BRPI0911678A2 - forma cristalina anidrosa de maleato de orvepitant - Google Patents

forma cristalina anidrosa de maleato de orvepitant

Info

Publication number: BRPI0911678A2
Authority: BR; Brazil
Prior art keywords: crystalline form; anhydrous crystalline; orvepitant maleate; orvepitant; maleate
Prior art date: 2008-04-11

Application number

BRPI0911678A

Other languages

English (en)

Inventor

Franco Sartor

Ian Philip Steeples

Stefania Beato

Original Assignee

Glaxo Group Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2008-04-11

Filing date

2009-04-09

Publication date

2015-10-13

2009-04-09 Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd

2015-10-13 Publication of BRPI0911678A2 publication Critical patent/BRPI0911678A2/pt

2021-03-02 Publication of BRPI0911678B1 publication Critical patent/BRPI0911678B1/pt

2021-05-25 Publication of BRPI0911678B8 publication Critical patent/BRPI0911678B8/pt

Links

IPACOHTZCSBGBV-WUXDIRCFSA-N (2r,4s)-4-[(8as)-6-oxo-1,3,4,7,8,8a-hexahydropyrrolo[1,2-a]pyrazin-2-yl]-n-[(1r)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl]-2-(4-fluoro-2-methylphenyl)-n-methylpiperidine-1-carboxamide;(z)-but-2-enedioic acid Chemical compound OC(=O)\C=C/C(O)=O.C1([C@H]2C[C@H](CCN2C(=O)N(C)[C@H](C)C=2C=C(C=C(C=2)C(F)(F)F)C(F)(F)F)N2C[C@H]3N(C(CC3)=O)CC2)=CC=C(F)C=C1C IPACOHTZCSBGBV-WUXDIRCFSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Anesthesiology (AREA)
Hospice & Palliative Care (AREA)
Otolaryngology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Cephalosporin Compounds (AREA)
Analysing Materials By The Use Of Radiation (AREA)
Medicinal Preparation (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Liquid Crystal Substances (AREA)

BRPI0911678A 2008-04-11 2009-04-09 maleato de orvepitant cristalino anidro, composição farmacêutica compreedendo o dito maleato e uso do mesmo para o tratamento ou profilaxia de doenças do sistema nervoso central BRPI0911678B8 (pt)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GB0806652.4		2008-04-11
GBGB0806652.4A GB0806652D0 (en)	2008-04-11	2008-04-11	Anhydrous crystal form of orvepitant maleate
PCT/EP2009/054295 WO2009124996A1 (en)	2008-04-11	2009-04-09	Anhydrous crystal form of orvepitant maleate

Publications (3)

Publication Number	Publication Date
BRPI0911678A2 true BRPI0911678A2 (pt)	2015-10-13
BRPI0911678B1 BRPI0911678B1 (pt)	2021-03-02
BRPI0911678B8 BRPI0911678B8 (pt)	2021-05-25

Family

ID=39433527

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI0911678A BRPI0911678B8 (pt)	2008-04-11	2009-04-09	maleato de orvepitant cristalino anidro, composição farmacêutica compreedendo o dito maleato e uso do mesmo para o tratamento ou profilaxia de doenças do sistema nervoso central

Country Status (27)

