BRPI0818673A2 - terapia de combinação de um anticorpo anti-cd20 tipo ii com um agente ativo anti-bcl-2 - Google Patents
terapia de combinação de um anticorpo anti-cd20 tipo ii com um agente ativo anti-bcl-2Info
- Publication number
- BRPI0818673A2 BRPI0818673A2 BRPI0818673A BRPI0818673A BRPI0818673A2 BR PI0818673 A2 BRPI0818673 A2 BR PI0818673A2 BR PI0818673 A BRPI0818673 A BR PI0818673A BR PI0818673 A BRPI0818673 A BR PI0818673A BR PI0818673 A2 BRPI0818673 A2 BR PI0818673A2
- Authority
- BR
- Brazil
- Prior art keywords
- bcl
- antibody
- type
- active agent
- combination therapy
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2887—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07020120 | 2007-10-15 | ||
| PCT/EP2008/008635 WO2009049841A1 (en) | 2007-10-15 | 2008-10-13 | Combination therapy of a type ii anti-cd20 antibody with an anti-bcl-2 active agent |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0818673A2 true BRPI0818673A2 (pt) | 2015-09-08 |
Family
ID=38904707
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0818673A BRPI0818673A2 (pt) | 2007-10-15 | 2008-10-13 | terapia de combinação de um anticorpo anti-cd20 tipo ii com um agente ativo anti-bcl-2 |
Country Status (16)
| Country | Link |
|---|---|
| US (6) | US20090098118A1 (pt) |
| EP (2) | EP2604277A1 (pt) |
| JP (1) | JP5416124B2 (pt) |
| KR (1) | KR101278395B1 (pt) |
| CN (1) | CN101827611B (pt) |
| AR (1) | AR068862A1 (pt) |
| AU (1) | AU2008314068B2 (pt) |
| BR (1) | BRPI0818673A2 (pt) |
| CA (1) | CA2702300A1 (pt) |
| CL (1) | CL2008003035A1 (pt) |
| IL (1) | IL204744A0 (pt) |
| MX (1) | MX2010003815A (pt) |
| PE (1) | PE20090966A1 (pt) |
| RU (1) | RU2541805C2 (pt) |
| TW (1) | TWI430809B (pt) |
| WO (1) | WO2009049841A1 (pt) |
Families Citing this family (49)
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| US9296820B2 (en) * | 2003-11-05 | 2016-03-29 | Roche Glycart Ag | Polynucleotides encoding anti-CD20 antigen binding molecules with increased Fc receptor binding affinity and effector function |
| US20110021440A1 (en) * | 2007-05-16 | 2011-01-27 | University Of Maryland, Baltimore | Apoptotic pathway targeting for the diagnosis and treatment of cancer |
| AR073295A1 (es) | 2008-09-16 | 2010-10-28 | Genentech Inc | Metodos para tratar la esclerosis multiple progresiva. articulo de fabricacion. |
| WO2010043582A1 (en) * | 2008-10-17 | 2010-04-22 | Santaris Pharma A/S | Method for the treatment of cancer |
| US8586754B2 (en) | 2008-12-05 | 2013-11-19 | Abbvie Inc. | BCL-2-selective apoptosis-inducing agents for the treatment of cancer and immune diseases |
| US8728516B2 (en) * | 2009-04-30 | 2014-05-20 | Abbvie Inc. | Stabilized lipid formulation of apoptosis promoter |
| WO2010138588A2 (en) * | 2009-05-26 | 2010-12-02 | Abbott Laboratories | Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases |
| US20220315555A1 (en) | 2009-05-26 | 2022-10-06 | Abbvie Inc. | Apoptosis inducing agents for the treatment of cancer and immune and autoimmune diseases |
| US8546399B2 (en) | 2009-05-26 | 2013-10-01 | Abbvie Inc. | Apoptosis inducing agents for the treatment of cancer and immune and autoimmune diseases |
| AR078161A1 (es) | 2009-09-11 | 2011-10-19 | Hoffmann La Roche | Formulaciones farmaceuticas muy concentradas de un anticuerpo anti cd20. uso de la formulacion. metodo de tratamiento. |
| US8927009B2 (en) * | 2009-12-22 | 2015-01-06 | Abbvie Inc. | ABT-263 capsule |
| WO2012019168A2 (en) | 2010-08-06 | 2012-02-09 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| US20130203709A1 (en) * | 2010-08-09 | 2013-08-08 | The Penn State Research Foundation | Acylsulfonamides and processes for producing the same |
| EP2603529A1 (en) | 2010-08-13 | 2013-06-19 | Roche Glycart AG | Anti-tenascin-c a2 antibodies and methods of use |
| EP2625189B1 (en) | 2010-10-01 | 2018-06-27 | ModernaTX, Inc. | Engineered nucleic acids and methods of use thereof |
| WO2012080389A1 (en) * | 2010-12-16 | 2012-06-21 | Roche Glycart Ag | Combination therapy of an afucosylated cd20 antibody with a mdm2 inhibitor |
| KR101274731B1 (ko) * | 2011-01-18 | 2013-06-18 | 동아대학교 산학협력단 | 레스베라트롤의 유사체인 hs-1793 또는 이의 약학적으로 허용가능한 염을 유효성분으로 하는 전립선 암 치료용 약학적 조성물 |
| AU2012236099A1 (en) | 2011-03-31 | 2013-10-03 | Moderna Therapeutics, Inc. | Delivery and formulation of engineered nucleic acids |
| JO3733B1 (ar) * | 2011-04-05 | 2021-01-31 | Bayer Ip Gmbh | استخدام 3,2-دايهيدروايميدازو[1, 2 -c]كوينازولينات مستبدلة |
| CN102222176A (zh) * | 2011-06-01 | 2011-10-19 | 山东大学 | 一种快速发现以Bcl-2蛋白为靶点的先导化合物的方法 |
| US9464124B2 (en) | 2011-09-12 | 2016-10-11 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| DE19216461T1 (de) | 2011-10-03 | 2021-10-07 | Modernatx, Inc. | Modifizierte nukleoside, nukleotide und nukleinsäuren und verwendungen davon |
| CA3018046A1 (en) | 2011-12-16 | 2013-06-20 | Moderna Therapeutics, Inc. | Modified nucleoside, nucleotide, and nucleic acid compositions |
| US9254311B2 (en) | 2012-04-02 | 2016-02-09 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of proteins |
| US9572897B2 (en) | 2012-04-02 | 2017-02-21 | Modernatx, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
| US9283287B2 (en) | 2012-04-02 | 2016-03-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of nuclear proteins |
| WO2013151665A2 (en) | 2012-04-02 | 2013-10-10 | modeRNA Therapeutics | Modified polynucleotides for the production of proteins associated with human disease |
| HK1212240A1 (en) | 2012-09-07 | 2016-06-10 | 吉宁特有限公司 | Combination therapy of a type ii anti-cd20 antibody with a selective bcl-2 inhibitor |
| PL2922554T3 (pl) | 2012-11-26 | 2022-06-20 | Modernatx, Inc. | Na zmodyfikowany na końcach |
| US20150313906A1 (en) * | 2012-12-19 | 2015-11-05 | Glaxosmithkline Llc | Combination |
| US8980864B2 (en) | 2013-03-15 | 2015-03-17 | Moderna Therapeutics, Inc. | Compositions and methods of altering cholesterol levels |
| WO2015048744A2 (en) | 2013-09-30 | 2015-04-02 | Moderna Therapeutics, Inc. | Polynucleotides encoding immune modulating polypeptides |
| EP3052521A1 (en) | 2013-10-03 | 2016-08-10 | Moderna Therapeutics, Inc. | Polynucleotides encoding low density lipoprotein receptor |
| PE20180454A1 (es) * | 2015-05-26 | 2018-03-05 | Hoffmann La Roche | Terapia combinada de un anticuerpo anti-cd20 con un inhibidor de bcl-2 y un inhibidor de mdm2 |
| WO2018106945A1 (en) | 2016-12-07 | 2018-06-14 | Progenity Inc. | Gastrointestinal tract detection methods, devices and systems |
| TR201703149A2 (tr) * | 2017-03-01 | 2018-09-21 | Univ Yeditepe | Kemoterapi̇k i̇laç kompozi̇syonu |
| WO2018183929A1 (en) | 2017-03-30 | 2018-10-04 | Progenity Inc. | Treatment of a disease of the gastrointestinal tract with an immune modulatory agent released using an ingestible device |
| JP2020528061A (ja) * | 2017-07-26 | 2020-09-17 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | BET阻害剤、Bcl−2阻害剤及び抗CD20抗体を用いた併用療法 |
| WO2019246312A1 (en) | 2018-06-20 | 2019-12-26 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with an immunomodulator |
| WO2019246317A1 (en) | 2018-06-20 | 2019-12-26 | Progenity, Inc. | Treatment of a disease or condition in a tissue originating from the endoderm |
| US11554127B2 (en) * | 2018-07-31 | 2023-01-17 | Ascentage Pharma (Suzhou) Co., Ltd. | Synergistic antitumor effect of Bcl-2 inhibitor combined with rituximab and/or bendamustine or Bcl-2 inhibitor combined with CHOP |
| EP3883635A1 (en) | 2018-11-19 | 2021-09-29 | Progenity, Inc. | Methods and devices for treating a disease with biotherapeutics |
| KR20220034782A (ko) | 2019-06-12 | 2022-03-18 | 주노 쎄러퓨티크스 인코퍼레이티드 | 세포 매개 세포 독성 요법 및 친생존 bcl2 패밀리 단백질 억제제의 병용 요법 |
| CN115666704B (zh) | 2019-12-13 | 2025-09-26 | 比特比德科有限责任公司 | 用于将治疗剂递送至胃肠道的可摄取装置 |
| WO2021222295A1 (en) * | 2020-04-27 | 2021-11-04 | Aruna Bio, Inc. | Binding agents and uses thereof for central nervous system delivery |
| WO2022133030A1 (en) | 2020-12-16 | 2022-06-23 | Juno Therapeutics, Inc. | Combination therapy of a cell therapy and a bcl2 inhibitor |
| US12441816B2 (en) | 2021-09-21 | 2025-10-14 | Qilu Puget Sound Biotherapeutics Corporation | Heterodimeric Fc for making fusion proteins and bispecific antibodies |
| TW202337494A (zh) | 2021-11-16 | 2023-10-01 | 美商建南德克公司 | 用莫蘇妥珠單抗治療全身性紅斑狼瘡(sle)之方法及組成物 |
| WO2023220655A1 (en) | 2022-05-11 | 2023-11-16 | Celgene Corporation | Methods to overcome drug resistance by re-sensitizing cancer cells to treatment with a prior therapy via treatment with a t cell therapy |
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| US371191A (en) | 1887-10-11 | Cloth-sponging machine | ||
| US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
| US5202238A (en) | 1987-10-27 | 1993-04-13 | Oncogen | Production of chimeric antibodies by homologous recombination |
| US5204244A (en) | 1987-10-27 | 1993-04-20 | Oncogen | Production of chimeric antibodies by homologous recombination |
| US5734033A (en) * | 1988-12-22 | 1998-03-31 | The Trustees Of The University Of Pennsylvania | Antisense oligonucleotides inhibiting human bcl-2 gene expression |
