BRPI0906612A2 - Composição para preservar células, tecidos e órgãos, e, métodos para usar a composição e de preparação de uima composição - Google Patents
Composição para preservar células, tecidos e órgãos, e, métodos para usar a composição e de preparação de uima composiçãoInfo
- Publication number
- BRPI0906612A2 BRPI0906612A2 BRPI0906612-8A BRPI0906612A BRPI0906612A2 BR PI0906612 A2 BRPI0906612 A2 BR PI0906612A2 BR PI0906612 A BRPI0906612 A BR PI0906612A BR PI0906612 A2 BRPI0906612 A2 BR PI0906612A2
- Authority
- BR
- Brazil
- Prior art keywords
- composition
- organs
- tissues
- preparation
- methods
- Prior art date
Links
- 210000000056 organ Anatomy 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Toxicology (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Materials For Medical Uses (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR20080001477 | 2008-01-04 | ||
| PCT/KR2009/000031 WO2009088192A2 (ko) | 2008-01-04 | 2009-01-05 | 세포, 조직 및 장기 보존 효과를 갖는 인돌 및 인다졸 유도체 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0906612A2 true BRPI0906612A2 (pt) | 2015-07-14 |
Family
ID=40853579
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0906612-8A BRPI0906612A2 (pt) | 2008-01-04 | 2009-01-05 | Composição para preservar células, tecidos e órgãos, e, métodos para usar a composição e de preparação de uima composição |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US20100291533A1 (pt) |
| EP (1) | EP2230238B1 (pt) |
| JP (1) | JP5188583B2 (pt) |
| KR (1) | KR101098583B1 (pt) |
| CN (1) | CN101952281B (pt) |
| BR (1) | BRPI0906612A2 (pt) |
| RU (1) | RU2460525C2 (pt) |
| WO (1) | WO2009088192A2 (pt) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113406051B (zh) * | 2021-06-17 | 2022-07-05 | 中国农业科学院农业质量标准与检测技术研究所 | 一种联合筛查鱼上皮细胞早期损伤的高通量分析方法 |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006047022A1 (en) | 2004-10-25 | 2006-05-04 | Virginia Commonwealth University | Nuclear sulfated oxysterol, potent regulator of cholesterol homeostasis, for therapy of hypercholesterolemia, hyperlipidemia, and atherosclerosis |
| DK2178870T3 (en) * | 2007-08-17 | 2018-10-22 | Lg Chemical Ltd | INDOLE AND INDAZOLIC COMPOUNDS AS AN INHIBITOR OF CELLULAR NECROSE |
| KR101133772B1 (ko) | 2007-12-20 | 2012-04-24 | 주식회사 엘지생명과학 | 글루코키나아제 활성화제 및 이를 활성성분으로 함유하는 약제학적 조성물 |
| RS53378B (sr) | 2008-04-10 | 2014-10-31 | Takeda Pharmaceutical Company Limited | Jedinjenja sa kondenzovanim prstenom i njihova upotreba |
| TW201119651A (en) * | 2009-10-26 | 2011-06-16 | Lg Life Sciences Ltd | Pharmaceutical composition comprising indole compound |
| US9034859B2 (en) | 2011-04-06 | 2015-05-19 | Virginia Commonwealth University | Sulfated oxysterol and oxysterol sulfation by hydroxysterol sulfotransferase promote lipid homeostasis and liver proliferation |
| US20150038500A1 (en) * | 2011-11-25 | 2015-02-05 | Catholic University Industry-Academic Cooperation Foundation | Pharmaceutical composition for preventing and treating ophthalmic disorders |
| KR101377478B1 (ko) * | 2012-05-10 | 2014-03-26 | 부산대학교 산학협력단 | 골량 저하 관련 질환의 예방 또는 치료용 약학 조성물 및 건강기능식품 |
| US10907193B2 (en) * | 2012-05-21 | 2021-02-02 | Acumen Detection, Llc | Methods and systems for the detection of ricin and other ribosome inactivating proteins |
| KR101941004B1 (ko) | 2013-03-25 | 2019-01-23 | 주식회사 엘지화학 | 조절 t 세포로의 분화 유도 및 증식 촉진을 통한 면역 반응 억제용 약학 조성물 |
| JP6315853B2 (ja) * | 2013-08-22 | 2018-04-25 | エルジー・ケム・リミテッド | 細胞壊死阻害剤としてのインドール化合物 |
| EP3037412B1 (en) * | 2013-08-22 | 2020-09-30 | LG Chem, Ltd. | Indole amide compound as inhibitor of necrosis |
