BRPI0818978A2 - "novos análogos não-seletivos da somatostatina" - Google Patents

"novos análogos não-seletivos da somatostatina"

Info

Publication number: BRPI0818978A2
Authority: BR; Brazil
Prior art keywords: new non; somatostatin analogs; selective somatostatin; selective; analogs
Prior art date: 2007-12-03

Application number

BRPI0818978A

Other languages

English (en)

Inventor

Andrea Vitali

Massimo Pinori

Paolo Mascagni

Original Assignee

Italfarmaco Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-12-03

Filing date

2008-11-24

Publication date

2016-05-03

2007-12-03 Priority claimed from ITMI20072266 external-priority patent/ITMI20072266A1/it

2007-12-07 Priority claimed from EP07425778A external-priority patent/EP2067786A1/en

2008-11-24 Application filed by Italfarmaco Spa filed Critical Italfarmaco Spa

2016-05-03 Publication of BRPI0818978A2 publication Critical patent/BRPI0818978A2/pt

2019-09-10 Publication of BRPI0818978B1 publication Critical patent/BRPI0818978B1/pt

2021-05-25 Publication of BRPI0818978B8 publication Critical patent/BRPI0818978B8/pt

Links

102000005157 Somatostatin Human genes 0.000 title 1
108010056088 Somatostatin Proteins 0.000 title 1
NHXLMOGPVYXJNR-ATOGVRKGSA-N somatostatin Chemical class C([C@H]1C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N1)[C@@H](C)O)NC(=O)CNC(=O)[C@H](C)N)C(O)=O)=O)[C@H](O)C)C1=CC=CC=C1 NHXLMOGPVYXJNR-ATOGVRKGSA-N 0.000 title 1
229960000553 somatostatin Drugs 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/655—Somatostatins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/655—Somatostatins
- C07K14/6555—Somatostatins at least 1 amino acid in D-form

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Endocrinology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Gastroenterology & Hepatology (AREA)
Zoology (AREA)
Toxicology (AREA)
Immunology (AREA)
Physical Education & Sports Medicine (AREA)
Rheumatology (AREA)
Diabetes (AREA)
Urology & Nephrology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Orthopedic Medicine & Surgery (AREA)
Pain & Pain Management (AREA)
Ophthalmology & Optometry (AREA)
Transplantation (AREA)
Vascular Medicine (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)

BRPI0818978A 2007-12-03 2008-11-24 novos análogos não-seletivos da somatostatina BRPI0818978B8 (pt)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
ITMI20072266 ITMI20072266A1 (it)	2007-12-03	2007-12-03	Nuovi analoghi non selettivi di somatostatina
EP07425778A EP2067786A1 (en)	2007-12-07	2007-12-07	Novel non selective analogs of somatostatin
PCT/EP2008/066081 WO2009071460A2 (en)	2007-12-03	2008-11-24	New non-selective somatostatin analogues

Publications (3)

Publication Number	Publication Date
BRPI0818978A2 true BRPI0818978A2 (pt)	2016-05-03
BRPI0818978B1 BRPI0818978B1 (pt)	2019-09-10
BRPI0818978B8 BRPI0818978B8 (pt)	2021-05-25

Family

ID=40667736

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI0818978A BRPI0818978B8 (pt)	2007-12-03	2008-11-24	novos análogos não-seletivos da somatostatina

Country Status (15)

Country	Link
US (1)	US8937152B2 (pt)
EP (1)	EP2225271B1 (pt)
JP (1)	JP5331817B2 (pt)
KR (1)	KR101500528B1 (pt)
CN (1)	CN101883785B (pt)
BR (1)	BRPI0818978B8 (pt)
CA (1)	CA2702940C (pt)
CY (1)	CY1114490T1 (pt)
DK (1)	DK2225271T3 (pt)
ES (1)	ES2431573T3 (pt)
HR (1)	HRP20130948T1 (pt)
PL (1)	PL2225271T3 (pt)
PT (1)	PT2225271E (pt)
SI (1)	SI2225271T1 (pt)
WO (1)	WO2009071460A2 (pt)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US8592377B2 (en)	2007-03-28	2013-11-26	President And Fellows Of Harvard College	Stitched polypeptides
US8937152B2 (en) *	2007-12-03	2015-01-20	Italfarmaco Spa	Non-selective somatostatin analogues
ES2711526T3 (es)	2010-08-13	2019-05-06	Aileron Therapeutics Inc	Macrociclos peptidomiméticos
BR112014004936A2 (pt) *	2011-09-04	2017-04-04	Glytech Inc	polipeptídeo glicosilado e composição de drogas contendo referido polipeptídeo
TW201806968A (zh)	2011-10-18	2018-03-01	艾利倫治療公司	擬肽巨環化合物
EP2819688A4 (en)	2012-02-15	2015-10-28	Aileron Therapeutics Inc	TRIAZOL AND THIOETHER-COUPLED PEPTIDOMIMETIC MACROCYCLES
BR112014020103A2 (pt)	2012-02-15	2018-10-09	Aileron Therapeutics, Inc.	macrociclos peptidomiméticos
WO2014071241A1 (en)	2012-11-01	2014-05-08	Aileron Therapeutics, Inc.	Disubstituted amino acids and methods of preparation and use thereof
JP6869720B2 (ja) *	2013-06-13	2021-05-12	アンチセンスセラピューティクスリミテッド	併用療法
CN103467575B (zh) *	2013-08-22	2016-03-02	深圳翰宇药业股份有限公司	一种帕西瑞肽的制备方法
CN103641894B (zh) *	2013-12-06	2015-10-28	深圳翰宇药业股份有限公司	一种治疗库欣病的多肽药物的制备方法
EP3197478A4 (en)	2014-09-24	2018-05-30	Aileron Therapeutics, Inc.	Peptidomimetic macrocycles and uses thereof
CN104447962B (zh) *	2014-12-29	2018-07-17	成都圣诺生物科技股份有限公司	一种合成帕瑞肽的方法
WO2016154058A1 (en)	2015-03-20	2016-09-29	Aileron Therapeutics, Inc.	Peptidomimetic macrocycles and uses thereof
WO2020064693A1 (en) *	2018-09-25	2020-04-02	Advanced Accelerator Applications (Italy) Srl	Combination therapy
GB201816637D0 (en) *	2018-10-12	2018-11-28	Heptares Therapeutics Ltd	Selective somatostatin receptor agonists
IL305248A (en) *	2021-03-04	2023-10-01	Starget Pharma Ltd	Structurally constrained peptide ligands for the somatostatin-3 receptor, their derivatives, and their uses
IT202100032615A1 (it)	2021-12-24	2023-06-24	Italfarmaco Spa	Uso di un agonista della somatostatina nel trattamento di tumori che esprimono SSTR3
CN119708199A (zh) *	2023-09-27	2025-03-28	钱杭江医药科技(嘉兴)有限公司	生长抑素肽类类似物、螯合物及其应用

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
MY147327A (en) *	1995-06-29	2012-11-30	Novartis Ag	Somatostatin peptides
GB0018891D0 (en) *	2000-08-01	2000-09-20	Novartis Ag	Organic compounds
US6365380B2 (en) *	2000-02-23	2002-04-02	Pcbu Services, Inc.	Method for stereoselectively inverting a chiral center of a chemical compound using an enzyme and a metal catalyst
CA2476324A1 (en) *	2002-03-12	2003-09-25	The Procter & Gamble Company	Cosmetic composition comprising double coated pigment and a gelling agent
GB0206415D0 (en)	2002-03-19	2002-05-01	Glaxo Group Ltd	Deracemisation of amines
GB0300095D0 (en) *	2003-01-03	2003-02-05	Novartis Ag	Organic compounds
AR044852A1 (es) *	2003-06-24	2005-10-05	Novartis Ag	Una composicion farmaceutica para la administracion parenteral que comprende un analogo de somatostatina
JP2007501775A (ja) *	2003-08-07	2007-02-01	ノバルティスアクチエンゲゼルシャフト	免疫抑制剤としてのヒストンデアセチラーゼ阻害剤
GB0318682D0 (en)	2003-08-08	2003-09-10	Novartis Ag	Organic compounds
EP1522311A1 (fr) *	2003-10-10	2005-04-13	Institut National De La Sante Et De La Recherche Medicale (Inserm)	Utilisation de la somatostine ou d'un de ses analogues pour préparer un médicament destiné à réguler la réserve folliculaire ovarienne chez la femme non ménopausée
JP2007518702A (ja) *	2003-11-25	2007-07-12	ノバルティスアクチエンゲゼルシャフト	ソマトスタチン類似体処置の効力についてのバイオマーカー
ITFI20040057A1 (it) *	2004-03-10	2004-06-10	Mauro Giuntini	Analoghi della somatostatina
GB0428151D0 (en)	2004-12-22	2005-01-26	Novartis Ag	Organic compounds
US7824663B2 (en) *	2005-03-10	2010-11-02	Kokyu Alcohol Kogyo Co., Ltd.	Lip gloss composition
ES2383303T3 (es) *	2005-11-10	2012-06-20	Chemi S.P.A.	Formulaciones de inhibidores de la liberación prolongada de la hormona del crecimiento análogos de la somatostatina
US8937152B2 (en) *	2007-12-03	2015-01-20	Italfarmaco Spa	Non-selective somatostatin analogues

2008
- 2008-11-24 US US12/734,475 patent/US8937152B2/en active Active
- 2008-11-24 DK DK08856519.7T patent/DK2225271T3/da active
- 2008-11-24 EP EP08856519.7A patent/EP2225271B1/en active Active
- 2008-11-24 CA CA2702940A patent/CA2702940C/en active Active
- 2008-11-24 KR KR1020107010880A patent/KR101500528B1/ko active Active
- 2008-11-24 CN CN200880118937.1A patent/CN101883785B/zh active Active
- 2008-11-24 PL PL08856519T patent/PL2225271T3/pl unknown
- 2008-11-24 ES ES08856519T patent/ES2431573T3/es active Active
- 2008-11-24 SI SI200831046T patent/SI2225271T1/sl unknown
- 2008-11-24 WO PCT/EP2008/066081 patent/WO2009071460A2/en not_active Ceased
- 2008-11-24 PT PT88565197T patent/PT2225271E/pt unknown
- 2008-11-24 BR BRPI0818978A patent/BRPI0818978B8/pt active IP Right Grant
- 2008-11-24 HR HRP20130948AT patent/HRP20130948T1/hr unknown
- 2008-11-24 JP JP2010535349A patent/JP5331817B2/ja active Active
2013
- 2013-10-10 CY CY20131100895T patent/CY1114490T1/el unknown

Also Published As

Publication number	Publication date
US20100323964A1 (en)	2010-12-23
SI2225271T1 (sl)	2013-10-30
HRP20130948T1 (hr)	2013-11-08
ES2431573T3 (es)	2013-11-27
EP2225271A2 (en)	2010-09-08
BRPI0818978B8 (pt)	2021-05-25
WO2009071460A2 (en)	2009-06-11
CN101883785B (zh)	2014-01-15
KR20100103464A (ko)	2010-09-27
DK2225271T3 (da)	2013-10-07
PT2225271E (pt)	2013-09-27
EP2225271B1 (en)	2013-07-31
JP5331817B2 (ja)	2013-10-30
JP2011505345A (ja)	2011-02-24
CA2702940A1 (en)	2009-06-11
PL2225271T3 (pl)	2013-12-31
US8937152B2 (en)	2015-01-20
WO2009071460A3 (en)	2009-12-17
CY1114490T1 (el)	2016-10-05
KR101500528B1 (ko)	2015-03-09
CN101883785A (zh)	2010-11-10
BRPI0818978B1 (pt)	2019-09-10
CA2702940C (en)	2016-09-13

Legal Events

Date	Code	Title	Description
2017-10-10	B07D	Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
2018-04-17	B06F	Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
2018-05-08	B07E	Notice of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
2018-10-09	B06A	Notification to applicant to reply to the report for non-patentability or inadequacy of the application [chapter 6.1 patent gazette]
2019-03-26	B06A	Notification to applicant to reply to the report for non-patentability or inadequacy of the application [chapter 6.1 patent gazette]
2019-08-06	B09A	Decision: intention to grant [chapter 9.1 patent gazette]
2019-09-10	B16A	Patent or certificate of addition of invention granted	Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 10/09/2019, OBSERVADAS AS CONDICOES LEGAIS. (CO) 10 (DEZ) ANOS CONTADOS A PARTIR DE 10/09/2019, OBSERVADAS AS CONDICOES LEGAIS
2021-05-25	B16C	Correction of notification of the grant	Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 24/11/2008 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF

Publication	Publication Date	Title
BRPI0818978A2 (pt)	2016-05-03	"novos análogos não-seletivos da somatostatina"
BRPI0720972A2 (pt)	2016-03-15	análogos de ciclopamina
EP2233474A4 (en)	2011-11-02	CONDENSED AMINODIHYDROTHIAZINE DERIVATIVE
EP2280916A4 (en)	2014-07-23	HYDROCHLORFLUOROLEFINZUSAMMENSETZUNGEN
EP1994182A4 (en)	2013-11-13	Slide-off nucleobase Analogs
BRPI0922904A2 (pt)	2018-05-29	"compostos"
BRPI0810928A2 (pt)	2019-09-24	"composição farmacêutica"
BRPI0719626A2 (pt)	2014-06-24	'' composto ''
EP2044055A4 (en)	2011-03-23	amide compounds
BRPI0816970A2 (pt)	2015-03-24	1,3-dissubstituídas-4-fenil-1h-piridin-2-onas
BRPI0911743A2 (pt)	2015-07-07	"peptídeo"
EP2491025A4 (en)	2013-01-23	AZAAZULENVERBINDUNGEN
DK2205562T3 (da)	2011-06-14	1,1,1-trifluor-2-hydroxy-3-phenylpropanderivater
FR2921069B1 (fr)	2010-07-30	Composition polyamide
FR2930895B3 (fr)	2010-09-10	Escalier d'exercice
EP2278748A4 (en)	2014-08-20	INTERFACE CIRCUIT
FR2930894B3 (fr)	2011-04-01	Escalier d'exercice
CR10675A (es)	2009-04-17	Analogos de 2-fenoxipirimidinona
EP2258697A4 (en)	2011-08-03	HYDROXYCHINOXALINCARBOXAMIDDERIVAT
EP2060563A4 (en)	2010-12-22	CYCLIC AMINO ALKYL CY CARBOXYL AMIDE DERIVATIVE
ITMI20061291A1 (it)	2008-01-04	Composizioni (per) fluoroelastomeriche
CR10745A (es)	2009-05-22	Analogos de pirazol
EP2042556A4 (en)	2011-07-20	Polyamide composition
IT1393508B1 (it)	2012-04-27	Dicarba-analoghi dell'octreotide
DK2134733T3 (da)	2013-10-14	Palladium(0)-dibenzylidenacetonekomplekser