BRPI0709633B8 - derivados de piridina e pirimidina como antagonistas de mglur2, composição farmacêutica e uso dos mesmos - Google Patents

derivados de piridina e pirimidina como antagonistas de mglur2, composição farmacêutica e uso dos mesmos

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Publication number
BRPI0709633B8
BRPI0709633B8 BRPI0709633A BRPI0709633A BRPI0709633B8 BR PI0709633 B8 BRPI0709633 B8 BR PI0709633B8 BR PI0709633 A BRPI0709633 A BR PI0709633A BR PI0709633 A BRPI0709633 A BR PI0709633A BR PI0709633 B8 BRPI0709633 B8 BR PI0709633B8
Authority
BR
Brazil
Prior art keywords
pyridine
pharmaceutical composition
pyrimidine derivatives
mglur2 antagonists
antagonists
Prior art date
Application number
BRPI0709633A
Other languages
English (en)
Inventor
Goetschi Erwin
Wichmann Juergen
Gatti Mcarthur Silvia
Johannes Woltering Thomas
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36862654&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0709633(B8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BRPI0709633A2 publication Critical patent/BRPI0709633A2/pt
Publication of BRPI0709633B1 publication Critical patent/BRPI0709633B1/pt
Publication of BRPI0709633B8 publication Critical patent/BRPI0709633B8/pt

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    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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Abstract

derivados de piridina e pirimidina como antagonistas de mgiur2 composição farmacêutica e uso dos mesmos. a presente invenção refere-se a compostos de fórmula (i), um processo para a fabricação destes, seu uso para a preparação de medicamentos para tratar distúrbios do cns e composições farmacêuticas contendo-os: em que a, b, x, y, r^ 1^, r^ 2^, r^ 3^ e r^ 4^ são como definido na descrição e reivindicações.
BRPI0709633A 2006-03-29 2007-03-19 derivados de piridina e pirimidina como antagonistas de mglur2, composição farmacêutica e uso dos mesmos BRPI0709633B8 (pt)

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EP06111939.2 2006-03-29
EP06111939 2006-03-29
PCT/EP2007/052560 WO2007110337A1 (en) 2006-03-29 2007-03-19 Pyridine and pyrimidine derivatives as mglur2 antagonists

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KR20120034772A (ko) 2012-04-12
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US7642264B2 (en) 2010-01-05
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