BRPI0911989A2 - uniões micélicas - Google Patents

uniões micélicas

Info

Publication number
BRPI0911989A2
BRPI0911989A2 BRPI0911989A BRPI0911989A BRPI0911989A2 BR PI0911989 A2 BRPI0911989 A2 BR PI0911989A2 BR PI0911989 A BRPI0911989 A BR PI0911989A BR PI0911989 A BRPI0911989 A BR PI0911989A BR PI0911989 A2 BRPI0911989 A2 BR PI0911989A2
Authority
BR
Brazil
Prior art keywords
mycelic
unions
mycelic unions
Prior art date
Application number
BRPI0911989A
Other languages
English (en)
Inventor
Allan S Hoffman
Amber Paschal
Anna Gall
Anthony J Convertine
Charbel Diab
Craig L Duvall
Danielle Benoit
Mary Prieve
Patrick S Stayton
Paul Johnson
Priyadarsi De
Robert Overell
Original Assignee
Phaserx Inc
Univ Washington
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Phaserx Inc, Univ Washington filed Critical Phaserx Inc
Publication of BRPI0911989A2 publication Critical patent/BRPI0911989A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
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    • C08F290/00—Macromolecular compounds obtained by polymerising monomers on to polymers modified by introduction of aliphatic unsaturated end or side groups
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    • C08F290/06—Polymers provided for in subclass C08G
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    • C08F293/00—Macromolecular compounds obtained by polymerisation on to a macromolecule having groups capable of inducing the formation of new polymer chains bound exclusively at one or both ends of the starting macromolecule
    • C08F293/005—Macromolecular compounds obtained by polymerisation on to a macromolecule having groups capable of inducing the formation of new polymer chains bound exclusively at one or both ends of the starting macromolecule using free radical "living" or "controlled" polymerisation, e.g. using a complexing agent
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
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    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Biophysics (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Plant Pathology (AREA)
  • Polymers & Plastics (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Dispersion Chemistry (AREA)
  • Obesity (AREA)
  • Nanotechnology (AREA)
  • Rheumatology (AREA)
BRPI0911989A 2008-05-13 2009-05-13 uniões micélicas BRPI0911989A2 (pt)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US5291408P 2008-05-13 2008-05-13
US5290808P 2008-05-13 2008-05-13
US9129408P 2008-08-22 2008-08-22
US11204808P 2008-11-06 2008-11-06
US14077408P 2008-12-24 2008-12-24
US17136909P 2009-04-21 2009-04-21
PCT/US2009/043849 WO2009140429A2 (en) 2008-05-13 2009-05-13 Micellic assemblies

Publications (1)

Publication Number Publication Date
BRPI0911989A2 true BRPI0911989A2 (pt) 2015-10-20

Family

ID=41319324

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0911989A BRPI0911989A2 (pt) 2008-05-13 2009-05-13 uniões micélicas

Country Status (13)

Country Link
US (4) US9339558B2 (pt)
EP (1) EP2285853B1 (pt)
JP (2) JP5755563B2 (pt)
KR (1) KR101764427B1 (pt)
CN (1) CN102066444A (pt)
AU (1) AU2009246329B8 (pt)
BR (1) BRPI0911989A2 (pt)
CA (1) CA2724014C (pt)
ES (1) ES2404136T3 (pt)
IL (1) IL209239A0 (pt)
MX (1) MX2010012239A (pt)
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Families Citing this family (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7981688B2 (en) 2007-03-08 2011-07-19 University Of Washington Stimuli-responsive magnetic nanoparticles and related methods
US8034396B2 (en) 2008-04-01 2011-10-11 Tyco Healthcare Group Lp Bioadhesive composition formed using click chemistry
ES2404136T3 (es) 2008-05-13 2013-05-24 University Of Washington Ensamblajes micelares
ES2404131T3 (es) 2008-05-13 2013-05-24 University Of Washington Copolímeros de dibloques y sus complejos con polinucleótidos para el suministro en células
CN102065902A (zh) * 2008-05-13 2011-05-18 华盛顿大学 聚合物载体
JP2012500793A (ja) 2008-08-22 2012-01-12 ユニヴァーシティ オブ ワシントン 細胞内デリバリーのための異種性ポリマーミセル
CA2742880A1 (en) * 2008-11-06 2010-05-14 University Of Washington Multiblock copolymers
JP2012507581A (ja) 2008-11-06 2012-03-29 ユニヴァーシティ オブ ワシントン 二重特異性細胞内送達媒体
WO2010077678A2 (en) 2008-12-08 2010-07-08 University Of Washington Omega-functionalized polymers, junction-functionalized block copolymers, polymer bioconjugates, and radical chain extension polymerization
US8535477B2 (en) 2009-02-21 2013-09-17 Sofradim Production Medical devices incorporating functional adhesives
US8877170B2 (en) 2009-02-21 2014-11-04 Sofradim Production Medical device with inflammatory response-reducing coating
US8968733B2 (en) 2009-02-21 2015-03-03 Sofradim Production Functionalized surgical adhesives
US8512728B2 (en) 2009-02-21 2013-08-20 Sofradim Production Method of forming a medical device on biological tissue
US8663689B2 (en) 2009-02-21 2014-03-04 Sofradim Production Functionalized adhesive medical gel
US8426214B2 (en) 2009-06-12 2013-04-23 University Of Washington System and method for magnetically concentrating and detecting biomarkers
US9080933B2 (en) 2009-11-09 2015-07-14 University Of Washington Through Its Center For Commercialization Stimuli-responsive polymer diagnostic assay comprising magnetic nanoparticles and capture conjugates
US20130017167A1 (en) * 2009-11-13 2013-01-17 University Of Washington Through Its Center For Commercialization Hydrophobic block conjugated therapeutic agents
WO2011062965A2 (en) 2009-11-18 2011-05-26 University Of Washington Through Its Center For Commercialization Targeting monomers and polymers having targeting blocks
EP2553019A1 (en) 2010-03-26 2013-02-06 Mersana Therapeutics, Inc. Modified polymers for delivery of polynucleotides, method of manufacture, and methods of use thereof
AU2011276443A1 (en) 2010-06-29 2013-01-31 Covidien Lp Microwave-powered reactor and method for in situ forming implants
WO2012001532A2 (en) 2010-07-01 2012-01-05 Sofradim Production Medical device with predefined activated cellular integration
CA2811692C (en) 2010-09-22 2020-02-18 The Board Of Regents Of The University Of Texas System Novel block copolymer and micelle compositions and methods of use thereof
JP5952423B2 (ja) * 2011-12-15 2016-07-13 バイオニア コーポレーションBioneer Corporation 新規オリゴヌクレオチド接合体およびその用途
EP2807177B1 (en) * 2012-01-27 2019-11-13 The Regents of The University of California Stabilization of biomolecules using sugar polymers
US9808480B2 (en) 2012-04-27 2017-11-07 Nanocarrier Co., Ltd. Unit structure-type pharmaceutical composition for nucleic acid delivery
WO2014015367A1 (en) * 2012-07-23 2014-01-30 The University Of Queensland Polymers for sirna delivery
US10046086B2 (en) 2012-09-21 2018-08-14 Vanderbilt University Poly(thioketal-urethane) scaffolds and methods of use
US9463261B2 (en) 2012-09-21 2016-10-11 Vanderbilt University Poly(thioketal-urethane) scaffolds and methods of use
US10172956B2 (en) * 2012-10-26 2019-01-08 Vanderbilt University Polymeric nanoparticles
EP2958557B1 (en) 2013-02-25 2019-11-27 University Of Rochester Nanoparticles for controlled release of anti-biofilm agents
CN103319661B (zh) * 2013-05-24 2015-05-20 天津大学 琼脂糖基硫代甜菜碱丙烯酸酯接枝聚合物及其制备方法
US9775928B2 (en) 2013-06-18 2017-10-03 Covidien Lp Adhesive barbed filament
AU2014296278C1 (en) 2013-07-30 2023-02-02 Genevant Sciences Gmbh Block copolymers and their conjugates or complexes with oligonucleotides
US10717803B2 (en) 2014-03-27 2020-07-21 Sika Technology Ag Block copolymer
US10695288B2 (en) 2014-11-19 2020-06-30 Vanderbilt University Reactive oxygen species (ROS)-responsive compositions and methods thereof
CN114642735A (zh) 2015-01-21 2022-06-21 菲泽尔克斯公司 用于将治疗剂和诊断剂递送到细胞中的方法、组合物和系统
WO2018026764A1 (en) 2016-08-01 2018-02-08 University Of Rochester Nanoparticles for controlled release of anti-biofilm agents and methods of use
EP3504188A4 (en) 2016-08-26 2020-04-22 Chelation Partners Incorporated Polymeric metal chelating compositions and methods of preparing same for controlling growth and activities of living cells and organisms
WO2018045317A1 (en) 2016-09-02 2018-03-08 Dicerna Pharmaceuticals, Inc. 4'-phosphate analogs and oligonucleotides comprising the same
ES3039978T3 (en) * 2016-10-04 2025-10-28 Univ Cornell Lubricating block copolymers and their use as biomimetic boundary lubricants
JP6912876B2 (ja) * 2016-10-06 2021-08-04 三洋化成工業株式会社 アクリル系医薬固形製剤用添加剤
SG11201903610TA (en) * 2016-10-28 2019-05-30 Oji Holdings Corp Pattern forming method, under coating agent, and laminate
US11684584B2 (en) 2016-12-30 2023-06-27 Genevant Sciences Gmbh Branched peg molecules and related compositions and methods
JP7169671B2 (ja) 2017-06-02 2022-11-11 テイカ製薬株式会社 難水溶性成分可溶化ミセル及びそれを含有する液剤
EP3677268A4 (en) 2017-08-31 2021-04-21 The University Of Tokyo UNIFORM POLYIONAL COMPLEX LOADED WITH NUCLEIC ACID
CN108392471B (zh) * 2018-03-01 2020-06-16 苏州大学张家港工业技术研究院 基于末端含硫辛酰基星型聚合物的纳米药物
IL282794B2 (en) * 2018-11-02 2025-06-01 Genevant Sciences Gmbh A membrane-destabilizing polymer and a nucleic acid conjugate for use in delivering a nucleic acid to a cell
CN109528648A (zh) * 2018-12-11 2019-03-29 中国药科大学 肿瘤基质微酸环境响应的两亲性高分子前药胶束及其制备方法和应用
SG11202110174PA (en) 2019-03-29 2021-10-28 Dicerna Pharmaceuticals Inc Compositions and methods for the treatment of kras associated diseases or disorders
AU2020268798A1 (en) 2019-05-03 2021-11-04 Dicerna Pharmaceuticals, Inc. Double-stranded nucleic acid inhibitor molecules with shortened sense strands
US20220226239A1 (en) * 2019-06-04 2022-07-21 Aravasc Inc. Polymeric micelle complexes, formulations, and uses thereof
JP2021046542A (ja) * 2019-09-10 2021-03-25 独立行政法人国立高等専門学校機構 両親媒性ブロック共重合体
JP2022547609A (ja) * 2019-09-13 2022-11-14 ザ・ボーイング・カンパニー 抗菌ナノワーム
CA3163857A1 (en) 2020-01-15 2021-07-22 Weimin Wang 4'-o-methylene phosphonate nucleic acids and analogues thereof
US11786464B2 (en) 2020-04-24 2023-10-17 The Board Of Regents Of The University Of Texas System PH responsive block copolymer compositions and micelles that inhibit MCT 1 and related proteins
JP7820306B2 (ja) * 2020-04-30 2026-02-25 ダウ グローバル テクノロジーズ エルエルシー Raft重合によるオレフィン-アクリレートブロックコポリマーを調製するためのプロセス
WO2022010764A1 (en) * 2020-07-06 2022-01-13 Vivtex Corporation Mucopenetrating formulations
CA3187220A1 (en) 2020-08-04 2022-02-10 Dicerna Pharmaceuticals, Inc. Systemic delivery of oligonucleotides
CN112279983B (zh) * 2020-10-30 2022-12-20 金陵科技学院 一种电荷翻转两亲嵌段共聚物、制备方法、前体聚合物、纳米胶束和应用
CN116887866A (zh) 2020-12-03 2023-10-13 巴特尔纪念研究院 聚合物纳米颗粒和dna纳米结构组合物及用于非病毒递送的方法
JP2024516108A (ja) 2021-04-07 2024-04-12 バテル・メモリアル・インスティテュート 非ウイルス性担体を同定および使用するための迅速な設計、構築、試験、および学習技術
WO2025038596A1 (en) * 2023-08-15 2025-02-20 University Of Washington De novo genetically-encodable polypeptides for extracellular protein degradation, and fusion proteins thereof
WO2025072751A1 (en) 2023-09-29 2025-04-03 Battelle Memorial Institute Polymer nanoparticle compositions for in vivo expression of polypeptides
US12441996B2 (en) 2023-12-08 2025-10-14 Battelle Memorial Institute Use of DNA origami nanostructures for molecular information based data storage systems