| HRP20220112T1 (hr) * | 2013-12-24 | 2022-04-15 | Virginia Commonwealth University | Upotreba oksidacijskog sulfata kolesterola (ocs) za liječenje akutne insuficijencije jetre |
| WO2015111947A1 (en) * | 2014-01-24 | 2015-07-30 | Lg Life Sciences Ltd. | Composition for preventing or treating acute lung injury and acute respiratory distress syndrome |
| US20170057996A1 (en) * | 2014-02-20 | 2017-03-02 | University Of Florida Research Foundation, Incorporated | Macrocyclic therapeutic agents, methods of manufacture, and methods of treatment |
| US9814726B2 (en) * | 2014-04-18 | 2017-11-14 | Lg Chem, Ltd. | Composition for preventing or treating fatty liver diseases |
| CN104098498A (zh) * | 2014-07-30 | 2014-10-15 | 天津市斯芬克司药物研发有限公司 | 一种吲唑类化合物及其制备方法 |
| WO2016154452A2 (en) | 2015-03-24 | 2016-09-29 | Osiris Therapeutics, Inc. | Compositions comprising meniscal tissues and uses thereof |
| EP3494125B1 (en) | 2016-08-02 | 2022-06-22 | Virginia Commonwealth University | Compositions comprising 5-cholesten-3, 25-diol, 3-sulfate (25hc3s) or pharmaceutically acceptable salt thereof and at least one cyclic oligosaccharide |
| CA3044746A1 (en) * | 2016-11-24 | 2018-05-31 | Sigmadrugs Kutato Korlatolt Felelossegu Tarsasag | Compositions for organ preservation |
| WO2020256429A1 (ko) * | 2019-06-19 | 2020-12-24 | 주식회사 엘지화학 | 인돌 또는 인다졸 화합물의 제조방법 |
| WO2020256430A1 (ko) * | 2019-06-19 | 2020-12-24 | 주식회사 엘지화학 | 인돌 또는 인다졸 화합물의 제조방법 |
| EP3971186B1 (en) * | 2019-06-19 | 2023-08-02 | LG Chem, Ltd. | Preparation method for indole or indazole compound |
| WO2020256432A1 (ko) * | 2019-06-19 | 2020-12-24 | 주식회사 엘지화학 | 인돌 또는 인다졸 화합물의 제조방법 |
| CN110790923A (zh) * | 2019-10-12 | 2020-02-14 | 天津大学 | 一种γ-聚谷氨酸-接枝-吲哚结构伯胺及制备方法和应用 |
| CN115361866B (zh) * | 2020-03-31 | 2025-07-18 | 株式会社Lg化学 | 用于保护胰岛移植的组合物 |
| EP4382106A4 (en) * | 2021-04-12 | 2025-04-02 | MitoImmune Therapeutics Inc. | Composition for inhibiting inflammation or ageing of stem cells and method for inhibiting inflammation or ageing therewith |
| WO2022220518A1 (ko) | 2021-04-12 | 2022-10-20 | 주식회사 미토이뮨테라퓨틱스 | 5-[(1,1-디옥시도-4-티오몰포리닐)메틸]-2-페닐-n-(테트라하이드로-2h-피란-4-일)-1h-인돌-7-아민 황산염 및 이의 신규 결정형 |
| KR102780533B1 (ko) | 2021-04-12 | 2025-03-18 | 주식회사 미토이뮨테라퓨틱스 | 5-[(1,1-디옥시도-4-티오몰포리닐)메틸]-2-페닐-n-(테트라하이드로-2h-피란-4-일)-1h-인돌-7-아민의 신규 결정형 |
| KR102846783B1 (ko) | 2021-08-02 | 2025-08-19 | 주식회사 미토이뮨테라퓨틱스 | 신규한 인돌 유도체, 이를 포함하는 약학적 조성물, 및 이의 용도 |
| CN117794922A (zh) | 2021-08-02 | 2024-03-29 | 水疗免疫疗法有限公司 | 吲哚衍生物、其制备方法及其用途 |
| KR20240117495A (ko) | 2023-01-25 | 2024-08-01 | 주식회사 미토이뮨테라퓨틱스 | 치환기를 가지는 인돌 유도체, 및 약학적 용도 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE792078A (fr) * | 1971-12-01 | 1973-05-29 | Wander Ag Dr A | Nouveaux derives de l'indazole, leur preparation et leur application comme medicaments |
| DE2653005A1 (de) * | 1975-12-03 | 1977-06-08 | Sandoz Ag | Neue organische verbindungen, ihre verwendung und herstellung |
| JPS6160648A (ja) * | 1984-08-31 | 1986-03-28 | Teikoku Hormone Mfg Co Ltd | ２−（３，５−ジアルキル−４−ヒドロキシフエニル）インド−ル誘導体 |
| US5177088A (en) * | 1991-04-17 | 1993-01-05 | Hoechst-Roussel Pharmaceuticals Incorporated | Substituted 3-(pyridinylamino)-indoles |
| SE9302431D0 (sv) * | 1993-07-16 | 1993-07-16 | Ab Astra | Use of indenoindole compounds |
| WO1995007276A1 (en) | 1993-09-10 | 1995-03-16 | Eisai Co., Ltd. | Bicyclic heterocyclic sulfonamide and sulfonic ester derivatives |
| KR100383835B1 (ko) * | 1996-06-26 | 2003-08-27 | 쥬가이 세이야쿠 가부시키가이샤 | 신장질환치료제및장기보존제 |
| SE9702651D0 (sv) | 1997-07-09 | 1997-07-09 | Astra Pharma Prod | Novel compounds |
| AU2548699A (en) * | 1998-02-23 | 1999-09-06 | Rei Asakai | Cell death inhibitors |
| JP5230042B2 (ja) * | 1999-06-02 | 2013-07-10 | 株式会社ビーエムジー | 動物の細胞または臓器の保存剤およびその保存方法。 |
| WO2001015525A1 (en) * | 1999-08-31 | 2001-03-08 | Fujisawa Pharmaceutical Co., Ltd. | Organ preservatives |
| DE10009000A1 (de) | 2000-02-25 | 2001-08-30 | Basf Ag | Verfahren zur Herstellung substituierter Indole |
| US6897231B2 (en) * | 2000-07-31 | 2005-05-24 | Signal Pharmaceuticals, Inc. | Indazole derivatives as JNK inhibitors and compositions and methods related thereto |
| US6951946B2 (en) | 2002-03-19 | 2005-10-04 | Lexicon Pharmaceuticals, Inc. | Large scale synthesis of 1,2,4- and 1,3,4-oxadiazole carboxylates |
| US20040110802A1 (en) | 2002-08-23 | 2004-06-10 | Atli Thorarensen | Antibacterial benzoic acid derivatives |
| FR2873119B1 (fr) | 2004-07-13 | 2008-02-01 | Vichem Soc Par Actions Simplif | Procede perfectionne de fabrication d'acide phosphorique |
| WO2006053227A2 (en) * | 2004-11-10 | 2006-05-18 | Synta Pharmaceuticals Corp. | Il-12 modulatory compounds |
| US7741479B2 (en) * | 2004-12-07 | 2010-06-22 | Locus Pharmaceuticals, Inc. | Urea inhibitors of MAP kinases |
| US8957070B2 (en) * | 2005-04-20 | 2015-02-17 | Takeda Pharmaceutical Company Limited | Glucokinase activator compounds, methods of activating glucokinase and methods of treating diabetes and obesity |
| WO2007040289A1 (en) | 2005-10-05 | 2007-04-12 | Promeditech Inc. | Deformylase inhibitor, process for the preparation thereof, and composition comprising the same |
| RU2454415C9 (ru) * | 2006-10-19 | 2013-02-27 | Такеда Фармасьютикал Компани Лимитед | Производное индола |
| JP2008208086A (ja) * | 2007-02-27 | 2008-09-11 | Institute Of Physical & Chemical Research | ３−アミノ−２−インドリルブチロラクタム誘導体、その製造法、及びこれを有効成分とする医薬 |
| DK2178870T3 (en) * | 2007-08-17 | 2018-10-22 | Lg Chemical Ltd | INDOLE AND INDAZOLIC COMPOUNDS AS AN INHIBITOR OF CELLULAR NECROSE |
| KR101133772B1 (ko) * | 2007-12-20 | 2012-04-24 | 주식회사 엘지생명과학 | 글루코키나아제 활성화제 및 이를 활성성분으로 함유하는 약제학적 조성물 |
-
2009
- 2009-01-05 US US12/811,525 patent/US20100291533A1/en not_active Abandoned
- 2009-01-05 WO PCT/KR2009/000031 patent/WO2009088192A2/ko not_active Ceased
- 2009-01-05 RU RU2010132644/15A patent/RU2460525C2/ru active
- 2009-01-05 EP EP09700417.0A patent/EP2230238B1/en active Active
- 2009-01-05 KR KR1020090000363A patent/KR101098583B1/ko active Active
- 2009-01-05 BR BRPI0906612-8A patent/BRPI0906612A2/pt not_active Application Discontinuation
- 2009-01-05 JP JP2010541405A patent/JP5188583B2/ja active Active
- 2009-01-05 CN CN200980104944.0A patent/CN101952281B/zh active Active
-
2012
- 2012-06-27 US US13/534,682 patent/US8349885B2/en active Active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113406051B (zh) * | 2021-06-17 | 2022-07-05 | 中国农业科学院农业质量标准与检测技术研究所 | 一种联合筛查鱼上皮细胞早期损伤的高通量分析方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| JP5188583B2 (ja) | 2013-04-24 |
| US20100291533A1 (en) | 2010-11-18 |
| CN101952281B (zh) | 2014-04-02 |
| US8349885B2 (en) | 2013-01-08 |
| EP2230238B1 (en) | 2013-12-11 |
| WO2009088192A2 (ko) | 2009-07-16 |
| KR20090075638A (ko) | 2009-07-08 |
| CN101952281A (zh) | 2011-01-19 |
| RU2460525C2 (ru) | 2012-09-10 |
| JP2011509255A (ja) | 2011-03-24 |
| WO2009088192A9 (ko) | 2009-11-19 |
| EP2230238A2 (en) | 2010-09-22 |
| US20120270203A1 (en) | 2012-10-25 |
| WO2009088192A3 (ko) | 2009-10-01 |
| EP2230238A4 (en) | 2012-11-07 |
| KR101098583B1 (ko) | 2011-12-26 |
| RU2010132644A (ru) | 2012-02-10 |
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