Country	Link
US (1)	US8309553B2 (pt)
EP (1)	EP2297152B1 (pt)
JP (2)	JP5875863B2 (pt)
KR (1)	KR20110002090A (pt)
CN (1)	CN102066376B (pt)
AR (1)	AR071311A1 (pt)
AU (1)	AU2009235440B2 (pt)
BR (1)	BRPI0911678B8 (pt)
CA (1)	CA2721119C (pt)
CL (1)	CL2009000876A1 (pt)
CY (1)	CY1115961T1 (pt)
DK (1)	DK2297152T3 (pt)
EA (1)	EA017082B1 (pt)
ES (1)	ES2529295T3 (pt)
GB (1)	GB0806652D0 (pt)
HR (1)	HRP20141196T1 (pt)
IL (1)	IL208597A0 (pt)
MX (1)	MX2010011152A (pt)
PE (1)	PE20091839A1 (pt)
PL (1)	PL2297152T3 (pt)
PT (1)	PT2297152E (pt)
RS (1)	RS53732B1 (pt)
SI (1)	SI2297152T1 (pt)
TW (1)	TW201002714A (pt)
UY (1)	UY31758A (pt)
WO (1)	WO2009124996A1 (pt)
ZA (1)	ZA201007120B (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2009056151A1 (en) *	2007-10-30	2009-05-07	Elekta Ab (Publ)	Radiotherapy apparatus
GB0806652D0 (en) *	2008-04-11	2008-05-14	Glaxo Group Ltd	Anhydrous crystal form of orvepitant maleate
HUE046508T2 (hu)	2012-10-11	2020-03-30	Nerre Therapeutics Ltd	Orvepitant krónikus viszketés kezelésére
SI3377064T1 (sl) *	2016-01-08	2019-11-29	Nerre Therapeutics Ltd	Orvepitant za zdravljenje kroničnega kašlja
IL312486B2 (en)	2017-04-10	2025-05-01	Chase Therapeutics Corp	NK1 antagonist combination and method for treating synucleinopathies
JP7158425B2 (ja)	2017-06-30	2022-10-21	チェイスセラピューティクスコーポレイション	Ｎｋ－１アンタゴニスト組成物およびうつ病の処置における使用法
KR102758037B1 (ko)	2017-08-18	2025-01-22	코테라 바이오사이언스 인코포레이티드	Tg02의 다형성 형태
KR20220165251A (ko) *	2020-04-03	2022-12-14	네르 쎄라퓨틱스 리미티드	패혈증, 패혈성 쇼크, 급성 호흡 곤란 증후군 (ards) 또는 다발성 기관 기능장애 증후군 (mods)으로부터 선택된 질환을 치료하기 위한 nk-1 수용체 길항제
MX2022014901A (es)	2020-06-02	2023-01-18	Nerre Therapeutics Ltd	Antagonistas del receptor de neuroquinina (nk)-1 para su uso en el tratamiento de condiciones de fibrosis pulmonar promovidas por lesion mecanica a los pulmones.

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB0203020D0 (en) *	2002-02-08	2002-03-27	Glaxo Group Ltd	Chemical compounds
KR20090024140A (ko)	2006-05-22	2009-03-06	반다 파마슈티칼즈, 인코퍼레이티드.	우울증 질환에 대한 치료
GB0621229D0 (en) *	2006-10-20	2006-12-06	Glaxo Group Ltd	Novel use
US20110163540A1 (en) *	2007-11-02	2011-07-07	Entegris, Inc.	O-ringless seal couplings
GB0806652D0 (en) *	2008-04-11	2008-05-14	Glaxo Group Ltd	Anhydrous crystal form of orvepitant maleate

2008
- 2008-04-11 GB GBGB0806652.4A patent/GB0806652D0/en not_active Ceased
2009
- 2009-04-08 PE PE2009000500A patent/PE20091839A1/es not_active Application Discontinuation
- 2009-04-08 AR ARP090101268A patent/AR071311A1/es not_active Application Discontinuation
- 2009-04-09 SI SI200931110T patent/SI2297152T1/sl unknown
- 2009-04-09 JP JP2011503450A patent/JP5875863B2/ja active Active
- 2009-04-09 DK DK09731234.2T patent/DK2297152T3/da active
- 2009-04-09 US US12/936,407 patent/US8309553B2/en active Active
- 2009-04-09 PT PT9731234T patent/PT2297152E/pt unknown
- 2009-04-09 CL CL2009000876A patent/CL2009000876A1/es unknown
- 2009-04-09 TW TW098111752A patent/TW201002714A/zh unknown
- 2009-04-09 AU AU2009235440A patent/AU2009235440B2/en active Active
- 2009-04-09 CA CA2721119A patent/CA2721119C/en active Active
- 2009-04-09 CN CN200980122132.9A patent/CN102066376B/zh active Active
- 2009-04-09 ES ES09731234.2T patent/ES2529295T3/es active Active
- 2009-04-09 EA EA201071183A patent/EA017082B1/ru not_active IP Right Cessation
- 2009-04-09 KR KR1020107025211A patent/KR20110002090A/ko not_active Ceased
- 2009-04-09 EP EP09731234.2A patent/EP2297152B1/en active Active
- 2009-04-09 BR BRPI0911678A patent/BRPI0911678B8/pt active IP Right Grant
- 2009-04-09 HR HRP20141196AT patent/HRP20141196T1/hr unknown
- 2009-04-09 WO PCT/EP2009/054295 patent/WO2009124996A1/en not_active Ceased
- 2009-04-09 PL PL09731234T patent/PL2297152T3/pl unknown
- 2009-04-09 RS RS20150008A patent/RS53732B1/sr unknown
- 2009-04-09 MX MX2010011152A patent/MX2010011152A/es active IP Right Grant
- 2009-04-13 UY UY0001031758A patent/UY31758A/es not_active Application Discontinuation
2010
- 2010-10-06 ZA ZA2010/07120A patent/ZA201007120B/en unknown
- 2010-10-10 IL IL208597A patent/IL208597A0/en active IP Right Grant
2014
- 2014-06-09 JP JP2014118775A patent/JP2014205688A/ja active Pending
2015
- 2015-01-29 CY CY20151100093T patent/CY1115961T1/el unknown