Family Cites Families (79)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5057313A (en) 1986-02-25 1991-10-15 The Center For Molecular Medicine And Immunology Diagnostic and therapeutic antibody conjugates
US4699784A (en) 1986-02-25 1987-10-13 Center For Molecular Medicine & Immunology Tumoricidal methotrexate-antibody conjugate
US4877603A (en) 1987-12-18 1989-10-31 The Procter & Gamble Company Oral compositions
US5219945A (en) * 1992-02-20 1993-06-15 E. I. Du Pont De Nemours And Company ABC triblock methacrylate polymers
US6359054B1 (en) 1994-11-18 2002-03-19 Supratek Pharma Inc. Polynucleotide compositions for intramuscular administration
CA2258744A1 (en) * 1996-06-27 1997-12-31 G.D. Searle And Co. Particles comprising amphiphilic copolymers, having a cross-linked shell domain and an interior core domain, useful for pharmaceutical and other applications
FR2767829B1 (fr) 1997-09-01 1999-12-03 Georges Sturtz Composes phosphonates ou gem-bisphosphonates acryliques ou methacryliques
US6410057B1 (en) 1997-12-12 2002-06-25 Samyang Corporation Biodegradable mixed polymeric micelles for drug delivery
DE69840175D1 (de) 1997-12-12 2008-12-11 Samyang Corp Biologisch abbaubare gemischte polymerische mizellen zur genverabreichung
US6383811B2 (en) 1997-12-30 2002-05-07 Mirus Corporation Polyampholytes for delivering polyions to a cell
EP2138191A1 (en) 1998-01-05 2009-12-30 University Of Washington Enhanced transport using membrane disruptive agents
DE10220470A1 (de) * 2002-04-30 2003-11-20 Roehm Gmbh ph-sensitives Polymer
US6306994B1 (en) 1999-05-14 2001-10-23 E. I. Du Pont De Nemours And Company Inks with enhanced substrate binding characteristics
US7098032B2 (en) 2001-01-02 2006-08-29 Mirus Bio Corporation Compositions and methods for drug delivery using pH sensitive molecules
US6916488B1 (en) * 1999-11-05 2005-07-12 Biocure, Inc. Amphiphilic polymeric vesicles
US7033607B2 (en) 1999-12-31 2006-04-25 Mirus Bio Corporation pH-titratable polyampholytes for delivering polyions to a cell
WO2001051092A2 (en) 2000-01-07 2001-07-19 University Of Washington Enhanced transport of agents using membrane disruptive agents
US20030134420A1 (en) 2000-02-18 2003-07-17 Lollo Charles Peter Methods and compositions for gene delivery
EP1286643A2 (en) 2000-05-17 2003-03-05 Labopharm Inc. Drug containing polymeric micelles
SE517421C2 (sv) 2000-10-06 2002-06-04 Bioglan Ab Mikropartiklar, lämpade för parenteral administration, väsentligen bestående av stärkelse med minst 85 % amylopektin och med reducerad molekylvikt, samt framställning därav
AU2002367709A1 (en) 2001-04-26 2003-10-27 Nanosphere, Inc. Oligonucleotide-modified romp polymers and co-polymers
US6780428B2 (en) 2001-06-08 2004-08-24 Labopharm, Inc. Unimolecular polymeric micelles with an ionizable inner core
US6939564B2 (en) * 2001-06-08 2005-09-06 Labopharm, Inc. Water-soluble stabilized self-assembled polyelectrolytes
US7094810B2 (en) 2001-06-08 2006-08-22 Labopharm, Inc. pH-sensitive block copolymers for pharmaceutical compositions
KR100566911B1 (ko) * 2001-06-25 2006-04-03 주식회사 삼양사 약물 전달체용 음이온기-함유 양친성 블록 공중합체 및 그의 양이온성 약물과의 복합체
WO2003050195A2 (en) * 2001-12-12 2003-06-19 Rhodia Chimie Method for depositing a polymer onto a surface
