BRPI0820131A2 - Derivados de oxadiazol ativos em esfingosina-1-fosfato (s1p) - Google Patents

Derivados de oxadiazol ativos em esfingosina-1-fosfato (s1p)

Info

Publication number: BRPI0820131A2
Authority: BR; Brazil
Prior art keywords: sphingosine; oxadiazole derivatives; phosphate active; phosphate; active
Prior art date: 2007-12-21

Application number

Other languages

English (en)

Inventor

Jag Paul Heer

Ian David Wall

Thomas Daniel Heightman

David Nigel Hurst

Christopher Norbert Johnson

Emmanuel Hubert Demont

Jason Witherington

Original Assignee

Glaxo Group Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-12-21

Filing date

2008-12-19

Publication date

2015-05-12

2007-12-21 Priority claimed from GB0725120A external-priority patent/GB0725120D0/en

2008-12-01 Priority claimed from GB0821918A external-priority patent/GB0821918D0/en

2008-12-19 Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd

2015-05-12 Publication of BRPI0820131A2 publication Critical patent/BRPI0820131A2/pt

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D267/02—Seven-membered rings
- C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D267/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D267/14—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Diabetes (AREA)
Pain & Pain Management (AREA)
Oncology (AREA)
Pulmonology (AREA)
Dermatology (AREA)
Rheumatology (AREA)
Hematology (AREA)
Emergency Medicine (AREA)
Obesity (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Endocrinology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Virology (AREA)
Transplantation (AREA)
Communicable Diseases (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

BRPI0820131 2007-12-21 2008-12-19 Derivados de oxadiazol ativos em esfingosina-1-fosfato (s1p) BRPI0820131A2 (pt)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GB0725120A GB0725120D0 (en)	2007-12-21	2007-12-21	Compounds
GB0821918A GB0821918D0 (en)	2008-12-01	2008-12-01	Compounds
PCT/EP2008/067965 WO2009080725A1 (en)	2007-12-21	2008-12-19	Oxadiazole derivatives active on sphingosine-1-phosphate (sip)

Publications (1)

Publication Number	Publication Date
BRPI0820131A2 true BRPI0820131A2 (pt)	2015-05-12

Family

ID=40342566

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI0820131 BRPI0820131A2 (pt)	2007-12-21	2008-12-19	Derivados de oxadiazol ativos em esfingosina-1-fosfato (s1p)

Country Status (28)

Country	Link
US (2)	US8222245B2 (pt)
EP (1)	EP2222669B1 (pt)
JP (1)	JP2011506569A (pt)
KR (1)	KR20100108566A (pt)
CN (1)	CN101945863B (pt)
AR (1)	AR069916A1 (pt)
AU (1)	AU2008339988B2 (pt)
BR (1)	BRPI0820131A2 (pt)
CA (1)	CA2710130A1 (pt)
CO (1)	CO6290646A2 (pt)
CR (1)	CR11579A (pt)
DK (1)	DK2222669T3 (pt)
DO (1)	DOP2010000194A (pt)
EA (1)	EA017691B1 (pt)
ES (1)	ES2434730T3 (pt)
HR (1)	HRP20130957T1 (pt)
IL (1)	IL206235A0 (pt)
MA (1)	MA31924B1 (pt)
NZ (1)	NZ585996A (pt)
PE (1)	PE20091339A1 (pt)
PL (1)	PL2222669T3 (pt)
PT (1)	PT2222669E (pt)
RS (1)	RS53038B (pt)
SI (1)	SI2222669T1 (pt)
TW (1)	TWI415847B (pt)
UY (1)	UY31570A1 (pt)
WO (1)	WO2009080725A1 (pt)
ZA (1)	ZA201003963B (pt)

