BRPI0910461A8 - hormônio de estimulação do folículo recombinante, sua composição farmacêutica, seu método de produção e seu uso. - Google Patents

hormônio de estimulação do folículo recombinante, sua composição farmacêutica, seu método de produção e seu uso.

Info

Publication number
BRPI0910461A8
BRPI0910461A8 BRPI0910461A BRPI0910461A BRPI0910461A8 BR PI0910461 A8 BRPI0910461 A8 BR PI0910461A8 BR PI0910461 A BRPI0910461 A BR PI0910461A BR PI0910461 A BRPI0910461 A BR PI0910461A BR PI0910461 A8 BRPI0910461 A8 BR PI0910461A8
Authority
BR
Brazil
Prior art keywords
pharmaceutical composition
production method
recombinant follicle
stimulation hormone
follicle stimulation
Prior art date
Application number
BRPI0910461A
Other languages
English (en)
Inventor
Plaksin Daniel
Cottingham Ian
Boyd White Richard
Original Assignee
Ferring Int Center Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39717519&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0910461(A8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ferring Int Center Sa filed Critical Ferring Int Center Sa
Publication of BRPI0910461A2 publication Critical patent/BRPI0910461A2/pt
Publication of BRPI0910461A8 publication Critical patent/BRPI0910461A8/pt
Publication of BRPI0910461B1 publication Critical patent/BRPI0910461B1/pt
Publication of BRPI0910461B8 publication Critical patent/BRPI0910461B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/24—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g. HCG; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1081—Glycosyltransferases (2.4) transferring other glycosyl groups (2.4.99)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y204/00—Glycosyltransferases (2.4)
    • C12Y204/99—Glycosyltransferases (2.4) transferring other glycosyl groups (2.4.99)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y204/00—Glycosyltransferases (2.4)
    • C12Y204/99—Glycosyltransferases (2.4) transferring other glycosyl groups (2.4.99)
    • C12Y204/99006—N-Acetyllactosaminide alpha-2,3-sialyltransferase (2.4.99.6)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Reproductive Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Toxicology (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Gynecology & Obstetrics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
BRPI0910461A 2008-04-16 2009-04-16 hormônio de estimulação do folículo recombinante, sua composição farmacêutica, seu método de produção e seu uso BRPI0910461B8 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US4542408P 2008-04-16 2008-04-16
US61/045,424 2008-04-16
EP08251528 2008-04-25
EP08251528.9 2008-04-25
PCT/GB2009/000978 WO2009127826A1 (en) 2008-04-16 2009-04-16 Recombinant fsh including alpha 2,3- and alpha 2,6-sialylation

Publications (4)

Publication Number Publication Date
BRPI0910461A2 BRPI0910461A2 (pt) 2018-03-27
BRPI0910461A8 true BRPI0910461A8 (pt) 2018-10-16
BRPI0910461B1 BRPI0910461B1 (pt) 2021-02-23
BRPI0910461B8 BRPI0910461B8 (pt) 2021-05-25

Family

ID=39717519

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0910461A BRPI0910461B8 (pt) 2008-04-16 2009-04-16 hormônio de estimulação do folículo recombinante, sua composição farmacêutica, seu método de produção e seu uso

Country Status (29)

Country Link
US (7) US8951967B2 (pt)
EP (7) EP3098234B1 (pt)
JP (7) JP2011519359A (pt)
KR (5) KR102108377B1 (pt)
CN (3) CN105906703A (pt)
AR (1) AR071479A1 (pt)
AU (5) AU2009237479B2 (pt)
BR (1) BRPI0910461B8 (pt)
CA (1) CA2725257A1 (pt)
CY (1) CY1115413T1 (pt)
DK (6) DK3098234T3 (pt)
ES (5) ES2989729T3 (pt)
FI (4) FI4015527T3 (pt)
FR (3) FR17C1020I2 (pt)
HR (5) HRP20241187T1 (pt)
HU (9) HUE033830T2 (pt)
IL (2) IL208538A (pt)
LT (8) LT3045471T (pt)
MX (3) MX348622B (pt)
NO (4) NO2017025I1 (pt)
NZ (1) NZ588381A (pt)
PL (6) PL2808340T3 (pt)
PT (6) PT3144318T (pt)
RU (3) RU2682270C2 (pt)
SA (1) SA109300228B1 (pt)
SI (6) SI2808340T1 (pt)
TW (1) TWI488640B (pt)
WO (1) WO2009127826A1 (pt)
ZA (1) ZA201007373B (pt)

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TWI488640B (zh) 2008-04-16 2015-06-21 菲瑞茵國際中心股份有限公司 藥學製劑
TWI532495B (zh) 2009-10-05 2016-05-11 菲瑞茵國際中心股份有限公司 藥學製劑
EP2417982A1 (en) 2010-07-30 2012-02-15 Ferring B.V. Stabilization of gonadotropins
WO2012016576A1 (en) * 2010-08-04 2012-02-09 Glycotope Gmbh Improved recombinant human follicle-stimulating hormone
US9320778B2 (en) 2010-09-29 2016-04-26 Ferring B.V. Method for controlled ovarian stimulation with combined FSH and hCG
CN103154243A (zh) 2010-10-15 2013-06-12 日本化学研究株式会社 糖链的非还原末端为甘露糖残基的糖蛋白的制造方法
CA3163525A1 (en) 2011-03-31 2012-10-04 Ferring Bv. Pharmaceutical preparation
WO2012168680A1 (en) 2011-06-06 2012-12-13 Ferring B.V. Pharmaceutical preparation comprising recombinant fsh
JO3092B1 (ar) * 2011-08-08 2017-03-15 Ferring Bv مركب لتحفيز مسيطر عليه للمبيض
AU2012340501A1 (en) * 2011-12-19 2013-07-11 Grifols, S.A. Compositions, methods, and kits for preparing sialylated recombinant proteins
JP6279466B2 (ja) * 2012-04-27 2018-02-14 Jcrファーマ株式会社 新規な発現ベクター
EP2824176A1 (en) * 2013-07-11 2015-01-14 Siamed'xpress Methods for producing sialylated therapeutic proteins
JP6652334B2 (ja) * 2014-05-31 2020-02-19 Jcrファーマ株式会社 ウリジンとn−アセチル−d−マンノサミンとを含有する培地
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HUE054300T2 (hu) 2015-04-17 2021-08-30 Ferring Bv FSH-t tartalmazó, meddõség kezelésére szolgáló készítmény
US10906953B2 (en) 2015-06-26 2021-02-02 Ferring B.V. Methods of purification and/or viral inactivation
EP3205719A1 (en) * 2016-02-15 2017-08-16 CEVEC Pharmaceuticals GmbH Cell lines for producing recombinant glycoproteins with di-antennary n-glycans, methods using the same, and recombinant glycoproteins
GB201603280D0 (en) 2016-02-24 2016-04-13 Ferring Bv Stable liquid gonadotropin formulation
EP3382014A1 (en) 2017-03-29 2018-10-03 CEVEC Pharmaceuticals GmbH Recombinant glycoproteins with reduced antennary fucosylation
EP3441471A1 (en) 2017-08-08 2019-02-13 CEVEC Pharmaceuticals GmbH Use of constitutively active variants of growth factor receptors as selection makers for the generation of stable producer cell lines
SI3973982T1 (sl) 2017-09-01 2024-10-30 Ferring B. V. Sestavek za nadzorovano stimulacijo jajčnikov
WO2019211153A1 (en) 2018-04-30 2019-11-07 Ferring B.V. Composition for controlled ovarian stimulation
TWI846743B (zh) 2018-10-17 2024-07-01 荷蘭商菲林公司 用於控制性卵巢刺激之組成物及方法
US20220380785A1 (en) * 2019-11-01 2022-12-01 The University Of British Columbia Compositions and methods for sialylated mucin-type o-glycosylation of therapeutic proteins
TW202237173A (zh) 2020-12-09 2022-10-01 荷蘭商菲林公司 用於受控的卵巢刺激之組成物及方法
CN118922201A (zh) 2022-04-01 2024-11-08 辉凌公司 治疗不育症的混合方案
KR20250016113A (ko) 2022-05-26 2025-02-03 훼링 비.브이. 남성 불임 치료를 위한 조성물 및 방법
MA71382A (fr) 2022-07-08 2025-04-30 Ferring B.V. Compositions et procédés d'insémination intra-utérine (iiu)
KR20260041113A (ko) 2023-07-20 2026-03-26 훼링 비.브이. 서방형의 약물-로딩된 마이크로입자

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TWI532495B (zh) 2009-10-05 2016-05-11 菲瑞茵國際中心股份有限公司 藥學製劑
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US9320778B2 (en) 2010-09-29 2016-04-26 Ferring B.V. Method for controlled ovarian stimulation with combined FSH and hCG
CA3163525A1 (en) 2011-03-31 2012-10-04 Ferring Bv. Pharmaceutical preparation
WO2012168680A1 (en) 2011-06-06 2012-12-13 Ferring B.V. Pharmaceutical preparation comprising recombinant fsh
JO3092B1 (ar) 2011-08-08 2017-03-15 Ferring Bv مركب لتحفيز مسيطر عليه للمبيض
AR100132A1 (es) 2014-04-18 2016-09-14 Glycotope Gmbh Un método para hiperestimulación ovárica controlada para estimular el desarrollo de múltiples folículos ováricos en un sujeto femenino

Also Published As

Publication number Publication date
EP2268666A1 (en) 2011-01-05
SI3045471T1 (sl) 2017-07-31
KR20110005863A (ko) 2011-01-19
LT2808340T (lt) 2016-11-10
HRP20170958T1 (hr) 2017-09-22
PL3098234T3 (pl) 2025-01-07
JP2011519359A (ja) 2011-07-07
HUS2500029I1 (hu) 2025-07-28
FI3098234T3 (fi) 2024-10-31
EP3045471B1 (en) 2017-03-29
LT3098234T (lt) 2024-09-10
RU2745557C1 (ru) 2021-03-29
US20110105398A1 (en) 2011-05-05
JP6762916B2 (ja) 2020-09-30
CA2725257A1 (en) 2009-10-22
DK4015527T3 (da) 2025-04-14
SI3144318T1 (sl) 2020-12-31
ES2629392T3 (es) 2017-08-09
SI4015527T1 (sl) 2025-05-30
AU2017204258A1 (en) 2017-07-20
US9546204B2 (en) 2017-01-17
FR25C1025I1 (fr) 2025-09-19
EP3098234B1 (en) 2024-07-31
NO2025006I1 (no) 2025-01-16
HUE068565T2 (hu) 2025-01-28
US11952407B2 (en) 2024-04-09
AU2014203277C1 (en) 2017-07-27
MX2010011343A (es) 2011-01-20
PL4015527T3 (pl) 2025-05-26
CY1115413T1 (el) 2017-01-04
NO2017025I1 (no) 2017-06-06
JP2017060476A (ja) 2017-03-30
HUS1700025I1 (hu) 2017-06-28
AU2014203277B2 (en) 2017-04-06
WO2009127826A1 (en) 2009-10-22
PT4015527T (pt) 2025-04-10
NO2025032I1 (no) 2025-07-14
EP3144318A1 (en) 2017-03-22
RU2745557C3 (ru) 2021-12-10
SI2808340T1 (sl) 2016-12-30
SI2268666T1 (sl) 2014-07-31
PT2808340T (pt) 2016-11-21
RU2537268C2 (ru) 2014-12-27
KR101622944B1 (ko) 2016-05-23
PL3045471T3 (pl) 2017-10-31
EP3045471A1 (en) 2016-07-20
LT3045471T (lt) 2017-07-10
US20150065695A1 (en) 2015-03-05
CN105906703A (zh) 2016-08-31
ES3023526T3 (en) 2025-06-02
PL2268666T3 (pl) 2014-08-29
FR17C1020I1 (pt) 2020-04-10
HUE033830T2 (en) 2018-01-29
US20180079794A1 (en) 2018-03-22
HUE030652T2 (en) 2017-05-29
DK3098234T3 (da) 2024-10-21
JP6486310B2 (ja) 2019-03-20
US20240327487A1 (en) 2024-10-03
PT3045471T (pt) 2017-06-14
KR102108377B1 (ko) 2020-05-08
BRPI0910461A2 (pt) 2018-03-27
HUS2500008I1 (hu) 2025-02-28
KR20180095140A (ko) 2018-08-24
PT3144318T (pt) 2020-11-04
US9771407B2 (en) 2017-09-26
AU2017225020A1 (en) 2017-09-28
EP4015527B1 (en) 2025-01-22
FIC20250025I1 (fi) 2025-07-11
EP3098234A1 (en) 2016-11-30
JP7316905B2 (ja) 2023-07-28
AU2017225020B2 (en) 2019-11-14
LTPA2017018I1 (lt) 2017-06-26
ZA201007373B (en) 2011-06-29
FR17C1020I2 (fr) 2020-04-10
FIC20250003I1 (fi) 2025-01-15
US20210332099A1 (en) 2021-10-28
US10995128B2 (en) 2021-05-04
RU2014141994A (ru) 2016-05-10
JP2024038000A (ja) 2024-03-19
SI3098234T1 (sl) 2024-10-30
US8951967B2 (en) 2015-02-10
PT3098234T (pt) 2024-10-21
TW200948378A (en) 2009-12-01
RU2010141908A (ru) 2012-05-27
IL208538A (en) 2014-03-31
KR20160056960A (ko) 2016-05-20
AR071479A1 (es) 2010-06-23
HRP20241187T1 (hr) 2024-12-06
MX348622B (es) 2017-06-22
HUS1700036I1 (hu) 2017-10-30
JP2015120696A (ja) 2015-07-02
DK2268666T3 (da) 2014-05-12
TWI488640B (zh) 2015-06-21
BRPI0910461B8 (pt) 2021-05-25
CN102066414A (zh) 2011-05-18
US12516094B2 (en) 2026-01-06
FR25C1003I1 (fr) 2025-02-28
RU2014141994A3 (pt) 2018-05-28
ES2468318T3 (es) 2014-06-16
AU2009237479A1 (en) 2009-10-22
US20160347811A1 (en) 2016-12-01
AU2017204259B2 (en) 2017-08-17
IL230571A (en) 2015-11-30
BRPI0910461B1 (pt) 2021-02-23
JP2020040956A (ja) 2020-03-19
HUE071059T2 (hu) 2025-07-28
KR20190092608A (ko) 2019-08-07
ES2989729T3 (es) 2024-11-27
DK2808340T3 (en) 2016-12-05
AU2017204259A1 (en) 2017-07-20
NO2017050I1 (no) 2017-09-28
LT4015527T (lt) 2025-04-10
EP2808340A1 (en) 2014-12-03
IL208538A0 (en) 2010-12-30
PL2808340T3 (pl) 2017-02-28
PL3144318T3 (pl) 2021-02-08
HRP20161520T1 (hr) 2016-12-30
RU2682270C2 (ru) 2019-03-18
HUE030652T4 (en) 2017-09-28
HRP20250313T1 (hr) 2025-05-09
HK1146284A1 (en) 2011-05-20
LTPA2017029I1 (lt) 2017-10-10
EP2268666B1 (en) 2014-03-12
LTPA2025505I1 (pt) 2025-02-10
AU2017204258B2 (en) 2017-08-17
HK1199039A1 (en) 2015-06-19
KR20170110741A (ko) 2017-10-11
JP2018021037A (ja) 2018-02-08
DK3144318T3 (da) 2020-12-07
JP2022031652A (ja) 2022-02-22
US20260217782A1 (en) 2026-07-30
AU2009237479B2 (en) 2014-05-15
CN105906702A (zh) 2016-08-31
ES2610277T3 (es) 2017-04-26
HRP20140535T1 (hr) 2014-07-18
AU2014203277A1 (en) 2014-07-24
SA109300228B1 (ar) 2014-04-08
EP3144318B1 (en) 2020-09-23
NZ588381A (en) 2012-05-25
MX355457B (es) 2018-04-19
PT2268666E (pt) 2014-06-25
HUS1700024I1 (hu) 2017-06-28
DK3045471T3 (en) 2017-06-26
EP2808340B1 (en) 2016-08-17
FI4015527T3 (fi) 2025-04-29
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EP4015527A1 (en) 2022-06-22
EP2722339A1 (en) 2014-04-23

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