BRPI0820302A2 - Nanopartículas semelhantes a micelas de automontagem para liberação sistêmica de gene - Google Patents
Nanopartículas semelhantes a micelas de automontagem para liberação sistêmica de geneInfo
- Publication number
- BRPI0820302A2 BRPI0820302A2 BRPI0820302-4A BRPI0820302A BRPI0820302A2 BR PI0820302 A2 BRPI0820302 A2 BR PI0820302A2 BR PI0820302 A BRPI0820302 A BR PI0820302A BR PI0820302 A2 BRPI0820302 A2 BR PI0820302A2
- Authority
- BR
- Brazil
- Prior art keywords
- nanoparticles
- self
- systemic gene
- gene release
- micelle
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/513—Organic macromolecular compounds; Dendrimers
- A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6905—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion
- A61K47/6907—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion the form being a microemulsion, nanoemulsion or micelle
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Genetics & Genomics (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Nanotechnology (AREA)
- Dispersion Chemistry (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Plant Pathology (AREA)
- Optics & Photonics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US262607P | 2007-11-09 | 2007-11-09 | |
| PCT/US2008/012660 WO2009061515A1 (en) | 2007-11-09 | 2008-11-10 | Self-assembling micelle-like nanoparticles for systemic gene delivery |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0820302A2 true BRPI0820302A2 (pt) | 2015-05-19 |
Family
ID=40626108
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0820302-4A BRPI0820302A2 (pt) | 2007-11-09 | 2008-11-10 | Nanopartículas semelhantes a micelas de automontagem para liberação sistêmica de gene |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20100285111A1 (pt) |
| EP (1) | EP2207903A4 (pt) |
| JP (1) | JP2011503070A (pt) |
| CN (1) | CN101970687A (pt) |
| AU (1) | AU2008325122A1 (pt) |
| BR (1) | BRPI0820302A2 (pt) |
| CA (1) | CA2703852A1 (pt) |
| MX (1) | MX2010005089A (pt) |
| WO (1) | WO2009061515A1 (pt) |
Families Citing this family (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102036652B (zh) | 2008-04-25 | 2016-04-13 | 西北大学 | 适于螯合胆甾醇的纳米结构 |
| JP5681626B2 (ja) | 2008-07-14 | 2015-03-11 | ポリーペイド リミテッドＰｏｌｙｐｉｄ Ｌｔｄ． | 徐放性薬剤キャリア組成物 |
| US20100233270A1 (en) | 2009-01-08 | 2010-09-16 | Northwestern University | Delivery of Oligonucleotide-Functionalized Nanoparticles |
| ES2347119B2 (es) * | 2009-04-22 | 2011-04-28 | Universidad De Santiago De Compostela | Nanocapsulas de poliarginina. |
| EP2453911A1 (en) * | 2009-04-30 | 2012-05-23 | Genetic Immunity Kft | Immunogenic nanomedicine composition and preparation and uses thereof |
| CN102470105B (zh) | 2009-07-14 | 2015-07-29 | 波利皮得有限公司 | 持续释放药物载体组合物 |
| EP2464388B1 (en) * | 2009-08-11 | 2017-05-10 | Agency for Science, Technology and Research | Particulate hyaluronic acid formulations for cellular delivery of bioactive agents |
| AU2011208374B2 (en) | 2010-01-19 | 2016-09-08 | Polypid Ltd. | Sustained-release nucleic acid matrix compositions |
| JP5863670B2 (ja) | 2010-01-19 | 2016-02-17 | ノースウェスタン ユニバーシティ | 核酸および／または他の構成要素を含有している合成ナノ構造体 |
| EP3266873A1 (en) * | 2010-11-10 | 2018-01-10 | Nigel L. Webb | Nuclions and ribocapsids |
| WO2012112730A2 (en) | 2011-02-15 | 2012-08-23 | Merrimack Pharmaceuticals, Inc. | Compositions and methods for delivering nucleic acid to a cell |
| CN102516534B (zh) * | 2011-11-14 | 2013-11-20 | 上海交通大学 | 可降解为精胺的聚阳离子及其合成方法、纳米颗粒 |
| AU2013266238B2 (en) * | 2012-05-23 | 2017-07-27 | The Ohio State University | Lipid-coated albumin nanoparticle compositions and methods of making and method of using the same |
| KR102152751B1 (ko) * | 2012-09-28 | 2020-09-07 | (주)아모레퍼시픽 | 식물 유래 당단백질을 포함하는 마이크로캡슐 |
| US9801953B2 (en) | 2012-10-15 | 2017-10-31 | Emory University | Nanoparticles carrying nucleic acid cassettes for expressing RNA |
| WO2014165566A1 (en) * | 2013-04-03 | 2014-10-09 | Emory University | Hydrophilic particle compositions, processes of production, and uses in dietary management and digestive disorders |
| KR20160042917A (ko) | 2013-07-25 | 2016-04-20 | 엑시큐어, 인크. | 예방 및 치료 용도를 위한 면역자극제로서의 구형 핵산-기재 구축물 |
| WO2015023797A1 (en) | 2013-08-13 | 2015-02-19 | Northwestern University | Lipophilic nanoparticles for drug delivery |
| RU2670512C2 (ru) | 2013-09-23 | 2018-10-23 | Ренссилэйер Политекник Инститьют | Доставка генов, опосредованная наночастицами, геномная коррекция и лиганд-направленная модификация в различных клеточных популяциях |
| WO2015065773A1 (en) * | 2013-11-04 | 2015-05-07 | Northeastern University | System for co-delivery of polynucleotides and drugs into protease-expressing cells |
| JP6527516B2 (ja) | 2013-12-03 | 2019-06-05 | ノースウェスタン ユニバーシティ | リポソーム粒子、前述のものを作製する方法及びその使用 |
| KR101568565B1 (ko) * | 2014-01-06 | 2015-11-23 | 서울대학교산학협력단 | 이동성이 조절된 탐침이 결합된 지지형 지질 이중층을 포함하는 인공세포막 및 이를 이용하여 분자 간 상호작용을 분석하는 방법 |
| EP3164113B1 (en) | 2014-06-04 | 2019-03-27 | Exicure, Inc. | Multivalent delivery of immune modulators by liposomal spherical nucleic acids for prophylactic or therapeutic applications |
| WO2015188838A1 (en) | 2014-06-13 | 2015-12-17 | University Of Copenhagen | Self-assembling structures |
| CN104258416B (zh) * | 2014-09-25 | 2018-05-25 | 山东大学 | 基于寡聚核苷酸共递送药物和基因的纳米载体及制备方法 |
| EA201790802A1 (ru) | 2014-10-06 | 2017-08-31 | Экзикьюр, Инк. | Соединения против tnf |
| US11213593B2 (en) | 2014-11-21 | 2022-01-04 | Northwestern University | Sequence-specific cellular uptake of spherical nucleic acid nanoparticle conjugates |
| KR20170104550A (ko) | 2015-01-14 | 2017-09-15 | 엑시큐어, 인크. | 코어 모티프를 갖는 핵산 나노구조 |
| US11491115B2 (en) * | 2015-07-09 | 2022-11-08 | The Board Of Regents Of The University Of Texas System | Nanoparticles containing extracellular matrix for drug delivery |
| KR101741977B1 (ko) * | 2016-04-26 | 2017-05-31 | 한국교통대학교산학협력단 | 경구 투여용 유전자 전달을 위한 나노입자 및 이를 포함하는 약학 조성물 |
| JP7186094B2 (ja) | 2016-05-06 | 2022-12-08 | イグジキュア オペレーティング カンパニー | インターロイキン１７受容体ｍＲＮＡの特異的ノックダウンのためのアンチセンスオリゴヌクレオチド（ＡＳＯ）を提示するリポソーム系球状核酸（ＳＮＡ）構築物 |
| JP2019519501A (ja) * | 2016-05-12 | 2019-07-11 | ブライアン ピー． ハンリーＢｒｉａｎ Ｐ． ＨＡＮＬＥＹ | ヒトおよび動物における体細胞の大部分へのｃｒｉｓｐｒおよび他の遺伝子治療薬の安全な送達 |
| US11364304B2 (en) | 2016-08-25 | 2022-06-21 | Northwestern University | Crosslinked micellar spherical nucleic acids |
| US20180179553A1 (en) | 2016-12-14 | 2018-06-28 | Ligandal, Inc. | Compositions and methods for nucleic acid and/or protein payload delivery |
| KR101796036B1 (ko) * | 2016-12-29 | 2017-11-10 | 주식회사 무진메디 | Cas9 단백질, KRAS 유전자의 발현을 억제하는 가이드 RNA 및 양이온성 폴리머의 복합체가 봉입된 나노 리포좀 전달체 조성물 또는 이를 함유하는 KRAS 유전자 변이에 따른 항암제 저항성 대장암 치료제 |
| CN116392609A (zh) * | 2017-03-23 | 2023-07-07 | Dnarx公司 | 用于体内核酸表达的系统和方法 |
| US11696954B2 (en) | 2017-04-28 | 2023-07-11 | Exicure Operating Company | Synthesis of spherical nucleic acids using lipophilic moieties |
| JP2020526558A (ja) | 2017-07-13 | 2020-08-31 | ノースウェスタン ユニバーシティ | オリゴヌクレオチド官能化金属有機構造体ナノ粒子を調製するための一般的かつ直接的な方法 |
| MX2020007477A (es) | 2018-01-11 | 2020-11-12 | BioNTech SE | Formulacion para la administracion de arn. |
| WO2019231051A1 (ko) * | 2018-06-01 | 2019-12-05 | 서강대학교 산학협력단 | 지질을 이용한 표면 개질을 통해 세포 내 섭취 효율을 향상시킨 나노입자 복합체 및 이의 제조방법 |
| US11197827B2 (en) | 2018-10-31 | 2021-12-14 | Microsoft Technology Licensing, Llc | Polynucleotide encapsulation and preservation using self-assembling membranes |
| KR102198900B1 (ko) * | 2019-05-10 | 2021-01-07 | 서강대학교 산학협력단 | 질병 치료용 나노입자 복합체 및 이의 제조방법 |
| US12319711B2 (en) | 2019-09-20 | 2025-06-03 | Northwestern University | Spherical nucleic acids with tailored and active protein coronae |
| US12378560B2 (en) | 2019-10-29 | 2025-08-05 | Northwestern University | Sequence multiplicity within spherical nucleic acids |
| CN112574344B (zh) * | 2020-12-09 | 2021-10-15 | 浙江大学 | 一种氧化响应去电荷的阳离子聚合物及其制备方法和应用 |
| US20240090512A1 (en) * | 2021-01-21 | 2024-03-21 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Rnai nanoparticles and methods of using same in agriculture |
| CN113633613B (zh) * | 2021-07-20 | 2023-04-25 | 河南大学 | 一种siRNA胶束、制备方法、组合物及其应用 |
| CN114306639B (zh) * | 2022-01-06 | 2023-03-31 | 上海交通大学 | 一种疏水性药物纳米晶/siRNA共载荷有序结构脂质纳米制剂及制备方法与应用 |
| US20260069713A1 (en) * | 2022-08-29 | 2026-03-12 | Vivasor, Inc. | Lipid-Coated Nanoparticles |
| CN115624539A (zh) * | 2022-12-16 | 2023-01-20 | 首都医科大学附属北京朝阳医院 | 一种脂质纳米颗粒及其制备方法和应用 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2222328C (en) * | 1995-06-07 | 2012-01-10 | Inex Pharmaceuticals Corporation | Lipid-nucleic acid particles prepared via a hydrophobic lipid-nucleic acid complex intermediate and use for gene transfer |
| US5981501A (en) * | 1995-06-07 | 1999-11-09 | Inex Pharmaceuticals Corp. | Methods for encapsulating plasmids in lipid bilayers |
| US5705385A (en) * | 1995-06-07 | 1998-01-06 | Inex Pharmaceuticals Corporation | Lipid-nucleic acid particles prepared via a hydrophobic lipid-nucleic acid complex intermediate and use for gene transfer |
| US6410328B1 (en) * | 1998-02-03 | 2002-06-25 | Protiva Biotherapeutics Inc. | Sensitizing cells to compounds using lipid-mediated gene and compound delivery |
| CN101041079A (zh) * | 1999-12-30 | 2007-09-26 | 诺瓦提斯公司 | 用于基因治疗的新的胶体合成载体 |
| JP2001242005A (ja) * | 2000-02-28 | 2001-09-07 | Yamato Scale Co Ltd | 遠隔アクセス可能な組合せ秤及び組合せ秤システム |
| US20040142474A1 (en) * | 2000-09-14 | 2004-07-22 | Expression Genetics, Inc. | Novel cationic lipopolymer as a biocompatible gene delivery agent |
| WO2002024232A2 (en) * | 2000-09-25 | 2002-03-28 | Board Of Regents, The University Of Texas System | Pei: dna vector formulations for in vitro and in vivo gene delivery |
| EP1509203B1 (en) * | 2002-05-15 | 2016-04-13 | California Pacific Medical Center | Delivery of nucleic acid-like compounds |
| WO2004098569A1 (en) * | 2003-04-18 | 2004-11-18 | Northeastern University | Micelle delivery system loaded with a pharmaceutical agent |
| US7393924B2 (en) * | 2004-01-06 | 2008-07-01 | Franco Vitaliano | Smart bio-nanoparticle elements |
| US8057821B2 (en) * | 2004-11-03 | 2011-11-15 | Egen, Inc. | Biodegradable cross-linked cationic multi-block copolymers for gene delivery and methods of making thereof |
| WO2007056861A1 (en) * | 2005-11-18 | 2007-05-24 | Protiva Biotherapeutics, Inc. | Sirna silencing of influenza virus gene expression |
-
2008
- 2008-11-10 BR BRPI0820302-4A patent/BRPI0820302A2/pt not_active IP Right Cessation
- 2008-11-10 CA CA2703852A patent/CA2703852A1/en not_active Abandoned
- 2008-11-10 MX MX2010005089A patent/MX2010005089A/es unknown
- 2008-11-10 WO PCT/US2008/012660 patent/WO2009061515A1/en not_active Ceased
- 2008-11-10 EP EP08847078A patent/EP2207903A4/en not_active Withdrawn
- 2008-11-10 US US12/741,778 patent/US20100285111A1/en not_active Abandoned
- 2008-11-10 CN CN2008801154476A patent/CN101970687A/zh active Pending
- 2008-11-10 JP JP2010533120A patent/JP2011503070A/ja active Pending
- 2008-11-10 AU AU2008325122A patent/AU2008325122A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2009061515A1 (en) | 2009-05-14 |
| MX2010005089A (es) | 2010-05-21 |
| US20100285111A1 (en) | 2010-11-11 |
| CN101970687A (zh) | 2011-02-09 |
| JP2011503070A (ja) | 2011-01-27 |
| AU2008325122A1 (en) | 2009-05-14 |
| EP2207903A4 (en) | 2012-02-15 |
| CA2703852A1 (en) | 2009-05-14 |
| EP2207903A1 (en) | 2010-07-21 |
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