BRPI0911571A2 - método para tratar um mamífero, análogo de insulina, ácido nucléico e célula hospedeira - Google Patents

método para tratar um mamífero, análogo de insulina, ácido nucléico e célula hospedeira

Info

Publication number: BRPI0911571A2
Authority: BR; Brazil
Prior art keywords: mammal; treating; nucleic acid; host cell; insulin analog
Prior art date: 2008-04-22

Application number

BRPI0911571A

Other languages

English (en)

Inventor

Whittaker Jonathan

Weiss Michael

Original Assignee

Univ Case Western Reserve

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2008-04-22

Filing date

2009-04-22

Publication date

2018-04-03

2009-04-22 Application filed by Univ Case Western Reserve filed Critical Univ Case Western Reserve

2018-04-03 Publication of BRPI0911571A2 publication Critical patent/BRPI0911571A2/pt

Links

241000124008 Mammalia Species 0.000 title 1
NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical class N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title 1
239000004026 insulin derivative Substances 0.000 title 1
150000007523 nucleic acids Chemical class 0.000 title 1
102000039446 nucleic acids Human genes 0.000 title 1
108020004707 nucleic acids Proteins 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Diabetes (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Endocrinology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Epidemiology (AREA)
Immunology (AREA)
Gastroenterology & Hepatology (AREA)
Zoology (AREA)
Obesity (AREA)
Hematology (AREA)
Emergency Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

BRPI0911571A 2008-04-22 2009-04-22 método para tratar um mamífero, análogo de insulina, ácido nucléico e célula hospedeira BRPI0911571A2 (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US4698508P	2008-04-22	2008-04-22
PCT/US2009/041439 WO2009132129A2 (en)	2008-04-22	2009-04-22	Isoform-specific insulin analogues

Publications (1)

Publication Number	Publication Date
BRPI0911571A2 true BRPI0911571A2 (pt)	2018-04-03

Family

ID=41217411

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI0911571A BRPI0911571A2 (pt)	2008-04-22	2009-04-22	método para tratar um mamífero, análogo de insulina, ácido nucléico e célula hospedeira

Country Status (12)

Country	Link
US (1)	US20110195896A1 (pt)
EP (1)	EP2296692A4 (pt)
JP (1)	JP2011521621A (pt)
KR (1)	KR20110021758A (pt)
CN (1)	CN102065885A (pt)
AU (1)	AU2009240636A1 (pt)
BR (1)	BRPI0911571A2 (pt)
CA (1)	CA2722168A1 (pt)
MX (1)	MX2010011329A (pt)
NZ (1)	NZ588857A (pt)
RU (1)	RU2010147076A (pt)
WO (1)	WO2009132129A2 (pt)

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CA2942524A1 (en) *	2013-03-15	2014-09-18	Case Western Reserve University	Site 2 insulin analogues
US9884125B2 (en)	2013-10-04	2018-02-06	Merck Sharp & Dohme Corp.	Glucose-responsive insulin conjugates
SI3057984T1 (sl)	2013-10-17	2018-10-30	Zealand Pharma A/S	Acilirani glukagonski analogi
US9988429B2 (en)	2013-10-17	2018-06-05	Zealand Pharma A/S	Glucagon analogues
EA035688B1 (ru)	2013-11-06	2020-07-27	Зилэнд Фарма А/С	Соединения, которые представляют собой тройные агонисты глюкагона, glp-1 и gip
US10093713B2 (en)	2013-11-06	2018-10-09	Zealand Pharma A/S	GIP-GLP-1 dual agonist compounds and methods
WO2015106269A2 (en)	2014-01-13	2015-07-16	Thermalin Diabetes, Llc	Rapid action insulin formulations and pharmaceutical delivery systems
CN107108716A (zh) *	2014-10-06	2017-08-29	卡斯西部储备大学	双相性单链胰岛素类似物
TWI705973B (zh)	2014-10-29	2020-10-01	丹麥商西蘭製藥公司	Ｇｉｐ促效劑化合物及方法
SG10201809457YA (en)	2014-11-21	2018-11-29	Merck Sharp & Dohme	Insulin receptor partial agonists
TWI707867B (zh)	2015-04-16	2020-10-21	丹麥商西蘭製藥公司	醯化之昇糖素類似物
AR105616A1 (es)	2015-05-07	2017-10-25	Lilly Co Eli	Proteínas de fusión
UY36870A (es) *	2015-08-28	2017-03-31	Hanmi Pharm Ind Co Ltd	Análogos de insulina novedosos
EP3344651B1 (en)	2015-09-02	2022-03-02	Merck Sharp & Dohme Corp.	A process for obtaining insulin with correctly formed disulfide bonds
JP6951825B2 (ja)	2015-09-04	2021-10-20	ザスクリプスリサーチインスティテュート	インスリン免疫グロブリン融合タンパク質
SG11201803911PA (en) *	2015-12-23	2018-07-30	Univ Case Western Reserve	Encapsulation of ultra-stable insulin analogues with polymer melts
EP3448417B1 (en)	2016-04-26	2025-11-12	Merck Sharp & Dohme LLC	Insulin dimer-incretin conjugates
EP3922260A3 (en)	2016-05-24	2022-06-15	Merck Sharp & Dohme Corp.	Insulin receptor partial agonists and glp-1 analogues
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US8399407B2 (en) *	2009-09-17	2013-03-19	Case Western Reserve University	Non-standard insulin analogues
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2009
- 2009-04-22 CN CN2009801244782A patent/CN102065885A/zh active Pending
- 2009-04-22 MX MX2010011329A patent/MX2010011329A/es not_active Application Discontinuation
- 2009-04-22 US US12/989,399 patent/US20110195896A1/en not_active Abandoned
- 2009-04-22 NZ NZ588857A patent/NZ588857A/en not_active IP Right Cessation
- 2009-04-22 WO PCT/US2009/041439 patent/WO2009132129A2/en not_active Ceased
- 2009-04-22 AU AU2009240636A patent/AU2009240636A1/en not_active Abandoned
- 2009-04-22 BR BRPI0911571A patent/BRPI0911571A2/pt not_active IP Right Cessation
- 2009-04-22 KR KR1020107025017A patent/KR20110021758A/ko not_active Withdrawn
- 2009-04-22 JP JP2011506432A patent/JP2011521621A/ja active Pending
- 2009-04-22 EP EP09734135A patent/EP2296692A4/en not_active Withdrawn
- 2009-04-22 RU RU2010147076/10A patent/RU2010147076A/ru not_active Application Discontinuation
- 2009-04-22 CA CA2722168A patent/CA2722168A1/en not_active Abandoned

Also Published As

Publication number	Publication date
EP2296692A2 (en)	2011-03-23
WO2009132129A3 (en)	2010-01-21
MX2010011329A (es)	2011-03-15
CA2722168A1 (en)	2009-10-29
KR20110021758A (ko)	2011-03-04
JP2011521621A (ja)	2011-07-28
AU2009240636A1 (en)	2009-10-29
NZ588857A (en)	2012-07-27
CN102065885A (zh)	2011-05-18
RU2010147076A (ru)	2012-05-27
EP2296692A4 (en)	2012-06-06
WO2009132129A2 (en)	2009-10-29
US20110195896A1 (en)	2011-08-11

Legal Events

Date	Code	Title	Description
2018-04-10	B08F	Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]	Free format text: REFERENTE AS 5A, 6A, 7A, 8A E 9A ANUIDADES.
2018-07-31	B08K	Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

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