BRPI0910461A8 - hormônio de estimulação do folículo recombinante, sua composição farmacêutica, seu método de produção e seu uso. - Google Patents

hormônio de estimulação do folículo recombinante, sua composição farmacêutica, seu método de produção e seu uso.

Info

Publication number: BRPI0910461A8
Authority: BR; Brazil
Prior art keywords: pharmaceutical composition; production method; recombinant follicle; stimulation hormone; follicle stimulation
Prior art date: 2008-04-16

Application number

BRPI0910461A

Other languages

English (en)

Inventor

Plaksin Daniel

Cottingham Ian

Boyd White Richard

Original Assignee

Ferring Int Center Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2008-04-16

Filing date

2009-04-16

Publication date

2018-10-16

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39717519&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0910461(A8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2009-04-16 Application filed by Ferring Int Center Sa filed Critical Ferring Int Center Sa

2018-03-27 Publication of BRPI0910461A2 publication Critical patent/BRPI0910461A2/pt

2018-10-16 Publication of BRPI0910461A8 publication Critical patent/BRPI0910461A8/pt

2021-02-23 Publication of BRPI0910461B1 publication Critical patent/BRPI0910461B1/pt

2021-05-25 Publication of BRPI0910461B8 publication Critical patent/BRPI0910461B8/pt

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/24—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g. HCG; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
- C12N9/1081—Glycosyltransferases (2.4) transferring other glycosyl groups (2.4.99)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y204/00—Glycosyltransferases (2.4)
- C12Y204/99—Glycosyltransferases (2.4) transferring other glycosyl groups (2.4.99)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y204/00—Glycosyltransferases (2.4)
- C12Y204/99—Glycosyltransferases (2.4) transferring other glycosyl groups (2.4.99)
- C12Y204/99006—N-Acetyllactosaminide alpha-2,3-sialyltransferase (2.4.99.6)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Endocrinology (AREA)
General Health & Medical Sciences (AREA)
Zoology (AREA)
Engineering & Computer Science (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Biochemistry (AREA)
Reproductive Health (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Gastroenterology & Hepatology (AREA)
Molecular Biology (AREA)
Biophysics (AREA)
Wood Science & Technology (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Toxicology (AREA)
General Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Biotechnology (AREA)
Biomedical Technology (AREA)
Diabetes (AREA)
Immunology (AREA)
Epidemiology (AREA)
Microbiology (AREA)
Physics & Mathematics (AREA)
Plant Pathology (AREA)
Pregnancy & Childbirth (AREA)
Gynecology & Obstetrics (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

BRPI0910461A 2008-04-16 2009-04-16 hormônio de estimulação do folículo recombinante, sua composição farmacêutica, seu método de produção e seu uso BRPI0910461B8 (pt)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
US4542408P	2008-04-16	2008-04-16
US61/045,424		2008-04-16
EP08251528		2008-04-25
EP08251528.9		2008-04-25
PCT/GB2009/000978 WO2009127826A1 (en)	2008-04-16	2009-04-16	Recombinant fsh including alpha 2,3- and alpha 2,6-sialylation

Publications (4)

Publication Number	Publication Date
BRPI0910461A2 BRPI0910461A2 (pt)	2018-03-27
BRPI0910461A8 true BRPI0910461A8 (pt)	2018-10-16
BRPI0910461B1 BRPI0910461B1 (pt)	2021-02-23
BRPI0910461B8 BRPI0910461B8 (pt)	2021-05-25

Family

ID=39717519

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI0910461A BRPI0910461B8 (pt)	2008-04-16	2009-04-16	hormônio de estimulação do folículo recombinante, sua composição farmacêutica, seu método de produção e seu uso

Country Status (29)

