BRPI0817293A2 - Derivado de benzoquinona e3330 em combinação com agentes quimioterapêuticos para o tratamento de câncer e angiogenese - Google Patents

Derivado de benzoquinona e3330 em combinação com agentes quimioterapêuticos para o tratamento de câncer e angiogenese

Info

Publication number
BRPI0817293A2
BRPI0817293A2 BRPI0817293-5A BRPI0817293A BRPI0817293A2 BR PI0817293 A2 BRPI0817293 A2 BR PI0817293A2 BR PI0817293 A BRPI0817293 A BR PI0817293A BR PI0817293 A2 BRPI0817293 A2 BR PI0817293A2
Authority
BR
Brazil
Prior art keywords
benzoquinone
angiogenesis
cancer
derivative
treatment
Prior art date
Application number
BRPI0817293-5A
Other languages
English (en)
Inventor
Mark R Kelley
Original Assignee
Univ Indiana Res & Tech Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Indiana Res & Tech Corp filed Critical Univ Indiana Res & Tech Corp
Publication of BRPI0817293A2 publication Critical patent/BRPI0817293A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/201—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having one or two double bonds, e.g. oleic, linoleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/203—Retinoic acids ; Salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A61K31/282—Platinum compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/243—Platinum; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Endocrinology (AREA)
  • Immunology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Epoxy Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
BRPI0817293-5A 2007-09-26 2008-09-22 Derivado de benzoquinona e3330 em combinação com agentes quimioterapêuticos para o tratamento de câncer e angiogenese BRPI0817293A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US97539607P 2007-09-26 2007-09-26
US98956607P 2007-11-21 2007-11-21
PCT/US2008/077210 WO2009042542A1 (en) 2007-09-26 2008-09-22 Benzoquinone derivative e3330 in combination with chemotherapeutic agents for the treatment of cancer and angiogenesis

Publications (1)

Publication Number Publication Date
BRPI0817293A2 true BRPI0817293A2 (pt) 2015-06-16

Family

ID=39951652

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0817293-5A BRPI0817293A2 (pt) 2007-09-26 2008-09-22 Derivado de benzoquinona e3330 em combinação com agentes quimioterapêuticos para o tratamento de câncer e angiogenese

Country Status (13)

Country Link
US (6) US9089605B2 (pt)
EP (4) EP3299015A1 (pt)
JP (4) JP5646327B2 (pt)
KR (2) KR101572688B1 (pt)
AU (5) AU2008304619C1 (pt)
BR (1) BRPI0817293A2 (pt)
CA (2) CA2700365C (pt)
ES (2) ES2675951T3 (pt)
IL (1) IL204675A0 (pt)
MX (1) MX2010003315A (pt)
RU (1) RU2510270C2 (pt)
WO (2) WO2009042542A1 (pt)
ZA (1) ZA201002246B (pt)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11331294B2 (en) 2007-09-26 2022-05-17 Indiana University Research And Technology Corporation Benzoquinone derivative E3330 in combination with chemotherapeutic agents for the treatment of bladder cancer
BRPI0817293A2 (pt) * 2007-09-26 2015-06-16 Univ Indiana Res & Tech Corp Derivado de benzoquinona e3330 em combinação com agentes quimioterapêuticos para o tratamento de câncer e angiogenese
CN103298949A (zh) * 2010-10-29 2013-09-11 生命科技公司 生物素衍生物
WO2012145653A2 (en) * 2011-04-22 2012-10-26 University Of Florida Research Foundation Inc. Therapeutic combinations for use in neoplasia
MX357284B (es) * 2011-05-26 2018-07-04 Univ Indiana Res & Tech Corp Compuestos de quinona para tratar enfermedades mediadas por ape1.
US20140128398A1 (en) 2011-06-03 2014-05-08 Indiana University Research And Technology Corporation Compounds, compositions and methods for treating oxidative dna damage disorders
EP2740735A4 (en) 2011-08-05 2014-09-03 Teijin Ltd CONDENSED POLYCYCLIC AROMATIC COMPOUND, AROMATIC POLYMER AND METHOD FOR THE PRODUCTION OF THE AROMATIC COMPOUND
US9624235B2 (en) * 2012-01-31 2017-04-18 University of Pittsburgh—of the Commonwealth System of Higher Education Compounds and methods for inhibition of AP endonuclease-1/redox factor-1 (HAPE1) activity
CN104244934A (zh) 2012-03-14 2014-12-24 印第安纳大学研究及科技有限公司 用于治疗白血病的化合物和方法
EP3327046A1 (en) 2012-05-30 2018-05-30 Zeon Corporation Hydrazine compound
KR102094007B1 (ko) 2012-07-09 2020-03-26 제온 코포레이션 중합성 화합물, 중합성 조성물, 고분자, 광학 이방체, 및 중합성 화합물의 제조 방법
EP2910986B1 (en) 2012-10-22 2019-03-13 Zeon Corporation Retarder, circularly polarising plate, and image display device
CN105452311B (zh) 2013-08-22 2018-01-16 日本瑞翁株式会社 聚合性化合物、聚合性组合物、高分子以及光学各向异性体
US9868710B2 (en) 2013-10-31 2018-01-16 Zeon Corporation Polymerizable compound, polymerizable composition, polymer, and optically anisotropic product
KR101612097B1 (ko) 2015-01-07 2016-04-12 충남대학교산학협력단 아세틸화된 산화환원조절단백-1의 제조방법 및 이를 함유하는 유방암 예방 및 치료용 조성물
WO2016148047A1 (ja) 2015-03-19 2016-09-22 日本ゼオン株式会社 液晶性組成物、位相差層の製造方法及び円偏光板
BR112017024552A2 (pt) 2015-05-21 2018-07-24 Univ Indiana Res & Tech Corp métodos para direcionar ape1/ref-1 para inibir os genes de sinalização da hipóxia
EP3306364A4 (en) 2015-05-28 2019-01-23 Zeon Corporation CIRCULAR POLARIZATION LIGHT SEPARATING FILM AND METHOD FOR MANUFACTURING THE SAME
KR20170052345A (ko) * 2015-11-04 2017-05-12 충남대학교산학협력단 환원형 산화환원조절단백-1를 함유하는 염증 예방 및 치료용 약학 조성물
JPWO2017110638A1 (ja) 2015-12-22 2018-10-11 日本ゼオン株式会社 液晶性組成物、液晶硬化層及びその製造方法、並びに、光学フィルム
KR20180118133A (ko) 2016-03-08 2018-10-30 니폰 제온 가부시키가이샤 액정성 조성물, 액정 경화층 및 그 액정 경화층의 제조 방법
WO2018140286A1 (en) * 2017-01-25 2018-08-02 Indiana University Research And Technology Corporation Prophylaxis and treatment of acute myeloid leukemia
JP2020514349A (ja) * 2017-03-20 2020-05-21 インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーションＩｎｄｉａｎａ Ｕｎｉｖｅｒｓｉｔｙ Ｒｅｓｅａｒｃｈ Ａｎｄ Ｔｅｃｈｎｏｌｏｇｙ Ｃｏｒｐｏｒａｔｉｏｎ 癌の処置のための併用治療剤におけるａｐｅ１／ｒｅｆ−１阻害剤の使用
CN110392850A (zh) 2017-03-24 2019-10-29 日本瑞翁株式会社 液晶固化膜及其制造方法
CN110462465A (zh) 2017-03-24 2019-11-15 日本瑞翁株式会社 液晶组合物、液晶固化膜及其制造方法
EP3440047A4 (en) * 2017-04-17 2020-04-01 Indiana University Research & Technology Corporation PREVENTING AND REVERSING INFLAMMATION-INSPECTED DNA DAMAGE
WO2018232238A1 (en) * 2017-06-16 2018-12-20 Indiana University Research And Technology Corporation Therapeutic agent for tuberous sclerosis complex (tsc)
CA3090766A1 (en) * 2018-02-08 2019-08-15 Indiana University Research And Technology Corporation Targeting ocular diseases with novel ape1/ref-1 inhibitors
CN108440271A (zh) * 2018-04-03 2018-08-24 中山大学 一种6-甲氧基萘嵌苯酮类化合物的制备方法
EP3897601A4 (en) * 2018-12-17 2022-08-31 Indiana University Research And Technology Corporation TREATMENT OF GASTROINTESTINAL DISEASES AND THEIR SYMPTOMS
JP2024516003A (ja) * 2021-04-30 2024-04-11 オキュフィア・ファーマ・インコーポレイテッド 糖尿病網膜症および関連する状態を治療するための方法および組成物
JP2025529483A (ja) 2022-09-14 2025-09-04 オーパス・ジェネティクス・インコーポレイテッド Ａｐｘ３３３０の塩及びエステルならびにその治療的使用
WO2025147565A1 (en) * 2024-01-05 2025-07-10 Indiana University Research And Technology Corporation Treatment of necrotizing enterocolitis and symptoms thereof
WO2025194083A1 (en) * 2024-03-14 2025-09-18 Opus Genetics, Inc. Compositions comprising an apx3330 hemicalcium salt monohydrate and therapeutic uses thereof

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3438998A (en) * 1964-10-05 1969-04-15 Research Corp Antibiotic lambertellin and method for production
JPS51128932A (en) * 1975-04-30 1976-11-10 Takeda Chem Ind Ltd Organic compounds
JPS58177934A (ja) * 1982-04-13 1983-10-18 Takeda Chem Ind Ltd ベンゾキノン誘導体
FI102273B (fi) * 1989-09-11 1998-11-13 Eisai Co Ltd Kinonijohdannaiset, niiden valmistaminen ja niiden farmakologinen käyt tö
US5629327A (en) * 1993-03-01 1997-05-13 Childrens Hospital Medical Center Corp. Methods and compositions for inhibition of angiogenesis
US6228879B1 (en) * 1997-10-16 2001-05-08 The Children's Medical Center Methods and compositions for inhibition of angiogenesis
JPH07291859A (ja) * 1994-04-28 1995-11-07 Eisai Co Ltd 転写因子活性阻害剤
US5919643A (en) * 1996-06-11 1999-07-06 Advanced Research & Technology Institute Methods and compositions for the use of apurinic/apyrimidinic endonucleases
US6406917B1 (en) * 1996-06-11 2002-06-18 Advanced Research And Technology Institute Methods and compositions for the use of apurinic/apyrimidinic endonucleases
EP0813866A3 (en) * 1996-06-17 1999-01-20 Eisai Co., Ltd. Therapeutic agent for joint diseases
FR2757860B1 (fr) * 1996-12-27 1999-04-23 Oxis International Sa Composes organoselenies cycliques, leur preparation et leurs utilisations, notamment therapeutiques
US5849793A (en) * 1997-08-15 1998-12-15 The Picower Institute For Medical Research HIV matrix protein tyrosine position 29 pocket binders
WO2001000229A1 (en) 1999-06-24 2001-01-04 Pharmacia Corporation Combination of tumors necrocis factor (tnf) antagonists and cox-2 inhibitors for the treatment of inflammation
CA2441228A1 (en) * 2001-03-23 2002-10-03 Aphton Corporation Combination treatment of pancreatic cancer
SI1373263T1 (en) * 2001-04-05 2005-04-30 Torrent Pharmaceuticals Ltd Heterocyclic compounds for aging-related and diabetic vascular complications
US20030229004A1 (en) * 2002-03-20 2003-12-11 Pangene Corporation Modulation of tumor cells using BER inhibitors in combination with a sensitizing agent and DSBR inhibitors
JP2005529123A (ja) * 2002-04-24 2005-09-29 リサーチ　ディベロップメント　ファンデーション 核転写調節因子ＮＦ−κＢ抑制剤と抗腫瘍薬の相乗効果
RS20150135A1 (sr) * 2003-05-30 2015-08-31 Genentech Inc. Tretman sa anti-vegf antitelima
US20060024691A1 (en) * 2004-03-25 2006-02-02 Buck Institute For Age Research Novel pathways in the etiology of cancer
BRPI0817293A2 (pt) 2007-09-26 2015-06-16 Univ Indiana Res & Tech Corp Derivado de benzoquinona e3330 em combinação com agentes quimioterapêuticos para o tratamento de câncer e angiogenese

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Publication number Publication date
WO2009042542A1 (en) 2009-04-02
EP3725309B1 (en) 2022-11-23
EP2203162A1 (en) 2010-07-07
EP2203161B1 (en) 2018-05-09
AU2017203131A1 (en) 2017-06-01
KR101689796B1 (ko) 2016-12-27
US20100297113A1 (en) 2010-11-25
AU2018256605C1 (en) 2020-07-02
US20220184016A1 (en) 2022-06-16
JP2010540544A (ja) 2010-12-24
IL204675A0 (en) 2010-11-30
AU2015268612B2 (en) 2017-02-23
RU2510270C2 (ru) 2014-03-27
JP2015212293A (ja) 2015-11-26
ZA201002246B (en) 2016-02-24
ES2675951T3 (es) 2018-07-13
US20180325853A1 (en) 2018-11-15
US9040505B2 (en) 2015-05-26
MX2010003315A (es) 2011-03-15
KR101572688B1 (ko) 2015-11-27
JP5646327B2 (ja) 2014-12-24
EP2203161A1 (en) 2010-07-07
CA2700365A1 (en) 2009-04-02
AU2020200585A1 (en) 2020-02-13
CA2700365C (en) 2016-07-05
CA2700274C (en) 2017-08-22
RU2010113569A (ru) 2011-11-10
US20150265564A1 (en) 2015-09-24
AU2018256605B2 (en) 2019-10-31
EP2203162B1 (en) 2017-11-08
US9089605B2 (en) 2015-07-28
AU2017203131B2 (en) 2018-08-02
WO2009042544A1 (en) 2009-04-02
EP3299015A1 (en) 2018-03-28
US10058523B2 (en) 2018-08-28
US20190231728A1 (en) 2019-08-01
AU2008304619C1 (en) 2020-06-04
JP2015017091A (ja) 2015-01-29
KR20150038712A (ko) 2015-04-08
AU2008304619A1 (en) 2009-04-02
US20100285008A1 (en) 2010-11-11
AU2017203131C1 (en) 2020-06-04
KR20100084522A (ko) 2010-07-26
AU2008304619B2 (en) 2015-09-24
AU2018256605A1 (en) 2018-11-22
JP2010540545A (ja) 2010-12-24
AU2015268612A1 (en) 2016-01-07
EP3725309A1 (en) 2020-10-21
CA2700274A1 (en) 2009-04-02
JP5628674B2 (ja) 2014-11-19
ES2653855T3 (es) 2018-02-09

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