BRPI0911136A2 - ensaio baseado em fluorescência para detectar compostos de modulação de "modo reverso" de trocador de sódio/cálcio (ncx) - Google Patents

ensaio baseado em fluorescência para detectar compostos de modulação de "modo reverso" de trocador de sódio/cálcio (ncx)

Info

Publication number: BRPI0911136A2
Authority: BR; Brazil
Prior art keywords: ncx; fluorescence; calcium; based assay; reverse mode
Prior art date: 2008-03-20

Application number

BRPI0911136A

Other languages

English (en)

Inventor

Manfred Frey

Sven Geibel

Thomas Licher

Original Assignee

Sanofi Aventis

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2008-03-20

Filing date

2009-03-13

Publication date

2015-10-06

2009-03-13 Application filed by Sanofi Aventis filed Critical Sanofi Aventis

2015-10-06 Publication of BRPI0911136A2 publication Critical patent/BRPI0911136A2/pt

Links

OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 title 1
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 title 1
238000003556 assay Methods 0.000 title 1
239000011575 calcium Substances 0.000 title 1
229910052791 calcium Inorganic materials 0.000 title 1
150000001875 compounds Chemical class 0.000 title 1
239000011734 sodium Substances 0.000 title 1
229910052708 sodium Inorganic materials 0.000 title 1

Classifications

- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels

Landscapes

Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Chemical & Material Sciences (AREA)
Urology & Nephrology (AREA)
Biomedical Technology (AREA)
Hematology (AREA)
Immunology (AREA)
Cell Biology (AREA)
Physics & Mathematics (AREA)
Pathology (AREA)
Biotechnology (AREA)
Food Science & Technology (AREA)
Medicinal Chemistry (AREA)
Microbiology (AREA)
Analytical Chemistry (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
General Physics & Mathematics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Investigating Or Analysing Biological Materials (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
Peptides Or Proteins (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Plural Heterocyclic Compounds (AREA)

BRPI0911136A 2008-03-20 2009-03-13 ensaio baseado em fluorescência para detectar compostos de modulação de "modo reverso" de trocador de sódio/cálcio (ncx) BRPI0911136A2 (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP08290265A EP2103939A1 (en)	2008-03-20	2008-03-20	Fluorescence based assay to detect sodium/calcium exchanger (NCX) "reverse mode" modulating compounds
PCT/EP2009/001823 WO2009115238A1 (en)	2008-03-20	2009-03-13	Fluorescence based assay to detect sodium/calcium exchanger (ncx) "reverse mode" modulating compounds

Publications (1)

Publication Number	Publication Date
BRPI0911136A2 true BRPI0911136A2 (pt)	2015-10-06

Family

ID=39591244

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI0911136A BRPI0911136A2 (pt)	2008-03-20	2009-03-13	ensaio baseado em fluorescência para detectar compostos de modulação de "modo reverso" de trocador de sódio/cálcio (ncx)

Country Status (13)

Country	Link
US (1)	US20110124033A1 (pt)
EP (2)	EP2103939A1 (pt)
JP (1)	JP2011529564A (pt)
KR (1)	KR20100137458A (pt)
CN (1)	CN101978270A (pt)
AR (1)	AR070933A1 (pt)
AU (1)	AU2009226681A1 (pt)
BR (1)	BRPI0911136A2 (pt)
CA (1)	CA2718734A1 (pt)
IL (1)	IL208177A0 (pt)
MX (1)	MX2010010291A (pt)
TW (1)	TW201005294A (pt)
WO (1)	WO2009115238A1 (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
RS53748B1 (sr)	2011-09-12	2015-06-30	Sanofi	Supstituisani 2-(hroman-6-iloksi)-tiazoli i njihova upotreba kao farmaceutskih sredstava
SG11201400518RA (en)	2011-09-12	2014-04-28	Sanofi Sa	Substituted 2-(chroman-6-yloxy)-thiazoles and their use as pharmaceuticals
US8912224B2 (en)	2011-09-12	2014-12-16	Sanofi	Substituted 2-(chroman-6-yloxy)-thiazoles and their use as pharmaceuticals
KR101933620B1 (ko) *	2012-09-18	2018-12-28	삼성전자주식회사	소포를 검출하기 위한 조성물, 키트 및 이를 이용하여 소포를 분석하는 방법
TWI633095B (zh)	2013-03-08	2018-08-21	賽諾菲公司	經取代－６－基氧基－環烷類及其作為醫藥品之用途
CN109187504A (zh) *	2018-07-11	2019-01-11	佛山市顺德区欧罗拉生物科技有限公司	一种基于离子通道阅读器的离子转运通道活性分析方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5714666A (en)	1993-02-09	1998-02-03	Children's Hospital Of Philadelphia	Measurement of intracellular calcium using bioluminescent apoaequorin expressed in mammalian cells
DK1031556T3 (da)	1997-10-20	2003-02-24	Taisho Pharmaceutical Co Ltd	2-phenoxyanilinderivater
EP1526140B1 (en) *	2002-08-01	2008-11-05	Astellas Pharma Inc.	Potassium-dependent sodium-calcium exchanger
US20050112701A1 (en) *	2003-09-11	2005-05-26	Aventis Pharma Deutschland Gmbh	Test system for the identification of APJ receptor ligands
JP2006045142A (ja) *	2004-08-06	2006-02-16	Taisho Pharmaceut Co Ltd	ＮＣＸ１阻害剤を含有する、内因性Ｎａ＋ポンプ抑制物質と関連する循環障害の治療薬または診断用薬
EP1782064B1 (en) *	2004-08-19	2012-01-18	Sanofi-Aventis Deutschland GmbH	Process for identification of compounds for modulating the activity of a sodium/calcium exchange transporter
TWI372749B (en) *	2005-03-10	2012-09-21	Theravance Inc	Crystalline forms of a biphenyl compound
CA2618791C (en) *	2005-08-12	2014-05-13	Riken	Novel mucin-type glycoprotein and use thereof
CA2634147A1 (en) *	2005-12-22	2007-06-28	Icagen, Inc.	Calcium channel antagonists
EP2103944A1 (en) *	2008-03-20	2009-09-23	sanofi-aventis	Fluorescence based assay to detect sodium/calcium exchanger "forward mode" modulating compounds

2008
- 2008-03-20 EP EP08290265A patent/EP2103939A1/en not_active Ceased
2009
- 2009-03-13 AU AU2009226681A patent/AU2009226681A1/en not_active Abandoned
- 2009-03-13 MX MX2010010291A patent/MX2010010291A/es active IP Right Grant
- 2009-03-13 CN CN2009801106250A patent/CN101978270A/zh active Pending
- 2009-03-13 BR BRPI0911136A patent/BRPI0911136A2/pt not_active IP Right Cessation
- 2009-03-13 CA CA2718734A patent/CA2718734A1/en not_active Abandoned
- 2009-03-13 JP JP2011500081A patent/JP2011529564A/ja not_active Ceased
- 2009-03-13 US US12/922,741 patent/US20110124033A1/en not_active Abandoned
- 2009-03-13 EP EP09722532A patent/EP2257812A1/en not_active Withdrawn
- 2009-03-13 KR KR1020107020410A patent/KR20100137458A/ko not_active Withdrawn
- 2009-03-13 WO PCT/EP2009/001823 patent/WO2009115238A1/en not_active Ceased
- 2009-03-18 TW TW98108689A patent/TW201005294A/zh unknown
- 2009-03-18 AR ARP090100967A patent/AR070933A1/es not_active Application Discontinuation
2010
- 2010-09-15 IL IL208177A patent/IL208177A0/en unknown

Also Published As

Publication number	Publication date
AR070933A1 (es)	2010-05-12
WO2009115238A1 (en)	2009-09-24
EP2103939A1 (en)	2009-09-23
CA2718734A1 (en)	2009-09-24
KR20100137458A (ko)	2010-12-30
MX2010010291A (es)	2010-10-07
IL208177A0 (en)	2010-12-30
US20110124033A1 (en)	2011-05-26
TW201005294A (en)	2010-02-01
JP2011529564A (ja)	2011-12-08
EP2257812A1 (en)	2010-12-08
AU2009226681A1 (en)	2009-09-24
CN101978270A (zh)	2011-02-16

Legal Events

Date	Code	Title	Description
2015-12-08	B08F	Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]	Free format text: REFERENTE A 6A ANUIDADE.
2016-04-05	B08K	Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]	Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2344 DE 08-12-2015 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.

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