BRPI0911176A2 - Métodos de extinção melhorados para inativação de patógeno de células vermelhas sanguíneas - Google Patents

Métodos de extinção melhorados para inativação de patógeno de células vermelhas sanguíneas

Info

Publication number
BRPI0911176A2
BRPI0911176A2 BRPI0911176-0A BRPI0911176A BRPI0911176A2 BR PI0911176 A2 BRPI0911176 A2 BR PI0911176A2 BR PI0911176 A BRPI0911176 A BR PI0911176A BR PI0911176 A2 BRPI0911176 A2 BR PI0911176A2
Authority
BR
Brazil
Prior art keywords
blood cells
red blood
pathogen inactivation
improved extinction
extinction methods
Prior art date
Application number
BRPI0911176-0A
Other languages
English (en)
Inventor
Naheed Mufti
Anna Erickson
Anne North
Original Assignee
Cerus Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cerus Corp filed Critical Cerus Corp
Publication of BRPI0911176A2 publication Critical patent/BRPI0911176A2/pt
Publication of BRPI0911176B1 publication Critical patent/BRPI0911176B1/pt
Publication of BRPI0911176B8 publication Critical patent/BRPI0911176B8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/18—Erythrocytes
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A01N1/12—Chemical aspects of preservation
    • A01N1/122—Preservation or perfusion media
    • A01N1/124—Disinfecting agents, e.g. antimicrobials
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A01N1/12—Chemical aspects of preservation
    • A01N1/122—Preservation or perfusion media
    • A01N1/126—Physiologically active agents, e.g. antioxidants or nutrients
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
    • A01N43/40—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
    • A01N43/42—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Disinfection or sterilisation of materials or objects, in general; Accessories therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N2300/00—Combinations or mixtures of active ingredients covered by classes A01N27/00 - A01N65/48 with other active or formulation relevant ingredients, e.g. specific carrier materials or surfactants, covered by classes A01N25/00 - A01N65/48
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Disinfection or sterilisation of materials or objects, in general; Accessories therefor
    • A61L2/16—Disinfection or sterilisation of materials or objects, in general; Accessories therefor using chemical substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2103/00—Materials or objects being the target of disinfection or sterilisation
    • A61L2103/05—Living organisms or biological materials

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Environmental Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Biotechnology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Cell Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Biophysics (AREA)
  • Physiology (AREA)
  • Toxicology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
BRPI0911176A 2008-04-09 2009-04-09 método de tratar uma composição de célula vermelha sanguínea, composição de célula vermelha sanguínea, e método de reduzir a desidratação em uma composição de célula vermelha sanguínea BRPI0911176B8 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US4366608P 2008-04-09 2008-04-09
US61/043,666 2008-04-09
US8703408P 2008-08-07 2008-08-07
US61/087,034 2008-08-07
PCT/US2009/040032 WO2009126786A2 (en) 2008-04-09 2009-04-09 Improved quenching methods for red blood cell pathogen inactivation

Publications (3)

Publication Number Publication Date
BRPI0911176A2 true BRPI0911176A2 (pt) 2015-07-28
BRPI0911176B1 BRPI0911176B1 (pt) 2019-10-15
BRPI0911176B8 BRPI0911176B8 (pt) 2021-05-25

Family

ID=41162599

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0911176A BRPI0911176B8 (pt) 2008-04-09 2009-04-09 método de tratar uma composição de célula vermelha sanguínea, composição de célula vermelha sanguínea, e método de reduzir a desidratação em uma composição de célula vermelha sanguínea

Country Status (15)

