BRPI0906960A2 - Partículas selhantes a vírus de influenza (vlps) recombinante em plantas transgênitas expressando hemaglutinina - Google Patents

Partículas selhantes a vírus de influenza (vlps) recombinante em plantas transgênitas expressando hemaglutinina

Info

Publication number
BRPI0906960A2
BRPI0906960A2 BRPI0906960-7A BRPI0906960A BRPI0906960A2 BR PI0906960 A2 BRPI0906960 A2 BR PI0906960A2 BR PI0906960 A BRPI0906960 A BR PI0906960A BR PI0906960 A2 BRPI0906960 A2 BR PI0906960A2
Authority
BR
Brazil
Prior art keywords
vlps
influenza virus
transgenic plants
plants expressing
recombinant influenza
Prior art date
Application number
BRPI0906960-7A
Other languages
English (en)
Inventor
Marc-Andre D Aoust
Manon Couture
Frédéric Ors
Sonia Trépanier
Pierre-Olivier Lavoie
Michèle Dargis
LOUIS-PHILIPPE VéZINA
Nathalie Landry
Original Assignee
Medicago Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CA002615372A external-priority patent/CA2615372A1/en
Application filed by Medicago Inc filed Critical Medicago Inc
Publication of BRPI0906960A2 publication Critical patent/BRPI0906960A2/pt
Publication of BRPI0906960A8 publication Critical patent/BRPI0906960A8/pt
Publication of BRPI0906960B1 publication Critical patent/BRPI0906960B1/pt

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    • C—CHEMISTRY; METALLURGY
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
    • C12N15/8258—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon for the production of oral vaccines (antigens) or immunoglobulins
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541—Mucosal route
    • A61K2039/543—Mucosal route intranasal
    • A—HUMAN NECESSITIES
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    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
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    • A61K2039/58—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
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    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16151—Methods of production or purification of viral material
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    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16171—Demonstrated in vivo effect
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    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16211—Influenzavirus B, i.e. influenza B virus
    • C12N2760/16222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16211—Influenzavirus B, i.e. influenza B virus
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    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
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BRPI0906960-7A 2008-01-21 2009-01-12 Ácido nucleico compreendendo uma sequência de nucleotídeos codificando uma hemaglutinina do vírus de influenza (ha), partículas semelhantes a vírus (vlps), seu método de produção, composição e uso dos mesmos BRPI0906960B1 (pt)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US99060307P 2007-11-27 2007-11-27
US1327207P 2007-12-12 2007-12-12
CA002615372A CA2615372A1 (en) 2007-07-13 2008-01-21 Influenza virus-like particles (vlps) comprising hemagglutinin
CA2615372 2008-01-21
US2277508P 2008-01-22 2008-01-22
US61/022,775 2008-01-22
PCT/CA2008/001281 WO2009009876A1 (en) 2007-07-13 2008-07-11 Influenza virus-like particles (vlps) comprising hemagglutinin produced within a plant
CAPCT/CA2008/001281 2008-07-11
PCT/CA2009/000032 WO2009076778A1 (en) 2007-11-27 2009-01-12 Recombinant influenza virus-like particles (vlps) produced in transgenic plants expressing hemagglutinin

Publications (3)

Publication Number Publication Date
BRPI0906960A2 true BRPI0906960A2 (pt) 2015-07-14
BRPI0906960A8 BRPI0906960A8 (pt) 2015-09-29
BRPI0906960B1 BRPI0906960B1 (pt) 2023-07-11

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IL206967A (en) 2014-11-30
WO2009076778A1 (en) 2009-06-25
CA2707235A1 (en) 2009-06-25
US20190177739A1 (en) 2019-06-13
EP2610345A1 (en) 2013-07-03
NZ587108A (en) 2013-04-26
DK2610345T3 (en) 2015-12-07
AU2009202819A1 (en) 2009-06-25
CA2707235C (en) 2013-11-19
MX2010007962A (es) 2010-11-10
MA32439B1 (fr) 2011-07-03
JP2016052331A (ja) 2016-04-14
CR11612A (es) 2010-09-13
ZA201005917B (en) 2013-10-30
US9458470B2 (en) 2016-10-04
JP2016032477A (ja) 2016-03-10
JP2014097076A (ja) 2014-05-29
KR20100120157A (ko) 2010-11-12
US20100310604A1 (en) 2010-12-09
JP6215363B2 (ja) 2017-10-18
CN103122354B (zh) 2018-03-23
CN103122354A (zh) 2013-05-29
JP2011509661A (ja) 2011-03-31
IS8919A (is) 2010-08-04
CN101978066A (zh) 2011-02-16
EP2610345B1 (en) 2015-08-19
AU2009202819B2 (en) 2014-08-28
EP2238253A4 (en) 2011-04-06
PT2610345E (pt) 2016-01-11
BRPI0906960A8 (pt) 2015-09-29
WO2009076778A8 (en) 2009-08-27
EP2238253B1 (en) 2012-09-12
US20170088848A1 (en) 2017-03-30
EP2238253A1 (en) 2010-10-13
JP5990207B2 (ja) 2016-09-07
US10190132B2 (en) 2019-01-29
IS2982B (is) 2017-09-15
IL206967A0 (en) 2010-12-30
HK1186207A1 (en) 2014-03-07
US11434497B2 (en) 2022-09-06
US20130142826A1 (en) 2013-06-06
ES2554703T3 (es) 2015-12-22

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