BRPI1009145A2 - método para a fabricação de derivado de benzodiazepina - Google Patents
método para a fabricação de derivado de benzodiazepinaInfo
- Publication number
- BRPI1009145A2 BRPI1009145A2 BRPI1009145A BRPI1009145A BRPI1009145A2 BR PI1009145 A2 BRPI1009145 A2 BR PI1009145A2 BR PI1009145 A BRPI1009145 A BR PI1009145A BR PI1009145 A BRPI1009145 A BR PI1009145A BR PI1009145 A2 BRPI1009145 A2 BR PI1009145A2
- Authority
- BR
- Brazil
- Prior art keywords
- manufacture
- benzodiazepine derivative
- benzodiazepine
- derivative
- Prior art date
Links
- 125000003310 benzodiazepinyl group Chemical class N1N=C(C=CC2=C1C=CC=C2)* 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/12—1,5-Benzodiazepines; Hydrogenated 1,5-benzodiazepines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C269/06—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups by reactions not involving the formation of carbamate groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/26—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring
- C07C271/28—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring to a carbon atom of a non-condensed six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
- C07C311/19—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D203/00—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom
- C07D203/04—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D203/06—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D203/16—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with acylated ring nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2009087746 | 2009-03-31 | ||
| PCT/JP2010/002237 WO2010113458A1 (ja) | 2009-03-31 | 2010-03-29 | １，５－ベンゾジアゼピン誘導体の製造法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI1009145A2 true BRPI1009145A2 (pt) | 2016-04-19 |
Family
ID=42827768
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI1009145A BRPI1009145A2 (pt) | 2009-03-31 | 2010-03-29 | método para a fabricação de derivado de benzodiazepina |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20120010401A1 (pt) |
| EP (1) | EP2415766A4 (pt) |
| JP (1) | JPWO2010113458A1 (pt) |
| KR (1) | KR20120027111A (pt) |
| CN (1) | CN102333763A (pt) |
| AU (1) | AU2010231439A1 (pt) |
| BR (1) | BRPI1009145A2 (pt) |
| CA (1) | CA2757208A1 (pt) |
| MX (1) | MX2011010254A (pt) |
| RU (1) | RU2011143755A (pt) |
| SG (1) | SG174591A1 (pt) |
| TW (1) | TW201102371A (pt) |
| WO (1) | WO2010113458A1 (pt) |
| ZA (1) | ZA201106360B (pt) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102690239B (zh) * | 2012-04-01 | 2015-01-28 | 浙江工业大学 | 一种1,5-苯并二氮卓类衍生物的合成方法 |
| RU2693484C1 (ru) | 2013-11-22 | 2019-07-03 | СиЭль БАЙОСАЕНСИЗ ЭлЭлСи | Антагонисты гастрина для лечения и профилактики остеопороза |
| JP2019167295A (ja) * | 2016-07-04 | 2019-10-03 | ゼリア新薬工業株式会社 | １，５−ベンゾジアゼピン化合物カルシウム塩の製造法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9308421D0 (en) * | 1993-04-23 | 1993-06-09 | Glaxo Spa | Chemical compounds |
| DK0855397T3 (da) | 1995-07-28 | 2001-06-25 | Dainippon Pharmaceutical Co | (R)-5-brom-N-(ethyl-4-methylhexahydro-1H-1,4-diazepin-6-yl)-2-methoxy-6-methylamino-3-pyridincarboxamid, fremgangsmåde til dets fremstilling og medicinsk præparat indeholdende denne forbindelse |
| JP3999819B2 (ja) * | 1996-12-10 | 2007-10-31 | ゼリア新薬工業株式会社 | １，５―ベンゾジアセピン誘導体 |
| JPH10203987A (ja) | 1997-01-28 | 1998-08-04 | Dainippon Pharmaceut Co Ltd | （ｒ）−１−エチル−４−メチルヘキサヒドロ−１ｈ−１，４−ジアゼピン誘導体を有効成分とするモルヒネ様薬剤誘発嘔吐抑制剤 |
| JP2000026434A (ja) | 1998-06-05 | 2000-01-25 | Zeria Pharmaceut Co Ltd | 新規１，５−ベンゾジアゼピン誘導体 |
| EP1234818B1 (en) * | 1999-12-02 | 2004-09-08 | Zeria Pharmaceutical Co., Ltd. | Calcium salts of 1,5-benzodiazepine derivatives, process for producing the salts and drugs containing the same |
| ATE410161T1 (de) * | 2003-05-02 | 2008-10-15 | Elan Pharm Inc | 4-bromo-5-(2-chloro-benzoylamino)-1h-pyrazol-3- carbonsäureamid-derivate und verwandte verbindungen als bradykinin b1 rezeptor antagonisten zur behandlung von entzündlichen erkrankungen |
| PL1839662T3 (pl) | 2005-01-19 | 2010-08-31 | Zeria Pharm Co Ltd | Środek przeciwnowotworowy |
| JP2008012873A (ja) | 2006-07-10 | 2008-01-24 | Fujinon Sano Kk | 射出成形用金型装置 |
| WO2008039420A2 (en) * | 2006-09-27 | 2008-04-03 | Merck & Co., Inc. | Novel inhibitors of beta-lactamase |
-
2010
- 2010-03-29 CN CN201080009742.0A patent/CN102333763A/zh active Pending
- 2010-03-29 TW TW099109438A patent/TW201102371A/zh unknown
- 2010-03-29 AU AU2010231439A patent/AU2010231439A1/en not_active Abandoned
- 2010-03-29 BR BRPI1009145A patent/BRPI1009145A2/pt not_active IP Right Cessation
- 2010-03-29 RU RU2011143755/04A patent/RU2011143755A/ru unknown
- 2010-03-29 SG SG2011070034A patent/SG174591A1/en unknown
- 2010-03-29 EP EP10758238A patent/EP2415766A4/en not_active Withdrawn
- 2010-03-29 JP JP2011507011A patent/JPWO2010113458A1/ja active Pending
- 2010-03-29 WO PCT/JP2010/002237 patent/WO2010113458A1/ja not_active Ceased
- 2010-03-29 CA CA2757208A patent/CA2757208A1/en not_active Abandoned
- 2010-03-29 US US13/257,531 patent/US20120010401A1/en not_active Abandoned
- 2010-03-29 MX MX2011010254A patent/MX2011010254A/es not_active Application Discontinuation
- 2010-03-29 KR KR1020117020023A patent/KR20120027111A/ko not_active Withdrawn
-
2011
- 2011-08-30 ZA ZA2011/06360A patent/ZA201106360B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| TW201102371A (en) | 2011-01-16 |
| JPWO2010113458A1 (ja) | 2012-10-04 |
| SG174591A1 (en) | 2011-10-28 |
| WO2010113458A1 (ja) | 2010-10-07 |
| MX2011010254A (es) | 2011-10-11 |
| CN102333763A (zh) | 2012-01-25 |
| KR20120027111A (ko) | 2012-03-21 |
| US20120010401A1 (en) | 2012-01-12 |
| RU2011143755A (ru) | 2013-05-10 |
| ZA201106360B (en) | 2012-11-28 |
| CA2757208A1 (en) | 2010-10-07 |
| EP2415766A1 (en) | 2012-02-08 |
| AU2010231439A1 (en) | 2011-10-27 |
| EP2415766A4 (en) | 2012-11-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE AS 4A, 5A E 6A ANUIDADES. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2370 DE 07-06-2016 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |