BRPI1008300A8 - processo de purificação de daptomicina - Google Patents

processo de purificação de daptomicina

Info

Publication number
BRPI1008300A8
BRPI1008300A8 BRPI1008300A BRPI1008300A BRPI1008300A8 BR PI1008300 A8 BRPI1008300 A8 BR PI1008300A8 BR PI1008300 A BRPI1008300 A BR PI1008300A BR PI1008300 A BRPI1008300 A BR PI1008300A BR PI1008300 A8 BRPI1008300 A8 BR PI1008300A8
Authority
BR
Brazil
Prior art keywords
purification process
daptomycin
daptomycin purification
improved method
relates
Prior art date
Application number
BRPI1008300A
Other languages
English (en)
Inventor
Overballe-Petersen Carsten
Brian Hansen Dennis
Karin Dale Eli
Aastorp Hirth Kjersti
Månsson Martin
Hauge Sissel
Original Assignee
Xellia Pharmaceuticals Aps
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42116034&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI1008300(A8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Xellia Pharmaceuticals Aps filed Critical Xellia Pharmaceuticals Aps
Publication of BRPI1008300A2 publication Critical patent/BRPI1008300A2/pt
Publication of BRPI1008300A8 publication Critical patent/BRPI1008300A8/pt
Publication of BRPI1008300B1 publication Critical patent/BRPI1008300B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/20—Partition-, reverse-phase or hydrophobic interaction chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

processo de purificação de daptomicina. a invenção se refere a um processo de purificação de lipopeptídeos. mais particularmente, a invenção oferece um método aprimorado de purificação de daptomicina.
BRPI1008300-6A 2009-02-19 2010-02-19 Processo de purificação de daptomicina BRPI1008300B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US15366009P 2009-02-19 2009-02-19
US61/153,660 2009-02-19
PCT/NO2010/000066 WO2010095953A1 (en) 2009-02-19 2010-02-19 Process for purifying lipopeptides

Publications (3)

Publication Number Publication Date
BRPI1008300A2 BRPI1008300A2 (pt) 2016-03-15
BRPI1008300A8 true BRPI1008300A8 (pt) 2021-05-11
BRPI1008300B1 BRPI1008300B1 (pt) 2021-07-13

Family

ID=42116034

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI1008300-6A BRPI1008300B1 (pt) 2009-02-19 2010-02-19 Processo de purificação de daptomicina

Country Status (21)

Country Link
US (1) US9150894B2 (pt)
EP (1) EP2398817B2 (pt)
JP (1) JP5752609B2 (pt)
KR (1) KR101666144B1 (pt)
CN (1) CN102325785B (pt)
AU (1) AU2010216475B2 (pt)
BR (1) BRPI1008300B1 (pt)
CA (1) CA2748932C (pt)
DK (1) DK2398817T4 (pt)
ES (1) ES2543457T5 (pt)
HR (1) HRP20150761T4 (pt)
HU (1) HUE026818T2 (pt)
IL (1) IL214374A (pt)
MX (1) MX2011008621A (pt)
PL (1) PL2398817T5 (pt)
PT (1) PT2398817E (pt)
RU (1) RU2526391C2 (pt)
SI (1) SI2398817T2 (pt)
UA (1) UA105785C2 (pt)
WO (1) WO2010095953A1 (pt)
ZA (1) ZA201104848B (pt)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101666144B1 (ko) 2009-02-19 2016-10-13 셀리아 파마슈티칼즈 에이피에스 리포펩티드를 정제하는 방법
CN102690329B (zh) * 2011-03-25 2014-06-04 杭州九源基因工程有限公司 一种戈舍瑞林多肽的纯化生产方法
CN102875652A (zh) * 2011-07-13 2013-01-16 北大方正集团有限公司 一种分离纯化达托霉素的方法
CN103159829B (zh) * 2011-12-08 2014-11-05 北大方正集团有限公司 达托霉素的提取方法
CN102675426B (zh) * 2012-04-26 2013-12-11 杭州华东医药集团生物工程研究所有限公司 一种达托霉素的提取纯化方法
CN102924572B (zh) * 2012-11-12 2014-12-03 华北制药集团新药研究开发有限责任公司 一种高纯度达托霉素的制备方法
CN104387444B (zh) * 2014-11-13 2017-12-08 北大医药重庆大新药业股份有限公司 一种达托霉素杂质rs‑2高纯度样品的制备方法
CN107001411B (zh) * 2014-12-15 2021-07-23 默克专利股份公司 从粗溶液捕获靶分子
CN105001305A (zh) * 2015-04-29 2015-10-28 利穗科技(苏州)有限公司 利用层析技术提取高纯度达托霉素的方法
CN105481950B (zh) * 2016-01-28 2019-01-04 丽珠集团福州福兴医药有限公司 一种达托霉素提取方法
IT201600127655A1 (it) 2016-12-16 2018-06-16 Gnosis Spa Processo per la purificazione di antibiotici lipopolipeptidici
CN108250270A (zh) * 2016-12-29 2018-07-06 天津领世生物科技开发有限公司 一种从发酵液中富集提取达托霉素的方法
CN112979756B (zh) * 2019-12-13 2023-01-03 浙江昌海制药有限公司 达托霉素的提纯方法
CN113004373B (zh) * 2019-12-19 2024-08-13 鲁南制药集团股份有限公司 一种达托霉素的纯化方法
RU2762182C1 (ru) * 2020-12-08 2021-12-16 Федеральное государственное бюджетное научное учреждение "Научно-исследовательский институт по изысканию новых антибиотиков имени Г.Ф. Гаузе" Гауземицины А и В - гликолипопептидные антибактериальные антибиотики и способ их получения
CN113340691B (zh) * 2021-06-05 2023-12-12 清华大学 一种提取海洋沉积物中不同赋存形态磷的方法
CN119119201A (zh) * 2024-09-10 2024-12-13 丽珠集团福州福兴医药有限公司 一种达托霉素的生产方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4537717A (en) 1982-05-21 1985-08-27 Eli Lilly And Company Derivatives of A-21978C cyclic peptides
US4885243A (en) 1984-10-09 1989-12-05 Eli Lilly And Company Process for producing A-21978C derivatives
US4667016A (en) 1985-06-20 1987-05-19 Kirin-Amgen, Inc. Erythropoietin purification
US4874843A (en) * 1987-12-03 1989-10-17 Eli Lilly And Company Chromatographic purification process
CA1315229C (en) * 1987-06-10 1993-03-30 Eli Lilly And Company Chromatographic purification process
JP2661790B2 (ja) * 1990-11-27 1997-10-08 電気化学工業株式会社 入尿トリプシンインヒビターの精製方法
IL192290A0 (en) * 1993-08-17 2008-12-29 Kirin Amgen Inc Erythropoietin analogs
US5650496A (en) 1995-04-14 1997-07-22 Cephalon, Inc. IGF-I purification process
US6696412B1 (en) * 2000-01-20 2004-02-24 Cubist Pharmaceuticals, Inc. High purity lipopeptides, Lipopeptide micelles and processes for preparing same
KR20090122469A (ko) * 2000-12-18 2009-11-30 큐비스트 파마슈티컬즈 인코포레이티드 정제된 리포펩티드의 제조 방법
US20060014674A1 (en) 2000-12-18 2006-01-19 Dennis Keith Methods for preparing purified lipopeptides
US8969532B2 (en) * 2006-10-03 2015-03-03 Novo Nordisk A/S Methods for the purification of polypeptide conjugates comprising polyalkylene oxide using hydrophobic interaction chromatography
WO2009144739A1 (en) * 2008-05-26 2009-12-03 Biocon Limited Amorphous daptomycin and a method of purification thereof
KR101666144B1 (ko) 2009-02-19 2016-10-13 셀리아 파마슈티칼즈 에이피에스 리포펩티드를 정제하는 방법
CN101899094B (zh) * 2009-06-01 2012-11-21 安徽丰原发酵技术工程研究有限公司 一种高纯达托霉素的制备方法

Also Published As

Publication number Publication date
JP5752609B2 (ja) 2015-07-22
EP2398817B2 (en) 2021-06-23
EP2398817A1 (en) 2011-12-28
JP2012518034A (ja) 2012-08-09
CA2748932A1 (en) 2010-08-26
UA105785C2 (uk) 2014-06-25
WO2010095953A1 (en) 2010-08-26
HRP20150761T4 (hr) 2021-08-06
DK2398817T4 (da) 2021-08-23
PT2398817E (pt) 2015-08-28
BRPI1008300A2 (pt) 2016-03-15
BRPI1008300B1 (pt) 2021-07-13
DK2398817T3 (en) 2015-07-27
ZA201104848B (en) 2012-10-31
EP2398817B1 (en) 2015-04-29
CA2748932C (en) 2019-11-19
PL2398817T3 (pl) 2015-10-30
KR101666144B1 (ko) 2016-10-13
AU2010216475A1 (en) 2011-08-11
PL2398817T5 (pl) 2021-10-04
MX2011008621A (es) 2011-09-15
KR20110134884A (ko) 2011-12-15
US9150894B2 (en) 2015-10-06
HUE026818T2 (en) 2016-07-28
AU2010216475B2 (en) 2015-07-09
RU2011137010A (ru) 2013-03-27
US20100228006A1 (en) 2010-09-09
SI2398817T1 (sl) 2015-08-31
ES2543457T3 (es) 2015-08-19
CN102325785B (zh) 2015-01-21
HRP20150761T1 (hr) 2015-08-14
ES2543457T5 (es) 2021-12-22
CN102325785A (zh) 2012-01-18
RU2526391C2 (ru) 2014-08-20
IL214374A (en) 2017-03-30
IL214374A0 (en) 2011-09-27
SI2398817T2 (sl) 2021-09-30

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Legal Events

Date Code Title Description
B06T Formal requirements before examination [chapter 6.20 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 19/02/2010, OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF, QUE DETERMINA A ALTERACAO DO PRAZO DE CONCESSAO.