| US5736137A (en) * | 1992-11-13 | 1998-04-07 | Idec Pharmaceuticals Corporation | Therapeutic application of chimeric and radiolabeled antibodies to human B lymphocyte restricted differentiation antigen for treatment of B cell lymphoma |
| JP2001505401A (ja) | 1993-09-20 | 2001-04-24 | シー. リード,ジョン | bc1−2遺伝子発現の調節 |
| AU760549B2 (en) | 1998-04-03 | 2003-05-15 | University Of Iowa Research Foundation, The | Methods and products for stimulating the immune system using immunotherapeutic oligonucleotides and cytokines |
| DK1071700T3 (da) | 1998-04-20 | 2010-06-07 | Glycart Biotechnology Ag | Glykosylerings-modifikation af antistoffer til forbedring af antistofafhængig cellulær cytotoksicitet |
| KR20010071271A (ko) | 1998-05-15 | 2001-07-28 | 존 비. 랜디스 | 방사선 및 성장 인자 수용체 티로신 키나아제 억제제에의한 사람 종양의 치료법 |
| US7795232B1 (en) | 2000-08-25 | 2010-09-14 | Genta Incorporated | Methods of treatment of a bcl-2 disorder using bcl-2 antisense oligomers |
| RU2306952C2 (ru) * | 2001-01-31 | 2007-09-27 | Байоджен Айдек Инк. | Лечение в-клеточных злокачественных опухолей с использованием комбинации применений, связанных с антителами, уменьшающими количество b-клеток, и с иммуномодулирующими антителами |
| US7432304B2 (en) * | 2001-05-30 | 2008-10-07 | The Regents Of The University Of Michigan | Small molecule antagonists of Bcl-2 family proteins |
| BRPI0315295C1 (pt) | 2002-10-17 | 2021-05-25 | Genmab As | anticorpo monoclonal humano isolado, célula hospedeira procariótica, composição farmacêutica, molécula biespecífica, usos de um anticorpo, métodos in vitro de detectar a presença de antígeno de cd20 ou uma célula que expressa cd20 em uma amostra, kit, e, vetor de expressão |
| TWI335821B (en) | 2002-12-16 | 2011-01-11 | Genentech Inc | Immunoglobulin variants and uses thereof |
| WO2004056971A2 (en) | 2002-12-19 | 2004-07-08 | Genta Incorporated | Methods of treatment of a bcl-2 disorder using bcl-2 antisense oligomers |
| EP2248892B1 (en) | 2003-01-22 | 2015-04-22 | Roche Glycart AG | Fusion constructs and use of same to produce antibodies with increased FC receptor binding affinity and effector function |
| ES2382377T3 (es) | 2003-05-30 | 2012-06-07 | Gemin X Pharmaceuticals Canada Inc. | Compuestos triheterocíclicos, composiciones, y métodos para tratar cáncer |
| WO2005044307A2 (en) * | 2003-11-04 | 2005-05-19 | Chiron Corporation | Methods of therapy for b cell-related cancers |
| US9296820B2 (en) * | 2003-11-05 | 2016-03-29 | Roche Glycart Ag | Polynucleotides encoding anti-CD20 antigen binding molecules with increased Fc receptor binding affinity and effector function |
| EP1732529A4 (en) * | 2004-03-25 | 2009-02-25 | Univ Michigan | GOSSYPOL KOKRISTALLE AND ITS USE |
| US7850962B2 (en) | 2004-04-20 | 2010-12-14 | Genmab A/S | Human monoclonal antibodies against CD20 |
| WO2006089397A1 (en) | 2005-02-22 | 2006-08-31 | Gemin X Biotechnologies Inc. | Methods for treating arthritis using triheterocyclic compounds |
| WO2006099667A1 (en) | 2005-03-21 | 2006-09-28 | The Walter And Eliza Hall Institute Of Medical Research | Prophylactic and therapeutic agents and uses therefor |
| PL1888550T3 (pl) * | 2005-05-12 | 2014-12-31 | Abbvie Bahamas Ltd | Promotory apoptozy |
| JP2008541758A (ja) * | 2005-06-02 | 2008-11-27 | アストラゼネカ エービー | Cd20に対する抗体およびその使用 |
| AU2006290433B2 (en) | 2005-08-26 | 2012-06-07 | Roche Glycart Ag | Modified antigen binding molecules with altered cell signaling activity |
-
2008
- 2008-09-22 US US12/234,739 patent/US20090098118A1/en not_active Abandoned
- 2008-10-13 RU RU2010118448/15A patent/RU2541805C2/ru not_active IP Right Cessation
- 2008-10-13 EP EP13155433.9A patent/EP2604277A1/en not_active Withdrawn
- 2008-10-13 KR KR1020107008152A patent/KR101278395B1/ko not_active Expired - Fee Related
- 2008-10-13 EP EP08839967A patent/EP2203185A1/en not_active Withdrawn
- 2008-10-13 CN CN200880111728.4A patent/CN101827611B/zh not_active Expired - Fee Related
- 2008-10-13 MX MX2010003815A patent/MX2010003815A/es active IP Right Grant
- 2008-10-13 CA CA2702300A patent/CA2702300A1/en not_active Abandoned
- 2008-10-13 BR BRPI0818673A patent/BRPI0818673A2/pt not_active IP Right Cessation
- 2008-10-13 AU AU2008314068A patent/AU2008314068B2/en not_active Ceased
- 2008-10-13 JP JP2010528326A patent/JP5416124B2/ja not_active Expired - Fee Related
- 2008-10-13 WO PCT/EP2008/008635 patent/WO2009049841A1/en not_active Ceased
- 2008-10-14 TW TW097139389A patent/TWI430809B/zh not_active IP Right Cessation
- 2008-10-14 PE PE2008001762A patent/PE20090966A1/es not_active Application Discontinuation
- 2008-10-14 CL CL2008003035A patent/CL2008003035A1/es unknown
- 2008-10-14 AR ARP080104472A patent/AR068862A1/es unknown
-
2010
- 2010-03-25 IL IL204744A patent/IL204744A0/en unknown
- 2010-05-14 US US12/780,640 patent/US20110086025A1/en not_active Abandoned
-
2011
- 2011-07-26 US US13/190,752 patent/US20110287006A1/en not_active Abandoned
-
2012
- 2012-03-20 US US13/424,506 patent/US20120276085A1/en not_active Abandoned
-
2013
- 2013-01-31 US US13/756,319 patent/US20140004104A1/en not_active Abandoned
-
2014
- 2014-03-27 US US14/227,728 patent/US20150056186A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CN101827611A (zh) | 2010-09-08 |
| KR101278395B1 (ko) | 2013-06-24 |
| TWI430809B (zh) | 2014-03-21 |
| MX2010003815A (es) | 2010-08-04 |
| US20110086025A1 (en) | 2011-04-14 |
| AU2008314068B2 (en) | 2014-01-16 |
| AU2008314068A1 (en) | 2009-04-23 |
| RU2541805C2 (ru) | 2015-02-20 |
| US20140004104A1 (en) | 2014-01-02 |
| US20090098118A1 (en) | 2009-04-16 |
| CL2008003035A1 (es) | 2010-01-11 |
| WO2009049841A1 (en) | 2009-04-23 |
| CN101827611B (zh) | 2014-01-15 |
| KR20100056559A (ko) | 2010-05-27 |
| US20120276085A1 (en) | 2012-11-01 |
| US20150056186A1 (en) | 2015-02-26 |
| TW200920401A (en) | 2009-05-16 |
| AR068862A1 (es) | 2009-12-09 |
| US20110287006A1 (en) | 2011-11-24 |
| JP2011500521A (ja) | 2011-01-06 |
| EP2203185A1 (en) | 2010-07-07 |
| RU2010118448A (ru) | 2012-05-20 |
| CA2702300A1 (en) | 2009-04-23 |
| EP2604277A1 (en) | 2013-06-19 |
| JP5416124B2 (ja) | 2014-02-12 |
| PE20090966A1 (es) | 2009-07-13 |
| IL204744A0 (en) | 2010-11-30 |
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