BRPI0908075A2 - Antagonísta muscarínicos de pde4-duplos farmacóforos - Google Patents

Antagonísta muscarínicos de pde4-duplos farmacóforos

Info

Publication number
BRPI0908075A2
BRPI0908075A2 BRPI0908075-9A BRPI0908075A BRPI0908075A2 BR PI0908075 A2 BRPI0908075 A2 BR PI0908075A2 BR PI0908075 A BRPI0908075 A BR PI0908075A BR PI0908075 A2 BRPI0908075 A2 BR PI0908075A2
Authority
BR
Brazil
Prior art keywords
pde4
muscarinic antagonist
double
pharmacophores
antagonist pharmacophores
Prior art date
Application number
BRPI0908075-9A
Other languages
English (en)
Inventor
James Francis Callahan
Guoliang Lin
Zehong Wan
Hongxing Yan
Original Assignee
Glaxo Group Limided
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Limided filed Critical Glaxo Group Limided
Publication of BRPI0908075A2 publication Critical patent/BRPI0908075A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
BRPI0908075-9A 2008-02-06 2009-02-05 Antagonísta muscarínicos de pde4-duplos farmacóforos BRPI0908075A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2657208P 2008-02-06 2008-02-06
PCT/US2009/033130 WO2009100168A1 (en) 2008-02-06 2009-02-05 Dual pharmacophores - pde4-muscarinic antagonistics

Publications (1)

Publication Number Publication Date
BRPI0908075A2 true BRPI0908075A2 (pt) 2015-08-25

Family

ID=40932308

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0908075-9A BRPI0908075A2 (pt) 2008-02-06 2009-02-05 Antagonísta muscarínicos de pde4-duplos farmacóforos

Country Status (18)

Country Link
US (1) US8067408B2 (pt)
EP (1) EP2249647A4 (pt)
JP (1) JP2011511084A (pt)
KR (1) KR20100120296A (pt)
CN (1) CN101983010A (pt)
AR (1) AR070564A1 (pt)
AU (1) AU2009212410A1 (pt)
BR (1) BRPI0908075A2 (pt)
CA (1) CA2714419A1 (pt)
CL (1) CL2009000248A1 (pt)
DO (1) DOP2010000238A (pt)
EA (1) EA201070927A1 (pt)
IL (1) IL207351A0 (pt)
MX (1) MX2010008692A (pt)
PE (1) PE20091553A1 (pt)
TW (1) TW200946526A (pt)
UY (1) UY31635A1 (pt)
WO (1) WO2009100168A1 (pt)

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EP2552893B1 (en) 2010-03-31 2014-10-29 Actelion Pharmaceuticals Ltd. Antibacterial isoquinolin-3-ylurea derivatives
WO2011143106A1 (en) * 2010-05-10 2011-11-17 Gilead Sciences, Inc. Bi - functional pyrazolopyridine compounds
CA2896554C (en) * 2012-12-27 2019-11-05 Drexel University Novel antiviral agents against hbv infection
WO2016198691A1 (en) 2015-06-11 2016-12-15 Basilea Pharmaceutica Ag Efflux-pump inhibitors and therapeutic uses thereof
WO2017089347A1 (en) 2015-11-25 2017-06-01 Inserm (Institut National De La Sante Et De La Recherche Medicale) Methods and pharmaceutical compositions for the treatment of braf inhibitor resistant melanomas

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Also Published As

Publication number Publication date
PE20091553A1 (es) 2009-10-30
MX2010008692A (es) 2010-11-25
AR070564A1 (es) 2010-04-21
JP2011511084A (ja) 2011-04-07
CA2714419A1 (en) 2009-08-13
US20090197871A1 (en) 2009-08-06
DOP2010000238A (es) 2011-03-31
EA201070927A1 (ru) 2011-04-29
CL2009000248A1 (es) 2009-09-11
CN101983010A (zh) 2011-03-02
IL207351A0 (en) 2010-12-30
EP2249647A4 (en) 2012-07-18
EP2249647A1 (en) 2010-11-17
US8067408B2 (en) 2011-11-29
WO2009100168A1 (en) 2009-08-13
UY31635A1 (es) 2009-08-31
AU2009212410A1 (en) 2009-08-13
KR20100120296A (ko) 2010-11-15
TW200946526A (en) 2009-11-16

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 4A, 5A E 6A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2344 DE 08-12-2015 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.