BRPI0911176B8 - método de tratar uma composição de célula vermelha sanguínea, composição de célula vermelha sanguínea, e método de reduzir a desidratação em uma composição de célula vermelha sanguínea - Google Patents

método de tratar uma composição de célula vermelha sanguínea, composição de célula vermelha sanguínea, e método de reduzir a desidratação em uma composição de célula vermelha sanguínea

Info

Publication number
BRPI0911176B8
BRPI0911176B8 BRPI0911176A BRPI0911176A BRPI0911176B8 BR PI0911176 B8 BRPI0911176 B8 BR PI0911176B8 BR PI0911176 A BRPI0911176 A BR PI0911176A BR PI0911176 A BRPI0911176 A BR PI0911176A BR PI0911176 B8 BRPI0911176 B8 BR PI0911176B8
Authority
BR
Brazil
Prior art keywords
red blood
blood cell
cell composition
treating
reducing dehydration
Prior art date
Application number
BRPI0911176A
Other languages
English (en)
Inventor
Erickson Anna
North Anne
Mufti Naheed
Original Assignee
Cerus Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cerus Corp filed Critical Cerus Corp
Publication of BRPI0911176A2 publication Critical patent/BRPI0911176A2/pt
Publication of BRPI0911176B1 publication Critical patent/BRPI0911176B1/pt
Publication of BRPI0911176B8 publication Critical patent/BRPI0911176B8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/18—Erythrocytes
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A01N1/12—Chemical aspects of preservation
    • A01N1/122—Preservation or perfusion media
    • A01N1/124—Disinfecting agents, e.g. antimicrobials
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A01N1/12—Chemical aspects of preservation
    • A01N1/122—Preservation or perfusion media
    • A01N1/126—Physiologically active agents, e.g. antioxidants or nutrients
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
    • A01N43/40—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
    • A01N43/42—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Disinfection or sterilisation of materials or objects, in general; Accessories therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N2300/00—Combinations or mixtures of active ingredients covered by classes A01N27/00 - A01N65/48 with other active or formulation relevant ingredients, e.g. specific carrier materials or surfactants, covered by classes A01N25/00 - A01N65/48
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Disinfection or sterilisation of materials or objects, in general; Accessories therefor
    • A61L2/16—Disinfection or sterilisation of materials or objects, in general; Accessories therefor using chemical substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2103/00—Materials or objects being the target of disinfection or sterilisation
    • A61L2103/05—Living organisms or biological materials

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Dentistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Plant Pathology (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Developmental Biology & Embryology (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Biophysics (AREA)
  • Physiology (AREA)
  • Toxicology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

método de tratar uma composição de célula vermelha sanguínea, composição de célula vermelha sanguínea, e método de reduzir a desidratação em uma composição de célula vermelha sanguínea. a presente invenção refere-se a métodos para tratar composições de células sanguínea vermelha vermelha com um composto de inativação de patógeneo sob condições que forneçam inativação de patógeneo adequada ao mesmo tempo em que mantendo a vitalidade de célula. também fornecidos são métodos de reduzir a desidratação em células vermelhas sanguíneas, bem como composições de células sanguínea vermelha, bem como composições de célula sanguínea vermelha tratadas.
BRPI0911176A 2008-04-09 2009-04-09 método de tratar uma composição de célula vermelha sanguínea, composição de célula vermelha sanguínea, e método de reduzir a desidratação em uma composição de célula vermelha sanguínea BRPI0911176B8 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US4366608P 2008-04-09 2008-04-09
US61/043,666 2008-04-09
US8703408P 2008-08-07 2008-08-07
US61/087,034 2008-08-07
PCT/US2009/040032 WO2009126786A2 (en) 2008-04-09 2009-04-09 Improved quenching methods for red blood cell pathogen inactivation

Publications (3)

Publication Number Publication Date
BRPI0911176A2 BRPI0911176A2 (pt) 2015-07-28
BRPI0911176B1 BRPI0911176B1 (pt) 2019-10-15
BRPI0911176B8 true BRPI0911176B8 (pt) 2021-05-25

