BRPI0820302A2 - Nanopartículas semelhantes a micelas de automontagem para liberação sistêmica de gene - Google Patents
Nanopartículas semelhantes a micelas de automontagem para liberação sistêmica de geneInfo
- Publication number
- BRPI0820302A2 BRPI0820302A2 BRPI0820302-4A BRPI0820302A BRPI0820302A2 BR PI0820302 A2 BRPI0820302 A2 BR PI0820302A2 BR PI0820302 A BRPI0820302 A BR PI0820302A BR PI0820302 A2 BRPI0820302 A2 BR PI0820302A2
- Authority
- BR
- Brazil
- Prior art keywords
- nanoparticles
- self
- systemic gene
- gene release
- micelle
- Prior art date
Links
- 239000002105 nanoparticle Substances 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 title 1
- 230000009885 systemic effect Effects 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/513—Organic macromolecular compounds; Dendrimers
- A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6905—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion
- A61K47/6907—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion the form being a microemulsion, nanoemulsion or micelle
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Genetics & Genomics (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Physics & Mathematics (AREA)
- Wood Science & Technology (AREA)
- Nanotechnology (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Dispersion Chemistry (AREA)
- Zoology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Plant Pathology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Optics & Photonics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US262607P | 2007-11-09 | 2007-11-09 | |
| PCT/US2008/012660 WO2009061515A1 (en) | 2007-11-09 | 2008-11-10 | Self-assembling micelle-like nanoparticles for systemic gene delivery |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0820302A2 true BRPI0820302A2 (pt) | 2015-05-19 |
Family
ID=40626108
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0820302-4A BRPI0820302A2 (pt) | 2007-11-09 | 2008-11-10 | Nanopartículas semelhantes a micelas de automontagem para liberação sistêmica de gene |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20100285111A1 (pt) |
| EP (1) | EP2207903A4 (pt) |
| JP (1) | JP2011503070A (pt) |
| CN (1) | CN101970687A (pt) |
| AU (1) | AU2008325122A1 (pt) |
| BR (1) | BRPI0820302A2 (pt) |
| CA (1) | CA2703852A1 (pt) |
| MX (1) | MX2010005089A (pt) |
| WO (1) | WO2009061515A1 (pt) |
Families Citing this family (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5539962B2 (ja) | 2008-04-25 | 2014-07-02 | ノースウェスタン、ユニバーシティ | コレステロールを隔離するのに適したナノ構造体 |
| DK2299953T3 (en) | 2008-07-14 | 2017-06-19 | Polypid Ltd | CARBON COMPOSITION FOR MEDICINAL PRODUCTS WITH CONTINUOUS EXPOSURE |
| US20100233270A1 (en) | 2009-01-08 | 2010-09-16 | Northwestern University | Delivery of Oligonucleotide-Functionalized Nanoparticles |
| ES2347119B2 (es) * | 2009-04-22 | 2011-04-28 | Universidad De Santiago De Compostela | Nanocapsulas de poliarginina. |
| WO2010125544A1 (en) * | 2009-04-30 | 2010-11-04 | Genetic Immunity Kft. | Immunogenic nanomedicine composition and preparation and uses thereof |