Country Link
US (3) US8900805B2 (pt)
EP (2) EP3257375A1 (pt)
JP (2) JP5916383B2 (pt)
KR (2) KR101896430B1 (pt)
CN (1) CN102046006B (pt)
AU (1) AU2009233807B2 (pt)
BR (1) BRPI0911176B8 (pt)
CA (1) CA2720824C (pt)
EA (1) EA023596B1 (pt)
ES (1) ES2636563T3 (pt)
IL (1) IL208431A (pt)
MX (2) MX2010011018A (pt)
SG (2) SG189745A1 (pt)
WO (1) WO2009126786A2 (pt)
ZA (1) ZA201006936B (pt)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101896430B1 (ko) 2008-04-09 2018-09-10 세루스 코포레이션 적혈구 병원체 불활성화를 위한 개선된 퀀칭 방법
US12089589B2 (en) 2009-10-12 2024-09-17 Hemanext Inc. Irradiation of red blood cells and anaerobic storage
US11284616B2 (en) 2010-05-05 2022-03-29 Hemanext Inc. Irradiation of red blood cells and anaerobic storage
US9199016B2 (en) 2009-10-12 2015-12-01 New Health Sciences, Inc. System for extended storage of red blood cells and methods of use
EA201790265A1 (ru) 2014-07-23 2017-07-31 Сирус Корпорейшн Способы получения тромбоцит-содержащих продуктов
KR20250033333A (ko) 2015-03-10 2025-03-07 헤마넥스트 인코포레이티드 산소 감소 1회용 키트, 장치 및 이의 사용 방법
BR122022005103B1 (pt) 2015-04-23 2023-03-14 Hemanext Inc Dispositivo de armazenamento de sangue para armazenar sangue depletado de oxigênio e método para armazenar sangue depletado de oxigênio
PT3297641T (pt) 2015-05-18 2025-10-09 Hemanext Inc Métodos de armazenamento de sangue total e respetivas composições
CN122182613A (zh) 2015-06-26 2026-06-12 塞鲁斯公司 冷沉淀物组合物及其制备方法
US10799533B2 (en) 2015-10-23 2020-10-13 Cerus Corporation Plasma compositions and methods of use thereof
CN109195632A (zh) * 2016-05-27 2019-01-11 新健康科学股份有限公司 厌氧血液储存和病原体失活方法
IT201600079328A1 (it) * 2016-07-28 2018-01-28 Altergon Sa Metodo migliorato per la decontaminazione di materiale biologico mediante partizione e inattivazione
AU2017382449B2 (en) * 2016-12-23 2024-10-24 Cerus Corporation Systems and methods for testing and screening using compound bound substrates
US20190321407A1 (en) * 2016-12-31 2019-10-24 Cerus Corporation Compositions and methods for preparation of red blood cells
EP4606379A3 (en) 2017-03-03 2025-11-19 Cerus Corporation Kits and methods for preparing pathogen-inactivated platelet compositions
JP7311518B2 (ja) 2017-12-29 2023-07-19 シーラス コーポレイション 生物学的流体を処理するためのシステムおよび方法
US20210227827A1 (en) * 2018-07-27 2021-07-29 Zata Pharmaceuticals, Inc. Method for pathogens, microorganisms, and parasites inactivation
CA3113655A1 (en) * 2018-09-20 2020-03-26 Cerus Corporation Methods and kits for preparing pathogen-inactivated whole blood
US12103222B2 (en) 2018-12-21 2024-10-01 The Curators Of The University Of Missouri Methods and systems for drawn fused filament fabrication printing
WO2020263745A1 (en) 2019-06-22 2020-12-30 Cerus Corporation Systems and methods for implementing treatment of biological fluids
CN114173842B (zh) 2019-06-22 2026-07-14 塞鲁斯公司 生物流体处理系统
JP7645203B2 (ja) 2019-06-28 2025-03-13 シーラス コーポレイション 生物学的流体処理デバイスを実装するためのシステム及び方法
WO2025264876A1 (en) 2024-06-20 2025-12-26 Cerus Corporation Systems and methods for pathogen inactivation of blood products