Family

ID=41162599

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0911176A BRPI0911176B8 (pt) 2008-04-09 2009-04-09 método de tratar uma composição de célula vermelha sanguínea, composição de célula vermelha sanguínea, e método de reduzir a desidratação em uma composição de célula vermelha sanguínea

Country Status (15)

Country Link
US (3) US8900805B2 (pt)
EP (2) EP3257375A1 (pt)
JP (2) JP5916383B2 (pt)
KR (2) KR101896430B1 (pt)
CN (1) CN102046006B (pt)
AU (1) AU2009233807B2 (pt)
BR (1) BRPI0911176B8 (pt)
CA (1) CA2720824C (pt)
EA (1) EA023596B1 (pt)
ES (1) ES2636563T3 (pt)
IL (1) IL208431A (pt)
MX (2) MX2010011018A (pt)
SG (2) SG189745A1 (pt)
WO (1) WO2009126786A2 (pt)
ZA (1) ZA201006936B (pt)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2720824C (en) 2008-04-09 2021-09-14 Cerus Corporation Improved quenching methods for red blood cell pathogen inactivation
US11284616B2 (en) 2010-05-05 2022-03-29 Hemanext Inc. Irradiation of red blood cells and anaerobic storage
US12089589B2 (en) 2009-10-12 2024-09-17 Hemanext Inc. Irradiation of red blood cells and anaerobic storage
US9199016B2 (en) 2009-10-12 2015-12-01 New Health Sciences, Inc. System for extended storage of red blood cells and methods of use
US10842818B2 (en) 2014-07-23 2020-11-24 Cerus Corporation Methods for preparing platelet products
PT3970731T (pt) 2015-03-10 2026-02-24 Hemanext Inc Kits descartáveis de redução de oxigénio, dispositivos e métodos de utilização dos mesmos
WO2016172645A1 (en) 2015-04-23 2016-10-27 New Health Sciences, Inc. Anaerobic blood storage containers
CA2985799A1 (en) 2015-05-18 2016-11-24 New Health Sciences, Inc. Methods for the storage of whole blood, and compositions thereof
EP3313418B1 (en) 2015-06-26 2024-03-13 Cerus Corporation Cryoprecipitate compositions and methods of preparation thereof
CA3003097A1 (en) 2015-10-23 2017-04-27 Cerus Corporation Plasma compositions and methods of use thereof
KR20240132129A (ko) 2016-05-27 2024-09-02 헤마넥스트 인코포레이티드 혐기성 혈액 저장 및 병원체 불활성화 방법
IT201600079328A1 (it) * 2016-07-28 2018-01-28 Altergon Sa Metodo migliorato per la decontaminazione di materiale biologico mediante partizione e inattivazione
US20190369087A1 (en) * 2016-12-23 2019-12-05 Cerus Corporation Systems and methods for testing and screening using compound bound substrates
EP3562493A1 (en) 2016-12-31 2019-11-06 Cerus Corporation Compositions and methods for preparation of red blood cells
CA3055203A1 (en) 2017-03-03 2018-09-07 Cerus Corporation Kits and methods for preparing pathogen-inactivated platelet compositions
AU2018395525B2 (en) 2017-12-29 2023-09-14 Cerus Corporation Systems and methods for treating biological fluids
CA3107314A1 (en) * 2018-07-27 2020-01-30 Zata Pharmaceuticals, Inc. Method for pathogens, microorganisms, and parasites inactivation
EP4736892A2 (en) * 2018-09-20 2026-05-06 Cerus Corporation Methods for preparing pathogen-inactivated whole blood
WO2020132688A1 (en) 2018-12-21 2020-06-25 The Curators Of The University Of Missouri Methods and systems for drawn fused filament fabrication printing
US12011510B2 (en) 2019-06-22 2024-06-18 Cerus Corporation Biological fluid treatment systems
JP7571063B2 (ja) 2019-06-22 2024-10-22 シーラス コーポレイション 生物学的流体の処理を実施するシステム及び方法
CN114269394A (zh) 2019-06-28 2022-04-01 塞鲁斯公司 用于实现生物流体处理装置的系统和方法
WO2025264876A1 (en) 2024-06-20 2025-12-26 Cerus Corporation Systems and methods for pathogen inactivation of blood products

Family Cites Families (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2402665A (en) 1942-11-12 1946-06-25 Du Pont Chemical process
IT1093275B (it) 1978-01-26 1985-07-19 Snam Progetti Composizione adatta alla purificazione del sangue e suoi impieghi
US4337269A (en) 1979-07-23 1982-06-29 Sutton Laboratories, Inc. Preservative compositions
US4748120A (en) 1983-05-02 1988-05-31 Diamond Scientific Co. Photochemical decontamination treatment of whole blood or blood components
US4727027A (en) 1983-05-02 1988-02-23 Diamond Scientific Co. Photochemical decontamination treatment of whole blood or blood components
US5281579A (en) 1984-03-23 1994-01-25 Baxter International Inc. Purified virus-free hemoglobin solutions and method for making same
US4971760A (en) 1986-03-10 1990-11-20 University Of Southern California Novel method for disinfecting red blood cells, blood platelets, blood plasma, and optical corneas and sclerae
US4944920A (en) 1986-08-01 1990-07-31 University Of Southern California Novel method to treat blood
US4920143A (en) 1987-04-23 1990-04-24 University Of British Columbia Hydro-monobenzoporphyrin wavelength-specific cytotoxic agents
US5094960A (en) 1988-10-07 1992-03-10 New York Blood Center, Inc. Removal of process chemicals from labile biological mixtures by hydrophobic interaction chromatography
US5055485A (en) 1988-12-02 1991-10-08 New York Blood Center, Inc. Inactivation of viruses in cell- and protein-containing compositions using aryl diol epoxides
US5587490A (en) 1990-04-16 1996-12-24 Credit Managers Association Of California Method of inactivation of viral and bacterial blood contaminants
US5418130A (en) 1990-04-16 1995-05-23 Cryopharm Corporation Method of inactivation of viral and bacterial blood contaminants
US5658722A (en) 1990-05-15 1997-08-19 New York Blood Center, Inc. Process for the sterilization of biological compositions using UVA1 irradiation
US5120649A (en) 1990-05-15 1992-06-09 New York Blood Center, Inc. Photodynamic inactivation of viruses in blood cell-containing compositions
US5232844A (en) 1990-05-15 1993-08-03 New York Blood Center Photodynamic inactivation of viruses in cell-containing compositions
US5753258A (en) 1990-10-19 1998-05-19 University Of Florida Artificial viral envelopes
GB9218581D0 (en) 1992-09-02 1992-10-14 Pall Corp Removal of unwanted fluids from processed blood products
ZA944488B (en) 1993-06-23 1995-02-15 New York Blood Center Inc System for viral inactivation of blood
US5591350A (en) 1994-04-15 1997-01-07 Pall Corporation Iodine disinfection method using a gaseous iodine treated porous medium
SE9402472L (sv) 1994-07-13 1996-01-14 Forskarpatent I Linkoeping Ab Modifierade ytor
US5522385A (en) 1994-09-27 1996-06-04 Aradigm Corporation Dynamic particle size control for aerosolized drug delivery
US5660731A (en) 1994-11-08 1997-08-26 Pall Corporation Filter for separating photoactive agent
US5691132A (en) 1994-11-14 1997-11-25 Cerus Corporation Method for inactivating pathogens in red cell compositions using quinacrine mustard
US5637451A (en) 1995-03-29 1997-06-10 New York Blood Center, Inc. Photodynamic treatment of red blood cells with phthalocyanines and red light at higher light fluence rates is protective of red blood cells
