BRPI0920053A2 - pirazolilaminopiridinas como inibidores da fak - Google Patents

pirazolilaminopiridinas como inibidores da fak

Info

Publication number
BRPI0920053A2
BRPI0920053A2 BRPI0920053A BRPI0920053A BRPI0920053A2 BR PI0920053 A2 BRPI0920053 A2 BR PI0920053A2 BR PI0920053 A BRPI0920053 A BR PI0920053A BR PI0920053 A BRPI0920053 A BR PI0920053A BR PI0920053 A2 BRPI0920053 A2 BR PI0920053A2
Authority
BR
Brazil
Prior art keywords
pyrazolylaminopyridines
fak inhibitors
fak
inhibitors
Prior art date
Application number
BRPI0920053A
Other languages
English (en)
Inventor
Hong Lin
Jerry Leroy Adams
Jiri Kasparec
Mark Mellinger
Neil W Johnson
Ren Xie
Thomas H Faitg
Xin Peng
Original Assignee
Glaxosmithkline Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42132177&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0920053(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Glaxosmithkline Llc filed Critical Glaxosmithkline Llc
Publication of BRPI0920053A2 publication Critical patent/BRPI0920053A2/pt
Publication of BRPI0920053B1 publication Critical patent/BRPI0920053B1/pt
Publication of BRPI0920053B8 publication Critical patent/BRPI0920053B8/pt

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5752Immunoassay; Biospecific binding assay; Materials therefor for cancer of the lungs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
BRPI0920053A 2008-10-27 2009-10-27 composto pirazolilaminopiridina, composição contendo o dito composto e uso do mesmo para tratar câncer BRPI0920053B8 (pt)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US10856808P 2008-10-27 2008-10-27
US61/108,568 2008-10-27
US17851709P 2009-05-15 2009-05-15
US61/178,517 2009-05-15
US24243209P 2009-09-15 2009-09-15
US61/242.432 2009-09-15
PCT/US2009/062163 WO2010062578A1 (en) 2008-10-27 2009-10-27 Pyrazolylaminopyridines as inhibitors of fak

Publications (3)

Publication Number Publication Date
BRPI0920053A2 true BRPI0920053A2 (pt) 2015-12-15
BRPI0920053B1 BRPI0920053B1 (pt) 2019-11-26
BRPI0920053B8 BRPI0920053B8 (pt) 2021-05-25

Family

ID=42132177

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0920053A BRPI0920053B8 (pt) 2008-10-27 2009-10-27 composto pirazolilaminopiridina, composição contendo o dito composto e uso do mesmo para tratar câncer

Country Status (35)

Country Link
US (6) US20110207743A1 (pt)
EP (1) EP2421537B1 (pt)
JP (1) JP5642689B2 (pt)
KR (1) KR101512217B1 (pt)
CN (1) CN102264371B (pt)
AR (1) AR073993A1 (pt)
AU (1) AU2009320144B2 (pt)
BR (1) BRPI0920053B8 (pt)
CA (1) CA2741760C (pt)
CL (1) CL2011000933A1 (pt)
CO (1) CO6361929A2 (pt)
CR (1) CR20110264A (pt)
CY (1) CY1116399T1 (pt)
DK (1) DK2421537T3 (pt)
DO (1) DOP2011000113A (pt)
EA (1) EA021927B1 (pt)
ES (1) ES2539835T3 (pt)
HR (1) HRP20150531T1 (pt)
IL (1) IL212444A (pt)
JO (1) JO3067B1 (pt)
MA (1) MA32727B1 (pt)
MX (1) MX2011004369A (pt)
MY (1) MY161890A (pt)
NZ (1) NZ592477A (pt)
PE (1) PE20110941A1 (pt)
PL (1) PL2421537T3 (pt)
PT (1) PT2421537E (pt)
RS (1) RS54045B1 (pt)
SG (1) SG195608A1 (pt)
SI (1) SI2421537T1 (pt)
SM (1) SMT201500157B (pt)
TW (1) TWI454467B (pt)
UY (1) UY32200A (pt)
WO (1) WO2010062578A1 (pt)
ZA (1) ZA201102892B (pt)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8338441B2 (en) 2009-05-15 2012-12-25 Gilead Sciences, Inc. Inhibitors of human immunodeficiency virus replication
US20120244141A1 (en) 2010-09-28 2012-09-27 Boehringer Ingelheim International Gmbh Stratification of cancer patients for susceptibility to therapy with PTK2 inhibitors
EP2667871A4 (en) * 2011-01-26 2014-07-09 Glaxosmithkline Intellectual Property Ltd COMBINATIONS
US9174946B2 (en) 2011-02-17 2015-11-03 Cancer Therapeutics Crc Pty Ltd Selective FAK inhibitors
US20130324532A1 (en) 2011-02-17 2013-12-05 Cancer Therapeutics Crc Pty Limited Fak inhibitors
EP2726079A4 (en) * 2011-06-28 2014-12-17 Glaxosmithkline Ip No 2 Ltd ADMINISTRATIVE AND TREATMENT PROCEDURES
US10106834B2 (en) 2013-10-09 2018-10-23 The General Hospital Corporation Methods of diagnosing and treating B cell acute lymphoblastic leukemia
US10532056B2 (en) 2015-06-29 2020-01-14 Verastem, Inc. Therapeutic compositions, combinations, and methods of use
CN108948019B (zh) * 2017-05-18 2022-07-08 广东东阳光药业有限公司 黏着斑激酶抑制剂及其用途
WO2019117813A1 (en) * 2017-12-15 2019-06-20 National University Of Singapore Focal adhesion kinase targeted therapeutics for the treatment of glaucoma and fibrosis
US20210030703A1 (en) 2018-03-12 2021-02-04 INSERM (Institut National de la Santé et de la Recherche Médicale) Use of caloric restriction mimetics for potentiating chemo-immunotherapy for the treatment of cancers
CN108912095B (zh) * 2018-08-09 2019-08-20 广州安岩仁医药科技有限公司 苯并咪唑类化合物及其制备方法和应用
EP3856190A4 (en) * 2018-09-27 2022-09-21 Dana Farber Cancer Institute, Inc. DEGRADATION OF FAK OR FAK AND ALK BY CONJUGATION OF FAK AND ALK INHIBITORS WITH E3-LIGASE LIGANDS AND METHODS OF USE
KR102709127B1 (ko) * 2018-12-27 2024-09-24 하이노바 파마슈티컬스 인코포레이티드 Fak 억제제 및 그 약물 조합물
KR102866499B1 (ko) * 2019-03-15 2025-10-02 더 제너럴 하스피탈 코포레이션 Tead 전사인자의 신규한 소분자 저해제
CN113387947B (zh) * 2021-07-12 2022-07-01 中国科学院成都生物研究所 调节雌激素受体合成活性的吡唑并吡啶衍生物
TW202508595A (zh) 2023-05-04 2025-03-01 美商銳新醫藥公司 用於ras相關疾病或病症之組合療法
US20250049810A1 (en) 2023-08-07 2025-02-13 Revolution Medicines, Inc. Methods of treating a ras protein-related disease or disorder
AU2024360465A1 (en) 2023-10-12 2026-04-09 Revolution Medicines, Inc. Macrocyclic ras inhibitors
WO2025171296A1 (en) 2024-02-09 2025-08-14 Revolution Medicines, Inc. Ras inhibitors
TW202547461A (zh) 2024-05-17 2025-12-16 美商銳新醫藥公司 Ras抑制劑
WO2025255438A1 (en) 2024-06-07 2025-12-11 Revolution Medicines, Inc. Methods of treating a ras protein-related disease or disorder
WO2025265060A1 (en) 2024-06-21 2025-12-26 Revolution Medicines, Inc. Therapeutic compositions and methods for managing treatment-related effects
WO2026006747A1 (en) 2024-06-28 2026-01-02 Revolution Medicines, Inc. Ras inhibitors
WO2026015796A1 (en) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Methods of treating a ras related disease or disorder
WO2026015790A1 (en) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Methods of treating a ras related disease or disorder
WO2026015801A1 (en) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Methods of treating a ras related disease or disorder
WO2026015825A1 (en) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Use of ras inhibitor for treating pancreatic cancer
WO2026050446A1 (en) 2024-08-29 2026-03-05 Revolution Medicines, Inc. Ras inhibitors
WO2026072904A2 (en) 2024-09-26 2026-04-02 Revolution Medicines, Inc. Compositions and methods for treating lung cancer
CN119499253A (zh) * 2024-11-15 2025-02-25 贵州医科大学 一种化合物在抑制Aurora和JAK激酶家族活性及在几种肿瘤治疗方面的应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US166139A (en) * 1875-07-27 Improvement in dental pluggers
WO2000014105A1 (en) * 1998-09-08 2000-03-16 Agouron Pharmaceuticals, Inc. Modifications of the vegf receptor-2 protein and methods of use
US7102009B2 (en) * 2001-01-12 2006-09-05 Amgen Inc. Substituted amine derivatives and methods of use
PT1660458E (pt) * 2003-08-15 2012-04-27 Novartis Ag 2,4-pirimidinodiaminas úteis no tratamento de doenças neoplásicas, desordens inflamatórias e do sistema imunitário
GB0419161D0 (en) * 2004-08-27 2004-09-29 Novartis Ag Organic compounds
GB0419160D0 (en) * 2004-08-27 2004-09-29 Novartis Ag Organic compounds
EP1746096A1 (en) * 2005-07-15 2007-01-24 4Sc Ag 2-Arylbenzothiazole analogues and uses thereof in the treatment of cancer
EP2727909A1 (en) * 2007-03-16 2014-05-07 The Scripps Research Institute Inhibitors of focal adhesion kinase
WO2009105498A1 (en) * 2008-02-19 2009-08-27 Smithkline Beecham Corporation Anilinopyridines as inhibitors of fak
WO2009153589A1 (en) * 2008-06-17 2009-12-23 Astrazeneca Ab Pyridine compounds

Also Published As

Publication number Publication date
US9012479B2 (en) 2015-04-21
HRP20150531T1 (hr) 2015-06-19
BRPI0920053B1 (pt) 2019-11-26
CL2011000933A1 (es) 2011-10-21
ZA201102892B (en) 2012-02-29
IL212444A0 (en) 2011-06-30
ES2539835T3 (es) 2015-07-06
US20110269774A1 (en) 2011-11-03
PL2421537T3 (pl) 2015-08-31
AU2009320144A1 (en) 2010-06-03
SMT201500157B (it) 2015-09-07
JO3067B1 (ar) 2017-03-15
HK1161680A1 (en) 2012-08-03
SG195608A1 (en) 2013-12-30
CN102264371A (zh) 2011-11-30
KR101512217B1 (ko) 2015-04-15
CR20110264A (es) 2011-10-04
US20160095841A1 (en) 2016-04-07
US9446034B2 (en) 2016-09-20
IL212444A (en) 2015-11-30
EA021927B1 (ru) 2015-09-30
PT2421537E (pt) 2015-07-03
DOP2011000113A (es) 2011-07-15
CN102264371B (zh) 2013-10-02
DK2421537T3 (da) 2015-06-22
WO2010062578A1 (en) 2010-06-03
EP2421537B1 (en) 2015-04-08
CA2741760A1 (en) 2010-06-03
CA2741760C (en) 2016-02-23
PE20110941A1 (es) 2012-02-08
CY1116399T1 (el) 2017-02-08
MX2011004369A (es) 2011-05-25
TWI454467B (zh) 2014-10-01
AU2009320144B2 (en) 2013-11-21
EA201170617A1 (ru) 2011-12-30
TW201028394A (en) 2010-08-01
MA32727B1 (fr) 2011-10-02
UY32200A (es) 2010-05-31
BRPI0920053B8 (pt) 2021-05-25
JP2012506876A (ja) 2012-03-22
US20140107131A1 (en) 2014-04-17
JP5642689B2 (ja) 2014-12-17
US20100113475A1 (en) 2010-05-06
RS54045B1 (sr) 2015-10-30
EP2421537A4 (en) 2012-06-13
EP2421537A1 (en) 2012-02-29
AR073993A1 (es) 2010-12-15
NZ592477A (en) 2013-01-25
CO6361929A2 (es) 2012-01-20
MY161890A (en) 2017-05-15
KR20110080172A (ko) 2011-07-12
SI2421537T1 (sl) 2015-06-30
US20110207743A1 (en) 2011-08-25
US20150265589A1 (en) 2015-09-24

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B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
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B06T Formal requirements before examination [chapter 6.20 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

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B16C Correction of notification of the grant [chapter 16.3 patent gazette]

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