Family Cites Families (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2402665A (en) 1942-11-12 1946-06-25 Du Pont Chemical process
IT1093275B (it) 1978-01-26 1985-07-19 Snam Progetti Composizione adatta alla purificazione del sangue e suoi impieghi
US4337269A (en) 1979-07-23 1982-06-29 Sutton Laboratories, Inc. Preservative compositions
US4748120A (en) 1983-05-02 1988-05-31 Diamond Scientific Co. Photochemical decontamination treatment of whole blood or blood components
US4727027A (en) 1983-05-02 1988-02-23 Diamond Scientific Co. Photochemical decontamination treatment of whole blood or blood components
US5281579A (en) 1984-03-23 1994-01-25 Baxter International Inc. Purified virus-free hemoglobin solutions and method for making same
US4971760A (en) 1986-03-10 1990-11-20 University Of Southern California Novel method for disinfecting red blood cells, blood platelets, blood plasma, and optical corneas and sclerae
US4944920A (en) 1986-08-01 1990-07-31 University Of Southern California Novel method to treat blood
US4920143A (en) 1987-04-23 1990-04-24 University Of British Columbia Hydro-monobenzoporphyrin wavelength-specific cytotoxic agents
US5094960A (en) 1988-10-07 1992-03-10 New York Blood Center, Inc. Removal of process chemicals from labile biological mixtures by hydrophobic interaction chromatography
US5055485A (en) 1988-12-02 1991-10-08 New York Blood Center, Inc. Inactivation of viruses in cell- and protein-containing compositions using aryl diol epoxides
US5418130A (en) 1990-04-16 1995-05-23 Cryopharm Corporation Method of inactivation of viral and bacterial blood contaminants
US5587490A (en) 1990-04-16 1996-12-24 Credit Managers Association Of California Method of inactivation of viral and bacterial blood contaminants
US5232844A (en) 1990-05-15 1993-08-03 New York Blood Center Photodynamic inactivation of viruses in cell-containing compositions
US5658722A (en) 1990-05-15 1997-08-19 New York Blood Center, Inc. Process for the sterilization of biological compositions using UVA1 irradiation
US5120649A (en) 1990-05-15 1992-06-09 New York Blood Center, Inc. Photodynamic inactivation of viruses in blood cell-containing compositions
US5753258A (en) 1990-10-19 1998-05-19 University Of Florida Artificial viral envelopes
GB9218581D0 (en) 1992-09-02 1992-10-14 Pall Corp Removal of unwanted fluids from processed blood products
CA2165065A1 (en) 1993-06-23 1995-01-05 Henrietta Margolis-Nunno System for viral inactivation of blood
US5591350A (en) 1994-04-15 1997-01-07 Pall Corporation Iodine disinfection method using a gaseous iodine treated porous medium
SE9402472L (sv) 1994-07-13 1996-01-14 Forskarpatent I Linkoeping Ab Modifierade ytor
US5522385A (en) 1994-09-27 1996-06-04 Aradigm Corporation Dynamic particle size control for aerosolized drug delivery
US5660731A (en) 1994-11-08 1997-08-26 Pall Corporation Filter for separating photoactive agent
US5691132A (en) 1994-11-14 1997-11-25 Cerus Corporation Method for inactivating pathogens in red cell compositions using quinacrine mustard
US5637451A (en) 1995-03-29 1997-06-10 New York Blood Center, Inc. Photodynamic treatment of red blood cells with phthalocyanines and red light at higher light fluence rates is protective of red blood cells
US6177441B1 (en) 1995-06-05 2001-01-23 Cerus Corporation Treating red blood cell solutions with anti-viral agents
US6544727B1 (en) 1995-06-07 2003-04-08 Cerus Corporation Methods and devices for the removal of psoralens from blood products
US20020192632A1 (en) 1995-06-07 2002-12-19 Hei Derek J. Method and devices for the removal of psoralens from blood products
EP0840781B1 (en) 1995-06-07 2009-12-09 Cerus Corporation Methods and devices for the removal of psoralens from blood products
EP0773716A4 (en) 1995-06-07 1999-08-04 Cerus Corp TREATMENT OF RED BLOOD CELL SOLUTIONS WITH ANTIVRAL ACTIVE SUBSTANCES
AU703108B2 (en) 1995-06-07 1999-03-18 Baxter International Inc. Method of inactivation of viral and bacterial blood contaminants
AU7717396A (en) 1995-06-29 1997-02-05 Hemasure, Inc. Inactivation of pathogens using hydroxymethylamines
US6114108A (en) 1995-08-29 2000-09-05 V.I. Technologies, Inc. Methods and compositions for the selective modification of viral nucleic acids
US6136586A (en) 1995-08-29 2000-10-24 Vi Technologies, Inc. Methods for the selective modification of viral nucleic acids
CA2236873A1 (en) 1995-11-06 1997-05-15 New York Blood Center, Inc. Viral inactivation treatment of red blood cells using phthalocyanines and red light
WO1997018844A1 (en) 1995-11-21 1997-05-29 Pall Corporation Inactivation method and system in biological fluids
US6093725A (en) * 1997-01-06 2000-07-25 Cerus Corporation Frangible compounds for pathogen inactivation
US6514987B1 (en) 1997-01-06 2003-02-04 Cerus Corporation Frangible compounds for pathogen inactivation
ATE243198T1 (de) 1997-01-06 2003-07-15 Cerus Corp Verbindungen mit leicht spaltbaren bindungen zur inaktivierung von pathogenen
US20010018179A1 (en) 1998-01-06 2001-08-30 Derek J. Hei Batch devices for the reduction of compounds from biological compositions containing cells and methods of use
US20010009756A1 (en) 1998-01-06 2001-07-26 Derek Hei Flow devices for the reduction of compounds from biological compositions and methods of use
US6093564A (en) 1997-10-03 2000-07-25 V.I. Technologies, Inc. Methods and compositions for the selective modification of nucleic acids
DE69826521T2 (de) 1998-01-06 2005-09-29 Cerus Corp., Concord Verfahren zum quenchen von pathogen-inaktivatoren in biologischen materialien
US20030073650A1 (en) * 1998-07-21 2003-04-17 Heather Reddy Method and apparatus for inactivation of biological contaminants using photosensitizers
US6150109A (en) 1999-01-25 2000-11-21 V. I. TECHNOLOGIES, Inc. Lipophilic quenching of viral inactivating agents
US6288122B1 (en) 1999-02-23 2001-09-11 Icagen, Inc. Gardos channel antagonists
CN1436083A (zh) * 2000-05-31 2003-08-13 塞鲁斯公司 制备病原体灭活的低免疫原性红细胞溶液
TW590780B (en) * 2000-06-02 2004-06-11 Gambro Inc Additive solutions containing riboflavin
US20030113704A1 (en) * 2000-12-21 2003-06-19 Cerus Corporation Methods for inactivation of pathogens in biological materials
JP5346468B2 (ja) 2004-10-29 2013-11-20 シーラス コーポレイション 赤血球不活性化プロセスのための改善されたクエンチング方法
KR101896430B1 (ko) 2008-04-09 2018-09-10 세루스 코포레이션 적혈구 병원체 불활성화를 위한 개선된 퀀칭 방법

