BRPI0907186A2 - Composições proteicas pulverizadas e métodos para sua produção - Google Patents
Composições proteicas pulverizadas e métodos para sua produçãoInfo
- Publication number
- BRPI0907186A2 BRPI0907186A2 BRPI0907186-5A BRPI0907186A BRPI0907186A2 BR PI0907186 A2 BRPI0907186 A2 BR PI0907186A2 BR PI0907186 A BRPI0907186 A BR PI0907186A BR PI0907186 A2 BRPI0907186 A2 BR PI0907186A2
- Authority
- BR
- Brazil
- Prior art keywords
- production
- methods
- protein compositions
- powdered protein
- powdered
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39591—Stabilisation, fragmentation
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/241—Tumor Necrosis Factors
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Immunology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Physical Education & Sports Medicine (AREA)
- Oncology (AREA)
- Diabetes (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Hematology (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Dermatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Biochemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychiatry (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Genetics & Genomics (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2129808P | 2008-01-15 | 2008-01-15 | |
| PCT/EP2009/050385 WO2009090189A1 (en) | 2008-01-15 | 2009-01-14 | Powdered protein compositions and methods of making same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0907186A2 true BRPI0907186A2 (pt) | 2015-07-14 |
Family
ID=40567651
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0907186-5A BRPI0907186A2 (pt) | 2008-01-15 | 2009-01-14 | Composições proteicas pulverizadas e métodos para sua produção |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US9610301B2 (pt) |
| EP (1) | EP2249809A1 (pt) |
| JP (2) | JP6078217B2 (pt) |
| KR (1) | KR20100120289A (pt) |
| CN (2) | CN101969929B (pt) |
| AU (1) | AU2009204863B2 (pt) |
| BR (1) | BRPI0907186A2 (pt) |
| CA (1) | CA2711984A1 (pt) |
| IL (1) | IL206978A0 (pt) |
| MX (1) | MX2010007728A (pt) |
| NZ (3) | NZ586828A (pt) |
| RU (2) | RU2537139C2 (pt) |
| SG (2) | SG2013054218A (pt) |
| TW (2) | TW201603833A (pt) |
| WO (1) | WO2009090189A1 (pt) |
Families Citing this family (132)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6090382A (en) * | 1996-02-09 | 2000-07-18 | Basf Aktiengesellschaft | Human antibodies that bind human TNFα |
| ATE239041T1 (de) * | 1996-02-09 | 2003-05-15 | Basf Ag | Humane antikörper welche an humanen tnfalpha binden |
| US20140186361A1 (en) | 2012-09-07 | 2014-07-03 | Coherus Biosciences, Inc. | Stable Aqueous Formulations of Adalimumab |
| US20040131614A1 (en) * | 2002-07-19 | 2004-07-08 | Abbott Biotechnology Ltd. | Treatment of pulmonary disorders using TNFalpha inhibitor |
| US20090280065A1 (en) * | 2006-04-10 | 2009-11-12 | Willian Mary K | Uses and Compositions for Treatment of Psoriasis |
| US20040033228A1 (en) | 2002-08-16 | 2004-02-19 | Hans-Juergen Krause | Formulation of human antibodies for treating TNF-alpha associated disorders |
| MY150740A (en) * | 2002-10-24 | 2014-02-28 | Abbvie Biotechnology Ltd | Low dose methods for treating disorders in which tnf? activity is detrimental |
| GB0300427D0 (en) * | 2003-01-09 | 2003-02-05 | Univ Strathclyde | Pharmaceutical composition |
| TWI439284B (zh) * | 2004-04-09 | 2014-06-01 | 艾伯維生物技術有限責任公司 | 用於治療TNFα相關失調症之多重可變劑量療法 |
| GB0414054D0 (en) | 2004-06-23 | 2004-07-28 | Owen Mumford Ltd | Improvements relating to automatic injection devices |
| WO2006041970A2 (en) * | 2004-10-08 | 2006-04-20 | Abbott Biotechnology Ltd. | Treatment of respiratory syncytial virus (rsv) infection |
| JP5757495B2 (ja) * | 2005-05-16 | 2015-07-29 | アッヴィ バイオテクノロジー リミテッド | びらん性多発性関節炎の治療のためのtnf阻害剤の使用 |
| TW201337266A (zh) | 2005-11-01 | 2013-09-16 | Abbott Biotech Ltd | 利用生物標記診斷關節黏連脊椎炎之方法及組合物 |
| CN102391358B (zh) | 2006-04-05 | 2016-08-10 | 艾伯维生物技术有限公司 | 抗体纯化 |
| US20090317399A1 (en) * | 2006-04-10 | 2009-12-24 | Pollack Paul F | Uses and compositions for treatment of CROHN'S disease |
| US9399061B2 (en) | 2006-04-10 | 2016-07-26 | Abbvie Biotechnology Ltd | Methods for determining efficacy of TNF-α inhibitors for treatment of rheumatoid arthritis |
