BRPI0911497A2 - derivados de nip tiazol como inibidores de 11-beta-hidroxiesteroide desidrogenase-1. - Google Patents

derivados de nip tiazol como inibidores de 11-beta-hidroxiesteroide desidrogenase-1.

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Publication number
BRPI0911497A2
BRPI0911497A2 BRPI0911497A BRPI0911497A BRPI0911497A2 BR PI0911497 A2 BRPI0911497 A2 BR PI0911497A2 BR PI0911497 A BRPI0911497 A BR PI0911497A BR PI0911497 A BRPI0911497 A BR PI0911497A BR PI0911497 A2 BRPI0911497 A2 BR PI0911497A2
Authority
BR
Brazil
Prior art keywords
beta
inhibitors
hydroxysteroid dehydrogenase
thiazole derivatives
nip
Prior art date
Application number
BRPI0911497A
Other languages
English (en)
Inventor
Leriche Caroline
Charon Christine
Carniato Denis
Roche Didier
Doare Liliane
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of BRPI0911497A2 publication Critical patent/BRPI0911497A2/pt
Publication of BRPI0911497B1 publication Critical patent/BRPI0911497B1/pt
Publication of BRPI0911497B8 publication Critical patent/BRPI0911497B8/pt

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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P13/00—Drugs for disorders of the urinary system
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    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
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    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • A—HUMAN NECESSITIES
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    • A61P5/00—Drugs for disorders of the endocrine system
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    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
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    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
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  • Biomedical Technology (AREA)
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  • Physical Education & Sports Medicine (AREA)
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  • Ophthalmology & Optometry (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Communicable Diseases (AREA)
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  • Orthopedic Medicine & Surgery (AREA)
  • Psychiatry (AREA)
  • Immunology (AREA)
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  • Child & Adolescent Psychology (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)

Abstract

derivados de nip tiazol como inibidores de 11-beta-hidroxiesteroide desidrogenase-1 a presente invenção refere-se a derivados de nip tiazol de fórmula (i) como inibidores seletivos da enzima 11-beta-hidroxiesteroide desidrogenase tipo 1 (11-r-hsd-1) e ao uso de tais compostos para o tratamento e preven-ção de síndrome metabólica, diabetes, resistência à insulina, obesidade, dis-túrbios de lipídeo, glaucoma, osteoporose, distúrbios cognitivos, ansiedade, depressão, distúrbios imunes, hipertensão e outras doenças e condições.
BRPI0911497A 2008-05-05 2009-04-08 derivados de nip tiazol, seu processo de fabricação, medicamento, composição farmacêutica, e kit BRPI0911497B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP08290424.4 2008-05-05
EP08290424 2008-05-05
PCT/EP2009/002607 WO2009135581A2 (en) 2008-05-05 2009-04-08 Novel nip thiazole derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase-1

Publications (3)

Publication Number Publication Date
BRPI0911497A2 true BRPI0911497A2 (pt) 2019-01-15
BRPI0911497B1 BRPI0911497B1 (pt) 2021-01-26
BRPI0911497B8 BRPI0911497B8 (pt) 2021-05-25

Family

ID=40935480

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0911497A BRPI0911497B8 (pt) 2008-05-05 2009-04-08 derivados de nip tiazol, seu processo de fabricação, medicamento, composição farmacêutica, e kit

Country Status (18)

Country Link
US (1) US8546575B2 (pt)
EP (1) EP2271405B1 (pt)
JP (1) JP5735412B2 (pt)
KR (1) KR101604366B1 (pt)
CN (1) CN102015026B (pt)
AR (1) AR072666A1 (pt)
AU (1) AU2009243812B2 (pt)
BR (1) BRPI0911497B8 (pt)
CA (1) CA2723431C (pt)
CO (1) CO6331305A2 (pt)
EA (2) EA018920B1 (pt)
EC (1) ECSP10010656A (pt)
ES (1) ES2432383T3 (pt)
IL (1) IL208989A (pt)
MX (1) MX2010011917A (pt)
NZ (1) NZ589691A (pt)
WO (1) WO2009135581A2 (pt)
ZA (1) ZA201008723B (pt)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2369315T3 (es) * 2007-06-01 2011-11-29 F. Hoffmann-La Roche Ag Derivados de piperidina-amida.
WO2011107494A1 (de) 2010-03-03 2011-09-09 Sanofi Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
US8530413B2 (en) 2010-06-21 2013-09-10 Sanofi Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TW201215387A (en) 2010-07-05 2012-04-16 Sanofi Aventis Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
TW201221505A (en) 2010-07-05 2012-06-01 Sanofi Sa Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
TW201215388A (en) 2010-07-05 2012-04-16 Sanofi Sa (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
WO2013037390A1 (en) 2011-09-12 2013-03-21 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2013045413A1 (en) 2011-09-27 2013-04-04 Sanofi 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2015005305A1 (ja) 2013-07-09 2015-01-15 小野薬品工業株式会社 Ａｌｘｒ作動化合物
CN104910083A (zh) * 2015-07-13 2015-09-16 佛山市赛维斯医药科技有限公司 烷氧苯基三氮唑亚砜类11β-HSD1抑制剂、制备方法及其用途
CN104910084A (zh) * 2015-07-13 2015-09-16 佛山市赛维斯医药科技有限公司 末端胺基取代的三氮唑亚砜类化合物、其制备方法及其用途
EP3235813A1 (en) 2016-04-19 2017-10-25 Cidqo 2012, S.L. Aza-tetra-cyclo derivatives
KR20200105652A (ko) * 2017-09-08 2020-09-08 피아이 인더스트리스 엘티디. 새로운 살균성 헤테로시클릭 화합물

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7754709B2 (en) * 2003-06-10 2010-07-13 Solvay Pharmaceuticals Bv Tetracyclic thiophenepyrimidinone compounds as inhibitors of 17β hydroxysteroid dehydrogenase compounds
US20070231263A1 (en) * 2004-04-13 2007-10-04 Jun Qiu Human G protein-coupled receptor and modulators thereof for the treatment of hyperglycemia and related disorders
EP1637529A1 (en) 2004-09-20 2006-03-22 4Sc Ag Novel piperidin-4-yl-thiazole-carboxamide analogues as inhibitors of T-cell proliferation and uses thereof
DE102006010923A1 (de) * 2006-03-09 2007-09-13 Saltigo Gmbh Verfahren zur Herstellung von Chlor-1,4-dimethoxybenzol
BRPI0709595A2 (pt) * 2006-03-15 2011-07-19 4Sc Ag inibidores de nf-kapab heterocìclicos
EP1994017A2 (en) 2006-03-15 2008-11-26 4Sc Ag Novel heterocyclic nf-kb inhibitors

Also Published As

Publication number Publication date
KR101604366B1 (ko) 2016-03-17
NZ589691A (en) 2012-11-30
EA018920B1 (ru) 2013-11-29
JP5735412B2 (ja) 2015-06-17
BRPI0911497B1 (pt) 2021-01-26
CN102015026A (zh) 2011-04-13
AU2009243812A1 (en) 2009-11-12
WO2009135581A3 (en) 2010-08-19
EA201300759A1 (ru) 2013-11-29
WO2009135581A9 (en) 2010-11-11
KR20110004468A (ko) 2011-01-13
IL208989A (en) 2014-01-30
CA2723431A1 (en) 2009-11-12
EP2271405B1 (en) 2013-07-24
AR072666A1 (es) 2010-09-15
EA201001737A1 (ru) 2011-06-30
EP2271405A2 (en) 2011-01-12
US8546575B2 (en) 2013-10-01
ECSP10010656A (es) 2011-01-31
IL208989A0 (en) 2011-01-31
MX2010011917A (es) 2010-11-26
CO6331305A2 (es) 2011-10-20
WO2009135581A2 (en) 2009-11-12
JP2011521907A (ja) 2011-07-28
ES2432383T3 (es) 2013-12-03
AU2009243812B2 (en) 2014-06-05
CN102015026B (zh) 2015-11-25
US20110060007A1 (en) 2011-03-10
ZA201008723B (en) 2012-01-25
CA2723431C (en) 2016-11-22
BRPI0911497B8 (pt) 2021-05-25

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