Country	Link
US (6)	US8951967B2 (pt)
EP (7)	EP4015527B1 (pt)
JP (7)	JP2011519359A (pt)
KR (5)	KR20160056960A (pt)
CN (3)	CN105906702A (pt)
AR (1)	AR071479A1 (pt)
AU (5)	AU2009237479B2 (pt)
BR (1)	BRPI0910461B8 (pt)
CA (1)	CA2725257A1 (pt)
CY (1)	CY1115413T1 (pt)
DK (6)	DK3045471T3 (pt)
ES (5)	ES2629392T3 (pt)
FI (4)	FI3098234T3 (pt)
FR (3)	FR17C1020I2 (pt)
HR (5)	HRP20250313T1 (pt)
HU (9)	HUE068565T2 (pt)
IL (2)	IL208538A (pt)
LT (8)	LT3045471T (pt)
MX (3)	MX2010011343A (pt)
NO (4)	NO2017025I1 (pt)
NZ (1)	NZ588381A (pt)
PL (6)	PL3144318T3 (pt)
PT (6)	PT2268666E (pt)
RU (3)	RU2537268C2 (pt)
SA (1)	SA109300228B1 (pt)
SI (6)	SI4015527T1 (pt)
TW (1)	TWI488640B (pt)
WO (1)	WO2009127826A1 (pt)
ZA (1)	ZA201007373B (pt)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TWI488640B (zh)	2008-04-16	2015-06-21	菲瑞茵國際中心股份有限公司	藥學製劑
TWI532495B (zh)	2009-10-05	2016-05-11	菲瑞茵國際中心股份有限公司	藥學製劑
EP2417982A1 (en)	2010-07-30	2012-02-15	Ferring B.V.	Stabilization of gonadotropins
WO2012016576A1 (en) *	2010-08-04	2012-02-09	Glycotope Gmbh	Improved recombinant human follicle-stimulating hormone
RS54214B2 (sr)	2010-09-29	2024-02-29	Ferring Bv	Smeša za upotrebu u lečenju infertiliteta
EP2628797B1 (en)	2010-10-15	2016-07-13	JCR Pharmaceuticals CO., LTD.	Method for producing glycoprotein having mannose residue as non-reducing end of sugar chain
WO2012131306A1 (en)	2011-03-31	2012-10-04	Ferring B.V.	Pharmaceutical preparation
AR090095A1 (es)	2011-06-06	2014-10-22	Ferring Bv	Preparacion farmaceutica que comprende hormona estimulante del foliculo recombinante
JO3092B1 (ar) *	2011-08-08	2017-03-15	Ferring Bv	مركب لتحفيز مسيطر عليه للمبيض
WO2013093760A2 (en) *	2011-12-19	2013-06-27	Grifols, S.A.	Compositions, methods, and kits for preparing sialylated recombinant proteins
EP2848687B1 (en) *	2012-04-27	2017-09-13	JCR Pharmaceuticals Co., Ltd.	Novel expression vector
EP2824176A1 (en)	2013-07-11	2015-01-14	Siamed'xpress	Methods for producing sialylated therapeutic proteins
JP6652334B2 (ja)	2014-05-31	2020-02-19	Ｊｃｒファーマ株式会社	ウリジンとｎ−アセチル−ｄ−マンノサミンとを含有する培地
CN107429237B (zh) *	2014-12-22	2021-09-28	豪夫迈·罗氏有限公司	Cmp依赖性的唾液酸酶活性
HUE054300T2 (hu)	2015-04-17	2021-08-30	Ferring Bv	FSH-t tartalmazó, meddõség kezelésére szolgáló készítmény
MX381279B (es)	2015-06-26	2025-03-12	Ferring Bv	Métodos de purificación y/o inactivación viral.
EP3205719A1 (en) *	2016-02-15	2017-08-16	CEVEC Pharmaceuticals GmbH	Cell lines for producing recombinant glycoproteins with di-antennary n-glycans, methods using the same, and recombinant glycoproteins
GB201603280D0 (en)	2016-02-24	2016-04-13	Ferring Bv	Stable liquid gonadotropin formulation
EP3382014A1 (en) *	2017-03-29	2018-10-03	CEVEC Pharmaceuticals GmbH	Recombinant glycoproteins with reduced antennary fucosylation
EP3441471A1 (en)	2017-08-08	2019-02-13	CEVEC Pharmaceuticals GmbH	Use of constitutively active variants of growth factor receptors as selection makers for the generation of stable producer cell lines
CN120617484A (zh)	2017-09-01	2025-09-12	辉凌公司	用于受控的卵巢刺激的组合物
US20210038694A1 (en)	2018-04-30	2021-02-11	Ferring B.V.	Composition for controlled ovarian stimulation
TWI846743B (zh)	2018-10-17	2024-07-01	荷蘭商菲林公司	用於控制性卵巢刺激之組成物及方法
WO2021081670A1 (en) *	2019-11-01	2021-05-06	The University Of British Columbia	Compositions and methods for sialylated mucin-type o-glycosylation of therapeutic proteins
TW202237173A (zh)	2020-12-09	2022-10-01	荷蘭商菲林公司	用於受控的卵巢刺激之組成物及方法
KR20240167660A (ko)	2022-04-01	2024-11-27	훼링 비.브이.	불임의 치료를 위한 혼합 프로토콜
KR20250016113A (ko)	2022-05-26	2025-02-03	훼링 비.브이.	남성 불임 치료를 위한 조성물 및 방법
AU2023302100A1 (en)	2022-07-08	2025-01-02	Ferring B.V.	Compositions and methods for intrauterine insemination (iui)
AR133300A1 (es)	2023-07-20	2025-09-17	Ferring Bv	Micropartículas cargadas con fármaco de liberación prolongada

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1206302B (it)	1987-06-26	1989-04-14	Serono Cesare Ist Ricerca	Ormone follicolo-stimolante urinario
US5541083A (en)	1989-10-24	1996-07-30	The Regents Of The University Of California	Method for producing secretable glycosyltransferases and other golgi processing enzymes
KR100470180B1 (ko)	1995-06-15	2005-02-04	크루셀 홀란드 비.브이.	유전자 요법에 사용할 수 있는 인간의 재조합아데노바이러스 패키징 시스템
JP3559652B2 (ja) *	1996-06-25	2004-09-02	グローリー工業株式会社	売上精算システムの管理装置
TW518235B (en) *	1997-01-15	2003-01-21	Akzo Nobel Nv	A gonadotropin-containing pharmaceutical composition with improved stability on prolong storage
NZ336780A (en)	1997-01-16	2000-12-22	Neose Technologies Inc	In vitro sialylation of glycoproteins
JPH1111665A (ja)	1997-06-28	1999-01-19	Shibuya Kogyo Co Ltd	無菌エア搬送コンベヤ装置
TWI235158B (en) *	1997-09-01	2005-07-01	Kirin Brewery	Human thrombopoietin produced by human established cell lines, processes foe preparing the same, and pharmaceutical composition comprising the same
EP1176976B2 (en)	1999-05-07	2015-10-21	Laboratoires Serono SA	Use of lh administered in mid- or late-follicular phase for the treatment of anovulatory women
JP2002011665A (ja)	2000-06-28	2002-01-15	Sintokogio Ltd	ショットブラスト装置モニタシステム
IL140110A0 (en)	2000-12-05	2002-02-10	Applied Research Systems	Improvement of homogeneity and secretion of recombinant proteins in mammalian systems
UA87433C2 (ru) *	2001-10-22	2009-07-27	Еплайд Рісьорч Системз Ерс Холдінг Н.В.	Гонадотропины для стимулирования фолликулогенеза
CN100347306C (zh)	2001-10-29	2007-11-07	克鲁塞尔荷兰公司	生产具有预定的翻译后修饰的蛋白质的方法和手段
JP4480398B2 (ja)	2001-12-07	2010-06-16	クルセルホランドベーヴェー	ウイルス、ウイルス分離株及びワクチンの製造方法
US20040248784A1 (en) *	2003-06-03	2004-12-09	Marco Filicori	Unitary combinations of FSH and hCG
US20080015142A1 (en) *	2003-12-03	2008-01-17	Defrees Shawn	Glycopegylated Follicle Stimulating Hormone
EP1711834B1 (en)	2004-02-04	2010-08-04	Centre National De La Recherche Scientifique	Process for screening glycoform-specific antibodies
EP1725673A1 (en)	2004-02-13	2006-11-29	Glycotope Gmbh	Sialytated glycoproteins-process conditions and an efficient method for their production
TWI488640B (zh)	2008-04-16	2015-06-21	菲瑞茵國際中心股份有限公司	藥學製劑
TWI532495B (zh)	2009-10-05	2016-05-11	菲瑞茵國際中心股份有限公司	藥學製劑
EP2417982A1 (en)	2010-07-30	2012-02-15	Ferring B.V.	Stabilization of gonadotropins
US8790322B2 (en)	2010-08-03	2014-07-29	King Saud University	Stoma coat
WO2012016576A1 (en)	2010-08-04	2012-02-09	Glycotope Gmbh	Improved recombinant human follicle-stimulating hormone
RS54214B2 (sr)	2010-09-29	2024-02-29	Ferring Bv	Smeša za upotrebu u lečenju infertiliteta
WO2012131306A1 (en)	2011-03-31	2012-10-04	Ferring B.V.	Pharmaceutical preparation
AR090095A1 (es)	2011-06-06	2014-10-22	Ferring Bv	Preparacion farmaceutica que comprende hormona estimulante del foliculo recombinante
JO3092B1 (ar)	2011-08-08	2017-03-15	Ferring Bv	مركب لتحفيز مسيطر عليه للمبيض
BR112016023668A2 (pt)	2014-04-18	2017-10-17	Glycotope Gmbh	hiperestimulação ovariana controlada com hormônio de estimulação de folículo humano recombinante aperfeiçoado