| WO2008063213A2 (en) | 2006-04-10 | 2008-05-29 | Abbott Biotechnology Ltd. | Uses and compositions for treatment of psoriatic arthritis |
| US9605064B2 (en) * | 2006-04-10 | 2017-03-28 | Abbvie Biotechnology Ltd | Methods and compositions for treatment of skin disorders |
| WO2007120626A2 (en) | 2006-04-10 | 2007-10-25 | Abbott Biotechnology Ltd. | Uses and compositions for treatment of ankylosing spondylitis |
| US20080118496A1 (en) * | 2006-04-10 | 2008-05-22 | Medich John R | Uses and compositions for treatment of juvenile rheumatoid arthritis |
| US20100021451A1 (en) | 2006-06-08 | 2010-01-28 | Wong Robert L | Uses and compositions for treatment of ankylosing spondylitis |
| US20080311043A1 (en) * | 2006-06-08 | 2008-12-18 | Hoffman Rebecca S | Uses and compositions for treatment of psoriatic arthritis |
| CN103316402A (zh) | 2006-06-30 | 2013-09-25 | 艾伯维生物技术有限公司 | 自动注射装置 |
| EP2684895A1 (en) | 2006-10-27 | 2014-01-15 | AbbVie Biotechnology Ltd | Crystalline anti-hTNFalpha antibodies |
| CA2681752A1 (en) | 2007-03-29 | 2008-10-09 | Abbott Laboratories | Crystalline anti-human 1l-12 antibodies |
| GB0707938D0 (en) * | 2007-04-25 | 2007-05-30 | Univ Strathclyde | Precipitation stabilising compositions |
| EP2171451A4 (en) | 2007-06-11 | 2011-12-07 | Abbott Biotech Ltd | METHOD FOR TREATING JUVENILIAN IDIOPATHIC ARTHRITIS |
| CA2693771A1 (en) * | 2007-07-13 | 2009-01-22 | Abbott Biotechnology Ltd. | Methods and compositions for pulmonary administration of a tnf.alpha. inhibitor |
| MX2010001488A (es) | 2007-08-08 | 2010-03-01 | Abbott Lab | Composiciones y metodos para cristalizar anticuerpos. |
| US8420081B2 (en) | 2007-11-30 | 2013-04-16 | Abbvie, Inc. | Antibody formulations and methods of making same |
| US8883146B2 (en) | 2007-11-30 | 2014-11-11 | Abbvie Inc. | Protein formulations and methods of making same |
| GB0724498D0 (en) * | 2007-12-15 | 2008-01-30 | Univ Strathclyde | Slow release compositions |
| MX2010007393A (es) * | 2008-01-03 | 2010-11-09 | Abbott Biotech Ltd | Anticipacion de eficacia a largo plazo de un compuesto en el tratamiento de psoriasis. |
| TWI442932B (zh) | 2008-02-11 | 2014-07-01 | Ferring Int Ct Sa | 以GnRH拮抗劑治療攝護腺癌的方法 |
| EP2111871A1 (de) * | 2008-04-26 | 2009-10-28 | Sandoz AG | Stabilisierte Flüssigformulierung |
| US9265834B2 (en) * | 2009-03-05 | 2016-02-23 | Ablynx N.V. | Stable formulations of polypeptides and uses thereof |
| EP2403873A1 (en) | 2009-03-05 | 2012-01-11 | Ablynx N.V. | Novel antigen binding dimer-complexes, methods of making/avoiding and uses thereof |
| EP2236520A1 (en) * | 2009-03-31 | 2010-10-06 | Leukocare Ag | Stabilizing composition for immobilized biomolecules |
| AU2010242972B2 (en) | 2009-04-29 | 2015-07-09 | Abbvie Biotechnology Ltd | Automatic injection device |
| BR112012002709A2 (pt) * | 2009-08-05 | 2019-04-30 | Pieris Ag | formulações de liberação controlada de muteínas de lipocalina |
| EP2473528B1 (en) | 2009-09-03 | 2014-12-03 | Ablynx N.V. | Stable formulations of polypeptides and uses thereof |
| US9289381B2 (en) * | 2009-12-03 | 2016-03-22 | The University Of North Carolina At Charlotte | Stabilization and storage of biological pharmaceutical compositions |
| EP2512558A4 (en) | 2009-12-15 | 2014-08-13 | Abbvie Biotechnology Ltd | IMPROVED TRIP KNOB FOR AUTOMATIC INJECTION DEVICE |
| KR101878369B1 (ko) * | 2010-03-22 | 2018-07-16 | 제넨테크, 인크. | 단백질-함유 제제의 안정화에 유용한 조성물 및 방법 |
| US9758558B2 (en) * | 2010-04-01 | 2017-09-12 | Board Of Supervisors Of Louisiana State University And Agriculture And Mechanical College | Whey protein isolate hydrogels and their uses |
| CA2796729C (en) | 2010-04-20 | 2020-06-23 | Octapharma Ag | Melezitose for stabilizing human blood plasma proteins |
| MX2012014080A (es) | 2010-06-03 | 2013-05-01 | Abbvie Biotechnology Ltd | Usos y composiciones para el tratamiento de hidradenitis superativa (hs). |
| TWI603739B (zh) | 2010-11-11 | 2017-11-01 | 艾伯維生物技術有限責任公司 | 具有增進高濃度之抗-TNFα抗體之液體調配物 |
| KR101756475B1 (ko) | 2010-11-30 | 2017-07-10 | 엘지이노텍 주식회사 | 전기 자전거의 허브와 휠의 결합구조 |
| US9149045B2 (en) | 2010-12-07 | 2015-10-06 | Kimberly-Clark Worldwide, Inc. | Wipe coated with a botanical emulsion having antimicrobial properties |