US6177441B1 (en) 1995-06-05 2001-01-23 Cerus Corporation Treating red blood cell solutions with anti-viral agents
US20020192632A1 (en) 1995-06-07 2002-12-19 Hei Derek J. Method and devices for the removal of psoralens from blood products
EP0830057A4 (en) 1995-06-07 2000-07-12 Baxter Int METHOD FOR INACTIVATING VIRAL AND BACTERIAL BLOOD IMPURITIES
DE69638094D1 (de) 1995-06-07 2010-01-21 Cerus Corp Verfahren und vorrichtungen zur entfernung von psoralenen aus blutprodukten.
US6544727B1 (en) 1995-06-07 2003-04-08 Cerus Corporation Methods and devices for the removal of psoralens from blood products
EP0773716A4 (en) 1995-06-07 1999-08-04 Cerus Corp TREATMENT OF RED BLOOD CELL SOLUTIONS WITH ANTIVRAL ACTIVE SUBSTANCES
WO1997002028A1 (en) 1995-06-29 1997-01-23 Hemasure, Inc. Inactivation of pathogens using hydroxymethylamines
US6136586A (en) 1995-08-29 2000-10-24 Vi Technologies, Inc. Methods for the selective modification of viral nucleic acids
US6114108A (en) 1995-08-29 2000-09-05 V.I. Technologies, Inc. Methods and compositions for the selective modification of viral nucleic acids
AU723016B2 (en) 1995-11-06 2000-08-17 New York Blood Center, Inc., The Viral inactivation treatment of red blood cells using phthalocyanines and red light
WO1997018844A1 (en) 1995-11-21 1997-05-29 Pall Corporation Inactivation method and system in biological fluids
US20010009756A1 (en) 1998-01-06 2001-07-26 Derek Hei Flow devices for the reduction of compounds from biological compositions and methods of use
US6514987B1 (en) 1997-01-06 2003-02-04 Cerus Corporation Frangible compounds for pathogen inactivation
US6093725A (en) * 1997-01-06 2000-07-25 Cerus Corporation Frangible compounds for pathogen inactivation
ATE243198T1 (de) 1997-01-06 2003-07-15 Cerus Corp Verbindungen mit leicht spaltbaren bindungen zur inaktivierung von pathogenen
US20010018179A1 (en) 1998-01-06 2001-08-30 Derek J. Hei Batch devices for the reduction of compounds from biological compositions containing cells and methods of use
US6093564A (en) 1997-10-03 2000-07-25 V.I. Technologies, Inc. Methods and compositions for the selective modification of nucleic acids
CN1203900C (zh) 1998-01-06 2005-06-01 塞鲁斯公司 用于淬灭生物材料中病原体灭活剂的方法
US20030073650A1 (en) * 1998-07-21 2003-04-17 Heather Reddy Method and apparatus for inactivation of biological contaminants using photosensitizers
US6150109A (en) 1999-01-25 2000-11-21 V. I. TECHNOLOGIES, Inc. Lipophilic quenching of viral inactivating agents
US6288122B1 (en) 1999-02-23 2001-09-11 Icagen, Inc. Gardos channel antagonists
US20020042043A1 (en) * 2000-05-31 2002-04-11 Adonis Stassinopoulos Preparation of a pathogen inactivated solution of red blood cells having reduced immunogenicity
TW590780B (en) 2000-06-02 2004-06-11 Gambro Inc Additive solutions containing riboflavin
EP1365750A2 (en) * 2000-12-21 2003-12-03 Cerus Corporation Methods for inactivation of pathogens in biological materials
AU2005302256B2 (en) * 2004-10-29 2011-01-20 Cerus Corporation Improved quenching methods for red blood cell inactivation process
CA2720824C (en) 2008-04-09 2021-09-14 Cerus Corporation Improved quenching methods for red blood cell pathogen inactivation