2009
- 2009-04-15 TW TW098112483A patent/TWI488640B/zh active
- 2009-04-16 DK DK16158141.8T patent/DK3045471T3/en active
- 2009-04-16 AR ARP090101333A patent/AR071479A1/es not_active Application Discontinuation
- 2009-04-16 PL PL16194925T patent/PL3144318T3/pl unknown
- 2009-04-16 KR KR1020167012148A patent/KR20160056960A/ko not_active Ceased
- 2009-04-16 HR HRP20250313TT patent/HRP20250313T1/hr unknown
- 2009-04-16 PT PT97334973T patent/PT2268666E/pt unknown
- 2009-04-16 HR HRP20140535AT patent/HRP20140535T1/hr unknown
- 2009-04-16 SI SI200932209T patent/SI4015527T1/sl unknown
- 2009-04-16 SI SI200931670A patent/SI3045471T1/sl unknown
- 2009-04-16 SI SI200931547A patent/SI2808340T1/sl unknown
- 2009-04-16 ES ES16158141.8T patent/ES2629392T3/es active Active
- 2009-04-16 LT LTEP16158141.8T patent/LT3045471T/lt unknown
- 2009-04-16 HU HUE16179121A patent/HUE068565T2/hu unknown
- 2009-04-16 PT PT212128730T patent/PT4015527T/pt unknown
- 2009-04-16 SI SI200930931T patent/SI2268666T1/sl unknown
- 2009-04-16 ES ES09733497.3T patent/ES2468318T3/es active Active
- 2009-04-16 EP EP21212873.0A patent/EP4015527B1/en active Active
- 2009-04-16 ES ES14178729.1T patent/ES2610277T3/es active Active
- 2009-04-16 EP EP09733497.3A patent/EP2268666B1/en not_active Revoked
- 2009-04-16 FI FIEP16179121.5T patent/FI3098234T3/fi active
- 2009-04-16 EP EP16194925.0A patent/EP3144318B1/en active Active
- 2009-04-16 ES ES16179121T patent/ES2989729T3/es active Active
- 2009-04-16 US US12/988,218 patent/US8951967B2/en active Active
- 2009-04-16 KR KR1020177026920A patent/KR20170110741A/ko not_active Ceased
- 2009-04-16 SI SI200932205T patent/SI3098234T1/sl unknown
- 2009-04-16 FI FIEP21212873.0T patent/FI4015527T3/fi active
- 2009-04-16 PL PL09733497T patent/PL2268666T3/pl unknown
- 2009-04-16 MX MX2010011343A patent/MX2010011343A/es active IP Right Grant
- 2009-04-16 PL PL21212873.0T patent/PL4015527T3/pl unknown
- 2009-04-16 EP EP16179121.5A patent/EP3098234B1/en active Active
- 2009-04-16 ES ES21212873T patent/ES3023526T3/es active Active
- 2009-04-16 KR KR1020197022294A patent/KR102108377B1/ko not_active Expired - Fee Related
- 2009-04-16 NZ NZ588381A patent/NZ588381A/en unknown
- 2009-04-16 MX MX2014011348A patent/MX348622B/es unknown
- 2009-04-16 KR KR1020107025581A patent/KR101622944B1/ko active Active
- 2009-04-16 DK DK21212873.0T patent/DK4015527T3/da active
- 2009-04-16 WO PCT/GB2009/000978 patent/WO2009127826A1/en not_active Ceased
- 2009-04-16 RU RU2010141908/10A patent/RU2537268C2/ru active
- 2009-04-16 AU AU2009237479A patent/AU2009237479B2/en active Active
- 2009-04-16 MX MX2017007881A patent/MX355457B/es unknown
- 2009-04-16 LT LTEP21212873.0T patent/LT4015527T/lt unknown
- 2009-04-16 EP EP14178729.1A patent/EP2808340B1/en not_active Revoked
- 2009-04-16 DK DK16179121.5T patent/DK3098234T3/da active
- 2009-04-16 DK DK14178729.1T patent/DK2808340T3/en active
- 2009-04-16 HR HRP20241187TT patent/HRP20241187T1/hr unknown
- 2009-04-16 CN CN201510933782.9A patent/CN105906702A/zh active Pending
- 2009-04-16 CN CN200980121391XA patent/CN102066414A/zh active Pending
- 2009-04-16 PT PT141787291T patent/PT2808340T/pt unknown
- 2009-04-16 PL PL14178729T patent/PL2808340T3/pl unknown
- 2009-04-16 PT PT161791215T patent/PT3098234T/pt unknown
- 2009-04-16 BR BRPI0910461A patent/BRPI0910461B8/pt active IP Right Grant
- 2009-04-16 CN CN201510933827.2A patent/CN105906703A/zh active Pending
- 2009-04-16 HU HUE21212873A patent/HUE071059T2/hu unknown
- 2009-04-16 DK DK09733497.3T patent/DK2268666T3/da active
- 2009-04-16 PL PL16158141T patent/PL3045471T3/pl unknown