| US9648874B2 (en) | 2010-12-07 | 2017-05-16 | Kimberly-Clark Worldwide, Inc. | Natural, multiple use and re-use, user saturated wipes |
| US10821085B2 (en) | 2010-12-07 | 2020-11-03 | Kimberly-Clark Worldwide, Inc. | Wipe coated with a botanical composition having antimicrobial properties |
| US8524264B2 (en) | 2010-12-07 | 2013-09-03 | Kimberly-Clark Worldwide, Inc. | Protein stabilized antimicrobial composition formed by melt processing |
| US9832993B2 (en) | 2010-12-07 | 2017-12-05 | Kimberly-Clark Worldwide, Inc. | Melt processed antimicrobial composition |
| US8445032B2 (en) | 2010-12-07 | 2013-05-21 | Kimberly-Clark Worldwide, Inc. | Melt-blended protein composition |
| EP2471554A1 (en) * | 2010-12-28 | 2012-07-04 | Hexal AG | Pharmaceutical formulation comprising a biopharmaceutical drug |
| SG192119A1 (en) | 2011-01-24 | 2013-08-30 | Abbvie Biotechnology Ltd | Automatic injection devices having overmolded gripping surfaces |
| WO2012122535A2 (en) | 2011-03-10 | 2012-09-13 | Xeris Pharmaceuticals, Inc. | Stable formulations for parenteral injection of peptide drugs |
| WO2012149197A2 (en) | 2011-04-27 | 2012-11-01 | Abbott Laboratories | Methods for controlling the galactosylation profile of recombinantly-expressed proteins |
| SG10201505454SA (en) | 2011-07-13 | 2015-09-29 | Abbvie Inc | Methods and compositions for treating asthma using anti-il-13 antibodies |
| AU2012326170B2 (en) * | 2011-10-18 | 2016-12-22 | Coherus Biosciences, Inc. | Etanercept formulations stabilized with metal ions |
| US10485869B2 (en) * | 2011-10-18 | 2019-11-26 | Coherus Biosciences, Inc. | Etanercept formulations stabilized with meglumine |
| JP6117811B2 (ja) | 2011-10-31 | 2017-04-19 | ゼリス ファーマシューティカルズ インコーポレイテッド | 糖尿病を処置するための製剤 |
| AU2012340107B2 (en) * | 2011-11-18 | 2017-06-15 | Regeneron Pharmaceuticals, Inc. | Polymer protein microparticles |
| US8574628B2 (en) | 2011-12-19 | 2013-11-05 | Kimberly-Clark Worldwide, Inc. | Natural, multiple release and re-use compositions |
| US9067990B2 (en) | 2013-03-14 | 2015-06-30 | Abbvie, Inc. | Protein purification using displacement chromatography |
| US9150645B2 (en) | 2012-04-20 | 2015-10-06 | Abbvie, Inc. | Cell culture methods to reduce acidic species |
| US9181572B2 (en) | 2012-04-20 | 2015-11-10 | Abbvie, Inc. | Methods to modulate lysine variant distribution |
| EP3184542A1 (en) * | 2012-05-14 | 2017-06-28 | Novo Nordisk A/S | Stabilised protein solutions |
| SI2849723T1 (sl) | 2012-05-18 | 2018-09-28 | Genentech, Inc. | Formulacije z visoko koncentracijo monoklonskih protiteles |
| US9249182B2 (en) | 2012-05-24 | 2016-02-02 | Abbvie, Inc. | Purification of antibodies using hydrophobic interaction chromatography |
| KR102140982B1 (ko) | 2012-06-01 | 2020-08-05 | 훼링 비.브이. | 데가렐릭스의 제조 방법 |
| US9125805B2 (en) | 2012-06-27 | 2015-09-08 | Xeris Pharmaceuticals, Inc. | Stable formulations for parenteral injection of small molecule drugs |
| US9512214B2 (en) | 2012-09-02 | 2016-12-06 | Abbvie, Inc. | Methods to control protein heterogeneity |
| HK1211981A1 (en) | 2012-09-02 | 2016-06-03 | Abbvie Inc. | Methods to control protein heterogeneity |
| EP2925297B1 (en) * | 2012-11-02 | 2017-06-21 | CyTuVax | Composition comprising cytokine macro-aggregates |
| US9018162B2 (en) * | 2013-02-06 | 2015-04-28 | Xeris Pharmaceuticals, Inc. | Methods for rapidly treating severe hypoglycemia |
| SG11201507230PA (en) | 2013-03-12 | 2015-10-29 | Abbvie Inc | Human antibodies that bind human tnf-alpha and methods of preparing the same |
| JP6450364B2 (ja) * | 2013-03-13 | 2019-01-09 | セセン バイオ, インコーポレイテッド | 眼送達のためのキメラサイトカイン製剤 |
| WO2014151878A2 (en) | 2013-03-14 | 2014-09-25 | Abbvie Inc. | Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosacharides |
| US9017687B1 (en) | 2013-10-18 | 2015-04-28 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same using displacement chromatography |
| WO2014159579A1 (en) | 2013-03-14 | 2014-10-02 | Abbvie Inc. | MUTATED ANTI-TNFα ANTIBODIES AND METHODS OF THEIR USE |
| NL1040254C2 (en) * | 2013-05-17 | 2014-11-24 | Ablynx Nv | Stable formulations of immunoglobulin single variable domains and uses thereof. |
