 2 -amino-pyrimidine derivatives as histamine h4 antagonists |
-
2008
- 2008-09-12 CA CA2705719A patent/CA2705719C/en active Active
- 2008-09-12 CN CN200880106875.2A patent/CN101998958B/zh not_active Expired - Fee Related
- 2008-09-12 JP JP2010524876A patent/JP5439377B2/ja not_active Expired - Fee Related
- 2008-09-12 US US12/283,700 patent/US8193178B2/en not_active Expired - Fee Related
- 2008-09-12 TW TW097135159A patent/TW200924781A/zh unknown
- 2008-09-12 AU AU2008301897A patent/AU2008301897B2/en not_active Ceased
- 2008-09-12 BR BRPI0816922 patent/BRPI0816922A2/pt not_active Application Discontinuation
- 2008-09-12 EP EP08831409.1A patent/EP2200595B1/en active Active
- 2008-09-12 KR KR1020107008023A patent/KR101470933B1/ko not_active Expired - Fee Related
- 2008-09-12 NZ NZ583509A patent/NZ583509A/en not_active IP Right Cessation
- 2008-09-12 MX MX2010002926A patent/MX2010002926A/es active IP Right Grant
- 2008-09-12 WO PCT/US2008/010691 patent/WO2009038673A2/en not_active Ceased
- 2008-09-15 CL CL2008002747A patent/CL2008002747A1/es unknown
- 2008-09-15 PA PA20088796001A patent/PA8796001A1/es unknown
- 2008-09-15 AR ARP080104005A patent/AR068513A1/es unknown
- 2008-09-15 PE PE2008001613A patent/PE20091083A1/es not_active Application Discontinuation
- 2008-09-15 UY UY31340A patent/UY31340A1/es unknown
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2012
- 2012-04-25 US US13/456,180 patent/US8927555B2/en active Active
- 2012-04-25 US US13/456,165 patent/US8937075B2/en active Active
- 2012-04-25 US US13/456,148 patent/US8440654B2/en not_active Expired - Fee Related
- 2012-04-25 US US13/456,174 patent/US8445482B2/en not_active Expired - Fee Related
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