BRPI0809076A2 - Ensaio com base na fluorescência para a detecção de compostos para a modulação do trocador de sódio-cálcio (ncx) nos compostos de modulação em "modo de avanço" - Google Patents

Ensaio com base na fluorescência para a detecção de compostos para a modulação do trocador de sódio-cálcio (ncx) nos compostos de modulação em "modo de avanço"

Info

Publication number
BRPI0809076A2
BRPI0809076A2 BRPI0809076-9A2A BRPI0809076A BRPI0809076A2 BR PI0809076 A2 BRPI0809076 A2 BR PI0809076A2 BR PI0809076 A BRPI0809076 A BR PI0809076A BR PI0809076 A2 BRPI0809076 A2 BR PI0809076A2
Authority
BR
Brazil
Prior art keywords
modulation
ncx
fluorescence
based test
calcium sodium
Prior art date
Application number
BRPI0809076-9A2A
Other languages
English (en)
Inventor
Martin Hug
Thomas Licher
Sven Geibel
Henning Vollert
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of BRPI0809076A2 publication Critical patent/BRPI0809076A2/pt

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/10—Screening for compounds of potential therapeutic value involving cells

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Food Science & Technology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
BRPI0809076-9A2A 2007-03-13 2008-03-04 Ensaio com base na fluorescência para a detecção de compostos para a modulação do trocador de sódio-cálcio (ncx) nos compostos de modulação em "modo de avanço" BRPI0809076A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102007011913A DE102007011913A1 (de) 2007-03-13 2007-03-13 Fluoreszenz-basiertes Assay zum Erkennen von Verbindungen zum Modulieren des Natrium-Calcium-Austauschers (NCX) im "Vorwärtsmodus"
PCT/EP2008/001707 WO2008110285A1 (de) 2007-03-13 2008-03-04 Fluoreszenz-basiertes assay zum erkennen von verbindungen zum modulieren des natrium-calcium-austauschers (ncx) im 'vorwärtsmodus'

Publications (1)

Publication Number Publication Date
BRPI0809076A2 true BRPI0809076A2 (pt) 2014-11-04

Family

ID=39563393

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0809076-9A2A BRPI0809076A2 (pt) 2007-03-13 2008-03-04 Ensaio com base na fluorescência para a detecção de compostos para a modulação do trocador de sódio-cálcio (ncx) nos compostos de modulação em "modo de avanço"

Country Status (14)

Country Link
US (1) US20100151497A1 (pt)
EP (1) EP2135092A1 (pt)
JP (1) JP2010520759A (pt)
KR (1) KR20090122287A (pt)
CN (1) CN101636658A (pt)
AR (1) AR065685A1 (pt)
AU (1) AU2008226101B2 (pt)
BR (1) BRPI0809076A2 (pt)
CA (1) CA2680768A1 (pt)
DE (1) DE102007011913A1 (pt)
IL (1) IL200789A0 (pt)
MX (1) MX2009009681A (pt)
TW (1) TW200907340A (pt)
WO (1) WO2008110285A1 (pt)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2103944A1 (en) * 2008-03-20 2009-09-23 sanofi-aventis Fluorescence based assay to detect sodium/calcium exchanger "forward mode" modulating compounds
JP5127783B2 (ja) * 2009-06-29 2013-01-23 日本電信電話株式会社 においセンサおよびにおい検知方法
US8568471B2 (en) * 2010-01-30 2013-10-29 Abbott Cardiovascular Systems Inc. Crush recoverable polymer scaffolds
US8808353B2 (en) * 2010-01-30 2014-08-19 Abbott Cardiovascular Systems Inc. Crush recoverable polymer scaffolds having a low crossing profile

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5714666A (en) 1993-02-09 1998-02-03 Children's Hospital Of Philadelphia Measurement of intracellular calcium using bioluminescent apoaequorin expressed in mammalian cells
DK1031556T3 (da) 1997-10-20 2003-02-24 Taisho Pharmaceutical Co Ltd 2-phenoxyanilinderivater
US20020132303A1 (en) * 2001-03-12 2002-09-19 Millennium Pharmaceuticals, Inc. 69318, a human sodium/calcium exchanger (transporter) family member and uses therefor
CA2425806A1 (en) * 2000-10-13 2002-04-18 Bristol-Myers Squibb Company Methods for detecting modulators of ion channels using thallium (i) sensitive assays
WO2003040303A2 (en) * 2001-11-09 2003-05-15 Pfizer Products Inc. Functional assay for agonist activation of receptors
KR100514090B1 (ko) * 2003-01-17 2005-09-13 한국과학기술연구원 Ｎｃｘ2 단백질의 활성을 억제함으로써 학습능력 및기억력을 증진시키는 방법
US20050112701A1 (en) * 2003-09-11 2005-05-26 Aventis Pharma Deutschland Gmbh Test system for the identification of APJ receptor ligands

Also Published As

Publication number Publication date
AU2008226101B2 (en) 2013-09-19
US20100151497A1 (en) 2010-06-17
KR20090122287A (ko) 2009-11-26
AR065685A1 (es) 2009-06-24
WO2008110285A1 (de) 2008-09-18
JP2010520759A (ja) 2010-06-17
CN101636658A (zh) 2010-01-27
CA2680768A1 (en) 2008-09-18
TW200907340A (en) 2009-02-16
AU2008226101A1 (en) 2008-09-18
DE102007011913A1 (de) 2008-10-23
EP2135092A1 (de) 2009-12-23
IL200789A0 (en) 2010-05-17
MX2009009681A (es) 2009-09-24

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 7A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2343 DE 01-12-2015 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.

B350 Update of information on the portal [chapter 15.35 patent gazette]