BRPI0911476A2 - compostos ativadores de glicoquinase de piridazinona, composição farmaceutica, uso dos compostos, método para tratamento de uma enfermidade e/ou distúbio metabólico e processo para a preparação dos compostos - Google Patents

compostos ativadores de glicoquinase de piridazinona, composição farmaceutica, uso dos compostos, método para tratamento de uma enfermidade e/ou distúbio metabólico e processo para a preparação dos compostos

Info

Publication number
BRPI0911476A2
BRPI0911476A2 BRPI0911476-9A BRPI0911476A BRPI0911476A2 BR PI0911476 A2 BRPI0911476 A2 BR PI0911476A2 BR PI0911476 A BRPI0911476 A BR PI0911476A BR PI0911476 A2 BRPI0911476 A2 BR PI0911476A2
Authority
BR
Brazil
Prior art keywords
compounds
preparing
pharmaceutical composition
pyridazinone
treating
Prior art date
Application number
BRPI0911476-9A
Other languages
English (en)
Inventor
Joseph Berthel Steven
Haynes Nancy-Ellen
Sarabu Ramakanth
Qian Yimin
Robert Scott Nathan
Wright Tilley Jefferson
Apostle Mcdermott Lee
Francis Kester Robert
Original Assignee
F. Hoffmann-La Roche Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F. Hoffmann-La Roche Ag filed Critical F. Hoffmann-La Roche Ag
Publication of BRPI0911476A2 publication Critical patent/BRPI0911476A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

"compostos derivados de piridazinona, composição farmacêutica contendo os mesmos e processo para a preparação dos referidos compostos" a presente invenção se refere a compostos de fórmula (i): (i) ' em que x, y, q e r1 a r3 são tais como definidos no relatório, bem como os seus sais farmaceuticamente aceitáveis , em que os substituintes são tais como aqueles expostos no relatório . estes compostos, e as composições farmacêuticas que os contêm, são de utilidade para o tratamento de enfermidades e distúrbios metabólicos tais como, por exemplo, diabetes mellitus do tipo ii .
BRPI0911476-9A 2008-04-16 2009-04-06 compostos ativadores de glicoquinase de piridazinona, composição farmaceutica, uso dos compostos, método para tratamento de uma enfermidade e/ou distúbio metabólico e processo para a preparação dos compostos BRPI0911476A2 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US4531808P 2008-04-16 2008-04-16
US61/045,318 2008-04-16
US11465408P 2008-11-14 2008-11-14
US61/114,654 2008-11-14
PCT/EP2009/054058 WO2009127544A1 (en) 2008-04-16 2009-04-06 Pyridazinone glucokinase activators

Publications (1)

Publication Number Publication Date
BRPI0911476A2 true BRPI0911476A2 (pt) 2019-03-19

Family

ID=40666944

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0911476-9A BRPI0911476A2 (pt) 2008-04-16 2009-04-06 compostos ativadores de glicoquinase de piridazinona, composição farmaceutica, uso dos compostos, método para tratamento de uma enfermidade e/ou distúbio metabólico e processo para a preparação dos compostos

Country Status (14)

Country Link
US (1) US8258134B2 (pt)
EP (1) EP2268633A1 (pt)
JP (1) JP5301655B2 (pt)
KR (1) KR101270389B1 (pt)
CN (1) CN102007116B (pt)
AR (1) AR071323A1 (pt)
AU (1) AU2009237792B2 (pt)
BR (1) BRPI0911476A2 (pt)
CA (1) CA2720559A1 (pt)
IL (1) IL207349A (pt)
MX (1) MX2010009922A (pt)
PE (1) PE20091725A1 (pt)
TW (1) TW200944517A (pt)
WO (1) WO2009127544A1 (pt)

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Also Published As

Publication number Publication date
KR101270389B1 (ko) 2013-06-05
JP5301655B2 (ja) 2013-09-25
AU2009237792A1 (en) 2009-10-22
AU2009237792B2 (en) 2014-07-24
CN102007116B (zh) 2014-10-22
IL207349A (en) 2014-08-31
PE20091725A1 (es) 2009-11-13
CN102007116A (zh) 2011-04-06
MX2010009922A (es) 2010-09-28
AR071323A1 (es) 2010-06-09
IL207349A0 (en) 2010-12-30
WO2009127544A1 (en) 2009-10-22
TW200944517A (en) 2009-11-01
KR20100124328A (ko) 2010-11-26
JP2011516592A (ja) 2011-05-26
CA2720559A1 (en) 2009-10-22
US20090264434A1 (en) 2009-10-22
EP2268633A1 (en) 2011-01-05
US8258134B2 (en) 2012-09-04

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