BRPI0818978A2 - "novos análogos não-seletivos da somatostatina" - Google Patents

"novos análogos não-seletivos da somatostatina"

Info

Publication number: BRPI0818978A2
Authority: BR; Brazil
Prior art keywords: new non; somatostatin analogs; selective somatostatin; selective; analogs
Prior art date: 2007-12-03

Application number

BRPI0818978A

Other languages

English (en)

Inventor

Andrea Vitali

Massimo Pinori

Paolo Mascagni

Original Assignee

Italfarmaco Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-12-03

Filing date

2008-11-24

Publication date

2016-05-03

2007-12-03 Priority claimed from ITMI20072266 external-priority patent/ITMI20072266A1/it

2007-12-07 Priority claimed from EP07425778A external-priority patent/EP2067786A1/en

2008-11-24 Application filed by Italfarmaco Spa filed Critical Italfarmaco Spa

2016-05-03 Publication of BRPI0818978A2 publication Critical patent/BRPI0818978A2/pt

2019-09-10 Publication of BRPI0818978B1 publication Critical patent/BRPI0818978B1/pt

2021-05-25 Publication of BRPI0818978B8 publication Critical patent/BRPI0818978B8/pt

Links

102000005157 Somatostatin Human genes 0.000 title 1
108010056088 Somatostatin Proteins 0.000 title 1
NHXLMOGPVYXJNR-ATOGVRKGSA-N somatostatin Chemical class C([C@H]1C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N1)[C@@H](C)O)NC(=O)CNC(=O)[C@H](C)N)C(O)=O)=O)[C@H](O)C)C1=CC=CC=C1 NHXLMOGPVYXJNR-ATOGVRKGSA-N 0.000 title 1
229960000553 somatostatin Drugs 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/655—Somatostatins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/655—Somatostatins
- C07K14/6555—Somatostatins at least 1 amino acid in D-form

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Endocrinology (AREA)
Toxicology (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Gastroenterology & Hepatology (AREA)
Zoology (AREA)
Immunology (AREA)
Urology & Nephrology (AREA)
Physical Education & Sports Medicine (AREA)
Rheumatology (AREA)
Diabetes (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Orthopedic Medicine & Surgery (AREA)
Ophthalmology & Optometry (AREA)
Pain & Pain Management (AREA)
Transplantation (AREA)
Vascular Medicine (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

BRPI0818978A 2007-12-03 2008-11-24 novos análogos não-seletivos da somatostatina BRPI0818978B8 (pt)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
ITMI20072266 ITMI20072266A1 (it)	2007-12-03	2007-12-03	Nuovi analoghi non selettivi di somatostatina
EP07425778A EP2067786A1 (en)	2007-12-07	2007-12-07	Novel non selective analogs of somatostatin
PCT/EP2008/066081 WO2009071460A2 (en)	2007-12-03	2008-11-24	New non-selective somatostatin analogues

Publications (3)

Publication Number	Publication Date
BRPI0818978A2 true BRPI0818978A2 (pt)	2016-05-03
BRPI0818978B1 BRPI0818978B1 (pt)	2019-09-10
BRPI0818978B8 BRPI0818978B8 (pt)	2021-05-25

Family

ID=40667736

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI0818978A BRPI0818978B8 (pt)	2007-12-03	2008-11-24	novos análogos não-seletivos da somatostatina

Country Status (15)

Country	Link
US (1)	US8937152B2 (pt)
EP (1)	EP2225271B1 (pt)
JP (1)	JP5331817B2 (pt)
KR (1)	KR101500528B1 (pt)
CN (1)	CN101883785B (pt)
BR (1)	BRPI0818978B8 (pt)
CA (1)	CA2702940C (pt)
CY (1)	CY1114490T1 (pt)
DK (1)	DK2225271T3 (pt)
ES (1)	ES2431573T3 (pt)
HR (1)	HRP20130948T1 (pt)
PL (1)	PL2225271T3 (pt)
PT (1)	PT2225271E (pt)
SI (1)	SI2225271T1 (pt)
WO (1)	WO2009071460A2 (pt)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP5631201B2 (ja)	2007-03-28	2014-11-26	プレジデントアンドフェローズオブハーバードカレッジ	ステッチングされたポリペプチド
KR101500528B1 (ko) *	2007-12-03	2015-03-09	이탈파마코 에스.피.에이.	새로운 비-선택적 소마토스타틴 유사체
KR102104762B1 (ko)	2010-08-13	2020-04-24	에일러론 테라퓨틱스 인코포레이티드	펩티도미메틱 거대고리
JP6211418B2 (ja) *	2011-09-04	2017-10-11	株式会社糖鎖工学研究所	糖鎖付加ポリペプチドおよび当該ポリペプチドを含む医薬組成物
EP2768518A4 (en)	2011-10-18	2015-05-27	Aileron Therapeutics Inc	PEPTIDOMIMETIC MACROCYCLES
CA2864120A1 (en)	2012-02-15	2013-08-22	Aileron Therapeutics, Inc.	Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles
RU2642299C2 (ru)	2012-02-15	2018-01-24	Эйлерон Терапьютикс, Инк.	P53 пептидомиметические макроциклы
BR112015009470A2 (pt)	2012-11-01	2019-12-17	Aileron Therapeutics Inc	aminoácidos dissubstituídos e seus métodos de preparação e uso
EP3007704B1 (en) *	2013-06-13	2021-01-06	Antisense Therapeutics Ltd	Combination therapy for acromegaly
CN103467575B (zh) *	2013-08-22	2016-03-02	深圳翰宇药业股份有限公司	一种帕西瑞肽的制备方法
CN103641894B (zh) *	2013-12-06	2015-10-28	深圳翰宇药业股份有限公司	一种治疗库欣病的多肽药物的制备方法
EP3197478A4 (en)	2014-09-24	2018-05-30	Aileron Therapeutics, Inc.	Peptidomimetic macrocycles and uses thereof
CN104447962B (zh) *	2014-12-29	2018-07-17	成都圣诺生物科技股份有限公司	一种合成帕瑞肽的方法
JP2018516844A (ja)	2015-03-20	2018-06-28	エルロン・セラピューティクス・インコーポレイテッドＡｉｌｅｒｏｎＴｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ．	ペプチド模倣大環状分子およびその使用
CN112867512A (zh) *	2018-09-25	2021-05-28	意大利国际先进加速器应用有限公司	联合疗法
GB201816637D0 (en) *	2018-10-12	2018-11-28	Heptares Therapeutics Ltd	Selective somatostatin receptor agonists
WO2022185315A1 (en) *	2021-03-04	2022-09-09	Starget Pharma Ltd.	Conformational constrained somatostatin receptor 3 peptide ligands and their conjugates and uses thereof
IT202100032615A1 (it)	2021-12-24	2023-06-24	Italfarmaco Spa	Uso di un agonista della somatostatina nel trattamento di tumori che esprimono SSTR3
CN119708199A (zh) *	2023-09-27	2025-03-28	钱杭江医药科技(嘉兴)有限公司	生长抑素肽类类似物、螯合物及其应用

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
MY147327A (en) *	1995-06-29	2012-11-30	Novartis Ag	Somatostatin peptides
GB0018891D0 (en)	2000-08-01	2000-09-20	Novartis Ag	Organic compounds
US6365380B2 (en) *	2000-02-23	2002-04-02	Pcbu Services, Inc.	Method for stereoselectively inverting a chiral center of a chemical compound using an enzyme and a metal catalyst
EP1482898A1 (en) *	2002-03-12	2004-12-08	The Procter & Gamble Company	Cosmetic composition comprising double coated pigment
GB0206415D0 (en)	2002-03-19	2002-05-01	Glaxo Group Ltd	Deracemisation of amines
GB0300095D0 (en) *	2003-01-03	2003-02-05	Novartis Ag	Organic compounds
PE20050285A1 (es) *	2003-06-24	2005-06-09	Novartis Ag	Composicion farmaceutica que comprende analogos ciclicos de somatostatina
US20060270730A1 (en) *	2003-08-07	2006-11-30	Andreas Katopodis	Histone deacetylase inhibitors as immunosuppressants
GB0318682D0 (en) *	2003-08-08	2003-09-10	Novartis Ag	Organic compounds
EP1522311A1 (fr) *	2003-10-10	2005-04-13	Institut National De La Sante Et De La Recherche Medicale (Inserm)	Utilisation de la somatostine ou d'un de ses analogues pour préparer un médicament destiné à réguler la réserve folliculaire ovarienne chez la femme non ménopausée
EP1689429A1 (en) *	2003-11-25	2006-08-16	Novartis AG	Biomarkers for the efficacy of somatostatin analogue treatment
ITFI20040057A1 (it) *	2004-03-10	2004-06-10	Mauro Giuntini	Analoghi della somatostatina
GB0428151D0 (en)	2004-12-22	2005-01-26	Novartis Ag	Organic compounds
US7824663B2 (en) *	2005-03-10	2010-11-02	Kokyu Alcohol Kogyo Co., Ltd.	Lip gloss composition
ES2383303T3 (es) *	2005-11-10	2012-06-20	Chemi S.P.A.	Formulaciones de inhibidores de la liberación prolongada de la hormona del crecimiento análogos de la somatostatina
KR101500528B1 (ko) *	2007-12-03	2015-03-09	이탈파마코 에스.피.에이.	새로운 비-선택적 소마토스타틴 유사체

2008
- 2008-11-24 KR KR1020107010880A patent/KR101500528B1/ko active Active
- 2008-11-24 ES ES08856519T patent/ES2431573T3/es active Active
- 2008-11-24 CN CN200880118937.1A patent/CN101883785B/zh active Active
- 2008-11-24 WO PCT/EP2008/066081 patent/WO2009071460A2/en not_active Ceased
- 2008-11-24 BR BRPI0818978A patent/BRPI0818978B8/pt active IP Right Grant
- 2008-11-24 PT PT88565197T patent/PT2225271E/pt unknown
- 2008-11-24 EP EP08856519.7A patent/EP2225271B1/en active Active
- 2008-11-24 PL PL08856519T patent/PL2225271T3/pl unknown
- 2008-11-24 JP JP2010535349A patent/JP5331817B2/ja active Active
- 2008-11-24 DK DK08856519.7T patent/DK2225271T3/da active
- 2008-11-24 HR HRP20130948AT patent/HRP20130948T1/hr unknown
- 2008-11-24 SI SI200831046T patent/SI2225271T1/sl unknown
- 2008-11-24 CA CA2702940A patent/CA2702940C/en active Active
- 2008-11-24 US US12/734,475 patent/US8937152B2/en active Active
2013
- 2013-10-10 CY CY20131100895T patent/CY1114490T1/el unknown

Also Published As

Publication number	Publication date
JP2011505345A (ja)	2011-02-24
US8937152B2 (en)	2015-01-20
EP2225271B1 (en)	2013-07-31
KR101500528B1 (ko)	2015-03-09
EP2225271A2 (en)	2010-09-08
CA2702940A1 (en)	2009-06-11
CA2702940C (en)	2016-09-13
ES2431573T3 (es)	2013-11-27
CN101883785A (zh)	2010-11-10
US20100323964A1 (en)	2010-12-23
SI2225271T1 (sl)	2013-10-30
KR20100103464A (ko)	2010-09-27
PT2225271E (pt)	2013-09-27
HRP20130948T1 (hr)	2013-11-08
BRPI0818978B1 (pt)	2019-09-10
CN101883785B (zh)	2014-01-15
JP5331817B2 (ja)	2013-10-30
WO2009071460A3 (en)	2009-12-17
WO2009071460A2 (en)	2009-06-11
CY1114490T1 (el)	2016-10-05
DK2225271T3 (da)	2013-10-07
BRPI0818978B8 (pt)	2021-05-25
PL2225271T3 (pl)	2013-12-31

Legal Events

Date	Code	Title	Description
2017-10-10	B07D	Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
2018-04-17	B06F	Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
2018-05-08	B07E	Notice of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
2018-10-09	B06A	Notification to applicant to reply to the report for non-patentability or inadequacy of the application [chapter 6.1 patent gazette]
2019-03-26	B06A	Notification to applicant to reply to the report for non-patentability or inadequacy of the application [chapter 6.1 patent gazette]
2019-08-06	B09A	Decision: intention to grant [chapter 9.1 patent gazette]
2019-09-10	B16A	Patent or certificate of addition of invention granted	Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 10/09/2019, OBSERVADAS AS CONDICOES LEGAIS. (CO) 10 (DEZ) ANOS CONTADOS A PARTIR DE 10/09/2019, OBSERVADAS AS CONDICOES LEGAIS
2021-05-25	B16C	Correction of notification of the grant	Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 24/11/2008 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF

Publication	Publication Date	Title
DK2225271T3 (da)	2013-10-07	Nye ikke-selektive somatostatin-analoger
BRPI0720972A2 (pt)	2016-03-15	análogos de ciclopamina
EP2233474A4 (en)	2011-11-02	CONDENSED AMINODIHYDROTHIAZINE DERIVATIVE
EP2280916A4 (en)	2014-07-23	HYDROCHLORFLUOROLEFINZUSAMMENSETZUNGEN
EP1994182A4 (en)	2013-11-13	Slide-off nucleobase Analogs
BRPI0922904A2 (pt)	2018-05-29	"compostos"
BRPI0810928A2 (pt)	2019-09-24	"composição farmacêutica"
BRPI0719626A2 (pt)	2014-06-24	'' composto ''
EP2044055A4 (en)	2011-03-23	amide compounds
BRPI0816970A2 (pt)	2015-03-24	1,3-dissubstituídas-4-fenil-1h-piridin-2-onas
BRPI0911743A2 (pt)	2015-07-07	"peptídeo"
EP2491025A4 (en)	2013-01-23	AZAAZULENVERBINDUNGEN
DK2205562T3 (da)	2011-06-14	1,1,1-trifluor-2-hydroxy-3-phenylpropanderivater
FR2921069B1 (fr)	2010-07-30	Composition polyamide
FR2930895B3 (fr)	2010-09-10	Escalier d'exercice
EP2278748A4 (en)	2014-08-20	INTERFACE CIRCUIT
FR2930894B3 (fr)	2011-04-01	Escalier d'exercice
CR10675A (es)	2009-04-17	Analogos de 2-fenoxipirimidinona
EP2258697A4 (en)	2011-08-03	HYDROXYCHINOXALINCARBOXAMIDDERIVAT
EP2060563A4 (en)	2010-12-22	CYCLIC AMINO ALKYL CY CARBOXYL AMIDE DERIVATIVE
ITMI20061291A1 (it)	2008-01-04	Composizioni (per) fluoroelastomeriche
CR10745A (es)	2009-05-22	Analogos de pirazol
EP2042556A4 (en)	2011-07-20	Polyamide composition
IT1393508B1 (it)	2012-04-27	Dicarba-analoghi dell'octreotide
DK2134733T3 (da)	2013-10-14	Palladium(0)-dibenzylidenacetonekomplekser