| US9598667B2 (en) | 2013-10-04 | 2017-03-21 | Abbvie Inc. | Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins |
| AU2014337263B2 (en) | 2013-10-16 | 2019-12-12 | Outlook Therapeutics, Inc. | Buffer formulations for enhanced antibody stability |
| US8946395B1 (en) | 2013-10-18 | 2015-02-03 | Abbvie Inc. | Purification of proteins using hydrophobic interaction chromatography |
| US9085618B2 (en) | 2013-10-18 | 2015-07-21 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same |
| US9181337B2 (en) | 2013-10-18 | 2015-11-10 | Abbvie, Inc. | Modulated lysine variant species compositions and methods for producing and using the same |
| US9144623B2 (en) * | 2013-11-06 | 2015-09-29 | Chung-Ping Lai | Refrigerator with plasma device |
| US20150139988A1 (en) | 2013-11-15 | 2015-05-21 | Abbvie, Inc. | Glycoengineered binding protein compositions |
| CN104707146B (zh) * | 2013-12-16 | 2019-04-16 | 浙江海正药业股份有限公司 | 一种含有阿达木单抗的药物组合物 |
| PE20170471A1 (es) * | 2014-06-13 | 2017-05-14 | Santa Maria Biotherapeutics Inc | Polipeptidos receptores formulados y metodos relacionados |
| KR102428675B1 (ko) | 2014-08-06 | 2022-08-02 | 엑스에리스 파머수티클스, 인크. | 페이스트의 피내 및/또는 피하 주사를 위한 주사기, 키트, 및 방법 |
| ES2964713T3 (es) * | 2014-10-23 | 2024-04-09 | Amgen Inc | Reducción de la viscosidad de formulaciones farmacéuticas |
| AU2015338717B2 (en) | 2014-10-31 | 2018-12-20 | Glaxosmithkline Intellectual Property Development Limited | Powder formulation |
| SI3215530T1 (sl) | 2014-11-07 | 2020-02-28 | Sesen Bio, Inc. | Izboljšana protitelesa IL-6 |
| EP3247718B1 (en) | 2015-01-21 | 2021-09-01 | Outlook Therapeutics, Inc. | Modulation of charge variants in a monoclonal antibody composition |
| KR102541889B1 (ko) * | 2015-02-06 | 2023-06-08 | 엘리멘탈 사이언티픽, 인코포레이티드 | 할로실란을 샘플링하기 위한 시스템 및 방법 |
| US9649364B2 (en) | 2015-09-25 | 2017-05-16 | Xeris Pharmaceuticals, Inc. | Methods for producing stable therapeutic formulations in aprotic polar solvents |
| US11590205B2 (en) | 2015-09-25 | 2023-02-28 | Xeris Pharmaceuticals, Inc. | Methods for producing stable therapeutic glucagon formulations in aprotic polar solvents |
| US11229702B1 (en) | 2015-10-28 | 2022-01-25 | Coherus Biosciences, Inc. | High concentration formulations of adalimumab |
| MY200764A (en) * | 2015-12-16 | 2024-01-14 | Regeneron Pharma | Compositions and methods of manufacturing protein microparticles |
| EP3411401A1 (en) | 2016-02-03 | 2018-12-12 | Oncobiologics, Inc. | Buffer formulations for enhanced antibody stability |
| BR112018017031A2 (pt) | 2016-02-23 | 2019-01-22 | Sesen Bio Inc | formulações de antagonista de il-6 e usos das mesmas |
| US11071782B2 (en) | 2016-04-20 | 2021-07-27 | Coherus Biosciences, Inc. | Method of filling a container with no headspace |
| KR101961902B1 (ko) * | 2016-07-01 | 2019-07-17 | 삼육대학교산학협력단 | 도축 혈액 유래 면역단백질의 제조 방법 및 구강 건강 개선을 위해 사용하는 용도 |
| BE1024122B1 (fr) * | 2016-07-27 | 2017-11-16 | Proteifood Sa | Produit alimentaire expanse sec a base de proteine et son procede de fabrication |
| AU2017364077A1 (en) * | 2016-11-22 | 2019-06-20 | Elektrofi, Inc. | Particles comprising a therapeutic or diagnostic agent and suspensions and methods of use thereof |
| US11110176B2 (en) * | 2016-11-25 | 2021-09-07 | The Board Of Trustees Of The California State University | Composition and method for the protection of proteins, cell components and cells during temperature stress |
| RU2764521C2 (ru) * | 2017-12-29 | 2022-01-18 | Закрытое Акционерное Общество "Биокад" | Водная фармацевтическая композиция рекомбинантного моноклонального антитела к ФНОа |
| CN117085022A (zh) | 2017-06-02 | 2023-11-21 | Xeris药物公司 | 抗沉淀的小分子药物制剂 |
| WO2019023392A1 (en) | 2017-07-25 | 2019-01-31 | Elektrofi, Inc. | FORMATION OF PARTICLES COMPRISING AGENTS |
| SG11202000387YA (en) | 2017-08-25 | 2020-03-30 | Five Prime Therapeutics Inc | B7-h4 antibodies and methods of use thereof |
| EP3459527B1 (en) * | 2017-09-20 | 2022-11-23 | Tillotts Pharma Ag | Method for preparing a solid dosage form comprising antibodies by wet granulation, extrusion and spheronization |
| EP3459529A1 (en) | 2017-09-20 | 2019-03-27 | Tillotts Pharma Ag | Preparation of sustained release solid dosage forms comprising antibodies by spray drying |
