BRPI0822323A2 - Imidazolil bifenil imidazóis como inibidores do vírus da hepatite c - Google Patents
Imidazolil bifenil imidazóis como inibidores do vírus da hepatite cInfo
- Publication number
- BRPI0822323A2 BRPI0822323A2 BRPI0822323-8A BRPI0822323A BRPI0822323A2 BR PI0822323 A2 BRPI0822323 A2 BR PI0822323A2 BR PI0822323 A BRPI0822323 A BR PI0822323A BR PI0822323 A2 BRPI0822323 A2 BR PI0822323A2
- Authority
- BR
- Brazil
- Prior art keywords
- hepatitis
- virus inhibitors
- imidazolyl
- imidazoles
- biphenyl imidazoles
- Prior art date
Links
- 241000711549 Hepacivirus C Species 0.000 title 1
- MZYZINVCXFAPDR-UHFFFAOYSA-N N1C=NC=C1.N1C(=NC=C1)C1=C(C=CC=C1)C1=CC=CC=C1 Chemical class N1C=NC=C1.N1C(=NC=C1)C1=C(C=CC=C1)C1=CC=CC=C1 MZYZINVCXFAPDR-UHFFFAOYSA-N 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Oncology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US2008/053779 WO2009102325A1 (en) | 2008-02-13 | 2008-02-13 | Imidazolyl biphenyl imidazoles as hepatitis c virus inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0822323A2 true BRPI0822323A2 (pt) | 2015-06-16 |
Family
ID=39661448
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0822323-8A BRPI0822323A2 (pt) | 2008-02-13 | 2008-02-13 | Imidazolil bifenil imidazóis como inibidores do vírus da hepatite c |
Country Status (20)
| Country | Link |
|---|---|
| EP (1) | EP2242752B1 (pt) |
| JP (1) | JP5312486B2 (pt) |
| KR (1) | KR101492672B1 (pt) |
| CN (1) | CN102007122B (pt) |
| AU (1) | AU2008350334B2 (pt) |
| BR (1) | BRPI0822323A2 (pt) |
| CA (1) | CA2715839C (pt) |
| CY (1) | CY1113259T1 (pt) |
| DK (1) | DK2242752T3 (pt) |
| EA (1) | EA018088B1 (pt) |
| ES (1) | ES2391600T3 (pt) |
| HR (1) | HRP20120706T1 (pt) |
| IL (1) | IL207469A (pt) |
| MX (1) | MX2010008863A (pt) |
| NZ (1) | NZ587557A (pt) |
| PL (1) | PL2242752T3 (pt) |
| PT (1) | PT2242752E (pt) |
| SI (1) | SI2242752T1 (pt) |
| WO (1) | WO2009102325A1 (pt) |
| ZA (1) | ZA201005573B (pt) |
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| US7906655B2 (en) | 2008-08-07 | 2011-03-15 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| US8383094B2 (en) | 2008-10-01 | 2013-02-26 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| EP2367823A1 (en) | 2008-12-23 | 2011-09-28 | Abbott Laboratories | Anti-viral compounds |
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| TWI438200B (zh) | 2009-02-17 | 2014-05-21 | 必治妥美雅史谷比公司 | Ｃ型肝炎病毒抑制劑 |
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| US8394968B2 (en) | 2009-02-17 | 2013-03-12 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| US9765087B2 (en) | 2009-02-27 | 2017-09-19 | Enanta Pharmaceuticals, Inc. | Benzimidazole derivatives |
| KR101411889B1 (ko) | 2009-02-27 | 2014-06-27 | 이난타 파마슈티칼스, 인코포레이티드 | Ｃ형 간염 바이러스 억제제 |
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| US8673954B2 (en) | 2009-02-27 | 2014-03-18 | Enanta Pharmaceuticals, Inc. | Benzimidazole derivatives |
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| US20190127365A1 (en) | 2017-11-01 | 2019-05-02 | Merck Sharp & Dohme Corp. | Inhibitors of hepatitis c virus replication |
| SG174929A1 (en) | 2009-03-27 | 2011-11-28 | Merck Sharp & Dohme | Inhibitors of hepatitis c virus replication |
| US8796466B2 (en) | 2009-03-30 | 2014-08-05 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| TW201038559A (en) | 2009-04-09 | 2010-11-01 | Bristol Myers Squibb Co | Hepatitis C virus inhibitors |
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| CN102459165B (zh) | 2009-04-15 | 2015-09-02 | Abbvie公司 | 抗病毒化合物 |
| PT3309157T (pt) | 2009-05-13 | 2019-12-02 | Gilead Pharmasset Llc | Compostos antivirais |
| US8138215B2 (en) | 2009-05-29 | 2012-03-20 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
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| US8716454B2 (en) | 2009-06-11 | 2014-05-06 | Abbvie Inc. | Solid compositions |
| US9394279B2 (en) | 2009-06-11 | 2016-07-19 | Abbvie Inc. | Anti-viral compounds |
| US8221737B2 (en) | 2009-06-16 | 2012-07-17 | Enanta Pharmaceuticals, Inc. | Hepatitis C virus inhibitors |
| US8609648B2 (en) | 2009-07-02 | 2013-12-17 | Enanta Pharmaceuticals, Inc. | Hepatitis C virus inhibitors |
| IN2012DN00999A (pt) | 2009-07-16 | 2015-04-10 | Vertex Pharma | |
| EA201290089A1 (ru) | 2009-09-04 | 2012-09-28 | ГЛАКСОСМИТКЛАЙН ЭлЭлСи | Химические соединения |
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| JP2013540122A (ja) | 2010-09-29 | 2013-10-31 | メルク・シャープ・エンド・ドーム・コーポレイション | 縮合四環式化合物誘導体およびウィルス疾患治療のためのそれの使用方法 |
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Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6080870A (en) * | 1996-04-03 | 2000-06-27 | Merck & Co., Inc. | Biaryl substituted imidazole compounds useful as farnesyl-protein transferase inhibitors |
| EP1532118A2 (en) * | 2002-07-05 | 2005-05-25 | Axxima Pharmaceuticals Aktiengesellschaft | Imidazole compounds for the treatment of hepatitis c virus infections |
| GB0416396D0 (en) * | 2004-07-22 | 2004-08-25 | Angeletti P Ist Richerche Bio | Therapeutic agents |
| US8143288B2 (en) * | 2005-06-06 | 2012-03-27 | Bristol-Myers Squibb Company | Inhibitors of HCV replication |
| US7659270B2 (en) * | 2006-08-11 | 2010-02-09 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| US8329159B2 (en) * | 2006-08-11 | 2012-12-11 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| US7759495B2 (en) * | 2006-08-11 | 2010-07-20 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
-
2008
- 2008-02-13 HR HRP20120706AT patent/HRP20120706T1/hr unknown
- 2008-02-13 KR KR20107020264A patent/KR101492672B1/ko not_active Expired - Fee Related
- 2008-02-13 CA CA2715839A patent/CA2715839C/en not_active Expired - Fee Related
- 2008-02-13 JP JP2010546739A patent/JP5312486B2/ja not_active Expired - Fee Related
- 2008-02-13 PL PL08768910T patent/PL2242752T3/pl unknown
- 2008-02-13 BR BRPI0822323-8A patent/BRPI0822323A2/pt not_active IP Right Cessation
- 2008-02-13 SI SI200830809T patent/SI2242752T1/sl unknown
- 2008-02-13 MX MX2010008863A patent/MX2010008863A/es active IP Right Grant
- 2008-02-13 AU AU2008350334A patent/AU2008350334B2/en not_active Ceased
- 2008-02-13 PT PT08768910T patent/PT2242752E/pt unknown
- 2008-02-13 CN CN2008801286329A patent/CN102007122B/zh not_active Expired - Fee Related
- 2008-02-13 EP EP08768910A patent/EP2242752B1/en not_active Not-in-force
- 2008-02-13 NZ NZ587557A patent/NZ587557A/en not_active IP Right Cessation
- 2008-02-13 WO PCT/US2008/053779 patent/WO2009102325A1/en not_active Ceased
- 2008-02-13 EA EA201001274A patent/EA018088B1/ru not_active IP Right Cessation
- 2008-02-13 ES ES08768910T patent/ES2391600T3/es active Active
- 2008-02-13 DK DK08768910.5T patent/DK2242752T3/da active
-
2010
- 2010-08-04 ZA ZA2010/05573A patent/ZA201005573B/en unknown
- 2010-08-08 IL IL207469A patent/IL207469A/en not_active IP Right Cessation
-
2012
- 2012-10-26 CY CY20121101023T patent/CY1113259T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN102007122B (zh) | 2013-09-04 |
| EP2242752B1 (en) | 2012-08-08 |
| DK2242752T3 (da) | 2012-11-19 |
| CA2715839C (en) | 2014-12-09 |
| HRP20120706T1 (hr) | 2012-09-30 |
| JP2011511833A (ja) | 2011-04-14 |
| MX2010008863A (es) | 2010-09-07 |
| ES2391600T3 (es) | 2012-11-28 |
| AU2008350334B2 (en) | 2013-10-17 |
| KR101492672B1 (ko) | 2015-02-16 |
| CN102007122A (zh) | 2011-04-06 |
| IL207469A0 (en) | 2010-12-30 |
| EP2242752A1 (en) | 2010-10-27 |
| CY1113259T1 (el) | 2016-04-13 |
| EA018088B1 (ru) | 2013-05-30 |
| IL207469A (en) | 2016-03-31 |
| EA201001274A1 (ru) | 2011-06-30 |
| AU2008350334A1 (en) | 2009-08-20 |
| CA2715839A1 (en) | 2009-08-20 |
| KR20100113629A (ko) | 2010-10-21 |
| NZ587557A (en) | 2012-04-27 |
| PT2242752E (pt) | 2012-10-29 |
| PL2242752T3 (pl) | 2012-12-31 |
| HK1144194A1 (en) | 2011-02-02 |
| JP5312486B2 (ja) | 2013-10-09 |
| ZA201005573B (en) | 2012-01-25 |
| WO2009102325A1 (en) | 2009-08-20 |
| SI2242752T1 (sl) | 2013-03-29 |
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