BRPI0909661A2 - Composto e métodos de síntese química e de formação ou preparação de compostos - Google Patents

Composto e métodos de síntese química e de formação ou preparação de compostos

Info

Publication number
BRPI0909661A2
BRPI0909661A2 BRPI0909661-2A BRPI0909661A BRPI0909661A2 BR PI0909661 A2 BRPI0909661 A2 BR PI0909661A2 BR PI0909661 A BRPI0909661 A BR PI0909661A BR PI0909661 A2 BRPI0909661 A2 BR PI0909661A2
Authority
BR
Brazil
Prior art keywords
compound
chemical synthesis
preparation methods
formation
compound formation
Prior art date
Application number
BRPI0909661-2A
Other languages
English (en)
Inventor
Ling Taotao
Samuel Danishefsky
Original Assignee
Nereus Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nereus Pharmaceuticals Inc filed Critical Nereus Pharmaceuticals Inc
Publication of BRPI0909661A2 publication Critical patent/BRPI0909661A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Epoxy Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
BRPI0909661-2A 2008-03-07 2009-03-06 Composto e métodos de síntese química e de formação ou preparação de compostos BRPI0909661A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US3490008P 2008-03-07 2008-03-07
US7354508P 2008-06-18 2008-06-18
PCT/US2009/036376 WO2009134531A2 (en) 2008-03-07 2009-03-06 Total synthesis of salinosporamide a and analogs thereof

Publications (1)

Publication Number Publication Date
BRPI0909661A2 true BRPI0909661A2 (pt) 2015-08-11

Family

ID=41063770

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0909661-2A BRPI0909661A2 (pt) 2008-03-07 2009-03-06 Composto e métodos de síntese química e de formação ou preparação de compostos

Country Status (13)

Country Link
US (3) US8003802B2 (pt)
EP (1) EP2262812A2 (pt)
JP (1) JP2011514352A (pt)
KR (1) KR20100131475A (pt)
CN (1) CN102015721A (pt)
AU (1) AU2009241635A1 (pt)
BR (1) BRPI0909661A2 (pt)
CA (1) CA2717715A1 (pt)
CO (1) CO6331341A2 (pt)
IL (1) IL208035A0 (pt)
MX (1) MX2010009860A (pt)
NZ (1) NZ587985A (pt)
WO (1) WO2009134531A2 (pt)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7176232B2 (en) 2002-06-24 2007-02-13 The Regents Of The University Of California Salinosporamides and methods for use thereof
EP2441767B1 (en) * 2003-06-20 2015-06-10 The Regents of The University of California Salinosporamides and methods for use thereof
KR20060026052A (ko) 2003-06-20 2006-03-22 니리어스 파마슈티컬즈, 인코퍼레이션 암, 염증 및 감염성 질환의 치료를 위한 [3.2.0]헤테로사이클릭 화합물 및 그 유사체의 사용방법
SG157365A1 (en) 2004-12-03 2009-12-29 Dana Farber Cancer Inst Inc Compositions and methods for treating neoplastic diseases
NZ572026A (en) * 2006-04-06 2011-12-22 Nereus Pharmaceuticals Inc Total synthesis of salinosporamide a and analogs thereof
US8394816B2 (en) * 2007-12-07 2013-03-12 Irene Ghobrial Methods of using [3.2.0] heterocyclic compounds and analogs thereof in treating Waldenstrom's Macroglobulinemia
JP2011514352A (ja) 2008-03-07 2011-05-06 ネレアス ファーマシューティカルズ インコーポレイテッド サリノスポラミドａおよびその類似体の全合成
CN102089312A (zh) * 2008-05-12 2011-06-08 尼瑞斯药品公司 作为蛋白酶体抑制剂的Salinosporamide衍生物
US9272014B2 (en) * 2011-03-29 2016-03-01 Texas Tech University System Galectin-3C combination therapy for human cancer
JP7171550B2 (ja) 2016-06-01 2022-11-15 セルジュヌ アンテルナシオナル ドゥジエム ソシエテ ア レスポンサビリテ リミティー 中枢神経系（ｃｎｓ）がんの処置のためのマリゾミブの使用
US10703760B2 (en) 2016-08-19 2020-07-07 Celgene International Ii Sàrl Morphic forms of marizomib and uses thereof
CN107383033A (zh) * 2017-06-29 2017-11-24 上海药明康德新药开发有限公司 顺式5‑叔丁氧羰基‑四氢呋喃并[3,4‑c]吡咯‑3A‑羧酸甲酯的合成方法

