BRPI0906352A2 - Derivado de tiazol e uso do mesmo como inibidores de vap-1 - Google Patents

Derivado de tiazol e uso do mesmo como inibidores de vap-1

Info

Publication number: BRPI0906352A2
Authority: BR; Brazil
Prior art keywords: thiazole; inhibitors; derivative; thiazole derivative; thiazole inhibitors
Prior art date: 2008-01-31

Application number

BRPI0906352-8A

Other languages

English (en)

Inventor

Tatsuya Matsukawa

Kazuhiro Masuzaki

Yosuke Kawai

Akiko Kawasaki

Akiko Akasaka

Makoto Takewaki

Original Assignee

R Tech Ueno Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2008-01-31

Filing date

2009-01-30

Publication date

2015-07-07

2009-01-30 Application filed by R Tech Ueno Ltd filed Critical R Tech Ueno Ltd

2015-07-07 Publication of BRPI0906352A2 publication Critical patent/BRPI0906352A2/pt

Links

FZWLAAWBMGSTSO-UHFFFAOYSA-N Thiazole Chemical compound C1=CSC=N1 FZWLAAWBMGSTSO-UHFFFAOYSA-N 0.000 title 1
239000003112 inhibitor Substances 0.000 title 1
150000007979 thiazole derivatives Chemical class 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/44—Acylated amino or imino radicals
- C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/12—Ophthalmic agents for cataracts
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Ophthalmology & Optometry (AREA)
Physical Education & Sports Medicine (AREA)
Immunology (AREA)
Diabetes (AREA)
Neurosurgery (AREA)
Heart & Thoracic Surgery (AREA)
Dermatology (AREA)
Rheumatology (AREA)
Cardiology (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Pulmonology (AREA)
Orthopedic Medicine & Surgery (AREA)
Hematology (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Urology & Nephrology (AREA)
Obesity (AREA)
Hospice & Palliative Care (AREA)
Vascular Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Thiazole And Isothizaole Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

BRPI0906352-8A 2008-01-31 2009-01-30 Derivado de tiazol e uso do mesmo como inibidores de vap-1 BRPI0906352A2 (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP2008021588		2008-01-31
PCT/JP2009/052015 WO2009096609A1 (en)	2008-01-31	2009-01-30	Thiazole derivative and use thereof as vap-1 inhibitor

Publications (1)

Publication Number	Publication Date
BRPI0906352A2 true BRPI0906352A2 (pt)	2015-07-07

Family

ID=40546096

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI0906352-8A BRPI0906352A2 (pt)	2008-01-31	2009-01-30	Derivado de tiazol e uso do mesmo como inibidores de vap-1

Country Status (17)

Country	Link
US (1)	US8507690B2 (pt)
EP (4)	EP2639229B9 (pt)
JP (1)	JP5415430B2 (pt)
KR (1)	KR101622414B1 (pt)
CN (1)	CN101932568B (pt)
AR (1)	AR070336A1 (pt)
AU (1)	AU2009209885B2 (pt)
BR (1)	BRPI0906352A2 (pt)
CA (1)	CA2712962C (pt)
DK (1)	DK2639229T3 (pt)
ES (2)	ES2527014T3 (pt)
MX (1)	MX2010008460A (pt)
NZ (1)	NZ587205A (pt)
PT (1)	PT2639229E (pt)
RU (1)	RU2496776C9 (pt)
TW (1)	TWI437986B (pt)
WO (1)	WO2009096609A1 (pt)

Families Citing this family (17)

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TWI490214B (zh) *	2008-05-30	2015-07-01	艾德克上野股份有限公司	苯或噻吩衍生物及該等作為ｖａｐ－１抑制劑之用途
UA112154C2 (uk)	2009-09-08	2016-08-10	Біоті Терапіс Корп.	Застосування повністю людського анти-vap-1-антитіла для лікування фіброзних станів
JP5947724B2 (ja) *	2009-12-21	2016-07-06	アンスティチュナショナルドゥラサンテエドゥラルシェルシュメディカル	シクロフィリンの新しいインヒビター及びその使用
TWI594764B (zh) *	2010-04-12	2017-08-11	生化治療公司	治療用途
KR101879011B1 (ko) *	2011-03-15	2018-07-16	아스테라스 세이야쿠 가부시키가이샤	구아니딘 화합물
CA2915163A1 (en)	2013-06-12	2014-12-18	Proximagen Limited	New therapeutic uses of enzyme inhibitors
WO2015189534A1 (en)	2014-06-12	2015-12-17	Proximagen Limited	Vap-1 inhibitors for treating muscular dystrophy
JP2018080113A (ja)	2015-05-27	2018-05-24	株式会社アールテック・ウエノ	脳梗塞処置剤
JP2018076236A (ja)	2015-06-05	2018-05-17	株式会社アールテック・ウエノ	がんを処置するための医薬組成物
FR3037954B1 (fr) *	2015-06-24	2017-08-11	Michelin & Cie	Procede de synthese de molecules azo-dicarbonylees porteuses de groupes associatifs
US20180360808A1 (en)	2015-12-07	2018-12-20	Benevolentai Cambridge Limited	Vap-1 inhibitors for treating pain
TW201828939A (zh) *	2016-11-28	2018-08-16	日商帝人製藥股份有限公司	糖尿病性腎病之治療藥或預防藥
US11471508B2 (en)	2019-05-09	2022-10-18	The Feinstein Institutes For Medical Research	HMGB1 antagonist treatment of diabetic peripheral neuropathy
IL322277A (en)	2019-05-09	2025-09-01	Feinstein Institutes For Medical Research	Thio-semicarbazide compounds and their use
US11883461B2 (en)	2019-05-09	2024-01-30	The Feinstein Institutes For Medical Research	HMGB1 antagonist treatment of severe sepsis
SE544131C2 (en) *	2020-03-16	2022-01-04	Pvac Medical Tech Ltd	Use of substance and pharmaceutical composition thereof, and medical treatments or uses thereof
EP4177245A1 (en) *	2020-07-10	2023-05-10	Adama Agan Ltd.	Process and intermediates for the preparation of fenoxasulfone

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IT1181871B (it)	1985-04-01	1987-09-30	Consiglio Nazionale Ricerche	Inibitori selettivi delle benzilamminossidasi rispetto ad altre amminossidasi
TW205041B (pt) *	1989-08-07	1993-05-01	Fujisawa Pharmaceutical Co
WO1993023023A1 (en)	1992-05-15	1993-11-25	University Of Saskatchewan	Method for preventing endothelium damage in mammals and for alleviating pain associated with gout and arthritis
US6114365A (en) *	1999-08-12	2000-09-05	Pharmacia & Upjohn S.P.A.	Arylmethyl-carbonylamino-thiazole derivatives, process for their preparation, and their use as antitumor agents
CN1450997A (zh) *	2000-07-05	2003-10-22	拜奥泰治疗公司	含铜的胺氧化酶的抑制剂
ES2168084B1 (es)	2000-11-07	2003-11-16	Univ Barcelona	Combinacion de aminas y compuestos de vanadio (iv) (v) para el tratatamiento y/o la prevencion de la diabetes mellitus.
AU2002214505A1 (en)	2000-11-09	2002-05-21	Biovitrum Ab	New use of 4, 5, 6, 7-tetrahydroimidazo-(4,5-c)pyridine derivatives
TWI336696B (en) *	2003-01-27	2011-02-01	Astellas Pharma Inc	Thiazole derivatives
CN100491361C (zh) *	2003-01-27	2009-05-27	安斯泰来制药有限公司	噻唑衍生物及其作为vap-1抑制剂的用途
KR20120045062A (ko) *	2003-03-31	2012-05-08	가부시키가이샤 아루떼꾸 우에노	혈관 과투과 질환의 치료방법
CN1933833B (zh) *	2004-03-18	2011-09-07	株式会社·R-技术上野	含有噻唑衍生物的含水组合物
DE602005013793D1 (de)	2004-07-27	2009-05-20	Astellas Pharma Inc	Thiazolderivate mit vap-1-hemmender wirkung
EP1791835A2 (en)	2004-09-09	2007-06-06	Astellas Pharma Inc.	Thiazole derivatives having vap-1 inhibitory activity
WO2008066145A1 (en) *	2006-11-30	2008-06-05	R-Tech Ueno, Ltd.	Thiazole derivative and use thereof as vap-1 inhibitor
US20100190834A1 (en) *	2007-06-25	2010-07-29	R-Tech Ueno, Ltd.	Composition for ophtalmic disease associated with hypoxia or ischemia
CN101903045B (zh)	2007-10-19	2013-03-13	株式会社·R-技术上野	用于治疗白内障的药物组合物

2009
- 2009-01-23 TW TW098102784A patent/TWI437986B/zh not_active IP Right Cessation
- 2009-01-30 WO PCT/JP2009/052015 patent/WO2009096609A1/en not_active Ceased
- 2009-01-30 PT PT131721268T patent/PT2639229E/pt unknown
- 2009-01-30 US US12/864,773 patent/US8507690B2/en not_active Expired - Fee Related
- 2009-01-30 CA CA2712962A patent/CA2712962C/en not_active Expired - Fee Related
- 2009-01-30 MX MX2010008460A patent/MX2010008460A/es active IP Right Grant
- 2009-01-30 JP JP2010529187A patent/JP5415430B2/ja not_active Expired - Fee Related
- 2009-01-30 EP EP13172126.8A patent/EP2639229B9/en not_active Not-in-force
- 2009-01-30 AU AU2009209885A patent/AU2009209885B2/en not_active Ceased
- 2009-01-30 AR ARP090100311A patent/AR070336A1/es unknown
- 2009-01-30 ES ES13172126.8T patent/ES2527014T3/es active Active
- 2009-01-30 EP EP13172130.0A patent/EP2650287B9/en not_active Not-in-force
- 2009-01-30 EP EP13185390.5A patent/EP2676955B1/en not_active Not-in-force
- 2009-01-30 RU RU2010136301/04A patent/RU2496776C9/ru not_active IP Right Cessation
- 2009-01-30 EP EP09705640.2A patent/EP2252604B1/en not_active Not-in-force
- 2009-01-30 NZ NZ587205A patent/NZ587205A/en not_active IP Right Cessation
- 2009-01-30 ES ES09705640.2T patent/ES2452834T3/es active Active
- 2009-01-30 CN CN200980103755.1A patent/CN101932568B/zh not_active Expired - Fee Related
- 2009-01-30 DK DK13172126.8T patent/DK2639229T3/da active
- 2009-01-30 KR KR1020107017937A patent/KR101622414B1/ko not_active Expired - Fee Related
- 2009-01-30 BR BRPI0906352-8A patent/BRPI0906352A2/pt active Search and Examination

Also Published As

Publication number	Publication date
CA2712962A1 (en)	2009-08-06
EP2252604A1 (en)	2010-11-24
AU2009209885B2 (en)	2013-12-05
JP2011510911A (ja)	2011-04-07
EP2676955B1 (en)	2015-03-11
PT2639229E (pt)	2015-02-04
AR070336A1 (es)	2010-03-31
KR20100112623A (ko)	2010-10-19
TWI437986B (zh)	2014-05-21
RU2496776C9 (ru)	2014-12-20
CA2712962C (en)	2016-08-16
EP2639229B1 (en)	2014-11-26
RU2010136301A (ru)	2012-03-10
EP2252604B1 (en)	2014-01-08
AU2009209885A1 (en)	2009-08-06
EP2650287B9 (en)	2015-08-05
US8507690B2 (en)	2013-08-13
JP5415430B2 (ja)	2014-02-12
NZ587205A (en)	2012-06-29
RU2496776C2 (ru)	2013-10-27
TW200934488A (en)	2009-08-16
MX2010008460A (es)	2010-08-30
WO2009096609A1 (en)	2009-08-06
EP2639229B9 (en)	2015-08-05
HK1185348A1 (en)	2014-02-14
EP2650287A1 (en)	2013-10-16
EP2676955A1 (en)	2013-12-25
ES2452834T3 (es)	2014-04-02
HK1152293A1 (en)	2012-02-24
KR101622414B1 (ko)	2016-05-18
ES2527014T3 (es)	2015-01-19
CN101932568A (zh)	2010-12-29
EP2639229A2 (en)	2013-09-18
EP2639229A3 (en)	2013-12-25
EP2650287B1 (en)	2014-12-03
CN101932568B (zh)	2014-08-06
US20110015240A1 (en)	2011-01-20
DK2639229T3 (da)	2015-02-02

Legal Events

Date	Code	Title	Description
2017-10-10	B07D	Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
2018-04-17	B06F	Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
2018-11-27	B08F	Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]	Free format text: REFERENTE A 10A ANUIDADE.
2019-03-26	B08K	Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]	Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2499 DE 27-11-2018 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.
2019-04-16	B07E	Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]	Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

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DOP2010000260A (es)	2010-10-15	Derivado heterociclico fusionado y su uso
BRPI0906186A2 (pt)	2015-09-22	composto e uso de um composto
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