BRPI0906090A2 - substrato para análise de uma enzima, molécula e método para detectar atividade enzimática . - Google Patents

substrato para análise de uma enzima, molécula e método para detectar atividade enzimática .

Info

Publication number
BRPI0906090A2
BRPI0906090A2 BRPI0906090A BRPI0906090A BRPI0906090A2 BR PI0906090 A2 BRPI0906090 A2 BR PI0906090A2 BR PI0906090 A BRPI0906090 A BR PI0906090A BR PI0906090 A BRPI0906090 A BR PI0906090A BR PI0906090 A2 BRPI0906090 A2 BR PI0906090A2
Authority
BR
Brazil
Prior art keywords
enzyme
molecule
analysis
substrate
enzymatic activity
Prior art date
Application number
BRPI0906090A
Other languages
English (en)
Inventor
Blas Cerda
Mark Norman Bobrow
Original Assignee
Perkinelmar Las Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Perkinelmar Las Inc filed Critical Perkinelmar Las Inc
Publication of BRPI0906090A2 publication Critical patent/BRPI0906090A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/924—Hydrolases (3) acting on glycosyl compounds (3.2)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2458/00—Labels used in chemical analysis of biological material
    • G01N2458/15—Non-radioactive isotope labels, e.g. for detection by mass spectrometry

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
BRPI0906090A 2008-03-13 2009-03-13 substrato para análise de uma enzima, molécula e método para detectar atividade enzimática . BRPI0906090A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3621108P 2008-03-13 2008-03-13
PCT/US2009/037087 WO2009114763A2 (en) 2008-03-13 2009-03-13 Enzymatic substrates for multiple detection systems

Publications (1)

Publication Number Publication Date
BRPI0906090A2 true BRPI0906090A2 (pt) 2016-05-03

Family

ID=41065853

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0906090A BRPI0906090A2 (pt) 2008-03-13 2009-03-13 substrato para análise de uma enzima, molécula e método para detectar atividade enzimática .

Country Status (9)

Country Link
US (2) US8173784B2 (pt)
EP (2) EP2265645A4 (pt)
JP (1) JP2011514809A (pt)
CN (1) CN102014929A (pt)
AU (1) AU2009223222A1 (pt)
BR (1) BRPI0906090A2 (pt)
CA (1) CA2718276A1 (pt)
IL (1) IL208521A0 (pt)
WO (1) WO2009114763A2 (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201017875D0 (en) * 2010-10-22 2010-12-01 Johnson Matthey Plc Method of identifying a material
US20140274798A1 (en) 2013-03-15 2014-09-18 University Of Washington Through Its Center For Commercialization Compounds and methods relating to lysosomal storage disorders
JP6624482B2 (ja) * 2014-07-29 2019-12-25 俊 保坂 超小型加速器および超小型質量分析装置
US9575064B2 (en) 2014-09-02 2017-02-21 Perkinelmer Health Sciences, Inc. Methods relating to testing for lysosomal storage disorders
PE20190393A1 (es) 2016-04-28 2019-03-13 Spark Therapeutics Inc Ensayo de potencia relativa para un vector viral que codifica isomero hidrolasas
WO2019056251A1 (zh) * 2017-09-21 2019-03-28 大连理工大学 一组用于氨基/酚羟基标记的同位素标记试剂及其合成方法
CN111269280B (zh) * 2020-03-27 2021-07-13 江苏豪思睦可生物科技有限公司 用于检测溶酶体贮积症相关酶的化合物、对应内标和试剂盒
CA3200234A1 (en) 2020-11-25 2022-06-02 Daryl C. Drummond Lipid nanoparticles for delivery of nucleic acids, and related methods of use
EP4531819A2 (en) 2022-05-25 2025-04-09 Akagera Medicines, Inc. Lipid nanoparticles for delivery of nucleic acids and methods of use thereof

Family Cites Families (22)

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Publication number Priority date Publication date Assignee Title
US2931833A (en) * 1954-12-29 1960-04-05 Armour & Co Benzyldialkyl-2-(1-hydroxy-alkyl) alkyl ammonium chloride compounds
US3636114A (en) * 1968-07-16 1972-01-18 Union Carbide Corp Novel quaternary ammonium compounds and method for preparation thereof
IT1116037B (it) * 1979-04-23 1986-02-10 Sigma Tau Ind Farmaceuti Esteri e ammidi di acil carnitine loro procedimenti di preparazione e loro uso terapeutico
US4968785A (en) * 1988-05-17 1990-11-06 Henkel Kommanditgesellschaft Auf Aktien Substituted glycoside compositions
JPH0243560A (ja) * 1988-08-04 1990-02-14 Canon Inc 電子写真感光体
US5138043A (en) * 1989-12-07 1992-08-11 Union Carbide Chemicals & Plastics Technology Corporation Alkoxylated alkyl glucoside ether quaternaries useful in personal care
IT1261984B (it) * 1993-06-22 1996-06-11 Avantgarde Spa Uso di esteri della l-carnitina o di acil l- carnitine con idrossiacidi per produrre composizioni farmaceutiche per il trattamento di affezioni cutanee.
EP0710107A4 (en) * 1993-07-23 1997-05-28 Biomembrane Inst DERIVATIVES OF N, N, N-TRIMETHYLSPHINGOSINE
US5627171A (en) * 1994-04-11 1997-05-06 Oncomembrane, Inc. Sphingosine-1-phosphate/trimethylsphingosine composition
WO1997014028A2 (en) 1995-10-11 1997-04-17 Luminex Corporation Multiplexed analysis of clinical specimens apparatus and method
FR2767134B1 (fr) * 1997-08-08 1999-09-24 Ceca Sa N-(dialkylamino)alkyl glycosylamines et derives, procedes de preparation,composition les contenant et utilisations, notamment dans le domaine de la cosmetique.
EP1329513B1 (en) 1998-08-25 2011-12-07 University of Washington Rapid quantitative analysis of proteins or protein function in complex mixtures
IT1306129B1 (it) * 1999-04-13 2001-05-30 Sigma Tau Ind Farmaceuti Esteri della l-carnitina o di alcanoil l-carnitine utilizzabili comelipidi cationici per l'immissione intracellulare di composti
DE60040603D1 (de) 1999-08-17 2008-12-04 Luminex Corp Verfahren zur analyse einer mehrzahl von proben verschiedenen ursprungs auf einen analyten
US20020042536A1 (en) 1999-10-08 2002-04-11 Prasad S. Raje Preparation of amino-protected lysine derivatives
WO2001077674A2 (en) 2000-04-10 2001-10-18 Mcw Research Foundation, Inc. Fluorescent hplc assay for 20-hete and other p-450 metabolites of arachidonic acid
JP4896708B2 (ja) * 2003-02-05 2012-03-14 ジーイー・ヘルスケア・バイオサイエンス・コーポレイション 新規リンカー類を有する末端リン酸標識ヌクレオチド類
WO2005101017A1 (en) * 2004-04-07 2005-10-27 Genentech, Inc. Mass spectrometry of antibody conjugates
EP1932888A4 (en) * 2005-07-28 2010-01-13 Shinichiro Isobe MARKING COLOR FOR BIOMOLECULES, MARKING ARRANGEMENT, AND METHOD FOR DETECTING A BIOMOLECULE
JP4364197B2 (ja) 2005-12-27 2009-11-11 日本リライアンス株式会社 交流電源装置およびその装置におけるアーク抑制方法
BRPI0709289A2 (pt) * 2006-03-13 2011-07-05 Perkinelmer Las Inc substrato para análise espectrométrica de massa de uma enzima, processo para analise espectrométrica de massa de uma enzima, embalagem comercial e método para usar o dito substrato
US8268865B2 (en) * 2007-05-11 2012-09-18 Rempex Pharmaceuticals, Inc. Quaternary alkyl ammonium bacterial efflux pump inhibitors and therapeutic uses thereof

Also Published As

Publication number Publication date
IL208521A0 (en) 2011-07-31
EP2706121A1 (en) 2014-03-12
US20090253117A1 (en) 2009-10-08
EP2265645A4 (en) 2011-03-23
US8173784B2 (en) 2012-05-08
WO2009114763A2 (en) 2009-09-17
CA2718276A1 (en) 2009-09-17
CN102014929A (zh) 2011-04-13
WO2009114763A3 (en) 2009-11-19
US8791246B2 (en) 2014-07-29
US20120190043A1 (en) 2012-07-26
JP2011514809A (ja) 2011-05-12
EP2265645A2 (en) 2010-12-29
AU2009223222A1 (en) 2009-09-17

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 6A E 7A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2385 DE 20-09-2016 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.