Also Published As

Publication number Publication date
SG189745A1 (en) 2013-05-31
KR20170037682A (ko) 2017-04-04
SG10201605663UA (en) 2016-09-29
KR20110009134A (ko) 2011-01-27
AU2009233807B2 (en) 2014-11-27
US9713627B2 (en) 2017-07-25
CA2720824C (en) 2021-09-14
BRPI0911176B1 (pt) 2019-10-15
MX373157B (es) 2020-04-21
ZA201006936B (en) 2016-03-30
AU2009233807A1 (en) 2009-10-15
BRPI0911176A2 (pt) 2015-07-28
IL208431A0 (en) 2010-12-30
US20180008639A1 (en) 2018-01-11
IL208431A (en) 2016-10-31
JP2011516570A (ja) 2011-05-26
US8900805B2 (en) 2014-12-02
KR101742533B1 (ko) 2017-06-01
US20150157665A1 (en) 2015-06-11
EP2285210B1 (en) 2017-05-17
WO2009126786A3 (en) 2010-07-15
MX2010011018A (es) 2010-11-12
EA023596B1 (ru) 2016-06-30
CN102046006A (zh) 2011-05-04
JP2014231528A (ja) 2014-12-11
US10357516B2 (en) 2019-07-23
US20110286987A1 (en) 2011-11-24
HK1157140A1 (en) 2012-06-29
EP2285210A2 (en) 2011-02-23
KR101896430B1 (ko) 2018-09-10
WO2009126786A2 (en) 2009-10-15
ES2636563T3 (es) 2017-10-06
EP3257375A1 (en) 2017-12-20
CA2720824A1 (en) 2009-10-15
CN102046006B (zh) 2014-09-24
EA201071178A1 (ru) 2011-06-30
JP5916383B2 (ja) 2016-05-11

Similar Documents

Publication Publication Date Title
BRPI0911176B8 (pt) método de tratar uma composição de célula vermelha sanguínea, composição de célula vermelha sanguínea, e método de reduzir a desidratação em uma composição de célula vermelha sanguínea
EA201100125A1 (ru) Производные пирролопиридинилпиримидин-2-иламина
BRPI1015952B8 (pt) Método de introdução de uma nuclease sequência-específica (ssn) em uma célula vegetal
BR112013018352A2 (pt) composição de minociclina tópica e método
CU24048B1 (es) Composiciones para tratar náusea y vómito centralmente mediados
BRPI0613811B8 (pt) uso de células tronco estromais alogênicas derivadas de tecido adiposo
BR112014031424A2 (pt) tratamento de células pluripotentes
MX2010009765A (es) Moleculas pequeñas que contienen boro como agentes anti-inflamatorios.
BR112013027307A2 (pt) método para tratar uma matriz de tecido; matriz de tecido acelular
EA201791850A1 (ru) Борсодержащие малые молекулы
BR112015007878A2 (pt) composto compreendendo oligonucleotídeo modificado, composição, combinação e uso dos mesmos
ECSP13012978A (es) Inhibidores de glucosilceramida sintasa
IN2015DN02938A (pt)
GB0920703D0 (en) Compositions containing satiogens and methods of use
BRPI1011934A8 (pt) Composição
BR112013002811A2 (pt) meios básicos simplificados para cultura celular pluripotente de humano
BR112014030812A2 (pt) "compostos tricíclicos substituídos como inibidores de fgfr, seus usos, composição farmacêutica e método para inibir uma enzima fgfr"
EA201290389A8 (ru) Применение 1,3-дифенилпроп-2-ен-1-оновых производных для лечения заболеваний печени
BR112012028711A2 (pt) métodos para a fabricação de uma emulsão de óleo em água, para a preparação de um kit de vacina e para redestilação de uma composição compreendendo 99% de esqualeno ou mais, assim como emulsão de óleo em água e kit
BR112013004700A2 (pt) método para prevenir ou tratar doenças ou distúrbios cardiovasculares
BR112012033548A2 (pt) métodos e composições para melhorar a mobilização de células-tronco
CR11870A (es) Composiciones de perácido y 2-hidroxi ácido orgánico y métodos para tratar productos agrícolas
ATE528013T1 (de) Impfstoff-zusammensetzungen
AR084652A1 (es) Glicoles como agentes inactivadores de patogenos
AU2012388759A8 (en) Methods and compositions for hypotensive resuscitation

Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 15/10/2019, OBSERVADAS AS CONDICOES LEGAIS. (CO) 10 (DEZ) ANOS CONTADOS A PARTIR DE 15/10/2019, OBSERVADAS AS CONDICOES LEGAIS

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 09/04/2009 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF