BRPI0908797A2 - Métodos para preparar a forma polimórfica a de acetato de bazedoxifeno - Google Patents

Métodos para preparar a forma polimórfica a de acetato de bazedoxifeno

Info

Publication number
BRPI0908797A2
BRPI0908797A2 BRPI0908797-4A BRPI0908797A BRPI0908797A2 BR PI0908797 A2 BRPI0908797 A2 BR PI0908797A2 BR PI0908797 A BRPI0908797 A BR PI0908797A BR PI0908797 A2 BRPI0908797 A2 BR PI0908797A2
Authority
BR
Brazil
Prior art keywords
preparing
methods
polymorphic form
bazedoxifene acetate
bazedoxifene
Prior art date
Application number
BRPI0908797-4A
Other languages
English (en)
Inventor
Paolo Andreella
Giuseppe Barreca
Francesco Tasinato
Massimo Verzini
Marco Demo
Fabio Bassan
Vincenzo Cannata
Giorgio Soriato
Roberto Brescello
Pietro Allegrini
Livius Cotarca
Original Assignee
Wyeth Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Llc filed Critical Wyeth Llc
Publication of BRPI0908797A2 publication Critical patent/BRPI0908797A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/32—Antioestrogens

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
BRPI0908797-4A 2008-02-11 2009-02-11 Métodos para preparar a forma polimórfica a de acetato de bazedoxifeno BRPI0908797A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2763408P 2008-02-11 2008-02-11
PCT/US2009/033772 WO2009102773A1 (en) 2008-02-11 2009-02-11 Methods of preparing polymorphic form a of bazedoxifene acetate

Publications (1)

Publication Number Publication Date
BRPI0908797A2 true BRPI0908797A2 (pt) 2015-07-21

Family

ID=40521908

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0908797-4A BRPI0908797A2 (pt) 2008-02-11 2009-02-11 Métodos para preparar a forma polimórfica a de acetato de bazedoxifeno

Country Status (14)

Country Link
US (2) US8183367B2 (pt)
EP (1) EP2252585B1 (pt)
JP (1) JP5199395B2 (pt)
KR (1) KR20100113627A (pt)
CN (1) CN101977897A (pt)
AU (1) AU2009214871A1 (pt)
BR (1) BRPI0908797A2 (pt)
CA (1) CA2714494A1 (pt)
ES (1) ES2436662T3 (pt)
IL (1) IL207504A0 (pt)
MX (1) MX2010008840A (pt)
RU (1) RU2010133603A (pt)
WO (1) WO2009102773A1 (pt)
ZA (1) ZA201006519B (pt)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2493477B1 (en) * 2009-10-27 2013-10-16 Wyeth LLC Bazedoxifene formulations with antioxidants
EP2616463A4 (en) 2010-09-14 2014-01-08 Reddys Lab Ltd Dr PREPARATION OF CRYSTALLINE BAZEDOXIFES AND THEIR SALTS
EP2471770A1 (en) 2010-12-28 2012-07-04 Sandoz Ag Method of preparing polymorphic pure form A of bazedoxifene acetate
US9751835B2 (en) 2013-05-15 2017-09-05 Indiana University Research And Technology Corporation Processes and intermediates for preparing indole pharmaceuticals
CN103864665B (zh) * 2014-03-04 2016-03-02 苏州特瑞药业有限公司 醋酸巴多昔芬的制备方法
CN103877581B (zh) * 2014-03-24 2016-03-02 江苏知原药业有限公司 一种性能优异的乙酸巴多昔芬缓释制剂
CN104030963A (zh) * 2014-06-30 2014-09-10 四川大学 一种巴多昔芬醋酸盐晶型a的制备方法
EP3179814B1 (en) * 2014-09-10 2019-04-03 Huawei Technologies Co., Ltd. Apparatus and method for establishing data transmission link, and communications system
CN104370796B (zh) * 2014-11-21 2016-09-14 扬子江药业集团有限公司 一种醋酸巴多昔芬多晶型b的制备方法
CN105669518B (zh) * 2014-12-04 2019-06-04 上海医药集团股份有限公司 醋酸巴多昔芬及其a晶型的制备方法
CN107628982B (zh) * 2016-07-19 2021-03-23 苏州立新制药有限公司 醋酸巴多昔芬多晶型a的制备方法
CN106631971B (zh) * 2016-12-19 2019-02-12 齐鲁天和惠世制药有限公司 一种醋酸巴多昔芬的制备方法
CN106748959A (zh) * 2017-01-17 2017-05-31 成都归合科技有限公司 一种纯醋酸巴多昔芬晶型a的制备方法
KR101940569B1 (ko) * 2017-05-24 2019-01-21 아주대학교산학협력단 바제독시펜 또는 이의 약학적으로 허용가능한 염을 포함하는 약학 조성물
IT201900001923A1 (it) * 2019-02-11 2020-08-11 Erregierre Spa Sali di bazedoxifene utili per la preparazione di bazedoxifene acetato
CN111004165A (zh) * 2019-12-03 2020-04-14 南京正济医药研究有限公司 一种醋酸巴多昔芬晶型a的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT802183E (pt) * 1996-04-19 2002-03-28 American Home Prod Agentes estrogenicos
JP2007532548A (ja) * 2004-04-07 2007-11-15 ワイス バゼドキシフェンアセテートの結晶質多形体
WO2005100316A1 (en) * 2004-04-07 2005-10-27 Wyeth Crystalline polymorph of a bazedoxifene acetate

Also Published As

Publication number Publication date
ES2436662T3 (es) 2014-01-03
US8618284B2 (en) 2013-12-31
EP2252585A1 (en) 2010-11-24
JP2011511843A (ja) 2011-04-14
AU2009214871A1 (en) 2009-08-20
CA2714494A1 (en) 2009-08-20
CN101977897A (zh) 2011-02-16
IL207504A0 (en) 2010-12-30
EP2252585B1 (en) 2013-11-06
MX2010008840A (es) 2010-11-10
KR20100113627A (ko) 2010-10-21
RU2010133603A (ru) 2012-03-20
ZA201006519B (en) 2011-05-25
WO2009102773A1 (en) 2009-08-20
JP5199395B2 (ja) 2013-05-15
US20100016581A1 (en) 2010-01-21
US8183367B2 (en) 2012-05-22
US20130018184A1 (en) 2013-01-17

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 5A E 6A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2344 DE 08-12-2015 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.