| WO2019165077A1 (en) * | 2018-02-21 | 2019-08-29 | Five Prime Therapeutics, Inc. | B7-h4 antibody formulations |
| WO2019226969A1 (en) | 2018-05-24 | 2019-11-28 | Elektrofi, Inc. | Particles comprising a therapeutic or diagnostic agent and suspensions and methods of use thereof |
| WO2020072306A1 (en) * | 2018-10-01 | 2020-04-09 | Amgen Inc. | Methods for reducing aggregation of bispecific antibodies |
| AU2019361923B2 (en) | 2018-10-15 | 2026-07-09 | Five Prime Therapeutics, Inc. | Combination therapy for cancer |
| AU2020214626B2 (en) | 2019-01-31 | 2025-10-16 | Halozyme Hypercon, Inc. | Particle formation and morphology |
| MY210034A (en) | 2019-03-15 | 2025-08-22 | Novo Nordisk As | Process for spray drying a glp-1 peptide |
| IL289370B1 (en) | 2019-07-02 | 2026-07-01 | Hoffmann La Roche | Process for preparing high water affinity products with controlled humidity |
| AU2020344675B2 (en) | 2019-09-13 | 2026-06-25 | Halozyme Hypercon, Inc. | Compositions and methods for the delivery of therapeutic biologics for treatment of disease |
| WO2021070203A1 (en) * | 2019-10-11 | 2021-04-15 | Dr. Reddy's Laboratories Limited | Stable formulation of integrin antibody |
| CN112807281A (zh) * | 2019-10-31 | 2021-05-18 | 南京海维医药科技有限公司 | 包含血管紧张素ii的稳定组合物及其制备方法、使用方法 |
| EP4121083A4 (en) * | 2020-03-18 | 2023-11-29 | Cara Therapeutics, Inc. | OLIGOSACCHARIDE FORMULATIONS OF KAPPA OPIOID RECEPTOR AGONISTS |
| US12478603B2 (en) | 2020-03-31 | 2025-11-25 | The Regents Of The University Of Michigan | Serum metabolites as biomarkers for carnitine treatment of sepsis |
| US12377050B2 (en) | 2020-04-17 | 2025-08-05 | Elektrofi, Inc. | Methods of forming particles by continuous droplet formation and dehydration |
| AU2021260989A1 (en) * | 2020-04-22 | 2022-11-17 | Novartis Ag | Pharmaceutical compositions and pharmaceutical products of heterodimeric human interleukin-15 (hetIL-15) |
| AU2021276071B2 (en) * | 2020-05-22 | 2026-06-18 | Hanmi Pharm. Co., Ltd. | Liquid formulation |
| CN112284861B (zh) * | 2020-10-21 | 2023-02-17 | 上海市农业科学院 | 用于真姬菇担孢子显微观察的固定液、制备方法、固定方法及应用 |
| IL313015A (en) * | 2021-11-25 | 2024-07-01 | Orexo Ab | A pharmaceutical preparation that includes biopharmaceutical drug compounds |
Family Cites Families (91)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU560087B2 (en) | 1981-09-08 | 1987-03-26 | Rockefeller University, The | Lipoprotein lipase suppression by endotoxin-induced mediator (shock assay) |
| US5672347A (en) | 1984-07-05 | 1997-09-30 | Genentech, Inc. | Tumor necrosis factor antagonists and their use |
| IL73883A (en) | 1984-12-20 | 1990-12-23 | Yeda Res & Dev | Monoclonal antibodies against tnf-alpha,hybridomas producing them and method for the purification of tnf-alpha |
| ATE114673T1 (de) | 1985-08-16 | 1994-12-15 | Univ Rockefeller | Modulator der anabolischen aktivität und seine verwendungen. |
| DE3631229A1 (de) | 1986-09-13 | 1988-03-24 | Basf Ag | Monoklonale antikoerper gegen humanen tumornekrosefaktor (tnf) und deren verwendung |
| JP2638652B2 (ja) | 1988-07-18 | 1997-08-06 | カイロン・コーポレーション | カケクチンと反応するモノクロナール抗体 |
| DE68914244T2 (de) | 1988-10-24 | 1994-10-27 | Otsuka Pharma Co Ltd | Monoklonaler Antikörper. |
| US5959087A (en) | 1989-08-07 | 1999-09-28 | Peptide Technology, Ltd. | Tumour necrosis factor binding ligands |
| EP0486526B2 (en) | 1989-08-07 | 2001-03-07 | Peptech Limited | Tumour necrosis factor binding ligands |
| US6448380B2 (en) | 1989-08-07 | 2002-09-10 | Peptech Limited | Tumor necrosis factor antibodies |
| GB8928874D0 (en) | 1989-12-21 | 1990-02-28 | Celltech Ltd | Humanised antibodies |
| US5859205A (en) | 1989-12-21 | 1999-01-12 | Celltech Limited | Humanised antibodies |
| GB9014932D0 (en) | 1990-07-05 | 1990-08-22 | Celltech Ltd | Recombinant dna product and method |
| GB9109645D0 (en) | 1991-05-03 | 1991-06-26 | Celltech Ltd | Recombinant antibodies |
| US5994510A (en) | 1990-12-21 | 1999-11-30 | Celltech Therapeutics Limited | Recombinant antibodies specific for TNFα |
| GB2279077B (en) | 1990-12-21 | 1995-06-14 | Celltech Ltd | Therapeutic compositions comprising recombinant antibodies specific for the TNFalpha |
| GB9028123D0 (en) | 1990-12-28 | 1991-02-13 | Erba Carlo Spa | Monoclonal antibodies against human tumor necrosis factor alpha |
| US20060246073A1 (en) | 1991-03-18 | 2006-11-02 | Knight David M | Anti-TNF antibodies and peptides of human tumor necrosis factor |
| US7192584B2 (en) | 1991-03-18 | 2007-03-20 | Centocor, Inc. | Methods of treating psoriasis with anti-TNF antibodies |
| US20070298040A1 (en) | 1991-03-18 | 2007-12-27 | Centocor, Inc. | Methods of treating seronegative arthropathy with anti-TNF antibodies |
| US6277969B1 (en) | 1991-03-18 | 2001-08-21 | New York University | Anti-TNF antibodies and peptides of human tumor necrosis factor |
| US5656272A (en) | 1991-03-18 | 1997-08-12 | New York University Medical Center | Methods of treating TNF-α-mediated Crohn's disease using chimeric anti-TNF antibodies |
| DE07012626T1 (de) | 1991-03-18 | 2010-01-21 | New York University | Monoklonale und chimäre Antikörper gegen humanen Tumornekrosefaktor |
| US20040120952A1 (en) | 2000-08-07 | 2004-06-24 | Centocor, Inc | Anti-TNF antibodies and peptides of human tumor necrosis factor |
| JP3540315B2 (ja) | 1991-09-23 | 2004-07-07 | メディカル リサーチ カウンシル | キメラ抗体の製造−組合せアプローチ |
| US6270766B1 (en) | 1992-10-08 | 2001-08-07 | The Kennedy Institute Of Rheumatology | Anti-TNF antibodies and methotrexate in the treatment of arthritis and crohn's disease |
| ATE204299T1 (de) | 1993-03-05 | 2001-09-15 | Bayer Ag | Humane monoklonale anti-tnf alpha antikörper |
| CA2163032C (en) | 1993-06-03 | 2001-02-06 | John Landon | Antibody fragments in therapy |
| EP0659766A1 (en) | 1993-11-23 | 1995-06-28 | Schering-Plough | Human monoclonal antibodies against human cytokines and methods of making and using such antibodies |
| WO1995023813A1 (en) | 1994-03-04 | 1995-09-08 | Merck & Co., Inc. | In vitro antibody affinity maturation using alanine scanning mutagenesis |
| IL116085A (en) * | 1994-12-16 | 1999-12-31 | Ortho Pharma Corp | Spray dried erythropoietin |
| US6685940B2 (en) * | 1995-07-27 | 2004-02-03 | Genentech, Inc. | Protein formulation |
| US6090382A (en) | 1996-02-09 | 2000-07-18 | Basf Aktiengesellschaft | Human antibodies that bind human TNFα |
| ATE239041T1 (de) | 1996-02-09 | 2003-05-15 | Basf Ag | Humane antikörper welche an humanen tnfalpha binden |
| NZ328751A (en) | 1997-09-16 | 1999-01-28 | Bernard Charles Sherman | Solid medicament containing an anionic surfactant and cyclosporin |
| US6284282B1 (en) * | 1998-04-29 | 2001-09-04 | Genentech, Inc. | Method of spray freeze drying proteins for pharmaceutical administration |
| US6914128B1 (en) | 1999-03-25 | 2005-07-05 | Abbott Gmbh & Co. Kg | Human antibodies that bind human IL-12 and methods for producing |
| US20030148955A1 (en) * | 1999-04-19 | 2003-08-07 | Pluenneke John D. | Soluble tumor necrosis factor receptor treatment of medical disorders |
| US20030064105A1 (en) | 2000-08-25 | 2003-04-03 | Myung-Jin Kim | Lipophilic-coated microparticle containing a protein drug and formulation comprising same |
| UA81743C2 (uk) | 2000-08-07 | 2008-02-11 | Центокор, Инк. | МОНОКЛОНАЛЬНЕ АНТИТІЛО ЛЮДИНИ, ЩО СПЕЦИФІЧНО ЗВ'ЯЗУЄТЬСЯ З ФАКТОРОМ НЕКРОЗУ ПУХЛИН АЛЬФА (ФНПα), ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ, ЩО ЙОГО МІСТИТЬ, ТА СПОСІБ ЛІКУВАННЯ РЕВМАТОЇДНОГО АРТРИТУ |
| US20050249735A1 (en) | 2000-08-07 | 2005-11-10 | Centocor, Inc. | Methods of treating ankylosing spondylitis using anti-TNF antibodies and peptides of human tumor necrosis factor |
| US20060018907A1 (en) | 2000-08-07 | 2006-01-26 | Centocor, Inc. | Anti-TNF antibodies and peptides of human tumor necrosis factor |
| MXPA03001092A (es) * | 2000-08-07 | 2003-09-25 | Nektar Therapeutics Al Corp | Polvos de proteina de haz de 4 helices secados por rocio, inhalables, que tienen agregacion minimizada. |
| BR0206160A (pt) | 2001-05-25 | 2004-10-26 | Abbott Gmbh & Co Kg | Uso de anticorpos anti-tnf como medicamentos no tratamento de distúrbios sépticos de pacientes anêmicos |
| CA2817619A1 (en) | 2001-06-08 | 2002-12-08 | Abbott Laboratories (Bermuda) Ltd. | Methods of administering anti-tnf.alpha. antibodies |
| RU2200002C1 (ru) * | 2001-07-30 | 2003-03-10 | Акционерное Курганское общество медицинских препаратов и изделий "Синтез" | Твердая фармацевтическая композиция и способ ее получения |
