BRPI0911971A2 - derivados de 2h-pirimido[2,1,b] quinazolin-2-ona e seu uso como agentes antiagregantes de plaqueta. - Google Patents

derivados de 2h-pirimido[2,1,b] quinazolin-2-ona e seu uso como agentes antiagregantes de plaqueta.

Info

Publication number
BRPI0911971A2
BRPI0911971A2 BRPI0911971A BRPI0911971A BRPI0911971A2 BR PI0911971 A2 BRPI0911971 A2 BR PI0911971A2 BR PI0911971 A BRPI0911971 A BR PI0911971A BR PI0911971 A BRPI0911971 A BR PI0911971A BR PI0911971 A2 BRPI0911971 A2 BR PI0911971A2
Authority
BR
Brazil
Prior art keywords
pyrimido
quinazolin
derivatives
antiplatelet agents
antiplatelet
Prior art date
Application number
BRPI0911971A
Other languages
English (en)
Inventor
Bernard Golding
Richard Franklin
Original Assignee
Shire Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shire Llc filed Critical Shire Llc
Publication of BRPI0911971A2 publication Critical patent/BRPI0911971A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
BRPI0911971A 2008-05-16 2009-05-13 derivados de 2h-pirimido[2,1,b] quinazolin-2-ona e seu uso como agentes antiagregantes de plaqueta. BRPI0911971A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0808967.4A GB0808967D0 (en) 2008-05-16 2008-05-16 Substitute quinazolines
PCT/GB2009/050511 WO2009138791A1 (en) 2008-05-16 2009-05-13 2h- pyrimido [2, 1-b] quinaz0lin-2-0ne derivatives and their use as platelet anti-aggregative agents

Publications (1)

Publication Number Publication Date
BRPI0911971A2 true BRPI0911971A2 (pt) 2015-10-13

Family

ID=39596042

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0911971A BRPI0911971A2 (pt) 2008-05-16 2009-05-13 derivados de 2h-pirimido[2,1,b] quinazolin-2-ona e seu uso como agentes antiagregantes de plaqueta.

Country Status (9)

Country Link
US (1) US20110071171A1 (pt)
EP (1) EP2297157A1 (pt)
JP (1) JP2011520861A (pt)
CN (1) CN102076698A (pt)
AU (1) AU2009247792A1 (pt)
BR (1) BRPI0911971A2 (pt)
CA (1) CA2724216A1 (pt)
GB (1) GB0808967D0 (pt)
WO (1) WO2009138791A1 (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7910597B2 (en) * 2006-11-28 2011-03-22 Shire Llc Substituted quinazolines
US8304420B2 (en) * 2006-11-28 2012-11-06 Shire Llc Substituted quinazolines for reducing platelet count
GB201412379D0 (en) 2014-07-11 2014-08-27 Rolls Royce Plc Ventilation inlet
JP2023533016A (ja) 2020-07-11 2023-08-01 ファイザー・インク 抗ウイルス性ヘテロアリールケトン誘導体
US11351149B2 (en) 2020-09-03 2022-06-07 Pfizer Inc. Nitrile-containing antiviral compounds

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3932407A (en) * 1973-11-19 1976-01-13 Bristol-Myers Company Optionally substituted 1,2,3,5-tetrahydroimidezo(2,1-b)-quinazolin-2-ones and 6(H)-1,2,3,4-tetrahydropyimido(2,1-b)quinazolin-2-ones
US3983119A (en) * 1974-11-06 1976-09-28 Bristol-Myers Company Process for the preparation of optionally substituted 1,2,3,5-tetrahydroimidazo[2,1-b]quinazolin-2-ones
NL7807507A (nl) * 1977-07-25 1979-01-29 Hoffmann La Roche Tricyclische verbindingen.
US4146718A (en) * 1978-04-10 1979-03-27 Bristol-Myers Company Alkyl 5,6-dichloro-3,4-dihydro-2(1h)-iminoquinazoline-3-acetate hydrohalides
US4943573A (en) * 1989-11-01 1990-07-24 Bristol-Myers Squibb Company Imidazo[4,5-b]quinolinyloxyalkanoic acid amides with enhanced water solubility
DK0571253T3 (da) * 1992-05-19 1999-07-19 Adir Benzimidazolderivater med antidiabetisk og antiblodpladekoagulerende virkning
US20060030574A1 (en) * 2004-08-04 2006-02-09 Shire Holdings Ag Quinazoline derivatives useful for the treatment of peripheral arterial disease and as phosphodiesterase inhibitors
US7700608B2 (en) * 2004-08-04 2010-04-20 Shire Holdings Ag Quinazoline derivatives and their use in the treatment of thrombocythemia

Also Published As

Publication number Publication date
GB0808967D0 (en) 2008-06-25
JP2011520861A (ja) 2011-07-21
EP2297157A1 (en) 2011-03-23
US20110071171A1 (en) 2011-03-24
CN102076698A (zh) 2011-05-25
WO2009138791A1 (en) 2009-11-19
CA2724216A1 (en) 2009-11-19
AU2009247792A1 (en) 2009-11-19

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 6A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2344 DE 08-12-2015 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.