BRPI0907656A2 - composto para testar a pureza de cisatracúrio, método para testar a pureza de uma amostra de besilato de cisatracúrio, uso de um composto para testar a pureza de cisatracúrio e processo para preparar compostos para testar a pureza de cisatracúrio - Google Patents

composto para testar a pureza de cisatracúrio, método para testar a pureza de uma amostra de besilato de cisatracúrio, uso de um composto para testar a pureza de cisatracúrio e processo para preparar compostos para testar a pureza de cisatracúrio Download PDF

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Publication number
BRPI0907656A2
BRPI0907656A2 BRPI0907656A BRPI0907656A BRPI0907656A2 BR PI0907656 A2 BRPI0907656 A2 BR PI0907656A2 BR PI0907656 A BRPI0907656 A BR PI0907656A BR PI0907656 A BRPI0907656 A BR PI0907656A BR PI0907656 A2 BRPI0907656 A2 BR PI0907656A2
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BR
Brazil
Prior art keywords
cisatracurium
purity
test compound
purity test
testing
Prior art date
Application number
BRPI0907656A
Other languages
English (en)
Inventor
Klopper Eyal
Shahar Lior
Arad Oded
Saeed Shady
Shteinman Vitaly
Naddaka Vladimir
Original Assignee
Chemagis Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chemagis Ltd filed Critical Chemagis Ltd
Publication of BRPI0907656A2 publication Critical patent/BRPI0907656A2/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)

Abstract

"composto para testar a pureza de cisatracúrio, método para testar a pureza de uma amostra de besilato de cisatracúr1o, uso de um composto para testar a pureza de cisatracürio e processo para preparar compostos para testar a pureza de cisatracúrio" a presente invenção provê compostos que são úteis, p.ex., como marcadores de referência para analisar a pureza de cisatracúrio e sais deste, um método para determinar a dita pureza e a processos para preparar marcadores de referência.
BRPI0907656A 2008-05-01 2009-04-28 composto para testar a pureza de cisatracúrio, método para testar a pureza de uma amostra de besilato de cisatracúrio, uso de um composto para testar a pureza de cisatracúrio e processo para preparar compostos para testar a pureza de cisatracúrio BRPI0907656A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4962008P 2008-05-01 2008-05-01
PCT/IL2009/000452 WO2009133556A2 (en) 2008-05-01 2009-04-28 Cisatracurium derivatives, preparation and uses thereof

Publications (1)

Publication Number Publication Date
BRPI0907656A2 true BRPI0907656A2 (pt) 2019-08-27

Family

ID=41255503

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0907656A BRPI0907656A2 (pt) 2008-05-01 2009-04-28 composto para testar a pureza de cisatracúrio, método para testar a pureza de uma amostra de besilato de cisatracúrio, uso de um composto para testar a pureza de cisatracúrio e processo para preparar compostos para testar a pureza de cisatracúrio

Country Status (6)

Country Link
US (1) US20110185796A1 (pt)
EP (1) EP2283005A4 (pt)
AU (1) AU2009241211A1 (pt)
BR (1) BRPI0907656A2 (pt)
CA (1) CA2722651A1 (pt)
WO (1) WO2009133556A2 (pt)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2008222298A1 (en) * 2007-03-08 2008-09-12 Chemagis Ltd. (1R,1'R)-atracurium salts separation process
BRPI0808581A2 (pt) * 2007-03-26 2014-09-16 Chemagis Ltd "método para separar cisatracúrio com alta pureza de uma mistura de isômeros de (1r, 1'r) - atracúrio"
WO2008132746A1 (en) * 2007-05-01 2008-11-06 Chemagis Ltd. Novel isoquinolinium compounds useful in the preparation of cisatracurium and associated intermediates
EP2155684B1 (en) 2007-05-01 2014-04-09 Chemagis Ltd. Process for producing cisatracurium compounds and associated intermediates
CA2687157A1 (en) 2007-06-18 2008-12-24 Chemagis Ltd. (1r,1'r)-atracurium salts separation process
AU2008320380A1 (en) 2007-10-29 2009-05-07 Chemagis Ltd. Novel R,R'-atracurium salts
CN104557703B (zh) * 2015-01-27 2018-01-16 江苏嘉逸医药有限公司 一种苯磺顺阿曲库铵精制方法
CN111072563A (zh) * 2019-12-20 2020-04-28 上药东英（江苏）药业有限公司 一种苯磺顺阿曲库铵中间体r,r`-顺酯的制备方法
CN112326809A (zh) * 2020-09-24 2021-02-05 南京斯泰尔医药科技有限公司 一种苯磺顺阿曲库铵对映异构体的检测方法
CN112778200B (zh) * 2021-01-20 2022-09-23 江苏诚信药业有限公司 一种苯磺顺阿曲库铵的制备方法及其应用
CN115947685A (zh) * 2023-02-07 2023-04-11 山东铂源药业股份有限公司 苯磺顺阿曲库铵手性异构体杂质的制备方法
CN116429940A (zh) * 2023-04-14 2023-07-14 江苏原创药物研发有限公司 一种苯磺酸阿曲库铵原料药中丙烯酸、丙烯酸甲酯及丙烯酸乙酯的检测方法

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US4491665A (en) * 1979-10-19 1985-01-01 Burroughs Wellcome Co. Method of preparing isomers of bis isoquinolinium compounds
US4701460A (en) * 1980-12-17 1987-10-20 Burroughs Wellcome Co. Long duration neuromuscular blocking agents
GB8418303D0 (en) * 1984-07-18 1984-08-22 Wellcome Found Compounds
JPS62265266A (ja) * 1986-05-13 1987-11-18 Takasago Corp Ｎ−アシル−テトラヒドロイソキノリン類の製造法
US4988815A (en) * 1989-10-26 1991-01-29 Riker Laboratories, Inc. 3-Amino or 3-nitro quinoline compounds which are intermediates in preparing 1H-imidazo[4,5-c]quinolines
US5453510A (en) * 1990-07-13 1995-09-26 Burroughs Wellcome Co. Neuromuscular blocking agents
US5240939A (en) * 1991-10-31 1993-08-31 Anaquest, Inc. Nitrogen bridge tetrahydroisoquinolines
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US5684154A (en) * 1996-02-16 1997-11-04 Abbott Laboratories Process for the preparation and isolation of atracurium besylate
ATE295351T1 (de) * 1997-03-25 2005-05-15 Avera Pharmaceuticals Inc Substituierte isochinoline als ultra kurz wirkende neuromuskuläre blocker
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US20060009485A1 (en) * 2005-06-23 2006-01-12 Chemagis Ltd Method of reprocessing quaternary ammonium-containing neuromuscular blocking agents
AU2006315610A1 (en) * 2005-11-14 2007-05-24 Peter D. Winch Novel colored solutions of injectable drugs and their pharmaceutically acceptable salts
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AU2008222298A1 (en) * 2007-03-08 2008-09-12 Chemagis Ltd. (1R,1'R)-atracurium salts separation process
BRPI0808581A2 (pt) * 2007-03-26 2014-09-16 Chemagis Ltd "método para separar cisatracúrio com alta pureza de uma mistura de isômeros de (1r, 1'r) - atracúrio"
WO2008132746A1 (en) * 2007-05-01 2008-11-06 Chemagis Ltd. Novel isoquinolinium compounds useful in the preparation of cisatracurium and associated intermediates
WO2009007946A1 (en) * 2007-07-09 2009-01-15 Chemagis Ltd. Process for producing cisatracurium and associated intermediates
EP2155684B1 (en) * 2007-05-01 2014-04-09 Chemagis Ltd. Process for producing cisatracurium compounds and associated intermediates
CA2687157A1 (en) * 2007-06-18 2008-12-24 Chemagis Ltd. (1r,1'r)-atracurium salts separation process
AU2008320380A1 (en) * 2007-10-29 2009-05-07 Chemagis Ltd. Novel R,R'-atracurium salts
ITMI20080319A1 (it) * 2008-02-28 2009-08-29 Recordati Chem Pharm Processo per la risoluzione di derivati isochinolinici
IT1396543B1 (it) * 2008-07-16 2012-12-14 Farmabios Spa Processo per la purificazione di bloccanti neuromuscolari

Also Published As

Publication number Publication date
US20110185796A1 (en) 2011-08-04
CA2722651A1 (en) 2009-11-05
AU2009241211A1 (en) 2009-11-05
EP2283005A4 (en) 2011-08-31
EP2283005A2 (en) 2011-02-16
WO2009133556A2 (en) 2009-11-05
WO2009133556A3 (en) 2010-03-11

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B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 6A, 7A, 8A, 9A E 10A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2539 DE 03-09-2019 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.

B350 Update of information on the portal [chapter 15.35 patent gazette]