| US20030161828A1 (en) | 2002-02-19 | 2003-08-28 | Abbott Gmbh & Co. Kg | Use of TNF antagonists as drugs for the treatment of patients with an inflammatory reaction and without suffering from total organ failure |
| US20040009172A1 (en) | 2002-04-26 | 2004-01-15 | Steven Fischkoff | Use of anti-TNFalpha antibodies and another drug |
| US20030206898A1 (en) | 2002-04-26 | 2003-11-06 | Steven Fischkoff | Use of anti-TNFalpha antibodies and another drug |
| US20090280065A1 (en) | 2006-04-10 | 2009-11-12 | Willian Mary K | Uses and Compositions for Treatment of Psoriasis |
| US20040131614A1 (en) | 2002-07-19 | 2004-07-08 | Abbott Biotechnology Ltd. | Treatment of pulmonary disorders using TNFalpha inhibitor |
| US20040033228A1 (en) | 2002-08-16 | 2004-02-19 | Hans-Juergen Krause | Formulation of human antibodies for treating TNF-alpha associated disorders |
| MY150740A (en) | 2002-10-24 | 2014-02-28 | Abbvie Biotechnology Ltd | Low dose methods for treating disorders in which tnf? activity is detrimental |
| WO2004043503A1 (ja) * | 2002-11-14 | 2004-05-27 | Juridical Foundation The Chemo-Sero-Therapeutic Research Institute | トロンビン固定化生体吸収性合成不織布 |
| AU2003293543A1 (en) * | 2002-12-13 | 2004-07-09 | Abgenix, Inc. | System and method for stabilizing antibodies with histidine |
| KR20050088175A (ko) * | 2002-12-17 | 2005-09-02 | 메드이뮨 백신즈 인코포레이티드 | 생물활성 물질의 고압 분무 건조 |
| WO2004060343A1 (en) * | 2002-12-31 | 2004-07-22 | Nektar Therapeutics | Antibody-containing particles and compositions |
| KR100466637B1 (ko) * | 2003-06-26 | 2005-01-13 | 주식회사 펩트론 | 서방성 미립구의 혼합 제형을 연속한 단일 공정으로제조하는 방법 |
| DE10339197A1 (de) * | 2003-08-22 | 2005-03-24 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Sprühgetrocknete amorphe Pulver mit geringer Restfeuchte und guter Lagerstabilität |
| US7968684B2 (en) | 2003-11-12 | 2011-06-28 | Abbott Laboratories | IL-18 binding proteins |
| TWI439284B (zh) | 2004-04-09 | 2014-06-01 | 艾伯維生物技術有限責任公司 | 用於治療TNFα相關失調症之多重可變劑量療法 |
| KR100486028B1 (ko) * | 2004-04-20 | 2005-05-03 | 주식회사 펩트론 | 단백질 함유 서방성 리피드 임플란트 및 이의 제조방법 |
| US7727962B2 (en) * | 2004-05-10 | 2010-06-01 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Powder comprising new compositions of oligosaccharides and methods for their preparation |
| WO2006041970A2 (en) | 2004-10-08 | 2006-04-20 | Abbott Biotechnology Ltd. | Treatment of respiratory syncytial virus (rsv) infection |
| JP5757495B2 (ja) | 2005-05-16 | 2015-07-29 | アッヴィ バイオテクノロジー リミテッド | びらん性多発性関節炎の治療のためのtnf阻害剤の使用 |
| CN103145837A (zh) | 2005-06-30 | 2013-06-12 | Abbvie公司 | Il-12/p40结合蛋白 |
| US20070041905A1 (en) | 2005-08-19 | 2007-02-22 | Hoffman Rebecca S | Method of treating depression using a TNF-alpha antibody |
| TW201337266A (zh) | 2005-11-01 | 2013-09-16 | Abbott Biotech Ltd | 利用生物標記診斷關節黏連脊椎炎之方法及組合物 |
| CN102391358B (zh) | 2006-04-05 | 2016-08-10 | 艾伯维生物技术有限公司 | 抗体纯化 |
| WO2008063213A2 (en) | 2006-04-10 | 2008-05-29 | Abbott Biotechnology Ltd. | Uses and compositions for treatment of psoriatic arthritis |
| WO2007120626A2 (en) | 2006-04-10 | 2007-10-25 | Abbott Biotechnology Ltd. | Uses and compositions for treatment of ankylosing spondylitis |
| US9399061B2 (en) | 2006-04-10 | 2016-07-26 | Abbvie Biotechnology Ltd | Methods for determining efficacy of TNF-α inhibitors for treatment of rheumatoid arthritis |
| US20090317399A1 (en) | 2006-04-10 | 2009-12-24 | Pollack Paul F | Uses and compositions for treatment of CROHN'S disease |
| US20080118496A1 (en) | 2006-04-10 | 2008-05-22 | Medich John R | Uses and compositions for treatment of juvenile rheumatoid arthritis |
| US20080131374A1 (en) | 2006-04-19 | 2008-06-05 | Medich John R | Uses and compositions for treatment of rheumatoid arthritis |
| US20100021451A1 (en) | 2006-06-08 | 2010-01-28 | Wong Robert L | Uses and compositions for treatment of ankylosing spondylitis |
| US20080311043A1 (en) | 2006-06-08 | 2008-12-18 | Hoffman Rebecca S | Uses and compositions for treatment of psoriatic arthritis |
| DE102006030164A1 (de) * | 2006-06-29 | 2008-01-03 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Inhalative Pulver |
| CN103316402A (zh) | 2006-06-30 | 2013-09-25 | 艾伯维生物技术有限公司 | 自动注射装置 |
| HUE052220T2 (hu) | 2006-09-08 | 2021-04-28 | Abbvie Bahamas Ltd | Interleukin-13 kötõfehérjék |
| TW201516149A (zh) | 2006-09-13 | 2015-05-01 | Abbvie Inc | 細胞培養改良 |
| EP2684895A1 (en) | 2006-10-27 | 2014-01-15 | AbbVie Biotechnology Ltd | Crystalline anti-hTNFalpha antibodies |
| EP2165194A4 (en) | 2007-05-31 | 2010-09-08 | Abbott Lab | BIOMARKERS FOR PREDICTING RESPONSABILITY TO TNF ALPHA INHIBITORS IN AUTOIMMUNE DISEASES |
| WO2008150490A2 (en) | 2007-06-01 | 2008-12-11 | Abbott Biotechnology Ltd. | Uses and compositions for treatment of psoriasis and crohn's disease |
| EP2171451A4 (en) | 2007-06-11 | 2011-12-07 | Abbott Biotech Ltd | METHOD FOR TREATING JUVENILIAN IDIOPATHIC ARTHRITIS |
| CA2693771A1 (en) | 2007-07-13 | 2009-01-22 | Abbott Biotechnology Ltd. | Methods and compositions for pulmonary administration of a tnf.alpha. inhibitor |
| MX2010001488A (es) | 2007-08-08 | 2010-03-01 | Abbott Lab | Composiciones y metodos para cristalizar anticuerpos. |
| US8420081B2 (en) | 2007-11-30 | 2013-04-16 | Abbvie, Inc. | Antibody formulations and methods of making same |
| MX2010007393A (es) | 2008-01-03 | 2010-11-09 | Abbott Biotech Ltd | Anticipacion de eficacia a largo plazo de un compuesto en el tratamiento de psoriasis. |
| MX2010010503A (es) | 2008-03-24 | 2010-11-09 | Abbott Biotech Ltd | Metodos y composiciones para tratar perdida osea. |
| US20100278822A1 (en) | 2009-05-04 | 2010-11-04 | Abbott Biotechnology, Ltd. | Stable high protein concentration formulations of human anti-tnf-alpha-antibodies |
-
2009
- 2009-01-14 SG SG2013054218A patent/SG2013054218A/en unknown
- 2009-01-14 NZ NZ586828A patent/NZ586828A/xx not_active IP Right Cessation
- 2009-01-14 NZ NZ601913A patent/NZ601913A/en not_active IP Right Cessation
- 2009-01-14 CN CN200980109096.2A patent/CN101969929B/zh not_active Expired - Fee Related
- 2009-01-14 KR KR1020107017828A patent/KR20100120289A/ko not_active Abandoned
- 2009-01-14 JP JP2010542619A patent/JP6078217B2/ja not_active Expired - Fee Related
- 2009-01-14 RU RU2010133997/15A patent/RU2537139C2/ru not_active IP Right Cessation
- 2009-01-14 AU AU2009204863A patent/AU2009204863B2/en not_active Ceased
- 2009-01-14 MX MX2010007728A patent/MX2010007728A/es active IP Right Grant
- 2009-01-14 BR BRPI0907186-5A patent/BRPI0907186A2/pt not_active IP Right Cessation
- 2009-01-14 CN CN201410301458.0A patent/CN104188911A/zh active Pending
- 2009-01-14 NZ NZ621174A patent/NZ621174A/en not_active IP Right Cessation
- 2009-01-14 SG SG2013002951A patent/SG187473A1/en unknown
- 2009-01-14 EP EP09701842A patent/EP2249809A1/en not_active Withdrawn
- 2009-01-14 CA CA2711984A patent/CA2711984A1/en not_active Abandoned
- 2009-01-14 WO PCT/EP2009/050385 patent/WO2009090189A1/en not_active Ceased
- 2009-01-15 US US12/354,665 patent/US9610301B2/en not_active Expired - Fee Related
- 2009-01-15 TW TW104121201A patent/TW201603833A/zh unknown
- 2009-01-15 TW TW098101431A patent/TW200944245A/zh unknown
-
2010
- 2010-07-13 IL IL206978A patent/IL206978A0/en unknown
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2014
- 2014-01-28 JP JP2014013546A patent/JP6043736B2/ja not_active Expired - Fee Related
- 2014-09-25 RU RU2014138803A patent/RU2014138803A/ru not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| NZ601913A (en) | 2014-02-28 |
| CA2711984A1 (en) | 2009-07-23 |
| RU2014138803A (ru) | 2016-04-20 |
| SG2013054218A (en) | 2014-10-30 |
| CN101969929A (zh) | 2011-02-09 |
| AU2009204863A1 (en) | 2009-07-23 |
| US9610301B2 (en) | 2017-04-04 |
| JP6078217B2 (ja) | 2017-02-08 |
| MX2010007728A (es) | 2010-12-21 |
| EP2249809A1 (en) | 2010-11-17 |
| AU2009204863B2 (en) | 2015-07-16 |
| RU2010133997A (ru) | 2012-02-27 |
| NZ621174A (en) | 2015-09-25 |
| TW201603833A (zh) | 2016-02-01 |
| SG187473A1 (en) | 2013-02-28 |
| IL206978A0 (en) | 2010-12-30 |
| CN104188911A (zh) | 2014-12-10 |
| TW200944245A (en) | 2009-11-01 |
| US20090226530A1 (en) | 2009-09-10 |
| NZ586828A (en) | 2012-12-21 |
| RU2537139C2 (ru) | 2014-12-27 |
| JP2011509972A (ja) | 2011-03-31 |
| CN101969929B (zh) | 2014-07-30 |
| JP6043736B2 (ja) | 2016-12-14 |
| WO2009090189A1 (en) | 2009-07-23 |
| JP2014129357A (ja) | 2014-07-10 |
| KR20100120289A (ko) | 2010-11-15 |
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