| CA2767973C (en) | 2009-07-14 | 2019-06-18 | Polypid Ltd. | Lipid-based sustained-release drug carrier matrix |
| US8753687B2 (en) * | 2009-08-11 | 2014-06-17 | Agency For Science, Technology And Research | Particulate hyaluronic acid/flavonoid suspensions for cellular delivery of bioactive agents |
| US8795726B2 (en) | 2010-01-19 | 2014-08-05 | Polypid Ltd. | Sustained-release nucleic acid matrix compositions |
| AU2011207563B2 (en) * | 2010-01-19 | 2016-03-10 | Northwestern University | Synthetic nanostructures including nucleic acids and/or other entities |
| CA2817218C (en) * | 2010-11-10 | 2020-02-18 | Nigel L. Webb | Nuclions and ribocapsids |
| CA2827118A1 (en) | 2011-02-15 | 2012-08-23 | Merrimack Pharmaceuticals, Inc. | Compositions and methods for delivering nucleic acid to a cell |
| CN102516534B (zh) * | 2011-11-14 | 2013-11-20 | 上海交通大学 | 可降解为精胺的聚阳离子及其合成方法、纳米颗粒 |
| CN105163721B (zh) * | 2012-05-23 | 2018-05-22 | 俄亥俄州立大学 | 脂质纳米颗粒组合物以及制备和使用其的方法 |
| KR102152751B1 (ko) * | 2012-09-28 | 2020-09-07 | (주)아모레퍼시픽 | 식물 유래 당단백질을 포함하는 마이크로캡슐 |
| US9801953B2 (en) | 2012-10-15 | 2017-10-31 | Emory University | Nanoparticles carrying nucleic acid cassettes for expressing RNA |
| WO2014165566A1 (en) * | 2013-04-03 | 2014-10-09 | Emory University | Hydrophilic particle compositions, processes of production, and uses in dietary management and digestive disorders |
| CA2919268C (en) | 2013-07-25 | 2023-09-05 | Exicure, Inc. | Spherical nucleic acid-based constructs as immunostimulatory agents for prophylactic and therapeutic use |
| US10568898B2 (en) | 2013-08-13 | 2020-02-25 | Northwestern University | Lipophilic nanoparticles for drug delivery |
| CA2924535C (en) | 2013-09-23 | 2022-12-13 | Shiva Prasad KOTHA | Nanoparticle-mediated gene delivery, genomic editing and ligand-targete d modification in various cell populations |
| WO2015065773A1 (en) * | 2013-11-04 | 2015-05-07 | Northeastern University | System for co-delivery of polynucleotides and drugs into protease-expressing cells |
| CA2932122C (en) | 2013-12-03 | 2022-04-19 | Northwestern University | Liposomal particles, methods of making same and uses thereof |
| KR101568565B1 (ko) * | 2014-01-06 | 2015-11-23 | 서울대학교산학협력단 | 이동성이 조절된 탐침이 결합된 지지형 지질 이중층을 포함하는 인공세포막 및 이를 이용하여 분자 간 상호작용을 분석하는 방법 |
| EP3508198A1 (en) | 2014-06-04 | 2019-07-10 | Exicure, Inc. | Multivalent delivery of immune modulators by liposomal spherical nucleic acids for prophylactic or therapeutic applications |
| WO2015188838A1 (en) | 2014-06-13 | 2015-12-17 | University Of Copenhagen | Self-assembling structures |
| CN104258416B (zh) * | 2014-09-25 | 2018-05-25 | 山东大学 | 基于寡聚核苷酸共递送药物和基因的纳米载体及制备方法 |
| EP3204499A4 (en) | 2014-10-06 | 2018-04-25 | Exicure, Inc. | Anti-tnf compounds |
| WO2016081911A2 (en) | 2014-11-21 | 2016-05-26 | Northwestern University | The sequence-specific cellular uptake of spherical nucleic acid nanoparticle conjugates |
| JP2018503377A (ja) | 2015-01-14 | 2018-02-08 | イグジキュア, インコーポレーテッドExicure, Inc. | コアモチーフを備えた核酸ナノ構造 |
| WO2017008016A1 (en) * | 2015-07-09 | 2017-01-12 | The Board Of Regents Of The University Of Texas System | Nanoparticles containing extracellular matrix for drug delivery |
| KR101741977B1 (ko) * | 2016-04-26 | 2017-05-31 | 한국교통대학교산학협력단 | 경구 투여용 유전자 전달을 위한 나노입자 및 이를 포함하는 약학 조성물 |
| AU2017261360A1 (en) | 2016-05-06 | 2018-11-29 | Exicure Operating Company | Liposomal Spherical Nucleic Acid (SNA) constructs presenting Antisense Oligonucleotides (ASO) for specific knockdown of interleukin 17 receptor MRNA |
| JP2019519501A (ja) * | 2016-05-12 | 2019-07-11 | ブライアン ピー． ハンリーＢｒｉａｎ Ｐ． ＨＡＮＬＥＹ | ヒトおよび動物における体細胞の大部分へのｃｒｉｓｐｒおよび他の遺伝子治療薬の安全な送達 |
| WO2018039629A2 (en) | 2016-08-25 | 2018-03-01 | Northwestern University | Micellar spherical nucleic acids from thermoresponsive, traceless templates |
| RU2019121992A (ru) | 2016-12-14 | 2021-01-15 | Лигандал, Инк. | Способы и композиции для доставки полезной нагрузки в виде нуклеиновых кислот и белков |
| KR101796036B1 (ko) * | 2016-12-29 | 2017-11-10 | 주식회사 무진메디 | Cas9 단백질, KRAS 유전자의 발현을 억제하는 가이드 RNA 및 양이온성 폴리머의 복합체가 봉입된 나노 리포좀 전달체 조성물 또는 이를 함유하는 KRAS 유전자 변이에 따른 항암제 저항성 대장암 치료제 |
| WO2018175932A1 (en) * | 2017-03-23 | 2018-09-27 | DNARx | Systems and methods for nucleic acid expression in vivo |
| US11696954B2 (en) | 2017-04-28 | 2023-07-11 | Exicure Operating Company | Synthesis of spherical nucleic acids using lipophilic moieties |
| EP3652186A4 (en) | 2017-07-13 | 2021-03-31 | Northwestern University | GENERAL AND DIRECT PROCESS FOR THE MANUFACTURE OF OLIGONUCLEOTIDE-FUNCTIONALIZED METAL-ORGANIC FRAMEWORK NANO PARTICLES |
| KR20200109310A (ko) | 2018-01-11 | 2020-09-22 | 비온테크 알엔에이 파마슈티컬스 게엠베하 | Rna의 투여를 위한 제형 |
| EP3808344A4 (en) * | 2018-06-01 | 2022-03-30 | Sogang University Research Foundation | NANOPARTICLE COMPOSITE WITH IMPROVED ENDOCYTICAL EFFICIENCY THROUGH SURFACE MODIFICATION USING A LIPID AND MANUFACTURING PROCESSES THEREOF |
| US11197827B2 (en) | 2018-10-31 | 2021-12-14 | Microsoft Technology Licensing, Llc | Polynucleotide encapsulation and preservation using self-assembling membranes |
| KR102198900B1 (ko) * | 2019-05-10 | 2021-01-07 | 서강대학교 산학협력단 | 질병 치료용 나노입자 복합체 및 이의 제조방법 |
| US12319711B2 (en) | 2019-09-20 | 2025-06-03 | Northwestern University | Spherical nucleic acids with tailored and active protein coronae |
| US12378560B2 (en) | 2019-10-29 | 2025-08-05 | Northwestern University | Sequence multiplicity within spherical nucleic acids |
| CN112574344B (zh) * | 2020-12-09 | 2021-10-15 | 浙江大学 | 一种氧化响应去电荷的阳离子聚合物及其制备方法和应用 |
| MX2023008604A (es) * | 2021-01-21 | 2023-10-10 | Yissum Res Dev Co Of Hebrew Univ Jerusalem Ltd | Nanopartículas de arni y métodos de uso de las mismas en agricultura. |
| CN113633613B (zh) * | 2021-07-20 | 2023-04-25 | 河南大学 | 一种siRNA胶束、制备方法、组合物及其应用 |
| CN114306639B (zh) * | 2022-01-06 | 2023-03-31 | 上海交通大学 | 一种疏水性药物纳米晶/siRNA共载荷有序结构脂质纳米制剂及制备方法与应用 |
| US20260069713A1 (en) * | 2022-08-29 | 2026-03-12 | Vivasor, Inc. | Lipid-Coated Nanoparticles |
| CN115624539A (zh) * | 2022-12-16 | 2023-01-20 | 首都医科大学附属北京朝阳医院 | 一种脂质纳米颗粒及其制备方法和应用 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5705385A (en) * | 1995-06-07 | 1998-01-06 | Inex Pharmaceuticals Corporation | Lipid-nucleic acid particles prepared via a hydrophobic lipid-nucleic acid complex intermediate and use for gene transfer |
| US5981501A (en) * | 1995-06-07 | 1999-11-09 | Inex Pharmaceuticals Corp. | Methods for encapsulating plasmids in lipid bilayers |
| ES2231819T3 (es) * | 1995-06-07 | 2005-05-16 | Inex Pharmaceuticals Corp | Particulas de lipido-acido nucleico preparadas a traves de un intermedio complejo de lipido-acido nucleico hidrofobo y uso para transferir genes. |
| US6410328B1 (en) * | 1998-02-03 | 2002-06-25 | Protiva Biotherapeutics Inc. | Sensitizing cells to compounds using lipid-mediated gene and compound delivery |
| EP1242609A2 (en) * | 1999-12-30 | 2002-09-25 | Novartis AG | Novel colloid synthetic vectors for gene therapy |
| JP2001242005A (ja) * | 2000-02-28 | 2001-09-07 | Yamato Scale Co Ltd | 遠隔アクセス可能な組合せ秤及び組合せ秤システム |
| US20040142474A1 (en) * | 2000-09-14 | 2004-07-22 | Expression Genetics, Inc. | Novel cationic lipopolymer as a biocompatible gene delivery agent |
| EP1322337A2 (en) * | 2000-09-25 | 2003-07-02 | Board of Regents, The University of Texas System | Pei : dna vector formulations for in vitro and in vivo gene delivery |
| US8496961B2 (en) * | 2002-05-15 | 2013-07-30 | Sutter West Bay Hospital | Delivery of nucleic acid-like compounds |
| AU2003230980A1 (en) * | 2003-04-18 | 2004-11-26 | Northeastern University | Micelle delivery system loaded with a pharmaceutical agent |
| US7393924B2 (en) * | 2004-01-06 | 2008-07-01 | Franco Vitaliano | Smart bio-nanoparticle elements |
| US8057821B2 (en) * | 2004-11-03 | 2011-11-15 | Egen, Inc. | Biodegradable cross-linked cationic multi-block copolymers for gene delivery and methods of making thereof |
| WO2007056861A1 (en) * | 2005-11-18 | 2007-05-24 | Protiva Biotherapeutics, Inc. | Sirna silencing of influenza virus gene expression |
-
2008
- 2008-11-10 BR BRPI0820302-4A patent/BRPI0820302A2/pt not_active IP Right Cessation
- 2008-11-10 EP EP08847078A patent/EP2207903A4/en not_active Withdrawn
- 2008-11-10 WO PCT/US2008/012660 patent/WO2009061515A1/en not_active Ceased
- 2008-11-10 US US12/741,778 patent/US20100285111A1/en not_active Abandoned
- 2008-11-10 CN CN2008801154476A patent/CN101970687A/zh active Pending
- 2008-11-10 CA CA2703852A patent/CA2703852A1/en not_active Abandoned
- 2008-11-10 MX MX2010005089A patent/MX2010005089A/es unknown
- 2008-11-10 JP JP2010533120A patent/JP2011503070A/ja active Pending
- 2008-11-10 AU AU2008325122A patent/AU2008325122A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP2207903A1 (en) | 2010-07-21 |
| AU2008325122A1 (en) | 2009-05-14 |
| CN101970687A (zh) | 2011-02-09 |
| US20100285111A1 (en) | 2010-11-11 |
| JP2011503070A (ja) | 2011-01-27 |
| EP2207903A4 (en) | 2012-02-15 |
| MX2010005089A (es) | 2010-05-21 |
| WO2009061515A1 (en) | 2009-05-14 |
| CA2703852A1 (en) | 2009-05-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE AS 5A, 6A E 7A ANUIDADES. |
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| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
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