CA2472170A1 (en) 2001-12-28 2003-07-24 Supratek Pharma Inc. Pharmaceutical compositions comprising polyanionic polymers and amphiphilic block copolymers and methods of use thereof to improve gene expression
JP3936966B2 (ja) * 2002-02-28 2007-06-27 サンノプコ株式会社 顔料塗被紙用塗料用コバインダーおよび顔料塗被紙
US20050220880A1 (en) 2002-03-07 2005-10-06 Lewis Andrew L Drug carriers comprising amphiphilic block copolymers
US7229973B2 (en) 2002-05-19 2007-06-12 You Han Bae pH-sensitive polymeric micelles for drug delivery
EP1400555A1 (en) 2002-09-17 2004-03-24 Kawamura Institute Of Chemical Research Water-soluble block copolymer and production method therefor
US7737237B2 (en) 2002-11-07 2010-06-15 Phodia Chimie Controlled structure copolymer comprising an amphoteric or zwitterionic part
US20070010632A1 (en) 2002-11-27 2007-01-11 Kaplan David L Antioxidant-functionalized polymers
CN100349963C (zh) 2002-12-30 2007-11-21 尼克塔治疗亚拉巴马公司 作为药物输送媒介物的多分支多肽-聚(乙二醇)嵌段共聚物
US7871818B2 (en) 2003-01-31 2011-01-18 Roche Madison Inc. Membrane active polymers
US7217776B1 (en) 2003-02-14 2007-05-15 Iowa State University Research Foundation pH-sensitive methacrylic copolymer gels and the production thereof
US20040162235A1 (en) 2003-02-18 2004-08-19 Trubetskoy Vladimir S. Delivery of siRNA to cells using polyampholytes
JP4535229B2 (ja) 2003-05-08 2010-09-01 国立大学法人 東京大学 ポリエチレングリコール−ポリカチオンブロック共重合体
WO2005021612A1 (en) * 2003-09-03 2005-03-10 Rhodia Inc New copolymer having a controlled structure, and use thereof
US7632905B2 (en) 2004-04-09 2009-12-15 L'oreal S.A. Block copolymer, composition comprising it and cosmetic treatment process
WO2005108614A2 (en) 2004-04-07 2005-11-17 Northwestern University Reversible and chemically programmable micelle assembly with dna block-copolymer amphiphiles
US8821859B2 (en) 2004-05-19 2014-09-02 Agency For Science, Technology And Research Methods and articles for the delivery of therapeutic agents
GB0418123D0 (en) 2004-08-13 2004-09-15 Asahi Chemical Ind Polymers useful as medical materials
WO2006060723A2 (en) 2004-12-03 2006-06-08 Vical Incorporated Methods for producing block copolymer/amphiphilic particles
WO2006071769A1 (en) 2004-12-28 2006-07-06 The Trustees Of The University Of Pennsylvania Controlled release from block co-polymer worm micelles
US20060171980A1 (en) 2005-02-01 2006-08-03 Helmus Michael N Implantable or insertable medical devices having optimal surface energy
JP2008534747A (ja) 2005-03-31 2008-08-28 エーピー ファーマ, インコーポレイテッド Peg−ポリアセタールグラフトコポリマーおよびpeg−ポリアセタール−poeグラフトコポリマーならびに医薬組成物
EP1868664A2 (en) 2005-04-15 2007-12-26 Interface Biologics Inc. Methods and compositions for the delivery of biologically active agents
US9139850B2 (en) 2005-05-19 2015-09-22 L'oreal Vectorization of dsRNA by cationic particles and topical use
JP5329949B2 (ja) 2005-05-31 2013-10-30 エコーレ ポリテクニーク フェデラーレ デ ローザンヌ 遺伝子に基づいた薬物の細胞質送達のためのトリブロックコポリマー
FR2890859B1 (fr) 2005-09-21 2012-12-21 Oreal Oligonucleotide d'arn double brin inhibant l'expression de la tyrosinase
WO2007109584A1 (en) 2006-03-16 2007-09-27 University Of Washington Temperature-and ph-responsive polymer compositions
EP2019691B1 (en) 2006-05-15 2020-08-12 Massachusetts Institute of Technology Polymers for functional particles
CN101501108A (zh) * 2006-07-05 2009-08-05 新加坡科技研究局 用于药物递送的胶束
BRPI0715375A2 (pt) 2006-08-18 2013-06-18 Hoffmann La Roche policonjugados para distribuiÇço in vivo de polinucleotÍdeos
JP2008050506A (ja) * 2006-08-25 2008-03-06 Canon Inc 組成物
US8414926B1 (en) 2006-09-12 2013-04-09 University Of South Florida Nanoparticles with covalently bound surfactant for drug delivery
US20080081075A1 (en) 2006-10-02 2008-04-03 National Tsing Hua University Multifunctional mixed micelle of graft and block copolymers and preparation thereof
GB0624729D0 (en) * 2006-12-12 2007-01-17 Univ Leeds Reversible micelles and applications for their use
WO2008071009A1 (en) 2006-12-15 2008-06-19 The Governors Of The University Of Alberta Novel ligand guided block copolymers for targeted drug delivery
AU2007343610C1 (en) 2007-01-17 2013-11-07 Immunomedics, Inc. Polymeric carriers of therapeutic agents and recognition moieties for antibody-based targeting of disease sites
US20080299177A1 (en) 2007-06-06 2008-12-04 Biovaluation & Analysis, Inc. Supramolecular Complexes for Use in Acoustically Mediated Intracellular Drug Delivery in vivo
EP2173382A4 (en) 2007-06-08 2012-11-14 Univ Queensland WOUND REPAIR COMPOSITION AND METHOD
US20080312134A1 (en) 2007-06-11 2008-12-18 Thomas Hirt Vesicles for active macromolecule delivery
KR20100037120A (ko) 2007-07-06 2010-04-08 노스이스턴 유니버시티 Rna 작용제의 양쪽성 컨주게이트를 포함하는 혼합 미쎌, 및 이의 용도
US20090036625A1 (en) 2007-08-01 2009-02-05 Chung Yuan Christian University Amphiphilic Polymer, Method for Forming the Same and Application thereof
EP2025348A1 (en) 2007-08-13 2009-02-18 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Targeted block copolymer micelles
ES2404136T3 (es) 2008-05-13 2013-05-24 University Of Washington Ensamblajes micelares
ES2404131T3 (es) 2008-05-13 2013-05-24 University Of Washington Copolímeros de dibloques y sus complejos con polinucleótidos para el suministro en células
CA2724472A1 (en) 2008-05-13 2009-11-19 University Of Washington Micelles for intracellular delivery of therapeutic agents
WO2009140423A2 (en) 2008-05-13 2009-11-19 University Of Washington Targeted polymer bioconjugates
CN102065902A (zh) 2008-05-13 2011-05-18 华盛顿大学 聚合物载体
JP2012500793A (ja) 2008-08-22 2012-01-12 ユニヴァーシティ オブ ワシントン 細胞内デリバリーのための異種性ポリマーミセル
EP2180004B1 (en) 2008-10-22 2011-05-18 Clariant Finance (BVI) Limited Olefinically unsaturated phosphonate compounds, polymers made therefrom and their use
US20110281934A1 (en) 2008-11-06 2011-11-17 Phaserx, Inc. Micelles of hydrophilically shielded membrane-destabilizing copolymers
CA2742880A1 (en) 2008-11-06 2010-05-14 University Of Washington Multiblock copolymers
JP2012507581A (ja) 2008-11-06 2012-03-29 ユニヴァーシティ オブ ワシントン 二重特異性細胞内送達媒体
US20100150952A1 (en) 2008-11-07 2010-06-17 University Of Washington pH-RESPONSIVE POLYMER CARRIER COMPOSITIONS FOR CYTOSOLIC PROTEIN DELIVERY
WO2010077678A2 (en) 2008-12-08 2010-07-08 University Of Washington Omega-functionalized polymers, junction-functionalized block copolymers, polymer bioconjugates, and radical chain extension polymerization

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