Also Published As

Publication number	Publication date
CN102066376A (zh)	2011-05-18
HRP20141196T1 (hr)	2015-02-13
JP5875863B2 (ja)	2016-03-02
EP2297152A1 (en)	2011-03-23
CY1115961T1 (el)	2017-01-25
WO2009124996A1 (en)	2009-10-15
PT2297152E (pt)	2015-02-16
TW201002714A (en)	2010-01-16
CN102066376B (zh)	2014-01-01
CA2721119A1 (en)	2009-10-15
DK2297152T3 (da)	2015-01-26
US20110166150A1 (en)	2011-07-07
CA2721119C (en)	2016-04-05
CL2009000876A1 (es)	2010-05-14
PL2297152T3 (pl)	2015-04-30
GB0806652D0 (en)	2008-05-14
BRPI0911678B1 (pt)	2021-03-02
RS53732B1 (sr)	2015-06-30
UY31758A (es)	2009-11-10
BRPI0911678B8 (pt)	2021-05-25
SI2297152T1 (sl)	2015-02-27
AU2009235440A1 (en)	2009-10-15
JP2011516532A (ja)	2011-05-26
KR20110002090A (ko)	2011-01-06
JP2014205688A (ja)	2014-10-30
EA017082B1 (ru)	2012-09-28
EA201071183A1 (ru)	2011-06-30
US8309553B2 (en)	2012-11-13
AU2009235440B2 (en)	2012-06-14
MX2010011152A (es)	2010-12-21
PE20091839A1 (es)	2010-01-07
EP2297152B1 (en)	2014-11-12
AR071311A1 (es)	2010-06-09
IL208597A0 (en)	2010-12-30
ES2529295T3 (es)	2015-02-18
ZA201007120B (en)	2011-11-30

Legal Events

Date	Code	Title	Description
2016-09-27	B25C	Requirement related to requested transfer of rights	Owner name: GLAXO GROUP LIMITED (GB) Free format text: A FIM DE ATENDER A TRANSFERENCIA, REQUERIDA ATRAVES DA PETICAO NO 20130082868 DE 15/10/2013, E NECESSARIO APRESENTAR O DOCUMENTO COM A DEVIDA LEGALIZACAO CONSULAR.
2017-02-14	B25L	Entry of change of name and/or headquarter and transfer of application, patent and certificate of addition of invention: publication cancelled	Owner name: GLAXO GROUP LIMITED (GB)
2017-03-07	B25A	Requested transfer of rights approved	Owner name: NERRE THERAPEUTICS LIMITED (GB)
2018-03-06	B07D	Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
2018-04-17	B06F	Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
2019-07-16	B07E	Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]	Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI
2019-07-23	B06U	Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
2020-03-17	B09A	Decision: intention to grant [chapter 9.1 patent gazette]
2021-03-02	B16A	Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]	Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 02/03/2021, OBSERVADAS AS CONDICOES LEGAIS.
2021-05-25	B16C	Correction of notification of the grant [chapter 16.3 patent gazette]	Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 09/04/2009 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF

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