- 2009-04-16 DK DK16194925.0T patent/DK3144318T3/da active
- 2009-04-16 EP EP16158141.8A patent/EP3045471B1/en not_active Revoked
- 2009-04-16 SI SI200932094T patent/SI3144318T1/sl unknown
- 2009-04-16 PL PL16179121.5T patent/PL3098234T3/pl unknown
- 2009-04-16 LT LTEP14178729.1T patent/LT2808340T/lt unknown
- 2009-04-16 HU HUE16158141A patent/HUE033830T2/en unknown
- 2009-04-16 JP JP2011504527A patent/JP2011519359A/ja active Pending
- 2009-04-16 HU HUE14178729A patent/HUE030652T4/en unknown
- 2009-04-16 PT PT161581418T patent/PT3045471T/pt unknown
- 2009-04-16 PT PT161949250T patent/PT3144318T/pt unknown
- 2009-04-16 KR KR1020187023820A patent/KR20180095140A/ko not_active Ceased
- 2009-04-16 EP EP13193214.7A patent/EP2722339A1/en active Pending
- 2009-04-16 CA CA2725257A patent/CA2725257A1/en active Pending
- 2009-04-16 LT LTEP16179121.5T patent/LT3098234T/lt unknown
- 2009-04-16 RU RU2014141994A patent/RU2682270C2/ru active
- 2009-04-18 SA SA109300228A patent/SA109300228B1/ar unknown
2010
- 2010-10-07 IL IL208538A patent/IL208538A/en active Protection Beyond IP Right Term
- 2010-10-14 ZA ZA2010/07373A patent/ZA201007373B/en unknown
2014
- 2014-01-21 IL IL230571A patent/IL230571A/en active IP Right Grant
- 2014-06-06 CY CY20141100402T patent/CY1115413T1/el unknown
- 2014-06-17 AU AU2014203277A patent/AU2014203277C1/en active Active
- 2014-11-14 US US14/541,852 patent/US9546204B2/en active Active
- 2014-12-25 JP JP2014262056A patent/JP2015120696A/ja active Pending
2016
- 2016-08-16 US US15/238,362 patent/US9771407B2/en active Active
- 2016-10-07 JP JP2016198588A patent/JP6486310B2/ja active Active
- 2016-11-16 HR HRP20161520TT patent/HRP20161520T1/hr unknown
2017
- 2017-05-30 HU HUS1700024C patent/HUS1700024I1/hu unknown
- 2017-05-31 HU HUS1700025C patent/HUS1700025I1/hu unknown
- 2017-06-05 LT LTPA2017018C patent/LTPA2017018I1/lt unknown
- 2017-06-06 NO NO2017025C patent/NO2017025I1/no unknown
- 2017-06-06 FR FR17C1020C patent/FR17C1020I2/fr active Active
- 2017-06-23 AU AU2017204258A patent/AU2017204258B2/en active Active
- 2017-06-23 AU AU2017204259A patent/AU2017204259B2/en active Active
- 2017-06-26 HR HRP20170958TT patent/HRP20170958T1/hr unknown
- 2017-08-01 JP JP2017148823A patent/JP6762916B2/ja active Active
- 2017-08-29 US US15/690,061 patent/US10995128B2/en active Active
- 2017-09-05 AU AU2017225020A patent/AU2017225020B2/en active Active
- 2017-09-27 HU HUS1700036C patent/HUS1700036I1/hu unknown
- 2017-09-27 LT LTPA2017029C patent/LTPA2017029I1/lt unknown
- 2017-09-28 NO NO2017050C patent/NO2017050I1/no unknown
2018
- 2018-11-08 RU RU2018139379A patent/RU2745557C3/ru active Protection Beyond IP Right Term
2019
- 2019-10-25 JP JP2019194476A patent/JP7316905B2/ja active Active
2021
- 2021-04-30 US US17/246,348 patent/US11952407B2/en active Active
- 2021-10-27 JP JP2021175403A patent/JP2022031652A/ja active Pending
2023
- 2023-12-21 JP JP2023215339A patent/JP2024038000A/ja active Pending
2024
- 2024-03-14 US US18/605,381 patent/US12516094B2/en active Active
2025
- 2025-01-15 FI FIC20250003C patent/FIC20250003I1/fi unknown
- 2025-01-16 FR FR25C1003C patent/FR25C1003I1/fr active Active
- 2025-01-16 NO NO2025006C patent/NO2025006I1/no unknown
- 2025-01-24 LT LTPA2025505C patent/LTPA2025505I1/lt unknown
- 2025-01-28 HU HUS2500008C patent/HUS2500008I1/hu unknown
- 2025-07-02 FR FR25C1025C patent/FR25C1025I1/fr active Active
- 2025-07-07 LT LTPA2025525C patent/LTPA2025525I1/lt unknown
- 2025-07-07 HU HUS2500029C patent/HUS2500029I1/hu unknown
- 2025-07-11 FI FIC20250025C patent/FIC20250025I1/fi unknown
- 2025-07-14 NO NO2025032C patent/NO2025032I1/no unknown

Also Published As

Publication number	Publication date
PL2268666T3 (pl)	2014-08-29
BRPI0910461B1 (pt)	2021-02-23
PL3045471T3 (pl)	2017-10-31
DK3098234T3 (da)	2024-10-21
AU2017225020B2 (en)	2019-11-14
LTPA2017029I1 (lt)	2017-10-10
RU2682270C2 (ru)	2019-03-18
RU2745557C3 (ru)	2021-12-10
LT4015527T (lt)	2025-04-10
PT3144318T (pt)	2020-11-04
SI3098234T1 (sl)	2024-10-30
JP6486310B2 (ja)	2019-03-20
JP2011519359A (ja)	2011-07-07
JP2022031652A (ja)	2022-02-22
JP2020040956A (ja)	2020-03-19
HRP20250313T1 (hr)	2025-05-09
HUS1700036I1 (hu)	2017-10-30
JP6762916B2 (ja)	2020-09-30
MX2010011343A (es)	2011-01-20
PL4015527T3 (pl)	2025-05-26
NO2025006I1 (no)	2025-01-16
IL230571A (en)	2015-11-30
PL2808340T3 (pl)	2017-02-28
SA109300228B1 (ar)	2014-04-08
NZ588381A (en)	2012-05-25
DK2268666T3 (da)	2014-05-12
DK2808340T3 (en)	2016-12-05
CY1115413T1 (el)	2017-01-04
EP2808340A1 (en)	2014-12-03
FR25C1003I1 (fr)	2025-02-28
EP3098234B1 (en)	2024-07-31
US9546204B2 (en)	2017-01-17
EP2808340B1 (en)	2016-08-17
US9771407B2 (en)	2017-09-26
AU2017204259B2 (en)	2017-08-17
ES2610277T3 (es)	2017-04-26
HRP20140535T1 (hr)	2014-07-18
US20110105398A1 (en)	2011-05-05
MX355457B (es)	2018-04-19
FIC20250003I1 (fi)	2025-01-15
DK4015527T3 (da)	2025-04-14
AU2017204258B2 (en)	2017-08-17
BRPI0910461A2 (pt)	2018-03-27
SI2808340T1 (sl)	2016-12-30
EP4015527B1 (en)	2025-01-22
CN105906703A (zh)	2016-08-31
FR17C1020I1 (pt)	2020-04-10
HUE033830T2 (en)	2018-01-29
FIC20250025I1 (fi)	2025-07-11
BRPI0910461B8 (pt)	2021-05-25
PT2808340T (pt)	2016-11-21
RU2537268C2 (ru)	2014-12-27
IL208538A0 (en)	2010-12-30
JP2024038000A (ja)	2024-03-19
LT3098234T (lt)	2024-09-10
DK3045471T3 (en)	2017-06-26
SI2268666T1 (sl)	2014-07-31
HRP20241187T1 (hr)	2024-12-06
AU2009237479B2 (en)	2014-05-15
HUE068565T2 (hu)	2025-01-28
EP2268666B1 (en)	2014-03-12
US11952407B2 (en)	2024-04-09
HUE030652T2 (en)	2017-05-29
LTPA2025525I1 (pt)	2025-07-25
US20160347811A1 (en)	2016-12-01
JP2015120696A (ja)	2015-07-02
US10995128B2 (en)	2021-05-04
US20180079794A1 (en)	2018-03-22
PT3098234T (pt)	2024-10-21
RU2014141994A (ru)	2016-05-10
FR17C1020I2 (fr)	2020-04-10
JP2017060476A (ja)	2017-03-30
LT2808340T (lt)	2016-11-10
JP2018021037A (ja)	2018-02-08
KR20110005863A (ko)	2011-01-19
PT4015527T (pt)	2025-04-10
AU2017225020A1 (en)	2017-09-28
NO2017025I1 (no)	2017-06-06
HUS1700024I1 (hu)	2017-06-28
PT3045471T (pt)	2017-06-14
FI3098234T3 (fi)	2024-10-31
US20210332099A1 (en)	2021-10-28
ZA201007373B (en)	2011-06-29
NO2017050I1 (no)	2017-09-28
AU2014203277A1 (en)	2014-07-24
LTPA2017018I1 (lt)	2017-06-26
HUE071059T2 (hu)	2025-07-28
CN102066414A (zh)	2011-05-18
HUS2500008I1 (hu)	2025-02-28
AU2017204259A1 (en)	2017-07-20
MX348622B (es)	2017-06-22
HRP20161520T1 (hr)	2016-12-30
KR20170110741A (ko)	2017-10-11
TWI488640B (zh)	2015-06-21
FR25C1025I1 (fr)	2025-09-19
SI3045471T1 (sl)	2017-07-31
AU2009237479A1 (en)	2009-10-22
HUS2500029I1 (hu)	2025-07-28
IL208538A (en)	2014-03-31
RU2014141994A3 (pt)	2018-05-28
RU2745557C1 (ru)	2021-03-29
SI4015527T1 (sl)	2025-05-30
LTPA2025505I1 (pt)	2025-02-10
SI3144318T1 (sl)	2020-12-31
AU2014203277C1 (en)	2017-07-27
EP3144318B1 (en)	2020-09-23
HUS1700025I1 (hu)	2017-06-28
ES2989729T3 (es)	2024-11-27
HK1199039A1 (en)	2015-06-19
HUE030652T4 (en)	2017-09-28
AU2014203277B2 (en)	2017-04-06
PL3144318T3 (pl)	2021-02-08
EP3144318A1 (en)	2017-03-22
EP3098234A1 (en)	2016-11-30
CN105906702A (zh)	2016-08-31
JP7316905B2 (ja)	2023-07-28
HRP20170958T1 (hr)	2017-09-22
KR101622944B1 (ko)	2016-05-23
KR102108377B1 (ko)	2020-05-08
KR20160056960A (ko)	2016-05-20
DK3144318T3 (da)	2020-12-07
ES2629392T3 (es)	2017-08-09
WO2009127826A1 (en)	2009-10-22
US8951967B2 (en)	2015-02-10
AU2017204258A1 (en)	2017-07-20
CA2725257A1 (en)	2009-10-22
AR071479A1 (es)	2010-06-23
US20150065695A1 (en)	2015-03-05
NO2025032I1 (no)	2025-07-14
US20240327487A1 (en)	2024-10-03
LT3045471T (lt)	2017-07-10
EP3045471B1 (en)	2017-03-29
ES2468318T3 (es)	2014-06-16
PT2268666E (pt)	2014-06-25
EP2268666A1 (en)	2011-01-05
HK1146284A1 (en)	2011-05-20
EP4015527A1 (en)	2022-06-22
KR20180095140A (ko)	2018-08-24
EP3045471A1 (en)	2016-07-20
KR20190092608A (ko)	2019-08-07
RU2010141908A (ru)	2012-05-27
PL3098234T3 (pl)	2025-01-07
US12516094B2 (en)	2026-01-06
FI4015527T3 (fi)	2025-04-29
ES3023526T3 (en)	2025-06-02
TW200948378A (en)	2009-12-01
EP2722339A1 (en)	2014-04-23

Legal Events

Date	Code	Title	Description
2018-04-17	B06F	Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
2018-10-02	B07D	Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]	Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001
2019-12-03	B07E	Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
2020-02-27	B06U	Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
2020-09-24	B06A	Patent application procedure suspended [chapter 6.1 patent gazette]
2021-01-05	B09A	Decision: intention to grant [chapter 9.1 patent gazette]
2021-02-23	B16A	Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]	Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 23/02/2021, OBSERVADAS AS CONDICOES LEGAIS.
2021-05-25	B16C	Correction of notification of the grant [chapter 16.3 patent gazette]	Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 16/04/2009 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF

Publication	Publication Date	Title
BR112013019083A2 (pt)	2017-04-04	combinação de (a) um imunoconjugado, composição farmacêutica, uso de (a) um imunoconjugado, método de tratamento de uma doença em um individuo, método de estímulo de função celular efetora em um indivíduo e kit destinado ao tratamento de uma doença.
BRPI1010621A2 (pt)	2016-06-21	derivado de imidazoquinolinonas, sua composição farmacêutica e seu uso
SMT201600398B (it)	2017-01-10	Inibitori di proteina chinasi (varianti), uso di questi nel trattamento di malattie oncologiche e composizione farmaceutica basata su questi
BRPI1008145A2 (pt)	2016-03-15	proteína de ligação de antígeno biespecífico, método para preparação de uma proteína de ligação de antígeno biespecífico, célula hospedeira, composição farmacêutica, uso da proteína de ligação de antígeno biespecífico e método para o tratamento de um paciente.
BR112012003800A2 (pt)	2016-11-22	composição, peptídeo, e formulação farmacêutica.
BR112012004335A2 (pt)	2015-09-08	composto, composição farmacêutica, e, uso do composto.
BR112012022879A2 (pt)	2016-06-14	composto, composição farmacêutica, uso do composto e método de tratamento
IL215603A0 (en)	2011-12-29	Human protein scaffold with controlled serum pharmacokinetics, compositions comprising the same and uses thereof
BRPI0813897A2 (pt)	2014-12-30	Uso de uma substância, composição cosmética ou dermo-cosmética ou neutracêutica, composição farmacêutica, método de cuidado cosmético, e, seqüência de nucleotídeos.
BRPI0918502A2 (pt)	2015-12-01	aminoindanos substituídos e análogos dos mesmos, e o uso farmacêutico dos mesmos
BRPI0917315A2 (pt)	2015-11-17	anticorpo, composicao farmaceutico, e, uso de uma composicao farmaceutica
BRPI0819714A2 (pt)	2015-05-26	Formulações de proteína e métodos de produção das mesmas.
BRPI0816097A2 (pt)	2016-11-01	composição farmacêutica, método para tratar eritema em um paciente com rosácea, e, uso de uma composição.
BRPI0924183A2 (pt)	2016-07-05	inibidores de proteína quinase, formas cristalinas, formulações farmacêuticas e uso
BRPI1011423A2 (pt)	2016-03-15	composição injetável, kit e método cosmético.
BR112014022788A2 (pt)	2017-11-14	peptídeo, polipeptídeos, ácido nucleico, composição farmacêutica, conjugado e método in vitro
IT1397663B1 (it)	2013-01-18	Bocchettone e procedimento per la sua fabbricazione.
BRPI1015983A2 (pt)	2016-04-19	composto, uso do composto, método para tratar um paciente, e, composição farmacêutica.
DK2238110T3 (da)	2012-02-20	5.6-bisaryl-2-pyridin-carboxamid-derivater, fremstilling heraf og terapeutisk anvendelse heraf som urotensin II-receptorantagonister
BRPI1006996A2 (pt)	2015-09-15	composição, método e uso
BRPI0821915A2 (pt)	2015-06-16	Piridil-n-(1,3,4)-tiadiazol-2-il-benzeno sulfonamidas cíclicas, processos para sua preparação e seu uso como produtos farmacêuticos
BRPI0921717A2 (pt)	2018-10-09	composto, sequência de peptídeo isolada, composição farmacêutica, uso de um composto, anticorpo, e, método de tratamento
BRPI0911772A2 (pt)	2017-06-27	composto, composição farmacêutica, e, uso do composto.
BRPI0915527A2 (pt)	2016-01-26	pepitídeos, composição farmacêutica e exossomos compreendendo os mesmos, métodos e usos
BRPI0919694A2 (pt)	2015-12-08	composto, composto farmacêutica, uso de um composto, e, método de tratamento de uma doença.