BRPI0909695A2 - processo para a preparação de nebivolol - Google Patents

processo para a preparação de nebivolol

Info

Publication number
BRPI0909695A2
BRPI0909695A2 BRPI0909695A BRPI0909695A BRPI0909695A2 BR PI0909695 A2 BRPI0909695 A2 BR PI0909695A2 BR PI0909695 A BRPI0909695 A BR PI0909695A BR PI0909695 A BRPI0909695 A BR PI0909695A BR PI0909695 A2 BRPI0909695 A2 BR PI0909695A2
Authority
BR
Brazil
Prior art keywords
nebivolol
preparation
halocetone
refers
formula
Prior art date
Application number
BRPI0909695A
Other languages
English (en)
Inventor
Massaccesi Franco
Munari Ilaria
Foletto Johnny
Cotarca Livius
Maragni Paolo
Volpicelli Raffaella
Original Assignee
Zach System Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zach System Spa filed Critical Zach System Spa
Publication of BRPI0909695A2 publication Critical patent/BRPI0909695A2/pt
Publication of BRPI0909695B1 publication Critical patent/BRPI0909695B1/pt
Publication of BRPI0909695B8 publication Critical patent/BRPI0909695B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)

Abstract

processo para a preparação de nebivolol a presente invenção preparação de nebivolol método para a redução halocetona de fórmula (i): se refere a um processo para a e, mais particularmente, a um estereosseletiva intermediário útil para a preparação e nebivolol.p
BRPI0909695A 2008-03-31 2009-03-16 processo de redução, processo de preparação de compostos e processo de preparação de nebivolol BRPI0909695B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IT000547A ITMI20080547A1 (it) 2008-03-31 2008-03-31 Processo di preparazione di nebivololo
ITMI2008A000547 2008-03-31
PCT/EP2009/053051 WO2009121710A2 (en) 2008-03-31 2009-03-16 Process for preparing nebivolol

Publications (3)

Publication Number Publication Date
BRPI0909695A2 true BRPI0909695A2 (pt) 2019-02-26
BRPI0909695B1 BRPI0909695B1 (pt) 2021-03-23
BRPI0909695B8 BRPI0909695B8 (pt) 2021-05-25

Family

ID=40293002

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0909695A BRPI0909695B8 (pt) 2008-03-31 2009-03-16 processo de redução, processo de preparação de compostos e processo de preparação de nebivolol

Country Status (14)

Country Link
US (1) US8084629B2 (pt)
EP (1) EP2265596B1 (pt)
JP (1) JP5502849B2 (pt)
CN (1) CN101952270B (pt)
AU (1) AU2009231345B2 (pt)
BR (1) BRPI0909695B8 (pt)
CA (1) CA2714051C (pt)
ES (1) ES2588982T3 (pt)
HR (1) HRP20160740T1 (pt)
HU (1) HUE029929T2 (pt)
IL (1) IL207222A (pt)
IT (1) ITMI20080547A1 (pt)
SI (1) SI2265596T1 (pt)
WO (1) WO2009121710A2 (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1395354B1 (it) * 2009-07-23 2012-09-14 Zach System Spa Processo di preparazione di nebivololo
DE102010005953A1 (de) 2010-01-27 2011-07-28 Corden PharmaChem GmbH, 68305 Verfahren zur Herstellung von Nebivolol
CN102180855B (zh) * 2011-03-01 2015-11-25 浙江华海药业股份有限公司 一种奈必洛尔中间体的提纯方法
CN102816141A (zh) * 2012-09-10 2012-12-12 济南爱思医药科技有限公司 一种制备奈必洛尔消旋体盐酸盐的方法
CN105503842A (zh) * 2015-12-24 2016-04-20 广安凯特医药化工有限公司 盐酸奈必洛尔环氧中间体6-氟-2-环氧乙基色满的制备方法
CN110015944A (zh) * 2019-05-06 2019-07-16 福建康鸿生物科技有限公司 一种高选择性的卢立康唑中间体的合成方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1337429C (en) * 1983-12-05 1995-10-24 Guy Rosalia Eugene Van Lommen Derivatives of 2,2'-iminobisethanol
CA1337432C (en) * 1988-03-23 1995-10-24 Raymond M. Xhonneux Method of lowering the blood pressure
CN100546987C (zh) * 2005-03-03 2009-10-07 浙江医药股份有限公司新昌制药厂 Dl-奈必洛尔及其盐酸盐的制备方法
US7560575B2 (en) * 2005-12-28 2009-07-14 Acino Pharma Ag Process for preparation of racemic Nebivolol
EP1803716B1 (en) * 2005-12-28 2012-07-25 Acino Pharma AG A process for preparation of racemic nebivolol
ITMI20061889A1 (it) * 2006-10-03 2008-04-04 Zambon Spa Processo di preparazione di nebivololo
WO2008064826A1 (en) * 2006-11-27 2008-06-05 Zach System S.P.A. Process for preparing nebivolol

Also Published As

Publication number Publication date
JP5502849B2 (ja) 2014-05-28
CA2714051C (en) 2016-02-02
US8084629B2 (en) 2011-12-27
HUE029929T2 (en) 2017-04-28
SI2265596T1 (sl) 2016-08-31
HRP20160740T1 (hr) 2016-07-15
ITMI20080547A1 (it) 2009-10-01
BRPI0909695B8 (pt) 2021-05-25
CN101952270B (zh) 2013-04-24
AU2009231345A1 (en) 2009-10-08
CA2714051A1 (en) 2009-10-08
AU2009231345B2 (en) 2013-08-01
WO2009121710A2 (en) 2009-10-08
US20110021793A1 (en) 2011-01-27
EP2265596A2 (en) 2010-12-29
BRPI0909695B1 (pt) 2021-03-23
JP2011516418A (ja) 2011-05-26
CN101952270A (zh) 2011-01-19
IL207222A (en) 2015-05-31
EP2265596B1 (en) 2016-06-01
WO2009121710A3 (en) 2010-02-25
ES2588982T3 (es) 2016-11-08
IL207222A0 (en) 2010-12-30

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B25A Requested transfer of rights approved

Owner name: F.I.S. - FABBRICA ITALIANA SINTETICI S.P.A. (IT)

B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 23/03/2021, OBSERVADAS AS CONDICOES LEGAIS.

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 16/03/2009 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF