BRPI0820696A2 - hidantoínas substituídas como inibidores de cinase de mek - Google Patents

hidantoínas substituídas como inibidores de cinase de mek

Info

Publication number
BRPI0820696A2
BRPI0820696A2 BRPI0820696A BRPI0820696A BRPI0820696A2 BR PI0820696 A2 BRPI0820696 A2 BR PI0820696A2 BR PI0820696 A BRPI0820696 A BR PI0820696A BR PI0820696 A BRPI0820696 A BR PI0820696A BR PI0820696 A2 BRPI0820696 A2 BR PI0820696A2
Authority
BR
Brazil
Prior art keywords
kinase inhibitors
mek kinase
substituted hydantoins
hydantoins
substituted
Prior art date
Application number
BRPI0820696A
Other languages
English (en)
Inventor
Anthony Moliterni John
John Silvester Huby Nicholas
Kong Norman
Jose Morales Omar
Chen Shaoqing
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BRPI0820696A2 publication Critical patent/BRPI0820696A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72—Two oxygen atoms, e.g. hydantoin
    • C07D233/74—Two oxygen atoms, e.g. hydantoin with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to other ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72—Two oxygen atoms, e.g. hydantoin
    • C07D233/76—Two oxygen atoms, e.g. hydantoin with substituted hydrocarbon radicals attached to the third ring carbon atom
    • C07D233/78—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
BRPI0820696A 2007-12-20 2008-12-10 hidantoínas substituídas como inibidores de cinase de mek BRPI0820696A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US1522207P 2007-12-20 2007-12-20
US10325908P 2008-10-07 2008-10-07
PCT/EP2008/067221 WO2009080523A1 (en) 2007-12-20 2008-12-10 Substituted hydantoins as mek kinase inhibitors

Publications (1)

Publication Number Publication Date
BRPI0820696A2 true BRPI0820696A2 (pt) 2019-09-24

Family

ID=40380157

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0820696A BRPI0820696A2 (pt) 2007-12-20 2008-12-10 hidantoínas substituídas como inibidores de cinase de mek

Country Status (15)

Country Link
US (1) US8063085B2 (pt)
EP (1) EP2234982A1 (pt)
JP (1) JP2011506533A (pt)
KR (1) KR20100086503A (pt)
CN (1) CN101896469A (pt)
AR (1) AR069795A1 (pt)
AU (1) AU2008341680A1 (pt)
BR (1) BRPI0820696A2 (pt)
CA (1) CA2707650A1 (pt)
CL (1) CL2008003814A1 (pt)
IL (1) IL205605A0 (pt)
MX (1) MX2010006331A (pt)
PE (1) PE20091452A1 (pt)
TW (1) TW200932217A (pt)
WO (1) WO2009080523A1 (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2538785T3 (en) * 2010-02-24 2018-05-22 Medivation Prostate Therapeutics Llc Methods for the synthesis of diarylthiohydantoin and diarylhydantoin compounds
CN102020651B (zh) 2010-11-02 2012-07-18 北京赛林泰医药技术有限公司 6-芳基氨基吡啶酮甲酰胺mek抑制剂
CN103342693A (zh) * 2013-07-31 2013-10-09 上海康鹏化学有限公司 反式-2-(4-卤-3-氟苯基)-5-烷基-[1,3]二氧六环的制备方法
CN104860869B (zh) * 2015-04-03 2017-11-03 北京大学 具有mek激酶抑制功能的化合物及其制备方法与应用
CN105152977B (zh) * 2015-09-28 2017-06-23 西南大学 D‑对羟基苯甘氨酸衍生物及其制备方法和应用
US10577357B2 (en) 2016-09-19 2020-03-03 The Texas A&M University System Inhibitors of LDLR-PCSK9 protein-protein interaction and methods of their use
WO2025043043A2 (en) * 2023-08-24 2025-02-27 Musc Foundation For Research Development Mek1 inhibitors and uses thereof

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ501276A (en) 1997-07-01 2000-10-27 Warner Lambert Co 4-bromo or 4-iodo phenylamino benzhydroxamic acid derivatives and their use as MEK inhibitors in treating proliferative disorders
KR19990012061A (ko) * 1997-07-26 1999-02-25 성재갑 파네실 전이효소 저해제로 유용한 하이덴토인 유도체
AU5227001A (en) 2000-05-03 2001-11-12 Hoffmann La Roche Hydantoin-containing glucokinase activators
JP3811775B2 (ja) 2000-07-19 2006-08-23 ワーナー−ランバート カンパニー リミティド ライアビリティー カンパニー ４−ヨードフェニルアミノベンズヒドロキサム酸の酸素化エステル
US7235537B2 (en) 2002-03-13 2007-06-26 Array Biopharma, Inc. N3 alkylated benzimidazole derivatives as MEK inhibitors
KR100984595B1 (ko) 2002-03-13 2010-09-30 어레이 바이오파마 인크. Ｍｅｋ 억제제로서의 ｎ3 알킬화 벤즈이미다졸 유도체
US7041693B2 (en) 2002-10-04 2006-05-09 Bristol-Myers Squibb Company Hydantoin derivatives as inhibitors of matrix metalloproteinases and/or TNF-α converting enzyme (TACE)
ES2331246T3 (es) 2003-07-24 2009-12-28 Warner-Lambert Company Llc Derivados de benzamidazol como inhibidores del mek.
BRPI0514515A (pt) * 2004-08-17 2008-06-10 Hoffmann La Roche hidantoìnas substituìdas
TW200621766A (en) * 2004-09-17 2006-07-01 Hoffmann La Roche Substituted hydantoins
WO2006124780A2 (en) 2005-05-12 2006-11-23 Kalypsys, Inc. Ih-benzo [d] imidazole compounds as inhibitors of b-raf kinase
FR2891543A1 (fr) 2005-10-05 2007-04-06 Oreal Composes phenyl-furyl-methyl-thiazolidine-2,4-diones ou phenyl-thienyl-methyl-thiazolidine-2,4-diones ; utilisations pour stimuler ou induire la pousse des fibres keratiniques et/ou freiner leur chute ; compositions le contenant
US7612212B2 (en) 2006-02-22 2009-11-03 Hoffmann-La Roche Inc. Substituted hydantoins

Also Published As

Publication number Publication date
KR20100086503A (ko) 2010-07-30
CA2707650A1 (en) 2009-07-02
MX2010006331A (es) 2010-07-05
AU2008341680A1 (en) 2009-07-02
CN101896469A (zh) 2010-11-24
US20090170920A1 (en) 2009-07-02
US8063085B2 (en) 2011-11-22
EP2234982A1 (en) 2010-10-06
WO2009080523A1 (en) 2009-07-02
TW200932217A (en) 2009-08-01
AR069795A1 (es) 2010-02-17
CL2008003814A1 (es) 2009-10-23
JP2011506533A (ja) 2011-03-03
PE20091452A1 (es) 2009-09-23
IL205605A0 (en) 2010-11-30

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2543 DE 01-10-2019 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.