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6335358B1 (en) 1995-04-12 2002-01-01 President And Fellows Of Harvard College Lactacystin analogs
BR9811304A (pt) 1997-08-15 2001-11-13 Francois Soucy Sìntese de clasto-lactacistina" beta"-lactona eseus análogos
WO1999015183A1 (en) 1997-09-25 1999-04-01 Proscript Inc. PROTEASOME INHIBITORS, UBIQUITIN PATHWAY INHIBITORS OR AGENTS THAT INTERFERE WITH THE ACTIVATION OF NF-λB VIA THE UBIQUITIN PROTEASOME PATHWAY TO TREAT INFLAMMATORY AND AUTOIMMUNE DISEASES
JP4395549B2 (ja) 2000-11-16 2010-01-13 ザ レジェンツ オブ ザ ユニヴァースティ オブ カリフォルニア 薬物及び発酵生成物の発見のための海洋放線菌分類群
US7176232B2 (en) 2002-06-24 2007-02-13 The Regents Of The University Of California Salinosporamides and methods for use thereof
US7179834B2 (en) 2002-06-24 2007-02-20 The Regents Of The University Of California Salinosporamides and methods for use thereof
ATE448232T1 (de) 2003-02-14 2009-11-15 Intermed Discovery Gmbh Substituierte heterozyklen
EP2441767B1 (en) 2003-06-20 2015-06-10 The Regents of The University of California Salinosporamides and methods for use thereof
KR20060026052A (ko) 2003-06-20 2006-03-22 니리어스 파마슈티컬즈, 인코퍼레이션 암, 염증 및 감염성 질환의 치료를 위한 [3.2.0]헤테로사이클릭 화합물 및 그 유사체의 사용방법
US7371875B2 (en) 2004-03-12 2008-05-13 Miikana Therapeutics, Inc. Cytotoxic agents and methods of use
WO2005099687A2 (en) 2004-04-09 2005-10-27 President And Fellows Of Harvard College Analogs of salinosporamide a
US7183417B2 (en) 2004-04-09 2007-02-27 President And Fellows Of Harvard College Simple stereocontrolled synthesis of salinosporamide A
BRPI0509824A (pt) 2004-04-30 2007-10-09 Nereus Pharmaceuticals Inc compostos heterocìclicos [3.2.0] e métodos de uso dos mesmos
US7579371B2 (en) 2004-04-30 2009-08-25 Nereus Pharmaceuticals, Inc. Methods of using [3.2.0] heterocyclic compounds and analogs thereof
US20060264495A1 (en) 2004-04-30 2006-11-23 Michael Palladino Methods of using [3.2.0] heterocyclic compounds and analogs thereof
MX2007000392A (es) 2004-07-12 2007-06-15 Bayer Cropscience Ag Derivados de 2-pirrolidona sustituida como fungicidas e insecticidas.
CA2590334A1 (en) 2004-12-03 2006-06-08 Nereus Pharmaceuticals, Inc. Methods of using [3.2.0] heterocyclic compounds and analogs thereof
SG157365A1 (en) 2004-12-03 2009-12-29 Dana Farber Cancer Inst Inc Compositions and methods for treating neoplastic diseases
WO2006118973A2 (en) 2005-04-29 2006-11-09 Nereus Pharmaceuticals, Inc. Methods of using heterobyclic compounds for treatment of rectal cancer
WO2006124902A2 (en) 2005-05-16 2006-11-23 Sloan-Kettering Institute For Cancer Research Synthesis of salinosporamide a and analogues thereof
US7691896B2 (en) 2005-08-10 2010-04-06 President And Fellows Of Harvard College Analogs of salinosporamide A
WO2007021897A1 (en) 2005-08-10 2007-02-22 President And Fellows Of Harvard College Analogs of salinosporamide a
US7465720B2 (en) 2005-09-12 2008-12-16 President And Fellows Of Harvard College Proteasome inhibiting β-lactam compounds
BRPI0618198A2 (pt) 2005-11-04 2018-06-26 Nereus Pharmaceuticals Inc métodos de tratamento, prevenção ou inibição de câncer e de linfoma, composição, kit, e, método de tratamento de câncer resistente a terapia
WO2007068090A1 (en) * 2005-12-12 2007-06-21 Audiokinetic Inc. System and method for authoring media content
US7759327B2 (en) 2006-01-06 2010-07-20 The Trustees Of Columbia University In The City Of New York Compositions containing zinc salts for coating medical articles
NZ572026A (en) * 2006-04-06 2011-12-22 Nereus Pharmaceuticals Inc Total synthesis of salinosporamide a and analogs thereof
WO2008137780A2 (en) 2007-05-04 2008-11-13 Nereus Pharmaceuticals, Inc. Use of [3.2.0] heterocyclic compounds and analogs thereof for treating infectious diseases
US8394816B2 (en) 2007-12-07 2013-03-12 Irene Ghobrial Methods of using [3.2.0] heterocyclic compounds and analogs thereof in treating Waldenstrom's Macroglobulinemia
JP2011514352A (ja) 2008-03-07 2011-05-06 ネレアス ファーマシューティカルズ インコーポレイテッド サリノスポラミドａおよびその類似体の全合成
CN102089312A (zh) 2008-05-12 2011-06-08 尼瑞斯药品公司 作为蛋白酶体抑制剂的Salinosporamide衍生物

Also Published As

Publication number Publication date
WO2009134531A2 (en) 2009-11-05
WO2009134531A3 (en) 2010-11-18
KR20100131475A (ko) 2010-12-15
MX2010009860A (es) 2010-09-30
CO6331341A2 (es) 2011-10-20
IL208035A0 (en) 2010-12-30
US20090234137A1 (en) 2009-09-17
CN102015721A (zh) 2011-04-13
AU2009241635A1 (en) 2009-11-05
CA2717715A1 (en) 2009-11-05
JP2011514352A (ja) 2011-05-06
NZ587985A (en) 2012-07-27
EP2262812A2 (en) 2010-12-22
US20130012720A1 (en) 2013-01-10
US20110269969A1 (en) 2011-11-03
US8314251B2 (en) 2012-11-20
US8003802B2 (en) 2011-08-23

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 5A E 6A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2344 DE 08-12-2015 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.