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DE102007026341A1 (de)	2007-06-06	2008-12-11	Merck Patent Gmbh	Benzoxazolonderivate
DE102007032507A1 (de)	2007-07-12	2009-04-02	Merck Patent Gmbh	Pyridazinonderivate
TWI431010B (zh)	2007-12-19	2014-03-21	Lilly Co Eli	礦皮質素受體拮抗劑及使用方法
GB0725102D0 (en) *	2007-12-21	2008-01-30	Glaxo Group Ltd	Compounds
GB0725105D0 (en)	2007-12-21	2008-01-30	Glaxo Group Ltd	Compounds
GB0725101D0 (en)	2007-12-21	2008-01-30	Glaxo Group Ltd	Compounds
DE102007061963A1 (de)	2007-12-21	2009-06-25	Merck Patent Gmbh	Pyridazinonderivate
DE102008019907A1 (de)	2008-04-21	2009-10-22	Merck Patent Gmbh	Pyridazinonderivate
GB0807910D0 (en)	2008-04-30	2008-06-04	Glaxo Group Ltd	Compounds
DE102008028905A1 (de)	2008-06-18	2009-12-24	Merck Patent Gmbh	3-(3-Pyrimidin-2-yl-benzyl)-[1,2,4]triazolo[4,3-b]pyridazinderivate
US8586599B2 (en)	2008-12-22	2013-11-19	Merck Patent Gmbh	Polymorphic forms of 6-(1-methyl-1H-pyrazol-4-yl)-2-{3-[5-(2-morpholin-4-yl-ethoxy)-pyrimidin-2-yl]-benzyl}-2H-pyridazin-3-one dihydrogenphosphate and processes of manufacturing thereof
GB0910674D0 (en)	2009-06-19	2009-08-05	Glaxo Group Ltd	Novel compounds
WO2011028927A1 (en) *	2009-09-04	2011-03-10	Allergan, Inc.	Selective sphingosine-1-phosphate receptor antagonists
ES2648820T3 (es)	2011-05-10	2018-01-08	Gilead Sciences, Inc.	Compuestos heterocíclicos condensados como moduladores de los canales de sodio
CN102250035A (zh) *	2011-06-10	2011-11-23	北京富卡生物技术有限公司	二芳基取代-1，3，4-噁二唑化合物的合成方法和其药物用途
TWI478908B (zh)	2011-07-01	2015-04-01	Gilead Sciences Inc	作為離子通道調節劑之稠合雜環化合物
NO3175985T3 (pt)	2011-07-01	2018-04-28
RU2543485C2 (ru) *	2013-02-26	2015-03-10	Андрей Александрович Иващенко	Гетероциклические агонисты рецепторов желчных кислот tgr5, фармацевтическая композиция, способы их получения и применения
CN104844535A (zh) *	2014-02-13	2015-08-19	吉利德科学公司	用于制备稠合杂环离子通道调节剂的方法
TWI689487B (zh)	2014-08-20	2020-04-01	美商必治妥美雅史谷比公司	經取代雙環化合物
EP3218371B1 (en) *	2014-11-14	2018-09-26	Boehringer Ingelheim International GmbH	Aryl and heteroaryl-fused tetrahydro-1,4-oxazepine amides as somatostatin receptor subtype 4 (sstr4) agonists
WO2016087370A1 (en) *	2014-12-01	2016-06-09	Actelion Pharmaceuticals Ltd	Cxcr7 receptor modulators
IL271149B2 (en) *	2017-06-14	2024-05-01	Trevena Inc	Compounds for modulating s1p1 activity and methods of using the same
WO2022173795A1 (en) *	2021-02-10	2022-08-18	Icahn School Of Medicine At Mount Sinai	OXADIAZOLYL DIHYDROPYRANO[2,3-b]PYRIDINE INHIBITORS OF HIPK2 FOR TREATING KIDNEY FIBROSIS
EP4426285A4 (en) *	2021-11-04	2025-10-22	Valo Health Inc	HISTONE DEACETYLASE 6 INHIBITOR COMPOUNDS AND USES THEREOF

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JP3964478B2 (ja)	1995-06-30	2007-08-22	エーザイ・アール・アンド・ディー・マネジメント株式会社	ヘテロ環含有カルボン酸誘導体及びそれを含有する医薬
JPH1180026A (ja)	1997-09-02	1999-03-23	Yoshitomi Pharmaceut Ind Ltd	新規免疫抑制剤、その使用方法およびその同定方法
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EP1549640A4 (en)	2002-06-17	2008-08-06	Merck & Co Inc	1 - ((5-ARYL-1,2,4-OXADIAZOL-3-YL) BENZYL) AZETIDINE-3-CARBOXYLATE AND 1 - ((5-ARYL-1,2,4-OXADIAZOL-3-YL) BENZYL) PYRROLIDIN-3-CARBOXYLATE AS EDG RECEPTOR AGONISTS
BRPI0410746A (pt)	2003-05-19	2006-06-27	Irm Llc	compostos e composições imunossupressoras
AU2004277947A1 (en) *	2003-10-01	2005-04-14	Merck & Co., Inc.	3,5-aryl, heteroaryl or cycloalkyl substituted-1,2,4-oxadiazoles as S1P receptor agonists
CN1894225A (zh)	2003-12-17	2007-01-10	默克公司	作为鞘氨醇1－磷酸(内皮分化基因)受体激动剂的(3,4－二取代)丙酸酯
EP1760071A4 (en)	2004-06-23	2008-03-05	Ono Pharmaceutical Co	COMPOUND WITH S1P RECEPTOR BINDING ABILITY AND USE THEREOF
GB0414795D0 (en)	2004-07-01	2004-08-04	Glaxo Group Ltd	Compounds
WO2006047195A2 (en)	2004-10-22	2006-05-04	Merck & Co., Inc.	2-(aryl)azacyclylmethyl carboxylates, sulfonates, phosphonates, phosphinates and heterocycles as s1p receptor agonists
EP2371811B1 (en)	2004-12-13	2014-10-08	Ono Pharmaceutical Co., Ltd.	Azetidinecarboxylic acid derivative and medicinal use thereof
WO2006100631A1 (en) *	2005-03-23	2006-09-28	Actelion Pharmaceuticals Ltd	Hydrogenated benzo (c) thiophene derivatives as immunomodulators
DE602006003642D1 (en)	2005-03-23	2008-12-24	Actelion Pharmaceuticals Ltd	Neue thiophen-derivate als sphingosin-1-phosphat-1-rezeptorantagonisten
EP1873153B1 (en)	2005-04-22	2010-07-07	Daiichi Sankyo Company, Limited	3-azetidinecarboxylic acid derivatives for use as immunosuppressants
EP1893591A1 (en) *	2005-06-08	2008-03-05	Novartis AG	POLYCYCLIC OXADIAZOLES OR I SOXAZOLES AND THEIR USE AS SlP RECEPTOR LIGANDS
CA2619101A1 (en)	2005-08-23	2007-03-01	Irm Llc	Immunosuppressant compounds and compositions
JP2009517351A (ja)	2005-11-24	2009-04-30	グラクソグループリミテッド	化学物質
TWI382984B (zh)	2006-04-03	2013-01-21	Astellas Pharma Inc	雜環化合物
WO2008064337A2 (en)	2006-11-21	2008-05-29	University Of Virginia Patent Foundation	Benzocycloheptyl analogs having sphingosine 1-phosphate receptor activity
GB0725101D0 (en)	2007-12-21	2008-01-30	Glaxo Group Ltd	Compounds
GB0725104D0 (en)	2007-12-21	2008-01-30	Glaxo Group Ltd	Compounds
GB0725105D0 (en)	2007-12-21	2008-01-30	Glaxo Group Ltd	Compounds
GB0725102D0 (en)	2007-12-21	2008-01-30	Glaxo Group Ltd	Compounds

2008
- 2008-12-18 PE PE2008002122A patent/PE20091339A1/es not_active Application Discontinuation
- 2008-12-19 JP JP2010538741A patent/JP2011506569A/ja active Pending
- 2008-12-19 CN CN2008801273456A patent/CN101945863B/zh not_active Expired - Fee Related
- 2008-12-19 SI SI200831050T patent/SI2222669T1/sl unknown
- 2008-12-19 ES ES08864021T patent/ES2434730T3/es active Active
- 2008-12-19 TW TW097149553A patent/TWI415847B/zh not_active IP Right Cessation
- 2008-12-19 HR HRP20130957AT patent/HRP20130957T1/hr unknown
- 2008-12-19 NZ NZ585996A patent/NZ585996A/en not_active IP Right Cessation
- 2008-12-19 CA CA2710130A patent/CA2710130A1/en not_active Abandoned
- 2008-12-19 AR ARP080105590A patent/AR069916A1/es not_active Application Discontinuation
- 2008-12-19 WO PCT/EP2008/067965 patent/WO2009080725A1/en not_active Ceased
- 2008-12-19 BR BRPI0820131 patent/BRPI0820131A2/pt not_active IP Right Cessation
- 2008-12-19 US US12/747,205 patent/US8222245B2/en not_active Expired - Fee Related
- 2008-12-19 EP EP08864021.4A patent/EP2222669B1/en active Active
- 2008-12-19 RS RS20130479A patent/RS53038B/sr unknown
- 2008-12-19 AU AU2008339988A patent/AU2008339988B2/en not_active Expired - Fee Related
- 2008-12-19 PT PT88640214T patent/PT2222669E/pt unknown
- 2008-12-19 PL PL08864021T patent/PL2222669T3/pl unknown
- 2008-12-19 KR KR1020107016167A patent/KR20100108566A/ko not_active Ceased
- 2008-12-19 DK DK08864021.4T patent/DK2222669T3/da active
- 2008-12-19 UY UY31570A patent/UY31570A1/es unknown
- 2008-12-19 EA EA201070782A patent/EA017691B1/ru not_active IP Right Cessation
2009
- 2009-01-28 US US12/360,886 patent/US20100174065A1/en not_active Abandoned
2010
- 2010-06-03 ZA ZA2010/03963A patent/ZA201003963B/en unknown
- 2010-06-07 IL IL206235A patent/IL206235A0/en unknown
- 2010-06-16 MA MA32926A patent/MA31924B1/fr unknown
- 2010-06-21 DO DO2010000194A patent/DOP2010000194A/es unknown
- 2010-06-21 CO CO10074455A patent/CO6290646A2/es active IP Right Grant
- 2010-07-21 CR CR11579A patent/CR11579A/es not_active Application Discontinuation

Also Published As

Publication number	Publication date
US20100174065A1 (en)	2010-07-08
TWI415847B (zh)	2013-11-21
AU2008339988A1 (en)	2009-07-02
US20100273771A1 (en)	2010-10-28
DOP2010000194A (es)	2010-08-15
ES2434730T3 (es)	2013-12-17
MA31924B1 (fr)	2010-12-01
NZ585996A (en)	2012-06-29
JP2011506569A (ja)	2011-03-03
KR20100108566A (ko)	2010-10-07
CN101945863A (zh)	2011-01-12
HK1142062A1 (en)	2010-11-26
IL206235A0 (en)	2010-12-30
PT2222669E (pt)	2013-10-28
AU2008339988B2 (en)	2013-09-26
EA201070782A1 (ru)	2010-12-30
CA2710130A1 (en)	2009-07-02
EP2222669A1 (en)	2010-09-01
EA017691B1 (ru)	2013-02-28
PE20091339A1 (es)	2009-09-26
CN101945863B (zh)	2013-07-03
SI2222669T1 (sl)	2013-10-30
RS53038B (sr)	2014-04-30
PL2222669T3 (pl)	2014-01-31
EP2222669B1 (en)	2013-08-21
WO2009080725A1 (en)	2009-07-02
TW200940531A (en)	2009-10-01
ZA201003963B (en)	2011-11-30
DK2222669T3 (da)	2013-10-28
US8222245B2 (en)	2012-07-17
AR069916A1 (es)	2010-03-03
CO6290646A2 (es)	2011-06-20
UY31570A1 (es)	2009-05-29
HRP20130957T1 (hr)	2013-11-08
CR11579A (es)	2010-09-03

Publication	Publication Date	Title
BRPI0820131A2 (pt)	2015-05-12	Derivados de oxadiazol ativos em esfingosina-1-fosfato (s1p)
CY2020036I2 (el)	2021-06-25	Δοσολογικο σχημα για εναν αγωνιστη του υποδοχεα s1p
BRPI0818457A2 (pt)	2015-04-14	Derivados de oxadiazol
DE602008005285D1 (de)	2011-04-14	Oxadiazolsubstituierte indazolderivate zur verwendung als sphingosin-1-phosphat (s1p) -agonisten
PL2003132T3 (pl)	2014-10-31	Pochodne oksadiazolu jako agoniści S1P1
DK2300013T4 (da)	2025-02-03	Phosphorderivater som kinasehæmmere
BRPI1013422A2 (pt)	2016-04-05	derivados de oxadiazol
DK2102205T3 (da)	2010-12-06	Pyridopyrazinderivater anvendelige som herbicidale forbindelser
IL206278A0 (en)	2010-12-30	Oxadiazole derivatives active on sphingosine-1-phosphate (s1p)
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