BRPI0911531A2 - processo para preparar iopromida, e, composto. - Google Patents
processo para preparar iopromida, e, composto.Info
- Publication number
- BRPI0911531A2 BRPI0911531A2 BRPI0911531A BRPI0911531A BRPI0911531A2 BR PI0911531 A2 BRPI0911531 A2 BR PI0911531A2 BR PI0911531 A BRPI0911531 A BR PI0911531A BR PI0911531 A BRPI0911531 A BR PI0911531A BR PI0911531 A2 BRPI0911531 A2 BR PI0911531A2
- Authority
- BR
- Brazil
- Prior art keywords
- compound
- preparing iopromide
- iopromide
- preparing
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title 1
- DGAIEPBNLOQYER-UHFFFAOYSA-N iopromide Chemical compound COCC(=O)NC1=C(I)C(C(=O)NCC(O)CO)=C(I)C(C(=O)N(C)CC(O)CO)=C1I DGAIEPBNLOQYER-UHFFFAOYSA-N 0.000 title 1
- 229960002603 iopromide Drugs 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
- C07C233/24—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
- C07C233/25—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
- C07C233/65—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/68—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom and to a carbon atom of a six-membered aromatic ring wherein at least one ortho-hydrogen atom has been replaced
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Catalysts (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020080040521A KR101098553B1 (ko) | 2008-04-30 | 2008-04-30 | 이오프로마이드의 신규한 제조방법 |
| PCT/KR2009/001996 WO2009134030A1 (en) | 2008-04-30 | 2009-04-17 | Novel process for preparation of iopromide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0911531A2 true BRPI0911531A2 (pt) | 2015-10-13 |
Family
ID=41255206
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0911531A BRPI0911531A2 (pt) | 2008-04-30 | 2009-04-17 | processo para preparar iopromida, e, composto. |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US8420858B2 (pt) |
| EP (1) | EP2271615A4 (pt) |
| JP (1) | JP5156862B2 (pt) |
| KR (1) | KR101098553B1 (pt) |
| CN (1) | CN102015624B (pt) |
| AU (1) | AU2009243319B2 (pt) |
| BR (1) | BRPI0911531A2 (pt) |
| CA (1) | CA2720752C (pt) |
| RU (1) | RU2451667C1 (pt) |
| WO (1) | WO2009134030A1 (pt) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8921109B2 (en) | 2005-09-19 | 2014-12-30 | Histogenics Corporation | Cell-support matrix having narrowly defined uniformly vertically and non-randomly organized porosity and pore density and a method for preparation thereof |
| KR100976097B1 (ko) * | 2008-12-05 | 2010-08-16 | 주식회사 대웅제약 | 이오프로마이드의 ｚ 이성체를 선택적으로 결정화하는 방법 |
| CN102351735B (zh) * | 2011-07-21 | 2012-10-10 | 浙江司太立制药股份有限公司 | 一种碘普罗胺的制备方法 |
| CN103570580B (zh) * | 2012-08-08 | 2015-04-01 | 北京京卫信康医药科技发展有限公司 | 一种高纯度碘普罗胺的制备方法 |
| CN102964269B (zh) * | 2012-11-29 | 2015-01-28 | 浙江海昌药业有限公司 | 碘普罗胺的新制备方法 |
| KR101520187B1 (ko) * | 2013-10-25 | 2015-05-13 | 주식회사 대웅제약 | 이오프로마이드의 중간체의 제조방법 |
| CN105017062B (zh) * | 2014-04-18 | 2018-11-20 | 沈阳中海生物技术开发有限公司 | 制备碘普罗胺的新方法 |
| CN105001113B (zh) * | 2014-04-18 | 2018-11-20 | 沈阳中海生物技术开发有限公司 | 一种碘普罗胺的制备方法 |
| CN105017063B (zh) * | 2014-04-18 | 2018-11-20 | 沈阳中海生物技术开发有限公司 | 5-氨基-2,4,6-三碘间苯二甲酸衍生物及其盐、水合物或溶剂化物 |
| CN103965074B (zh) * | 2014-04-30 | 2016-10-05 | 淮海工学院 | 一种合成碘普罗胺的新方法 |
| US10077420B2 (en) | 2014-12-02 | 2018-09-18 | Histogenics Corporation | Cell and tissue culture container |
| CN106316878B (zh) * | 2015-06-15 | 2018-01-19 | 重庆常捷医药有限公司 | 一种碘美普尔杂质的制备方法 |
| CN106366016B (zh) * | 2015-07-22 | 2019-03-05 | 连云港润众制药有限公司 | 一种碘普罗胺的制备方法及其中间体 |
| CN106366015B (zh) * | 2015-07-22 | 2019-01-25 | 正大天晴药业集团股份有限公司 | 一种碘普罗胺的制备方法及其中间体 |
| CN110023279B (zh) * | 2016-12-05 | 2022-03-11 | 伯拉考成像股份公司 | 放射照相剂中间体的机械化学合成 |
| WO2018228546A1 (zh) * | 2017-06-16 | 2018-12-20 | 成都西岭源药业有限公司 | 一种高效率的造影剂合成方法及其应用 |
| CN114195673B (zh) * | 2020-09-18 | 2025-08-01 | 正大天晴药业集团股份有限公司 | 一种碘普罗胺中间体的制备方法及其用途 |
| CN114436880B (zh) * | 2020-11-03 | 2023-04-28 | 成都倍特药业股份有限公司 | 碘普罗胺中间体的制备方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3457302A (en) * | 1966-05-27 | 1969-07-22 | Allied Chem | Process for the preparation of tertiary amino acids |
| DE2909439A1 (de) * | 1979-03-08 | 1980-09-18 | Schering Ag | Neue nichtionische roentgenkontrastmittel |
| US5075502A (en) * | 1989-12-13 | 1991-12-24 | Mallinckrodt, Inc. | Nonionic x-ray contrast agents, compositions and methods |
| IT1286522B1 (it) * | 1996-12-04 | 1998-07-15 | Dibra Spa | Processo per la preparazione di derivati dell'acido 5-ammino-2,4,6- triiodo-1,3-benzenedicarbossilico |
| US5824821A (en) * | 1997-02-07 | 1998-10-20 | Nycomed Imaging As | Process for the preparation of iodinated contrast agents and intermediates therefor |
| IT1292037B1 (it) * | 1997-05-30 | 1999-01-25 | Bracco Spa | Processo per la preparazione di 5-(acetil 62,3-diidrossipropil)- ammino)-n,n'-bis(2,3-diidrossipropil)-2,4,6-triiodo-1,3-benzen- |
| IT1299202B1 (it) * | 1998-05-08 | 2000-02-29 | Dibra Spa | Processo per la preparazione della s-n,n'-bis (2-idrossi-1- (idrossimetil)etil) -5-((2-idrossi-1-ossopropil)ammino)-2,4,6-triiodo |
| KR100286639B1 (ko) * | 1999-03-31 | 2001-04-16 | 강재헌 | 이오프로마이드의 제조방법 |
-
2008
- 2008-04-30 KR KR1020080040521A patent/KR101098553B1/ko not_active Expired - Fee Related
-
2009
- 2009-04-17 BR BRPI0911531A patent/BRPI0911531A2/pt not_active IP Right Cessation
- 2009-04-17 RU RU2010148589/04A patent/RU2451667C1/ru not_active IP Right Cessation
- 2009-04-17 WO PCT/KR2009/001996 patent/WO2009134030A1/en not_active Ceased
- 2009-04-17 CN CN200980115336XA patent/CN102015624B/zh not_active Expired - Fee Related
- 2009-04-17 CA CA2720752A patent/CA2720752C/en not_active Expired - Fee Related
- 2009-04-17 US US12/988,674 patent/US8420858B2/en not_active Expired - Fee Related
- 2009-04-17 EP EP09738936.5A patent/EP2271615A4/en not_active Withdrawn
- 2009-04-17 AU AU2009243319A patent/AU2009243319B2/en not_active Ceased
- 2009-04-17 JP JP2011507339A patent/JP5156862B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US8420858B2 (en) | 2013-04-16 |
| CA2720752A1 (en) | 2009-11-05 |
| CA2720752C (en) | 2014-02-04 |
| KR20090114729A (ko) | 2009-11-04 |
| AU2009243319B2 (en) | 2011-09-08 |
| RU2451667C1 (ru) | 2012-05-27 |
| AU2009243319A1 (en) | 2009-11-05 |
| CN102015624A (zh) | 2011-04-13 |
| WO2009134030A1 (en) | 2009-11-05 |
| EP2271615A1 (en) | 2011-01-12 |
| US20110034730A1 (en) | 2011-02-10 |
| JP5156862B2 (ja) | 2013-03-06 |
| JP2011518878A (ja) | 2011-06-30 |
| CN102015624B (zh) | 2013-11-06 |
| EP2271615A4 (en) | 2014-05-21 |
| KR101098553B1 (ko) | 2011-12-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] | ||
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |