BRPI0911520A2 - novas aproximações terapêuticas para o tratamento da doença de alzheimer e doenças relacionadas através de uma modulação de angiogênese. - Google Patents
novas aproximações terapêuticas para o tratamento da doença de alzheimer e doenças relacionadas através de uma modulação de angiogênese.Info
- Publication number
- BRPI0911520A2 BRPI0911520A2 BRPI0911520A BRPI0911520A BRPI0911520A2 BR PI0911520 A2 BRPI0911520 A2 BR PI0911520A2 BR PI0911520 A BRPI0911520 A BR PI0911520A BR PI0911520 A BRPI0911520 A BR PI0911520A BR PI0911520 A2 BRPI0911520 A2 BR PI0911520A2
- Authority
- BR
- Brazil
- Prior art keywords
- alzheimer
- disease
- treatment
- related diseases
- new therapeutic
- Prior art date
Links
- 208000024827 Alzheimer disease Diseases 0.000 title 1
- 230000033115 angiogenesis Effects 0.000 title 1
- 238000013459 approach Methods 0.000 title 1
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
- A61K31/37—Coumarins, e.g. psoralen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/64—Sulfonylureas, e.g. glibenclamide, tolbutamide, chlorpropamide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Organic Chemistry (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4858308P | 2008-04-29 | 2008-04-29 | |
| PCT/EP2009/055205 WO2009133141A2 (en) | 2008-04-29 | 2009-04-29 | New therapeutic approaches for treating alzheimer disease and related disorders through a modulation of angiogenesis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0911520A2 true BRPI0911520A2 (pt) | 2017-06-13 |
Family
ID=41222690
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0911520A BRPI0911520A2 (pt) | 2008-04-29 | 2009-04-29 | novas aproximações terapêuticas para o tratamento da doença de alzheimer e doenças relacionadas através de uma modulação de angiogênese. |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US11291670B2 (pt) |
| EP (1) | EP2282778B1 (pt) |
| JP (1) | JP5721230B2 (pt) |
| KR (1) | KR101660401B1 (pt) |
| CN (1) | CN102065898B (pt) |
| AU (1) | AU2009242126B2 (pt) |
| BR (1) | BRPI0911520A2 (pt) |
| CA (1) | CA2722453C (pt) |
| CY (1) | CY1118956T1 (pt) |
| DK (1) | DK2282778T3 (pt) |
| EA (1) | EA021731B1 (pt) |
| ES (1) | ES2622504T3 (pt) |
| HR (1) | HRP20170531T1 (pt) |
| HU (1) | HUE033726T2 (pt) |
| IL (1) | IL208982B (pt) |
| LT (1) | LT2282778T (pt) |
| MX (1) | MX2010011881A (pt) |
| NZ (1) | NZ589307A (pt) |
| PL (1) | PL2282778T3 (pt) |
| PT (1) | PT2282778T (pt) |
| SI (1) | SI2282778T1 (pt) |
| WO (1) | WO2009133141A2 (pt) |
| ZA (1) | ZA201008037B (pt) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10164139A1 (de) | 2001-12-27 | 2003-07-10 | Bayer Ag | 2-Heteroarylcarbonsäureamide |
| CN102065858B (zh) * | 2008-04-29 | 2014-07-02 | 法奈科斯公司 | 使用唑尼沙胺和阿坎酸治疗阿尔茨海默病和相关病症的组合组合物 |
| EP2135607A1 (en) | 2008-06-18 | 2009-12-23 | Pharnext | Combination of pilocarpin and methimazol for treating Charcot-MarieTooth disease and related disorders |
| CA2894860C (en) | 2008-11-19 | 2018-11-06 | Gerhard Koenig | Treatment of cognitive disorders with (r)-7-chloro-n-(quinuclidin-3-yl)benzo[b]thiophene-2-carboxamide and pharmaceutically acceptable salts thereof |
| JP5808319B2 (ja) * | 2009-05-11 | 2015-11-10 | フォルム ファーマシューティカルズ、インコーポレイテッド | アセチルコリンエステラーゼ阻害剤と組み合わせた特定のα７ニコチン酸受容体を用いた認知障害の治療 |
| EP2322163A1 (en) * | 2009-11-03 | 2011-05-18 | Pharnext | New therapeutics approaches for treating alzheimer disease |
| US9387206B2 (en) | 2009-11-03 | 2016-07-12 | Pharnext | Therapeutic approaches for treating Alzheimer's disease |
| US9283211B1 (en) | 2009-11-11 | 2016-03-15 | Rapamycin Holdings, Llc | Oral rapamycin preparation and use for stomatitis |
| MX357676B (es) | 2010-05-17 | 2018-07-18 | Forum Pharmaceuticals Inc | Una forma cristalina de clorhidrato de (r)-7-cloro-n-(quinuclidin- 3-il)benzo[b]tiofeno-2-carboxamida monohidratado. |
| US8957098B2 (en) | 2010-08-24 | 2015-02-17 | Algiax Pharmaceuticals Gmbh | Use of leflunomide and malononitrilamides |
| DE102010062810B4 (de) * | 2010-09-07 | 2014-03-13 | Immungenetics Ag | 2-(R2-Thio)-10-[3-(4-R1-piperazin-1-yl)propyl]-10H-phenothiazine zur Behandlung neurodegenerativer Erkrankungen ausgewählt aus beta-Amyloidopathien und alpha-Synucleinopathien |
| ES2763087T3 (es) * | 2011-02-11 | 2020-05-27 | Univ Rockefeller | Método para la identificación de ácidos nucleicos que regulan la metastatización |
| SI2560631T1 (sl) | 2011-03-01 | 2014-06-30 | Pharnext | Na baklofenu in akamprosatu temeljeäśa terapija nevroloĺ kih nepravilnosti |
| US9867837B2 (en) | 2011-03-01 | 2018-01-16 | Pharnext | Compositions for treating neurological disorders |
| US9248111B2 (en) | 2011-03-01 | 2016-02-02 | Pharnext | Therapeutic approaches for treating parkinson's disease |
| JP6430445B2 (ja) * | 2011-03-01 | 2018-11-28 | ファーネクストＰｈａｒｎｅｘｔ | バクロフェンおよびアカンプロセートに基づく神経疾患の治療 |
| US9241933B2 (en) | 2011-03-01 | 2016-01-26 | Pharnext | Compositions for treating amyotrophic lateral sclerosis |
| US10010515B2 (en) | 2011-03-01 | 2018-07-03 | Pharnext | Therapeutic approaches for treating Parkinson's disease |
| EP2705842A1 (en) | 2012-09-05 | 2014-03-12 | Pharnext | Therapeutic approaches for treating parkinson's disease |
| UA115968C2 (uk) * | 2011-03-01 | 2018-01-25 | Фарнекст | Нові композиції для лікування неврологічних захворювань |
| US9931326B2 (en) | 2011-03-29 | 2018-04-03 | Pharnext | Composition comprising torasemide and baclofen for treating neurological disorders |
| AU2013224959B2 (en) * | 2012-03-01 | 2017-12-07 | Pharnext | New compositions for treating amyotrophic lateral sclerosis |
| EA031331B9 (ru) * | 2012-03-01 | 2019-02-28 | Фарнекст | Комбинация акампросата, баклофена и рилузола для лечения амиотрофического бокового склероза и родственного заболевания |
| EP3666272A1 (en) | 2012-05-08 | 2020-06-17 | Forum Pharmaceuticals Inc. | Use of encenicline in the treatment of cognitive impairment, alzheimer's disease, memory deficit |
| US8962020B2 (en) * | 2012-07-26 | 2015-02-24 | Glycadia Inc. | Long-acting and controlled release formulations of 2-[(3-chlorophenyl) amino] phenylacetic acid |
| EP2705841A1 (en) * | 2012-09-05 | 2014-03-12 | Pharnext | Combinations of nootropic agents for treating cognitive dysfunctions |
| US8652527B1 (en) | 2013-03-13 | 2014-02-18 | Upsher-Smith Laboratories, Inc | Extended-release topiramate capsules |
| US9101545B2 (en) | 2013-03-15 | 2015-08-11 | Upsher-Smith Laboratories, Inc. | Extended-release topiramate capsules |
| KR101579008B1 (ko) * | 2013-09-25 | 2015-12-22 | 경북대학교 산학협력단 | ERR-γ 저해제를 포함하는, 망막병증의 예방 또는 치료용 약학적 조성물 및 이의 용도 |
| US9700544B2 (en) | 2013-12-31 | 2017-07-11 | Neal K Vail | Oral rapamycin nanoparticle preparations |
| WO2015121218A1 (en) | 2014-02-11 | 2015-08-20 | Pharnext | Combination of baclofen, acamprosate and medium chain triglycerides for the treatment of neurological disorders |
| CN110643705A (zh) * | 2014-03-19 | 2020-01-03 | 上海吉凯基因化学技术有限公司 | 人dgkz基因的用途及其相关药物 |
| US20180028520A1 (en) * | 2014-09-30 | 2018-02-01 | The Trustees Of Columbia University In The City Of New York | Methods and pharmaceutical compositions for treatment of amyotrophic lateral sclerosis |
| WO2016201086A1 (en) * | 2015-06-12 | 2016-12-15 | Rush University Medical Center | Compositions and methods for stimulating adam10-mediated nonamyloidogenic proteolysis of amyloid precursor protein |
| JP7027318B2 (ja) * | 2016-02-05 | 2022-03-01 | ファーネクスト | 神経障害の新規の併用療法 |
| EP3544604A4 (en) | 2016-11-23 | 2020-07-22 | Ramot at Tel-Aviv University Ltd. | PROCESSES AND COMPOSITIONS FOR THE TREATMENT OF DISORDERS ASSOCIATED WITH CORTICO-HIPPOCAMPIC HYPERACTIVITY |
| CN111050761A (zh) | 2017-04-24 | 2020-04-21 | 法奈克斯公司 | 阿尔茨海默病的基于idalopirdine的组合治疗 |
| US11439608B2 (en) | 2017-09-25 | 2022-09-13 | Qun Lu | Roles of modulators of intersectin-CDC42 signaling in Alzheimer's disease |
| US11382897B2 (en) | 2017-11-07 | 2022-07-12 | The Regents Of The University Of Michigan | Therapeutic combination for treatment of cerebellar ataxia |
| US11213524B2 (en) * | 2018-08-21 | 2022-01-04 | Tenax Therapeutics, Inc. | Pharmaceutical compositions for subcutaneous administration of levosimendan |
| CN111084768A (zh) * | 2018-10-24 | 2020-05-01 | 中国科学院昆明动物研究所 | 吉非罗齐及其衍生物用于治疗和/或预防神经退行性疾病的用途 |
| JPWO2020111171A1 (ja) * | 2018-11-29 | 2021-11-25 | 雪印メグミルク株式会社 | 血管新生促進用組成物 |
| CN110806488B (zh) * | 2019-12-06 | 2020-09-25 | 南京医科大学 | Drd5及其激动剂在制备治疗炎症性疾病的药物中的应用 |
| CN116635019A (zh) * | 2020-03-31 | 2023-08-22 | 威尔弗雷德·杰弗里斯 | 阿尔茨海默病的治疗方法 |
| WO2023059867A1 (en) * | 2021-10-08 | 2023-04-13 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Compounds for treating or preventing alzheimer's disease |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH072688A (ja) * | 1991-06-11 | 1995-01-06 | Rikomu:Kk | 腸内有毒腐敗産物抑制剤 |
| US6177401B1 (en) * | 1992-11-13 | 2001-01-23 | Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften | Use of organic compounds for the inhibition of Flk-1 mediated vasculogenesis and angiogenesis |
| ES2124800T3 (es) * | 1993-01-08 | 1999-02-16 | Hoechst Ag | Empleo de leflunomida para la inhibicion de interleuquina 1 beta. |
| AUPS017702A0 (en) * | 2002-01-25 | 2002-02-14 | Atopic Pty Ltd | Methods and compositions for the treatment of asthma and related disorders |
-
2009
- 2009-04-29 DK DK09738185.9T patent/DK2282778T3/en active
- 2009-04-29 JP JP2011506707A patent/JP5721230B2/ja not_active Expired - Fee Related
- 2009-04-29 WO PCT/EP2009/055205 patent/WO2009133141A2/en not_active Ceased
- 2009-04-29 BR BRPI0911520A patent/BRPI0911520A2/pt not_active Application Discontinuation
- 2009-04-29 SI SI200931641A patent/SI2282778T1/sl unknown
- 2009-04-29 KR KR1020107026061A patent/KR101660401B1/ko not_active Expired - Fee Related
- 2009-04-29 PT PT97381859T patent/PT2282778T/pt unknown
- 2009-04-29 EP EP09738185.9A patent/EP2282778B1/en active Active
- 2009-04-29 AU AU2009242126A patent/AU2009242126B2/en not_active Ceased
- 2009-04-29 HR HRP20170531TT patent/HRP20170531T1/hr unknown
- 2009-04-29 CN CN200980122773.4A patent/CN102065898B/zh not_active Expired - Fee Related
- 2009-04-29 MX MX2010011881A patent/MX2010011881A/es active IP Right Grant
- 2009-04-29 CA CA2722453A patent/CA2722453C/en active Active
- 2009-04-29 HU HUE09738185A patent/HUE033726T2/en unknown
- 2009-04-29 NZ NZ589307A patent/NZ589307A/en not_active IP Right Cessation
- 2009-04-29 PL PL09738185T patent/PL2282778T3/pl unknown
- 2009-04-29 EA EA201071244A patent/EA021731B1/ru not_active IP Right Cessation
- 2009-04-29 ES ES09738185.9T patent/ES2622504T3/es active Active
- 2009-04-29 LT LTEP09738185.9T patent/LT2282778T/lt unknown
-
2010
- 2010-10-28 IL IL208982A patent/IL208982B/en active IP Right Grant
- 2010-10-29 US US12/915,709 patent/US11291670B2/en not_active Expired - Fee Related
- 2010-11-10 ZA ZA2010/08037A patent/ZA201008037B/en unknown
-
2017
- 2017-04-13 CY CY20171100439T patent/CY1118956T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2009242126B2 (en) | 2014-03-27 |
| NZ589307A (en) | 2012-04-27 |
| PL2282778T3 (pl) | 2017-08-31 |
| DK2282778T3 (en) | 2017-05-01 |
| KR20110010734A (ko) | 2011-02-07 |
| SI2282778T1 (sl) | 2017-07-31 |
| US11291670B2 (en) | 2022-04-05 |
| JP2011518864A (ja) | 2011-06-30 |
| CN102065898A (zh) | 2011-05-18 |
| US20120058992A1 (en) | 2012-03-08 |
| EP2282778B1 (en) | 2017-03-08 |
| PT2282778T (pt) | 2017-04-27 |
| HUE033726T2 (en) | 2017-12-28 |
| AU2009242126A1 (en) | 2009-11-05 |
| KR101660401B1 (ko) | 2016-09-27 |
| CA2722453A1 (en) | 2009-11-05 |
| CA2722453C (en) | 2018-03-20 |
| LT2282778T (lt) | 2017-06-26 |
| EP2282778A2 (en) | 2011-02-16 |
| EA021731B1 (ru) | 2015-08-31 |
| WO2009133141A2 (en) | 2009-11-05 |
| CN102065898B (zh) | 2015-08-26 |
| IL208982A0 (en) | 2011-01-31 |
| MX2010011881A (es) | 2011-07-01 |
| ES2622504T3 (es) | 2017-07-06 |
| EA201071244A1 (ru) | 2011-06-30 |
| IL208982B (en) | 2018-03-29 |
| CY1118956T1 (el) | 2018-01-10 |
| WO2009133141A3 (en) | 2009-12-30 |
| ZA201008037B (en) | 2011-08-31 |
| JP5721230B2 (ja) | 2015-05-20 |
| HRP20170531T1 (hr) | 2017-06-16 |
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