Also Published As

Publication number Publication date
US8900805B2 (en) 2014-12-02
US20150157665A1 (en) 2015-06-11
SG10201605663UA (en) 2016-09-29
CA2720824C (en) 2021-09-14
WO2009126786A3 (en) 2010-07-15
US20180008639A1 (en) 2018-01-11
AU2009233807A1 (en) 2009-10-15
HK1157140A1 (en) 2012-06-29
MX373157B (es) 2020-04-21
JP5916383B2 (ja) 2016-05-11
KR20170037682A (ko) 2017-04-04
US10357516B2 (en) 2019-07-23
KR20110009134A (ko) 2011-01-27
BRPI0911176B8 (pt) 2021-05-25
AU2009233807B2 (en) 2014-11-27
EP2285210A2 (en) 2011-02-23
IL208431A (en) 2016-10-31
EA023596B1 (ru) 2016-06-30
CN102046006A (zh) 2011-05-04
IL208431A0 (en) 2010-12-30
EP2285210B1 (en) 2017-05-17
KR101742533B1 (ko) 2017-06-01
SG189745A1 (en) 2013-05-31
KR101896430B1 (ko) 2018-09-10
EP3257375A1 (en) 2017-12-20
US20110286987A1 (en) 2011-11-24
JP2011516570A (ja) 2011-05-26
ZA201006936B (en) 2016-03-30
ES2636563T3 (es) 2017-10-06
WO2009126786A2 (en) 2009-10-15
MX2010011018A (es) 2010-11-12
BRPI0911176B1 (pt) 2019-10-15
CA2720824A1 (en) 2009-10-15
EA201071178A1 (ru) 2011-06-30
CN102046006B (zh) 2014-09-24
US9713627B2 (en) 2017-07-25
JP2014231528A (ja) 2014-12-11

Similar Documents

Publication Publication Date Title
IL208431A (en) Quenching methods for red blood cell pathogen inactivation
EP2768514A4 (en) LOCALIZED MODULATION OF TISSUE AND CELLS FOR IMPROVING THE THERAPEUTIC EFFECT, INCLUDING NIERENENENVIERUNG
DK3473278T3 (da) Fremgangsmåde til enzymatisk behandling af vævsprodukter
BRPI0919252A2 (pt) Métodos para cultivar células, propagação e purificação de vírus
IL250824A0 (en) Certain amino-pyridazines, compositions thereof, and methods of their use
LT3023102T (lt) Ibat inhibitoriai, skirti kepenų ligų gydymui
BRPI0908026A2 (pt) Métodos para o tratamento de doenças do intestino
BR112013012854A2 (pt) métodos de tratamento usando os inibidores de bcl-2 seletivos
LTPA2017039I1 (lt) Pirolopirimidino junginiai, kaip CDK inhibitoriai
DK3130923T3 (da) Terapeutiske fremgangsmåder i forbindelse med cancerstamceller
IT1391555B1 (it) Apparato trattamento extracorporeo sangue
DK2329012T3 (da) Behandling af slagtilfælde under anvendelse af isolerede placentaceller
BRPI0910854A2 (pt) métodos de tratamento
PL2601979T3 (pl) Sposób sterylizacji
PL3050571T3 (pl) Preparat enzymu trawiennego do leczenia rzucawki
DK2381965T3 (da) Modulation af præ-mrna under anvendelse af splejsningsmodulerende oligonukleotider som terapeutiske midler til behandling af sygdom
LTPA2016041I1 (lt) Gydymo būdai panaudojant vaistus - amoniako gaudykles
PL3321355T3 (pl) Sposoby i kompozycje do klinicznego pozyskiwania komórek alogenicznych oraz zastosowania terapeutyczne
PT2729151T (pt) Composição farmacêutica, métodos de tratamento e suas utilizações
SMT201500142B (it) Procedimento per la purificazione di proteine
EP2456440A4 (en) Quinolinone PDE2 INHIBITORS
EP2750705A4 (en) METHOD FOR THE EFFECTIVE AND FAST DESENSIBILIZATION OF ALLERGY PATIENTS
IL227827B (en) Methods and devices suitable for imaging blood-containing tissue
SI2358641T1 (sl) Postopek priprave titanatov
PL2718434T3 (pl) Kompozycje i sposoby leczenia choroby trzewnej

Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 15/10/2019, OBSERVADAS AS CONDICOES LEGAIS. (CO) 10 (DEZ) ANOS CONTADOS A PARTIR DE 15/10/2019, OBSERVADAS AS CONDICOES LEGAIS

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 09/04/2009 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF